Unsupervised Learning of Semantic Audio Representations

Even in the absence of any explicit semantic annotation, vast collections of audio recordings provide valuable information for learning the categorical structure of sounds. We consider several class-agnostic semantic constraints that apply to unlabeled nonspeech audio: (i) noise and translations in time do not change the underlying sound category, (ii) a mixture of two sound events inherits the categories of the constituents, and (iii) the categories of events in close temporal proximity are likely to be the same or related. Without labels to ground them, these constraints are incompatible with classification loss functions. However, they may still be leveraged to identify geometric inequalities needed for triplet loss-based training of convolutional neural networks. The result is low-dimensional embeddings of the input spectrograms that recover 41% and 84% of the performance of their fully-supervised counterparts when applied to downstream query-by-example sound retrieval and sound event classification tasks, respectively. Moreover, in limited-supervision settings, our unsupervised embeddings double the state-of-the-art classification performance.Comment: Submitted to ICASSP 201

CNN Architectures for Large-Scale Audio Classification

Convolutional Neural Networks (CNNs) have proven very effective in image classification and show promise for audio. We use various CNN architectures to classify the soundtracks of a dataset of 70M training videos (5.24 million hours) with 30,871 video-level labels. We examine fully connected Deep Neural Networks (DNNs), AlexNet [1], VGG [2], Inception [3], and ResNet [4]. We investigate varying the size of both training set and label vocabulary, finding that analogs of the CNNs used in image classification do well on our audio classification task, and larger training and label sets help up to a point. A model using embeddings from these classifiers does much better than raw features on the Audio Set [5] Acoustic Event Detection (AED) classification task.Comment: Accepted for publication at ICASSP 2017 Changes: Added definitions of mAP, AUC, and d-prime. Updated mAP/AUC/d-prime numbers for Audio Set based on changes of latest Audio Set revision. Changed wording to fit 4 page limit with new addition

Maximising the impact of qualitative research in feasibility studies for randomised controlled trials: guidance for researchers

Feasibility studies are increasingly undertaken in preparation for randomised controlled trials in order to explore uncertainties and enable trialists to optimise the intervention or the conduct of the trial. Qualitative research can be used to examine and address key uncertainties prior to a full trial. We present guidance that researchers, research funders and reviewers may wish to consider when assessing or undertaking qualitative research within feasibility studies for randomised controlled trials. The guidance consists of 16 items within five domains: research questions, data collection, analysis, teamwork and reporting. Appropriate and well conducted qualitative research can make an important contribution to feasibility studies for randomised controlled trials. This guidance may help researchers to consider the full range of contributions that qualitative research can make in relation to their particular trial. The guidance may also help researchers and others to reflect on the utility of such qualitative research in practice, so that trial teams can decide when and how best to use these approaches in future studies

Glassy Solutions of the Kardar-Pasrisi-Zhang Equation

It is shown that the mode-coupling equations for the strong-coupling limit of the KPZ equation have a solution for d>4 such that the dynamic exponent z is 2 (with possible logarithmic corrections) and that there is a delta function term in the height correlation function = (A/k^{d+4-z}) \delta(w/k^z) where the amplitude A vanishes as d -> 4. The delta function term implies that some features of the growing surface h(x,t) will persist to all times, as in a glassy state.Comment: 11 pages, Revtex, 1 figure available upon request (same as figure 1 in ref [10]) Important corrections have been made which yield a much simpler picture of what is happening. We still find "glassy" solutions for d>4 where z is 2 (with possible logarithmic corrections). However, we now find no glassy solutions below d=4. A (linear) stability analysis (for d>4) has been included. Also one Author has been adde

Star-forming galaxies in low-redshift clusters: Data and integrated galaxy properties

This paper is a continuation of an ongoing study of the evolutionary processes affecting cluster galaxies. Both CCD R band and H alpha narrow-band imaging was used to determine photometric parameters (m_(r), r_(24), H alpha flux and equivalent width) and derive star formation rates for 227 CGCG galaxies in 8 low-redshift clusters. The galaxy sample is a subset of CGCG galaxies in an objective prism survey of cluster galaxies for H alpha emission. It is found that detection of emission-line galaxies in the OPS is 85%, 70%, and 50% complete at the mean surface brightness values of 1.25 x 10^(-19), 5.19 x 10^(-20), and 1.76 x 10^(-20) W m^(-2) arcsec^(-2), respectively, measured within the R band isophote of 24 mag arcsec^(-2) for the galaxy. The CCD data, together with matched data from a recent H alpha galaxy survey of UGC galaxies within 3000 km s^(-1), will be used for a comparative study of R band and H alpha surface photometry between cluster and field spirals.Comment: Accepted for publication in A&A. 11 pages, including 6 figure

Quantitative trait loci for bone traits segregating independently of those for growth in an F-2 broiler X layer cross

An F broiler-layer cross was phenotyped for 18 skeletal traits at 6, 7 and 9 weeks of age and genotyped with 120 microsatellite markers. Interval mapping identified 61 suggestive and significant QTL on 16 of the 25 linkage groups for 16 traits. Thirty-six additional QTL were identified when the assumption that QTL were fixed in the grandparent lines was relaxed. QTL with large effects on the lengths of the tarsometatarsus, tibia and femur, and the weights of the tibia and femur were identified on GGA4 between 217 and 249 cM. Six QTL for skeletal traits were identified that did not co-locate with genome wide significant QTL for body weight and two body weight QTL did not coincide with skeletal trait QTL. Significant evidence of imprinting was found in ten of the QTL and QTL x sex interactions were identified for 22 traits. Six alleles from the broiler line for weight- and size-related skeletal QTL were positive. Negative alleles for bone quality traits such as tibial dyschondroplasia, leg bowing and tibia twisting generally originated from the layer line suggesting that the allele inherited from the broiler is more protective than the allele originating from the layer

GHASP : an H alpha kinematic survey of spiral and irregular galaxies. V. Dark matter distribution in 36 nearby spiral galaxies

The results obtained from a study of the mass distribution of 36 spiral galaxies are presented. The galaxies were observed using Fabry-Perot interferometry as part of the GHASP survey. The main aim of obtaining high resolution H alpha 2D velocity fields is to define more accurately the rising part of the rotation curves which should allow to better constrain the parameters of the mass distribution. The H alpha velocities were combined with low resolution HI data from the literature, when available. Combining the kinematical data with photometric data, mass models were derived from these rotation curves using two different functional forms for the halo: an isothermal sphere and an NFW profile. For the galaxies already modeled by other authors, the results tend to agree. Our results point at the existence of a constant density core in the center of the dark matter halos rather than a cuspy core, whatever the type of the galaxy from Sab to Im. This extends to all types the result already obtained by other authors studying dwarf and LSB galaxies but would necessitate a larger sample of galaxies to conclude more strongly. Whatever model is used (ISO or NFW), small core radius halos have higher central densities, again for all morphological types. We confirm different halo scaling laws, such as the correlations between the core radius and the central density of the halo with the absolute magnitude of a galaxy: low luminosity galaxies have small core radius and high central density. We find that the product of the central density with the core radius of the dark matter halo is nearly constant, whatever the model and whatever the absolute magnitude of the galaxy. This suggests that the halo surface density is independent from the galaxy type.Comment: 21 pages, 14 figures. MNRAS (accepted october 3rd 2007

Dose-dependent effects of Allopurinol on human foreskin fibroblast cell and human umbilical vein endothelial cell under hypoxia

Allopurinol, an inhibitor of xanthine oxidase, has been used in clinical trials of patients with cardiovascular and chronic kidney disease. These are two pathologies with extensive links to hypoxia and activation of the transcription factor hypoxia inducible factor (HIF) family. Here we analysed the effects of allopurinol treatment in two different cellular models, and their response to hypoxia. We explored the dose-dependent effect of allopurinol on Human Foreskin Fibroblasts (HFF) and Human Umbilical Vein Endothelial Cells (HUVEC) under hypoxia and normoxia. Under normoxia and hypoxia, high dose allopurinol reduced the accumulation of HIF-1α protein in HFF and HUVEC cells. Allopurinol had only marginal effects on HIF-1α mRNA level in both cellular systems. Interestingly, allopurinol effects over the HIF system were independent of prolyl-hydroxylase activity. Finally, allopurinol treatment reduced angiogenesis traits in HUVEC cells in an in vitro model. Taken together these results indicate that high doses of allopurinol inhibits the HIF system and pro-angiogenic traits in cells