Welfare Reform in Maryland: Flexibility in Action

This site visit took federal participants on a tour around Maryland, providing a three-way comparison of suburban, urban, and rural service delivery in a diverse state. The site visit focused on the Family Investment Program, a statewide effort to reduce the state\u27s welfare caseload through temporary cash assistance (TCA) and other needed supports to help customers become self-sufficient. In particular, site visitors examined rural perspectives on reform, substance abuse assessment and treatment innovations, and fatherhood and family support initiatives. The group heard from state officials, researchers, advocates, and a variety of direct service providers about the successes and challenges of the Family Investment Program and the effects of program implementation on low-income families. Site visitors had several opportunities to meet and interact with TCA customers to gain a clearer perspective of the issues faced each day

A NEWLY FORMING COLD FLOW PROTOGALACTIC DISK, A SIGNATURE of COLD ACCRETION from the COSMIC WEB

How galaxies form from, and are fueled by, gas from the intergalactic medium (IGM) remains one of the major unsolved problems in galaxy formation. While the classical Cold Dark Matter paradigm posits galaxies forming from cooling virialized gas, recent theory and numerical simulations have highlighted the importance of cold accretion flows - relatively cool (T ∼ few × 104 K) unshocked gas streaming along filaments into dark matter halos, including hot, massive, high-redshift halos. These flows are thought to deposit gas and angular momentum into the circumgalactic medium resulting in disk- or ring-like structures, eventually coalescing into galaxies forming at filamentary intersections. We earlier reported a bright, Lyα emitting filament near the QSO HS1549+19 at redshift z = 2.843 discovered with the Palomar Cosmic Web Imager. We now report that the bright part of this filament is an enormous (R > 100 kpc) rotating structure of hydrogen gas with a disk-like velocity profile consistent with a 4 × 1012 M o halo. The orbital time of the outer part of the what we term a "protodisk" is comparable to the virialization time and the age of the universe at this redshift. We propose that this protodisk can only have recently formed from cold gas flowing directly from the cosmic we

Experimental Implementation of Discrete Time Quantum Random Walk on an NMR Quantum Information Processor

We present an experimental implementation of the coined discrete time quantum walk on a square using a three qubit liquid state nuclear magnetic resonance (NMR) quantum information processor (QIP). Contrary to its classical counterpart, we observe complete interference after certain steps and a periodicity in the evolution. Complete state tomography has been performed for each of the eight steps making a full period. The results have extremely high fidelity with the expected states and show clearly the effects of quantum interference in the walk. We also show and discuss the importance of choosing a molecule with a natural Hamiltonian well suited to NMR QIP by implementing the same algorithm on a second molecule. Finally, we show experimentally that decoherence after each step makes the statistics of the quantum walk tend to that of the classical random walk.Comment: revtex4, 8 pages, 6 figures, submitted to PR

MODELING TRIBAL LEADERSHIP DYNAMICS: AN OPINION DYNAMICS MODEL OF PASHTUN LEADERSHIP SELECTION

We propose a new approach to modeling the selection of leaders in Pashtun tribal society. Pashtuns are the largest tribal group in Afghanistan. In traditional Pashtun society, leadership is manifested as an informal power system where potential leaders gain and maintain their position by means of group consensus. Leadership power is spread over three areas of influence resulting in a triad of leadership roles. These leaders compete, vying for power and control based on public opinion. The addition of extremists into this system who utilize threats of harm to gain power disrupts the traditional system, altering the balance of power. In this research we implement a bounded confidence opinion dynamics model to describe the dynamics of Pashtun leadership selection and to describe the changes resulting from the addition of extremists to the system. Keywords

Early Detection of Ovarian Cancer with Conventional and Contrast-Enhanced Transvaginal Sonography: Recent Advances and Potential Improvements

Recently, there have been several major technical advances in the sonographic diagnosis of ovarian cancer in its early stages. These include improved assessment of tumor morphology with transvaginal sonography (TVS), and detection and characterization of tumor neovascularity with transvaginal color Doppler sonography (TV-CDS) and contrast-enhanced transvaginal sonography (CE-TVS). This paper will discuss and illustrate these improvements and describe how they enhance detection of early-stage ovarian cancer. Our initial experience with parametric mapping of CE-TVS will also be mentioned

Climatic versus biotic constraints on carbon and water fluxes in seasonally drought-affected ponderosa pine ecosystems

We investigated the relative importance of climatic versus biotic controls on gross primary production (GPP) and water vapor fluxes in seasonally drought-affected ponderosa pine forests. The study was conducted in young (YS), mature (MS), and old stands (OS) over 4 years at the AmeriFlux Metolius sites. Model simulations showed that interannual variation of GPP did not follow the same trends as precipitation, and effects of climatic variation were smallest at the OS (50%), and intermediate at the YS (<20%). In the young, developing stand, interannual variation in leaf area has larger effects on fluxes than climate, although leaf area is a function of climate in that climate can interact with age-related shifts in carbon allocation and affect whole-tree hydraulic conductance. Older forests, with well-established root systems, appear to be better buffered from effects of seasonal drought and interannual climatic variation. Interannual variation of net ecosystem exchange (NEE) was also lowest at the OS, where NEE is controlled more by interannual variation of ecosystem respiration, 70% of which is from soil, than by the variation of GPP, whereas variation in GPP is the primary reason for interannual changes in NEE at the YS and MS. Across spatially heterogeneous landscapes with high frequency of younger stands resulting from natural and anthropogenic disturbances, interannual climatic variation and change in leaf area are likely to result in large interannual variation in GPP and NEE

Subnanogram proteomics: impact of LC column selection, MS instrumentation and data analysis strategy on proteome coverage for trace samples

One of the greatest challenges for mass spectrometry (MS)-based proteomics is the limited ability to analyze small samples. Here we investigate the relative contributions of liquid chromatography (LC), MS instrumentation and data analysis methods with the aim of improving proteome coverage for sample sizes ranging from 0.5 ng to 50 ng. We show that the LC separations utilizing 30-μm-i.d. columns increase signal intensity by >3-fold relative to those using 75-μm-i.d. columns, leading to 32% increase in peptide identifications. The Orbitrap Fusion Lumos MS significantly boosted both sensitivity and sequencing speed relative to earlier generation Orbitraps (e.g., LTQ-Orbitrap), leading to a ∼3-fold increase in peptide identifications and 1.7-fold increase in identified protein groups for 2 ng tryptic digests of the bacterium S. oneidensis. The Match Between Runs algorithm of open-source MaxQuant software further increased proteome coverage by ∼ 95% for 0.5 ng samples and by ∼42% for 2 ng samples. Using the best combination of the above variables, we were able to identify >3,000 proteins from 10 ng tryptic digests from both HeLa and THP-1 mammalian cell lines. We also identified >950 proteins from subnanogram archaeal/bacterial cocultures. The present ultrasensitive LC-MS platform achieves a level of proteome coverage not previously realized for ultra-small sample loadings, and is expected to facilitate the analysis of subnanogram samples, including single mammalian cells

S100A12 in Digestive Diseases and Health: A Scoping Review

Calgranulin proteins are an important class of molecules involved in innate immunity. These members of the S100 class of the EF-hand family of calcium-binding proteins have numerous cellular and antimicrobial functions. One protein in particular, S100A12 (also called EN-RAGE or calgranulin C), is highly abundant in neutrophils during acute inflammation and has been implicated in immune regulation. Structure-function analyses reveal that S100A12 has the capacity to bind calcium, zinc, and copper, processes that contribute to nutritional immunity against invading microbial pathogens. S100A12 is a ligand for the receptor for advanced glycation end products (RAGE), toll-like receptor 4 (TLR4), and CD36, which promote cellular and immunological pathways to alter inflammation. We conducted a scoping review of the existing literature to define what is known about the association of S100A12 with digestive disease and health. Results suggest that S100A12 is implicated in gastroenteritis, necrotizing enterocolitis, gastritis, gastric cancer, Crohn’s disease, irritable bowel syndrome, inflammatory bowel disease, and digestive tract cancers. Together, these results reveal S100A12 is an important molecule broadly associated with the pathogenesis of digestive diseases

A Newly Forming Cold Flow Protogalactic Disk, a Signature of Cold Accretion from the Cosmic Web

How galaxies form from, and are fueled by, gas from the intergalactic medium (IGM) remains one of the major unsolved problems in galaxy formation. While the classical Cold Dark Matter paradigm posits galaxies forming from cooling virialized gas, recent theory and numerical simulations have highlighted the importance of cold accretion flows—relatively cool (T ~ few × 104 K) unshocked gas streaming along filaments into dark matter halos, including hot, massive, high-redshift halos. These flows are thought to deposit gas and angular momentum into the circumgalactic medium resulting in disk- or ring-like structures, eventually coalescing into galaxies forming at filamentary intersections. We earlier reported a bright, Lyα emitting filament near the QSO HS1549+19 at redshift z = 2.843 discovered with the Palomar Cosmic Web Imager. We now report that the bright part of this filament is an enormous (R > 100 kpc) rotating structure of hydrogen gas with a disk-like velocity profile consistent with a 4 × 10^(12) M_⊙ halo. The orbital time of the outer part of the what we term a "protodisk" is comparable to the virialization time and the age of the universe at this redshift. We propose that this protodisk can only have recently formed from cold gas flowing directly from the cosmic web