Comparing Intravenous And Inhalation Anesthetics For Intraoperative Anesthesia In Adult Patients With An Acute Traumatic Brain Injury

As research and science has progressed to further analyze the effects of anesthetics on cerebral physiology, the margin of safety for each anesthetic is reassessed to enhance patient outcomes and recovery. The purpose of this review is to strategically examine and provide updated information on the impact of specific anesthetics administered during the intraoperative period as it applies to patients with acute traumatic brain injury (TBI). In efforts to preserve the cerebral physiology of the patient, current research has identified benefits of administering intravenous over inhalation anesthetics to reduce secondary injuries that have been linked to chronic TBI, morbidity, and mortality. Concentrating on common anesthetics used in the United States of America, research included in this review identified desflurane, sevoflurane, isoflurane, and nitrous oxide as the most studied and accessible inhalation anesthetics for this group of patients during the intraoperative period. Comparatively, intravenous anesthetics propofol, ketamine, benzodiazepines, opioids, and etomidate were more closely evaluated. At the conclusion of this review, the nurse anesthetist will be empowered with current clinical research to make a balanced and informed decision when caring for a patient with acute TBI

PoN-S : a systematic approach for applying the Physics of Notation (PoN)

Visual Modeling Languages (VMLs) are important instruments of communication between modelers and stakeholders. Thus, it is important to provide guidelines for designing VMLs. The most widespread approach for analyzing and designing concrete syntaxes for VMLs is the so-called Physics of Notation (PoN). PoN has been successfully applied in the analysis of several VMLs. However, despite its popularity, the application of PoN principles for designing VMLs has been limited. This paper presents a systematic approach for applying PoN in the design of the concrete syntax of VMLs. We propose here a design process establishing activities to be performed, their connection to PoN principles, as well as criteria for grouping PoN principles that guide this process. Moreover, we present a case study in which a visual notation for representing Ontology Pattern Languages is designed

The application of amino acid racemization in the acid soluble fraction of enamel to the estimation of the age of human teeth

Estimation of age-at-death for skeletonised forensic remains is one of the most significant problems in forensic anthropology. The majority of existing morphological and histological techniques are highly inaccurate, and show a bias towards underestimating the age of older individuals. One technique which has been successful in forensic age estimation is amino acid racemization in dentine. However, this method cannot be used on remains where the post-mortem interval is greater than 20 years. An alternative approach is to measure amino acid racemization in dental enamel, which is believed to be more resistant to change post-mortem. The extent of amino acid racemization in the acid soluble fraction of the enamel proteins was determined for modem known age teeth. A strong correlation was observed between the age of the tooth and the extent of racemization. No systematic bias in the direction of age estimation errors was detected. For the majority of teeth analyzed, the presence of dental caries did not affect the results obtained. In a minority of cases, carious teeth showed a higher level of racemization than would be expected given the age of the individual. These results indicate that amino acid racemization in enamel has the potential to be used in age estimation of skeletal remains. (C) 2007 Elsevier Ireland Ltd. All rights reserved

G-133: A soft x ray solar telescope

The GOLDHELOX Project, NASA payload number G-133, is a robotic soft x ray solar telescope designed and built by an organization of undergraduate students. The telescope is designed to observe the sun at a wavelength of 171 to 181 A. Since we require observations free from atmospheric interference, the telescope will be launched in a NASA Get-Away-Special (GAS) canister with a Motorized Door Assembly (MDA). In this paper we primarily discuss the most important elements of the telescope itself. We also elaborate on some of the technical difficulties associated with doing good science in space on a small budget (about $100,000) and mention ways in which controlling the instrument environment has reduced the complexity of the system and thus saved us money

Build a Leadership Greenhouse and Root Young Leaders in Learning Experiences

Over the years, the question of how to effectively use technology to facilitate student learning has dramatically changed. Although the benefits of e-Learning are numerous, recent employment surveys indicate that many employers think recent college graduates lack basic people and leadership skills. This paper suggests that when it comes to developing soft skills there is no substitute for learning by doing. A leadership class designed for graduating seniors will be discussed in terms of class activities selected to develop skills commonly associated with leadership. Student feedback suggested that they felt more confident about competing in today’s competitive job market

Population Pharmacokinetic and Pharmacodynamic Analysis of Buprenorphine for the Treatment of Neonatal Abstinence Syndrome

Neonatal abstinence syndrome (NAS) is a condition affecting newborns exposed to an opioid in utero. Symptoms of NAS include excessive crying, poor feeding, and disordered autonomic control. Up to 2/3 of infants will require pharmacologic therapies to reach symptom control. Opioids including morphine and methadone are the current first-line treatments. Buprenorphine is being investigated as a treatment of NAS. The purpose of this analysis was to evaluate the pharmacokinetics (PK) and pharmacodynamics (PD) of BUP in infants with NAS. Poster presented at American Society for Clinical Pharmacology and Therapeutics (ASCPT) 2017 Annual Meeting, March 15-18, 2017 in Washington DC.https://jdc.jefferson.edu/petposters/1004/thumbnail.jp

First measurement of the polarization observable E in the (p)over-right-arrow((gamma)over-right-arrow, pi(+))n reaction up to 2.25 GeV

First results from the longitudinally polarized frozen-spin target (FROST) program are reported. The double-polarization observable E, for the reaction (p) over right arrow((gamma) over right arrow, pi( + ))n, has been measured using a circularly polarized tagged-photon beam, with energies from 0.35 to 2.37 GeV. The final-state pions were detected with the CEBAF Large Acceptance Spectrometer in Hall B at the Thomas Jefferson National Accelerator Facility. These polarization data agree fairly well with previous partial-wave analyses at low photon energies. Over much of the covered energy range, however, significant deviations are observed, particularly in the high-energy region where high-L multipoles contribute. The data have been included in new multipole analyses resulting in updated nucleon resonance parameters. We report updated fits from the Bonn-Gatchina, Jfilich-Bonn, and SAID groups. (C) 2015 The Authors. Published by Elsevier B.V

(Anti)symmetric multivariate trigonometric functions and corresponding Fourier transforms

Four families of special functions, depending on n variables, are studied. We call them symmetric and antisymmetric multivariate sine and cosine functions. They are given as determinants or antideterminants of matrices, whose matrix elements are sine or cosine functions of one variable each. These functions are eigenfunctions of the Laplace operator, satisfying specific conditions at the boundary of a certain domain F of the n-dimensional Euclidean space. Discrete and continuous orthogonality on F of the functions within each family, allows one to introduce symmetrized and antisymmetrized multivariate Fourier-like transforms, involving the symmetric and antisymmetric multivariate sine and cosine functions.Comment: 25 pages, no figures; LaTaX; corrected typo