La chute des anges ; suivi de L'approche documentaire et la forme brève

La première partie de ce mémoire de maîtrise est un recueil de onze nouvelles. Réunies sous le titre « La Chute des anges », chacune propose, à sa façon, une rencontre. Le lecteur, qui traversera un recueil en apparence hétéroclite, fera ainsi successivement connaissance d'un vieil homme, d'un Indien quechua révolté, d'une vieille dame blessée, d'une future mariée ou d'une épouse déçue, etc. Il y visitera du même souffle le Pérou, une île de l'Atlantique ou le casino d'une grande ville. Chaque personnage y fait aussi en quelque sorte l'apprentissage de ses limites, qui sont celles d'un être humain devant un autre être humain, avec ce que cela implique de mystère et d'interrogation. En ce sens, ce recueil sera peut-être le récit d'une impuissance. Mais il peut aussi, du même souffle, devenir un hommage à la vie, dans son imperfection, et à l'ingéniosité humaine. La deuxième partie du mémoire est pour sa part consacrée à une réflexion sur l'apport documentaire en fiction et sur la forme brève privilégiée par l'auteur. Dans un premier temps, on y explore les liens étroits qui ont uni le journalisme et la fiction au cours des derniers siècles. On y retrouve plus particulièrement la pensée de Tom Wolfe, l'un des défenseurs de ce qu'on a appelé dans les années 1960 le nouveau journalisme, qui prétendait inventer une forme de journalisme se rapprochant de la fiction. L'auteur démontrera aussi comment le journalisme a servi de point de départ à son travail. Dans un deuxième temps, la réflexion portera sur le choix du genre bref, de la nouvelle en particulier, pour dire le monde moderne. Modelée par l'urgence, par le symbole, par les ellipses, mais aussi porte ouverte sur le temps, la nouvelle sait dire la face angoissante d'un monde fragmenté, où l'auteur part parfois à la recherche de lui-même. ______________________________________________________________________________ MOTS-CLÉS DE L’AUTEUR : Formes brèves, Nouvelles, Journalisme, Réalisme

Rain-on-Snow and Ice Layer Formation Detection Using Passive Microwave Radiometry: An Arctic Perspective

No abstract availabl

Disruption of AP1S1, Causing a Novel Neurocutaneous Syndrome, Perturbs Development of the Skin and Spinal Cord

Adaptor protein (AP) complexes regulate clathrin-coated vesicle assembly, protein cargo sorting, and vesicular trafficking between organelles in eukaryotic cells. Because disruption of the various subunits of the AP complexes is embryonic lethal in the majority of cases, characterization of their function in vivo is still lacking. Here, we describe the first mutation in the human AP1S1 gene, encoding the small subunit σ1A of the AP-1 complex. This founder splice mutation, which leads to a premature stop codon, was found in four families with a unique syndrome characterized by mental retardation, enteropathy, deafness, peripheral neuropathy, ichthyosis, and keratodermia (MEDNIK). To validate the pathogenic effect of the mutation, we knocked down Ap1s1 expression in zebrafish using selective antisens morpholino oligonucleotides (AMO). The knockdown phenotype consisted of perturbation in skin formation, reduced pigmentation, and severe motility deficits due to impaired neural network development. Both neural and skin defects were rescued by co-injection of AMO with wild-type (WT) human AP1S1 mRNA, but not by co-injecting the truncated form of AP1S1, consistent with a loss-of-function effect of this mutation. Together, these results confirm AP1S1 as the gene responsible for MEDNIK syndrome and demonstrate a critical role of AP1S1 in development of the skin and spinal cord

Advancing the research agenda on food systems governance and transformation

The food systems upon which humanity depends face multiple interdependent environmental, social and economic threats in the 21st Century. Yet, the governance of these systems, which determines to a large extent the ability to adapt and transform in response to these challenges, is underresearched. This perspective piece synthesises the findings of two recent reviews of food systems governance and transformations and proposes a comprehensive research agenda for the coming years. These reviews highlight the influence of governance on food systems, methodological obstacles to explaining the effectiveness of governance in realising food sustainability, and conditions that have historically supported food system transformations. We argue that the following steps are key to improving our knowledge of the role of governance in food systems: (1) developing more comparable research designs for building generalisable explanations of the governance elements that are most effective in realising food systems goals; (2) using the lens of polycentricity to help disentangle complex governance networks; (3) giving greater attention to the conditions and pre-conditions associated with historical food system transformations; (4) identifying adaptations that strengthen or weaken path dependency; and, (5) focusing research on how transformations can be supported by institutions that facilitate collective action and stakeholder agency

Consensus statement on physical rehabilitation in children and adolescents with osteogenesis imperfecta

On the occasion of the 13th International Conference on Osteogenesis imperfecta in August 2017 an expert panel was convened to develop an international consensus paper regarding physical rehabilitation in children and adolescents with Osteogenesis imperfecta. The experts were chosen based on their clinical experience with children with osteogenesis imperfecta and were identified by sending out questionnaires to specialized centers and patient organizations in 26 different countries. The final expert-group included 16 representatives (12 physiotherapists, two occupational therapists and two medical doctors) from 14 countries. Within the framework of a collation of personal experiences and the results of a literature search, the participating physiotherapists, occupational therapists and medical doctors formulated 17 expert-statements on physical rehabilitation in patients aged 0-18 years with osteogenesis imperfecta

Consensus statement on physical rehabilitation in children and adolescents with osteogenesis imperfecta

On the occasion of the 13th International Conference on Osteogenesis imperfecta in August 2017 an expert panel was convened to develop an international consensus paper regarding physical rehabilitation in children and adolescents with Osteogenesis imperfecta. The experts were chosen based on their clinical experience with children with osteogenesis imperfecta and were identified by sending out questionnaires to specialized centers and patient organizations in 26 different countries. The final expert-group included 16 representatives (12 physiotherapists, two occupational therapists and two medical doctors) from 14 countries. Within the framework of a collation of personal experiences and the results of a literature search, the participating physiotherapists, occupational therapists and medical doctors formulated 17 expert-statements on physical rehabilitation in patients aged 0-18 years with osteogenesis imperfecta