Assessing Perspective-Taking in Children through Different Formats of Deictic Framing Protocol

The modern behavioral account of human language and cognition known as Relational Frame Theory (RFT) has argued that deictic relations are key repertoires underlying the development of the ability to take the perspective of another individual. Several studies have employed a deictic framing-based test protocol as an assessment of perspective-taking. In recent years, the format of the protocol has been modified in different studies. However, no empirical investigations have compared the original protocol with the new formats. The present chapter reports two studies that investigated whether a deictic relational protocol based on modification from recent research demonstrated better performance versus traditional deictic relations measured, with typically developing children. Results of Study 1 showed that variability in the scenarios proposed by recent research could be the best option, although a series of modifications should be made for the target population. Results of Study 2 showed that a combination of both original and new protocols of deictic relations gave a better performance on the perspective-taking task in the sample used. This chapter supports the need to adapt perspective-taking protocol to the work with children

Tribo-mechanical and cellular behavior of superficially modified porous titanium samples using femtosecond laser

Abstract: In this work, the surface of porous titanium samples obtained by the space-holder technique was treated with a femtosecond laser to improve their osseointegration. Instrumented micro-indentation and scratch test were implemented to evaluate the tribo-mechanical behavior of the surface of the modified samples. A detailed study of micro-hardness, stiffness, scratch resistance and elastic recovery was performed. Also, in vitro analysis was carried out to evaluate the cellular behavior. Modified samples showed less ALP activity, which could indicate a greater differentiation of the cells. The cell culture was similar in all cases although more differentiated morphology, good cell adherence and biological response were observed on treated samples. Finally, the discs with a pore size between 100–200 μm present being potential candidates for the replacement of small portions of damaged cortical bone tissues.Ministerio de Ciencia e Innovación; PID2019-109371GB-I00 Junta de Andalucía; US-125977

Factors for the development of computational thinking in undergraduate students

El pensamiento computacional, asociado con disciplinas de ingeniería e informática, puede promoverse en otras áreas, ya que excede el fomentar las habilidades propias de la computación y abarca procesos de pensamientos crítico, lateral y creativo. Se partió de la pregunta ¿Cuáles son las diferencias en las dimensiones del pensamiento computacional entre áreas disciplinares de estudiantes de pregrado? Se trabajó con un diseño de estudio transversal y de muestreo por conveniencia, con una escala de 29 ítems para evaluar el pensamiento computacional en 95 estudiantes de pregrado, que estudian diversas disciplinas en dos universidades mexicanas. Los resultados ubicaron que si había diferencias con los estudiantes de ingeniería que tienen mayor pensamiento crítico, algorítmico, solución de problemas. En cooperación y creatividad no se ubicaron diferencias significativas entre estudiantes de psicología, informática administrativa e ingeniería. Este artículo pretende ser de valor para la comunidad académica interesada en escenarios que promuevan resolución de problemasComputational thinking, commonly associated with engineering and computer science disciplines, can be analyzed in other areas, since this process exceeds the fostering of computing skills and encompasses critical, lateral and creative thinking processes. This article was based on the question: What are the differences in the dimensions of computational thinking among disciplinary areas of undergraduate students? We worked with a cross-sectional study design and convenience sampling, with a 29-item scale to evaluate computational thinking in 95 undergraduate students studying various disciplines in two Mexican universities. The results showed that there were differences with engineering students who have greater critical, algorithmic and problem-solving thinking. In cooperativity and creativity, no significant differences were found between psychology, administrative informatics and engineering students. This article is intended to be of value to researchers, academics, students and decision makers interested in creating scenarios that promote problem solvin

Stability and pKa Modulation of Aminophenoxazinones and Their Disulfide Mimics by Host-Guest Interaction with Cucurbit[7]uril. Direct Applications in Agrochemical Wheat Models

Aqueous solubility and stability often limit the application of aminophenoxazinones and their sulfur mimics as promising agrochemicals in a sustainable agriculture inspired by allelopathy. This paper presents a solution to the problem using host-guest complexation with cucurbiturils (CBn). Computational studies show that CB7 is the most suitably sized homologue due to its strong affinity for guest molecules and its high water solubility. Complex formation has been studied by direct titrations monitored using UV-vis spectroscopy, finding a preferential interaction with protonated aminophenoxazinone species with high binding affinities (CB7 center dot APOH+ , Ka = (1.85 +/- 0.37) x 106 M-1; CB7 center dot DiS-NH3+ , Ka = (3.91 +/- 0.53) x 104 M-1; and DiS-(NH3+)2 , Ka= (1.27 +/- 0.42) x 105M-1). NMR characterization and stability analysis were also performed and revealed an interesting pKa modulation and stabilization by cucurbiturils (2-amino-3H-phenoxazin-3-one (APO), pKa = 2.94 +/- 0.30, and CB7 center dot APO, pKa = 4.12 +/- 0.15; 2,2 '-disulfanediyldianiline (DiS-NH2), pKa = 2.14 +/- 0.09, and CB7 center dot DiS-NH2 , pKa = 3.26 +/- 0.09), thus favoring applications in different kinds of crop soils. Kinetic studies have demonstrated the stability of the CB7 center dot APO complex at different pH media for more than 90 min. An in vitro bioassay with etiolated wheat coleoptiles showed that the bioactivity of APO and DiS-NH2 is enhanced upon complexation

Citodiagnóstico conjuntival en el perro

En este trabajo se presentan las imágenes citológicas obtenidas al realizar raspados conjuntivales, tanto de perros sin alteración ocular, como de perros con conjuntivitis.In this paper, we describe the cytologic results of conjunctival scrapings in dogs without ocular disease and dogs with conjunctivitis

Virtual reality and augmented reality as strategies for teaching social skills to individuals with intellectual disability: a systematic review

Virtual reality (VR) and augmented reality (AR) programs have proliferated significantly in recent years and they are finding their way into different educational and therapeutic purposes. This systematic review aims at analyzing the virtual reality and augmented reality programs designed to promote the development of social skills in individuals with intellectual disability. Searches were carried out in the Scopus, Science Direct, Springer and Web of Science databases in the period from 2005 to 2020. A total of six articles met the inclusion criteria. A descriptive data analysis was performed. The results show that the clinical profile of the individuals who participated in the interventions is diverse. It can be concluded that there is some scientific evidence that points to the usefulness of VR and AR in the development of intervention programs to improve the social skills of individuals diagnosed with developmental deficits. However, it is necessary to acknowledge methodological limitations such as the lack of control groups, follow-up measures and of generalization of the resultsAgencia Nacional de Investigación e Innovació

Comparative Analysis of Chromatin-Delivered Biomarkers in the Monitoring of Sepsis and Septic Shock: A Pilot Study

[EN] Sepsis management remains one of the most important challenges in modern clinical practice. Rapid progression from sepsis to septic shock is practically unpredictable, hence the critical need for sepsis biomarkers that can help clinicians in the management of patients to reduce the proba-bility of a fatal outcome. Circulating nucleoproteins released during the inflammatory response to infection, including neutrophil extracellular traps, nucleosomes, and histones, and nuclear pro-teins like HMGB1, have been proposed as markers of disease progression since they are related to inflammation, oxidative stress, endothelial damage, and impairment of the coagulation response, among other pathological features. The aim of this work was to evaluate the actual potential for decision making/outcome prediction of the most commonly proposed chromatin-related bi-omarkers (i.e., nucleosomes, citrullinated H3, and HMGB1). To do this, we compared different ELISA measuring methods for quantifying plasma nucleoproteins in a cohort of critically ill pa-tients diagnosed with sepsis or septic shock compared to nonseptic patients admitted to the inten-sive care unit (ICU), as well as to healthy subjects. Our results show that all studied biomarkers can be used to monitor sepsis progression, although they vary in their effectiveness to separate sepsis and septic shock patients. Our data suggest that HMGB1/citrullinated H3 determination in plasma is potentially the most promising clinical tool for the monitoring and stratification of septic patients.This activity received funding from the European Institute of Innovation and Technology (EIT). This body of the European Union receives support from the European Union's Horizon 2020 research and innovation program. C.R-M. thanks GVA for starting grant (GV/2018/127) and Spanish Ministry of Science and Innovation for research project (PID2020-119127RA-I00); J.B-G thanks ISCIII, AES2018 for iPFIS fellowship (IFI18/00015) and GVA for APOTI fellowship (APOTIP/2017/012); CG thanks Spanish Ministry of Universities for fellowship FPU18/03969; J.L.G-G and F.V.P thank INCLIVA, GVA and AES2016 and AES2019 (ISCIII) for starting grant (GV/2014/132), project PI16/01036 and PI19/00994 and project DTS17/00132 (co-financed by the ERDF). The project leading to these results has received funding from "la Caixa" Foundation (ID 100010434), under agreement CI18-0009. C.R-M., F.V.P. and A.M. thank Grand Challenges Canada. : We want to particularly acknowledge the patients and the INCLIVA Biobank (PT17/0015/0049; B.000768 ISCIII) integrated in the Valencian Biobanking Network and the Spanish National Biobanks Network for their collaboration.Beltrán-García, J.; Manclus Ciscar, JJ.; García-López, EM.; Carbonell, N.; Ferreres, J.; Rodríguez-Gimillo, M.; Garcés, C.... (2021). Comparative Analysis of Chromatin-Delivered Biomarkers in the Monitoring of Sepsis and Septic Shock: A Pilot Study. International Journal of Molecular Sciences. 22(18):1-15. https://doi.org/10.3390/ijms22189935115221

Habilidades da teoria da mente e compreensão de verbos metacognitivos em crianças com desenvolvimento normativo

El aprendizaje de habilidades de la teoría de la mente (ToM) se considera fundamental para garantizar un buen desempeño adaptativo en el contexto social dado que permite a las personas atribuir estados mentales a sí mismas y a otras, y así poder predecir el comportamiento de los demás. El objetivo del presente estudio consistió en analizar el desempeño en las tareas de ToM y en la comprensión de verbos mentalistas contextualizados en historias en niños con desarrollo normativo. Se utilizó una muestra de 41 niños con edades comprendidas entre 3 y 5 años con una metodología descriptiva. Los resultados muestran que el nivel 3 de ToM fue el que obtuvo menores niveles de logro. En relación con la prueba que evaluaba la comprensión de verbos mentalistas, los resultados más bajos se obtuvieron en aquella que hacía referencia al verbo saber. Los resultados encontrados sugieren que se aprenden primero verbos mentales referidos a deseos antes que a creencias, así como que los niveles de información defendidos por el modelo de ToM de Howlin et al. (1999) no parecerían estar secuenciados en niveles de complejidad.Agencia Nacional de Investigación e Innovació

Insights on the Early Pleistocene Hominin Population of the Guadix-Baza Depression (SE Spain) and a Review on the Ecology of the First Peopling of Europe

The chronology and environmental context of the first hominin dispersal in Europe have been subject to debate and controversy. The oldest settlements in Eurasia (e.g., Dmanisi, ∼1.8 Ma) suggest a scenario in which the Caucasus and southern Asia were occupied ∼0.4 Ma before the first peopling of Europe. Barranco León (BL) and Fuente Nueva 3 (FN3), two Early Pleistocene archeological localities dated to ∼1.4 Ma in Orce (Guadix-Baza Depression, SE Spain), provide the oldest evidence of hominin presence in Western Europe. At these sites, huge assemblages of large mammals with evidence of butchery and marrow processing have been unearthed associated to abundant Oldowan tools and a deciduous tooth of Homo sp. in the case of BL. Here, we: (i) review the Early Pleistocene archeological sites of Europe; (ii) discuss on the subsistence strategies of these hominins, including new estimates of resource abundance for the populations of Atapuerca and Orce; (iii) use cartographic data of the sedimentary deposits for reconstructing the landscape habitable in Guadix-Baza; and (iv) calculate the size of the hominin population using an estimate of population density based on resource abundance. Our results indicate that Guadix-Baza could be home for a small hominin population of 350–280 individuals. This basin is surrounded by the highest mountainous reliefs of the Alpine-Betic orogen and shows a limited number of connecting corridors with the surrounding areas, which could have limited gene flow with other hominin populations. Isolation would eventually lead to bottlenecks, genetic drift and inbreeding depression, conditions documented in the wild dog population of the basin, which probably compromised the viability of the hominin population in the medium to long term. This explains the discontinuous nature of the archeological record in Guadix-Baza, a situation that can also be extrapolated to the scarcity of hominin settlements for these ancient chronologies in Europe