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Today, mobile devices have become an integral part of their possessor’s life. Learning using mobile devices has the advantage of receiving educational content at the moment when it is actually needed, or when the learner feels like s/he is able to study. Moreover, mobile devices used in education can augment the learning experience by delivering further information to the learner, depending on the learner’s context. However, there are still challenges to overcome in order to achieve a widespread adoption of mobile learning. One of these is the high cost of delivering educational content over wireless networks, especially when multimedia content is transmitted. This research proposes a solution that predicts the learner’s economic behaviour and takes it into account when delivering educational multimedia content. A mechanism for reducing the cost of the educational content delivery over wireless networks is also presented

Tay Bridge Is a Negative Regulator of EGFR Signalling and Interacts with Erk and Mkp3 in theDrosophila melanogaster Wing

The regulation of Extracellular regulated kinase (Erk) activity is a key aspect of signalling by pathways activated by extracellular ligands acting through tyrosine kinase transmembrane receptors. In this process, participate proteins with kinase activity that phosphorylate and activate Erk, as well as different phosphatases that inactivate Erk by de-phosphorylation. The state of Erk phosphorylation affects not only its activity, but also its subcellular localization, defining the repertoire of Erk target proteins, and consequently, the cellular response to Erk. In this work, we characterise Tay bridge as a novel component of the EGFR/Erk signalling pathway. Tay bridge is a large nuclear protein with a domain of homology with human AUTS2, and was previously identified due to the neuronal phenotypes displayed by loss-of-function mutations. We show that Tay bridge antagonizes EGFR signalling in the Drosophila melanogaster wing disc and other tissues, and that the protein interacts with both Erk and Mkp3. We suggest that Tay bridge constitutes a novel element involved in the regulation of Erk activity, acting as a nuclear docking for Erk that retains this protein in an inactive form in the nucleus. © 2013 Molnar, de Celis.BFU2009-09403; BFU2012-33994; CSD2007-00008; Fundación Ramón ArecesPeer Reviewe

Drosophila as a model system for genetic and genomic research

The sequencing of the Drosophila genome allowed the identification of most coding sequences, highlighting the necessity for a functional assignation of the identified genes. The information extracted from the sequence directly classified a considerable fraction of genes into known molecular categories, although there is still a large proportion of them that, due to poor sequence conservation, are not included into any informative class. Furthermore, in many instances the molecular nature of a protein is not particularly revealing about its functional requirements and network of interactions. In this manner, complementary genomic approaches to gene identification by sequence conservation are fundamental both in Drosophila and other organisms to assign particular functions to annotated genes. The approach more successful in the Drosophila field is the undertaking of genetic screenings to identify sets of interacting genes and genes controlling particular cellular processes. Classic genetic screens comprise all those based on a “phenotypic” paradigm, where the generation of large collections of mutant chromosomes is followed by their mapping. This approach has been recently expanded to include “genomic” tools, such as the use of microarrays and interference RNA, as well as reverse-genetics techniques, seeding the way to a “functional” annotation of the Drosophila genome.Peer reviewe

Ethical Issues in AI-Enabled Disease Surveillance: Perspectives from Global Health

Infectious diseases, as COVID-19 is proving, pose a global health threat in an interconnected world. In the last 20 years, resistant infectious diseases such as severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), H1N1 influenza (swine flu), Ebola virus, Zika virus, and now COVID-19 have been impacting global health defences, and aggressively flourishing with the rise of global travel, urbanization, climate change, and ecological degradation. In parallel, this extraordinary episode in global human health highlights the potential for artificial intelligence (AI)-enabled disease surveillance to collect and analyse vast amounts of unstructured and real-time data to inform epidemiological and public health emergency responses. The uses of AI in these dynamic environments are increasingly complex, challenging the potential for human autonomous decisions. In this context, our study of qualitative perspectives will consider a responsible AI framework to explore its potential application to disease surveillance in a global health context. Thus far, there is a gap in the literature in considering these multiple and interconnected levels of disease surveillance and emergency health management through the lens of a responsible AI framework

What can people risk attitude tell us about people preference for multimedia quality?

Purpose – Multimedia content that is accessible through mobile devices has a larger size than other types of content (e.g. text, images). This may lead to higher prices for accessing the content via mobile devices, as mobile operators are capping mobile data billing plans in an effort to increase their revenues and prevent congestion. This poses problems for the users that are not willing/do not afford to pay the required price but still want to use multimedia content through the mobile networks. A price reduction for the user, as well as minimising bandwidth consumption can be obtained as a trade-off in multimedia quality. However, as previous research shows, not all people are willing to trade-off quality for a lower price; therefore, there is no straightforward approach to this problem. In this context, the purpose of this paper is to present a model of user willingness to pay for multimedia content quality as a function of the user risk attitude with the aim to provide personalised content depending on the user willingness to trade-off price for multimedia content quality. Design/methodology/approach – A user model was proposed based on a literature review and an existing data set. A stereotypical approach was used where users are divided in two groups: risk averse and risk seekers. An experimental study involving six scenarios was used to validate the findings. Findings – The results of the evaluation show that for the proposed user risk model, risk seekers preferred to pay for multimedia quality, whereas risk adverse users preferred to switch to a lower multimedia quality when monetary cost is involved. However, when the mobile data billing plan had the bandwidth limited, rather than a higher price to be paid when the bundle quantity was exceeded, the risk averse people’s preference for a lower quality still holds, but it does not show that most of the risk seekers prefer to pay for the multimedia quality. Research limitations/implications – This paper adds to the state of the art by providing a novel way to model the user preferences for multimedia quality based on their attitude towards risk, age, and gender. Practical implications – Mobile data users, content providers (application service providers, over-the-top providers), mobile network operators (MNOs) and internet service providers (ISPs) could benefit from the results of this research. For mobile data users, the outcome of this research could be beneficial, as they can obtain personalised content based on their needs. From the content providers’ point of view, providing personalised content can lead to more satisfied users. It could also reduce the bandwidth consumption and the traffic to the server and/or proxy. Reducing the bandwidth consumption could lead to the possibility to acquire more customers and hence increase the revenues. Originality/value – This is among the first studies to assess how the user preference towards multimedia quality if affected by the user attitude towards risk

¿Publicar o perecer? Reflexiones a partir del II Encuentro de Jóvenes Investigadores en Criminología

This special issue of the Criminological Bulletin contains nine of the best contributions presented during the 2nd Meeting of Spanish Early-Career Researchers in Criminology, which took place at the Law School of the University of Malaga (Spain) on the 13th and 14th of February 2020. This article presents firstly the nine contributions of the special issue. As well, it discusses the challenge of publishing while being an early-career researcher. In particular, we briefly review the literature on the “publish or perish” phenomenon to set out its assets, as well as its difficulties. Last, we outline several recommendations for publishing successfully while preserving the ethical and methodological principles of our discipline.Esta edición especial del Boletín Criminológico recoge nueve de las mejores contribuciones presentadas durante el II Encuentro de Jóvenes Investigadores en Criminología, que tuvo lugar en la Facultad de Derecho de la Universidad de Málaga (España) los días 13 y 14 de febrero de 2020. Tras presentar las nueve contribuciones, este artículo discute el reto que supone publicar siendo joven investigador. En particular, revisaremos de manera breve los escritos relativos al fenómeno “publica o perece” a fin de exponer sus aspectos positivos, así como sus dificultades, y, por último, esbozaremos algunas recomendaciones para publicar de manera exitosa, preservando los principios éticos y metodológicos de nuestra ciencia

Oxidative Stress Is Associated with Overgrowth in Drosophila l(3)mbt Mutant Imaginal Discs

The loss-of-function conditions for an l(3)malignant brain tumour (l(3)mbt) in larvae reared at 29 degrees C results in malignant brain tumours and hyperplastic imaginal discs. Unlike the former that have been extensively characterised, little is known about the latter. Here we report the results of a study of the hyperplastic l(3)mbt mutant wing imaginal discs. We identify the l(3)mbt wing disc tumour transcriptome and find it to include genes involved in reactive oxygen species (ROS) metabolism. Furthermore, we show the presence of oxidative stress in l(3)mbt hyperplastic discs, even in apoptosis-blocked conditions, but not in l(3)mbt brain tumours. We also find that chemically blocking oxidative stress in l(3)mbt wing discs reduces the incidence of wing disc overgrowths. Our results reveal the involvement of oxidative stress in l(3)mbt wing discs hyperplastic growth

Assessing Learning Achievements when Reducing Mobile Video Quality

When using mobile phones for learning purpose, video content is considered to be the preferred type of multimedia content. However, the video file has a big size in comparison to text or audio and might lead to a high delivery cost when transmitted over a mobile network, a cost that not all users are willing to pay. Concerns regarding the monetary cost for accessing data content through mobile networks have been raised by various researchers. A solution that considers the user preference for trading off between video quality and price in order to reduce the content delivery cost is presented. This paper also evaluates the proposed solution and presents the results of an experimental study that assesses the video content adaptation impact on information assimilation. The results show that although the video quality is reduced information assimilation is not negatively affected by the adaptation. This holds true regardless of the mobile device used in the study

Root Length Changes in Orthodontically Displaced Teeth Treated with the Corticotomy Approach

The aim of the study: Corticotomy-facilitated orthodontics is a modern approach to resolve complicated orthodontic cases that may increase the pace of tooth movement. The study's goal was to assess the changes that occurred at the root level following orthodontic treatment when corticotomy was used. Material and methods: Based on Cone Beam Computer Tomography, measurements of the root length at T0 (before corticotomy) and T1 (after corticotomy) were taken after splitting the individuals into two groups (maxillary and mandibular corticotomy) (6 months after surgery). For statistical analysis of the data, many tests were utilized. Results: The root length values obtained at T1 showed minimal changes in length, with statistically insignificant values (for the maxillary arch, the values obtained were 13.36 ± 2.41 mm for women and 14.26 ± 2.06 mm for men; for the lower arch, the measured values were 12.38 ± 2.09 mm for women and 11.56 ± 2.29 mm for men). The canine on the left hemiarcade had the most significant change in root length following treatment, with a value assessed at T1 of 16.72 ± 1.78 mm, which was statistically significant, p 0.05. Conclusion: According to the data obtained in this study, when orthodontic therapy is associated with corticotomy, there is a decrease in root resorption that may occur in the case of conventional orthodontic treatments