Study and characterization of modified silicon surfaces with organic molecules

Nanostructured thin films and subsequent biofunctionalization of silicon substrates are essential for the development of biosensors devices. The formation of organic monolayers on silicon substrates via Si-C bound allows specific interactions with biomolecules and presents several advantages like greater detection sensitivity and stability against hydrolytic cleavage.1 In this sense, to control the orientation and spacing between grafted functional moieties on the surface, tripodal oligo (p-phenylene)s have become ideal anisotropic adsorbates due to their shape-persistent and selfstanding characteristics.2 On the other hand, biomolecules such as tehtahydro[3]benzazepines are well-known to contain in their structure a phenetylamine skeleton, which is also present in dopaminergic receptors and drugs, therefore these molecules have a remarkable interest in medicinal chemistry. Here we report the synthesis and characterization of several tetrahydro[3]benzazepines and tripod-shaped oligo(p-phenylene)s which were suitably functionalized for its subsequent adsorption on silicon surfaces by hydrosilylation and/or CuAAc click reaction. X-ray photoemission spectroscopy (XPS) and atomic force microscopy (AFM) analysis were also carried out to reveal the presence of the grafted molecules on the different Si surfaces.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Social participation of the elders in Europe: the influence of individual and contextual variables.

This study analyzes the social participation of older people based on individual and contextual variables. For this purpose the data of the Survey of Health, Ageing and Retirement in Europe (SHARE) in particular waves 1, 2 and 4 have been used. A four-level model with fixed and random effects was carried out. The model obtained shows the effect of individual variables: a greater participation in more recent waves, in ages between 60-70 years and the effect of variables such as cognitive functioning, years of education and health self-perception. But significant differences were also found in participation in contextual variables and between countries. These results are important for public policy managers, who must take into account not only individual variables, but also contextual variables, which explain the differences in the participation rate of the elderly.pre-print1693 K

Regulación de la eutanasia y el suicidio asistido en España. ¿Hacia qué modelo se dirige la opinión pública?

Objective: To compare the attitudes of Spanish citizens with existing legal models on euthanasia and assisted suicide to identify which of them the citizens could agree with. Methods: Data collected by the Social Research Centre in Study 2,803 “care for patients who are terminally ill” in 2009 were analysed. Descriptive analysis and comparisons with McNemar test were carried out. Results: Spanish populationclearly supports the practice of euthanasia for the terminally ill. Agreement is lower in the case of physician assisted suicide and degenerative diseases. Conclusions: The Belgian model matches the approach favoured by Spanish public opinion closest. This represents a starting point for the social, political and legal debate needed to regulate individuals’ rights at the end of life.Introducción: Comparar las actitudes de los ciudadanos españoles con los modelos legales existentes sobre eutanasia y suicidio asistido para identificar con cuál de ellos la ciudadanía podría estar más de acuerdo. Metodología: Se analizaron los datos recogidos por el Centro de Investigaciones Sociológicas en el Estudio 2.803 “Atención para pacientes con enfermedad terminal”. Realizamos análisis descriptivos y comparaciones mediante la prueba de McNemar. Resultados: La población española apoya claramente la práctica de eutanasia en enfermos terminales. El suicidio médico asistido y los casos de enfermedad degenerativa hacen disminuir el grado de aceptación. Conclusiones: El modelo belga es el que mejor se ajusta a las opiniones de la ciudadanía española. Se considera un punto de partida, para conducir el debate social, político y jurídico, necesario para lograr una regulación de los derechos que asisten a los ciudadanos al final de la vida

Regulación de la eutanasia y el suicidio asistido en España. ¿Hacia qué modelo se dirige la opinión pública?

Objective: To compare the attitudes of Spanish citizens with existing legal models on euthanasia and assisted suicide to identify which of them the citizens could agree with. Methods: Data collected by the <em>Social Research Centre</em> in Study 2,803 “care for patients who are terminally ill” in 2009 were analysed. Descriptive analysis and comparisons with McNemar test were carried out. Results: Spanish populationclearly supports the practice of euthanasia for the terminally ill. Agreement is lower in the case of physician assisted suicide and degenerative diseases. Conclusions: The Belgian model matches the approach favoured by Spanish public opinion closest. This represents a starting point for the social, political and legal debate needed to regulate individuals’ rights at the end of life.<br><br>Introducción: Comparar las actitudes de los ciudadanos españoles con los modelos legales existentes sobre eutanasia y suicidio asistido para identificar con cuál de ellos la ciudadanía podría estar más de acuerdo. Metodología: Se analizaron los datos recogidos por el Centro de Investigaciones Sociológicas en el Estudio 2.803 “Atención para pacientes con enfermedad terminal”. Realizamos análisis descriptivos y comparaciones mediante la prueba de <em>McNemar</em>. Resultados: La población española apoya claramente la práctica de eutanasia en enfermos terminales. El suicidio médico asistido y los casos de enfermedad degenerativa hacen disminuir el grado de aceptación. Conclusiones: El modelo belga es el que mejor se ajusta a las opiniones de la ciudadanía española. Se considera un punto de partida, para conducir el debate social, político y jurídico, necesario para lograr una regulación de los derechos que asisten a los ciudadanos al final de la vida

Outcome of Antifungal Combination Therapy for Invasive Mold Infections in Hematological Patients is Independent of the Chosen Combination

Invasive mold infection (IMI) remains a major cause of mortality in high-risk hematological patients. The aim of this multicenter retrospective, observational study was to evaluate antifungal combination therapy (ACT) for proven and probable IMI in hematological patients. We analyzed 61 consecutive cases of proven (n=25) and probable (n=36) IMI treated with ACT collected from eight Spanish hospitals from January 2005 to December 2009. Causal pathogens were: Aspergillus spp (n=49), Zygomycetes (n=6), Fusarium spp (n=3), and Scedosporium spp (n=3). Patients were classified in three groups according to the antifungal combination employed: Group A, liposomal amphotericin B (L-AmB) plus caspofungin (n=20); Group B, LAmB plus a triazole (n=20), and Group C, voriconazole plus a candin (n=21). ACT was well tolerated with minimal adverse effects. Thirty-eight patients (62%) achieved a favorable response (35 complete). End of treatment and 12-week survival rates were 62% and 57% respectively, without statistical differences among groups. Granulocyte recovery was significantly related to favorable response and survival (p<0.001) in multivariate analysis. Our results suggest that comparable outcomes can be achieved with ACT in high risk hematological patients with proven or probable IMI, whatever the combination of antifungal agents used

Plan tecnológico 2018-2030 Centro Nacional de Asistencia Técnica a la Industria ASTIN

Se describe el plan tecnológico 2018-2030 del Centro Nacional de Asistencia Técnica a la Industria ASTIN, incluye servicios de formación profesional, investigación, desarrollo e innovación y servicios tecnológicos ofrecidos por el centro, se define el análisis externo e interno del centro, se identifican las tecnologías y resultados de la vigilancia tecnológica, se realiza el mapa de trayectoria tecnológica y análisis morfológico, iniciativas tecnológicas, proyectos, aliados estratégicos y posible oferta de formaciónThe technological plan 2018-2030 of the National Center of Technical Assistance to the Industry ASTIN is described, it includes services of professional formation, investigation, development and innovation and technological services offered by the center, the external and internal analysis of the center is defined, they are identified technologies and results of technological surveillance, the map of technological trajectory and morphological analysis, technological initiatives, projects, strategic allies and possible training offer is madeAnálisis y diagnóstico estratégico -- Vigilancia estratégica -- Vigilancia tecnológica -- Vigilancia competitiva -- Formulación estratégica -- Recomendaciones estratégicasPrimera ediciónnaEste documento ha contado con la participación de los integrantes del Grupo de Investigación en Innovación, Gestión Tecnológica y del Conocimiento INGETECASTIN y del Grupo de Investigación en Desarrollo de Materiales y Productos GIDEMP.69 página

Fish Oil Enriched Intravenous Lipid Emulsions Reduce Triglyceride Levels in Non-Critically Ill Patients with TPN and Type 2 Diabetes. A Post-Hoc Analysis of the INSUPAR Study

There are no studies that have specifically assessed the role of intravenous lipid emulsions (ILE) enriched with fish oil in people with diabetes receiving total parenteral nutrition (TPN). The objective of this study was to assess the metabolic control (glycemic and lipid) and in-hospital complications that occurred in non-critically ill inpatients with TPN and type 2 diabetes with regard to the use of fish oil emulsions compared with other ILEs. We performed a post-hoc analysis of the Insulin in Parenteral Nutrition (INSUPAR) trial that included patients who started with TPN for any cause and that would predictably continue with TPN for at least five days. The study included 161 patients who started with TPN for any cause. There were 80 patients (49.7%) on fish oil enriched ILEs and 81 patients (50.3%) on other ILEs. We found significant decreases in triglyceride levels in the fish oil group compared to the other patients. We did not find any differences in glucose metabolic control: mean capillary glucose, glycemic variability, and insulin dose, except in the number of mild hypoglycemic events that was significantly higher in the fish oil group. We did not observe any differences in other metabolic, liver or infectious complications, in-hospital length of stay or mortality

Association of Candidate Gene Polymorphisms With Chronic Kidney Disease: Results of a Case-Control Analysis in the Nefrona Cohort

Chronic kidney disease (CKD) is a major risk factor for end-stage renal disease, cardiovascular disease and premature death. Despite classical clinical risk factors for CKD and some genetic risk factors have been identified, the residual risk observed in prediction models is still high. Therefore, new risk factors need to be identified in order to better predict the risk of CKD in the population. Here, we analyzed the genetic association of 79 SNPs of proteins associated with mineral metabolism disturbances with CKD in a cohort that includes 2, 445 CKD cases and 559 controls. Genotyping was performed with matrix assisted laser desorption ionizationtime of flight mass spectrometry. We used logistic regression models considering different genetic inheritance models to assess the association of the SNPs with the prevalence of CKD, adjusting for known risk factors. Eight SNPs (rs1126616, rs35068180, rs2238135, rs1800247, rs385564, rs4236, rs2248359, and rs1564858) were associated with CKD even after adjusting by sex, age and race. A model containing five of these SNPs (rs1126616, rs35068180, rs1800247, rs4236, and rs2248359), diabetes and hypertension showed better performance than models considering only clinical risk factors, significantly increasing the area under the curve of the model without polymorphisms. Furthermore, one of the SNPs (the rs2248359) showed an interaction with hypertension, being the risk genotype affecting only hypertensive patients. We conclude that 5 SNPs related to proteins implicated in mineral metabolism disturbances (Osteopontin, osteocalcin, matrix gla protein, matrix metalloprotease 3 and 24 hydroxylase) are associated to an increased risk of suffering CKD