Estrés parental: Un programa de salud dirigido a padres de hijos con fibrosis quística

La fibrosis quística es una enfermedad crónica y genética que afecta mayoritariamente a niños y jóvenes. Se diagnostica gracias al cribado neonatal en el recién nacido. A lo largo de la vida del paciente pueden sufrir complicaciones que deriven en una reagudización necesitan tratamiento hospitalario. La fibrosis quística es una patología que requiere muchos cuidados y van a irse produciendo diferentes cambios en el niño, produciendo un gran nivel de estrés en los padres.<br /

La Facultad de Ciencias se pone en tu lugar

El RD 1393/2007 por el que se establece la ordenación de las enseñanzas universitarias oficiales, indica, entre otros aspectos, que la formación en cualquier actividad profesional debe contribuir al conocimiento y desarrollo de los principios de accesibilidad universal, diseño para todos y todas, igualdad entre hombres y mujeres y la protección del medioambiente. El objetivo de esta comunicación es realizar un estudio sobre el grado de cumplimiento de lo establecido en dicho RD en las enseñanzas universitarias de la Facultad de Ciencias de la Universidad de Alicante. Para ello el estudio se centra en dos partes bien diferenciadas, la primera consistente en un análisis de los títulos de grado en referencia a la formación en accesibilidad, diseño e igualdad anteriormente referenciados, y una segunda parte donde se analiza desde la perspectiva del espacio urbano y arquitectónico el edificio de Ciencias II, donde se imparte docencia, promoviendo una serie de mejoras que nos permitan conseguir espacios más accesibles e integradores

Me pongo en tu lugar

El RD 1393/2007 por el que se establece la ordenación de las enseñanzas universitarias oficiales, indica, entre otros aspectos, que la formación en cualquier actividad profesional debe contribuir al conocimiento y desarrollo de los principios de accesibilidad universal, diseño para todos y todas, igualdad entre hombres y mujeres y la protección del medioambiente. Atendiendo a estas necesidades formativas que deben ser recogidas en los títulos de grado, desde la Universidad de Alicante se ha puesto en marcha a través del Secretariado de Desarrollo de Campus del Vicerrectorado de Campus y Sostenibilidad el proyecto “Campus Accesible Campus Igualitario” para potenciar un campus inclusivo que tenga en cuenta esta perspectiva tanto en el espacio urbano como en el arquitectónico. El objetivo de esta comunicación es exponer la metodología seguida para potenciar el proceso de enseñanza aprendizaje de estas competencias básicas, que deberían estar incluidas en todos los planes de estudio. Para ello se expone un modelo de taller práctico que pretende potenciar la adquisición de las competencias necesarias sobre igualdad y accesibilidad en el espacio urbano y arquitectónico, así como desarrollar el pensamiento crítico y constructivo para que cada estudiante que se gradúe en nuestra universidad pueda contribuir a la construcción de una sociedad más inclusiva

ImmunoPEGliposomes for the targeted delivery of novel lipophilic drugs to red blood cells in a falciparum malaria murine model

Most drugs currently entering the clinical pipeline for severe malaria therapeutics are of lipophilic nature, with a relatively poor solubility in plasma and large biodistribution volumes. Low amounts of these compounds do consequently accumulate in circulating Plasmodium-infected red blood cells, exhibiting limited antiparasitic activity. These drawbacks can in principle be satisfactorily dealt with by stably encapsulating drugs in targeted nanocarriers. Here this approach has been adapted for its use in immunocompetent mice infected by the Plasmodium yoelii 17XL lethal strain, selected as a model for human blood infections by Plasmodium falciparum. Using immunoliposomes targeted against a surface protein characteristic of the murine erythroid lineage, the protocol has been applied to two novel antimalarial lipophilic drug candidates, an aminoquinoline and an aminoalcohol. Large encapsulation yields of >90% were obtained using a citrate-buffered pH gradient method and the resulting immunoliposomes reached in vivo erythrocyte targeting and retention efficacies of >80%. In P. yoelii-infected mice, the immunoliposomized aminoquinoline succeeded in decreasing blood parasitemia from severe to uncomplicated malaria parasite densities (i.e. from >/=25% to ca. 5%), whereas the same amount of drug encapsulated in non-targeted liposomes had no significant effect on parasite growth. Pharmacokinetic analysis indicated that this good performance was obtained with a rapid clearance of immunoliposomes from the circulation (blood half-life of ca. 2 h), suggesting a potential for improvement of the proposed model

Dissecting quasars with the J-PAS narrow-band photometric survey

Nuclear Activity in Galaxies Across Cosmic Time, Proceedings of the conference held 7-11 October 2019 in Addis Ababa, Ethiopia. Edited by Mirjana Pović et al. Proceedings of the International Astronomical Union, Volume 356, pp. 12-16The J-PAS survey will soon start observing thousands of square degrees of the Northern Sky with its unique set of 56 narrow band filters covering the entire optical wavelength range, providing, effectively, a low resolution spectra for every object detected. Active galaxies and quasars, thanks to their strong emission lines, can be easily identified and characterized with J-PAS data. A variety of studies can be performed, from IFU-like analysis of local AGN, to clustering of high-z quasars. We also expect to be able to extract intrinsic physical quasar properties from the J-PAS pseudo-spectra, including continuum slope and emission line luminosities. Here we show the first attempts of using the QSFit software package to derive the properties for 22 quasars at 0.8 < z < 2 observed by the miniJPAS survey, the first deg2 of J-PAS data obtained with an interim camera. Results are compared with the ones obtained by applying the same software to SDSS quasar spectra.Financial support from the State Agency for Research of the Spanish MCIU through the "Center of Excellence Severo Ochoa" award to the Instituto de Astrofísica de Andalucía (SEV-2017-0709

Ductular reaction promotes intrahepatic angiogenesis through Slit2-Roundabout 1 signaling

Background and aims: Ductular reaction (DR) expands in chronic liver diseases and correlates with disease severity. Besides its potential role in liver regeneration, DR plays a role in the wound-healing response of the liver, promoting periductular fibrosis and inflammatory cell recruitment. However, there is no information regarding its role in intrahepatic angiogenesis. In the current study we investigated the potential contribution of DR cells to hepatic vascular remodeling during chronic liver disease. Approach and results: In mouse models of liver injury, DR cells express genes involved in angiogenesis. Among angiogenesis-related genes, the expression of Slit2 and its receptor Roundabout 1 (Robo1) was localized in DR cells and neoangiogenic vessels, respectively. The angiogenic role of the Slit2-Robo1 pathway in chronic liver disease was confirmed in ROBO1/2-/+ mice treated with 3,5-diethoxycarbonyl-1,4-dihydrocollidine, which displayed reduced intrahepatic neovascular density compared to wild-type mice. However, ROBO1/2 deficiency did not affect angiogenesis in partial hepatectomy. In patients with advanced alcohol-associated disease, angiogenesis was associated with DR, and up-regulation of SLIT2-ROBO1 correlated with DR and disease severity. In vitro, human liver-derived organoids produced SLIT2 and induced tube formation of endothelial cells. Conclusions: Overall, our data indicate that DR expansion promotes angiogenesis through the Slit2-Robo1 pathway and recognize DR cells as key players in the liver wound-healing response.Supported by grants from Fondo de Investigación Sanitaria Carlos III (FIS), cofinanced by Fondo Europeo de Desarrollo Regional (FEDER), Unión Europea, “Una manera de hacer Europa” (FIS PI20/00765, PI17/00673, to P.S.-B; FIS 18-PI18/00862, to I.G and M.C); from the National Institute on Alcohol Abuse and Alcoholism (1U01AA026972-01 and AGAUR 2017-SGR-01456, to P.S.-B.); and from the European Foundation for Alcohol Research (EA1653, to P.S.-B.). M.C. is funded by the Ramon y Cajal program from the Ministerio de Ciencia e Innovación RYC2019-026662-I. P.G. is funded by the Agencia de Gestió d'Ajuts Universitaris i de Recerca 2014 SGR 708, Centro de Investigaciónen Red Enfermedades Hepáticas y Digestivas (CIBERehd), and Institució Catalana de Recerca i Estudis Avançats. S.A. received a grant from the Ministerio de Educación, Cultura y Deporte (FPU17/04992). B.A.-B. is funded by the Instituto de Salud Carlos III (FI16/00203

J-PAS: Forecasts for dark matter - dark energy elastic couplings

We consider a cosmological model where dark matter and dark energy feature a coupling that only affects their momentum transfer in the corresponding Euler equations. We perform a fit to cosmological observables and confirm previous findings within these scenarios that favour the presence of a coupling at more than $3\sigma$. This improvement is driven by the Sunyaev-Zeldovich data. We subsequently perform a forecast for future J-PAS data and find that clustering measurements will permit to clearly discern the presence of an interaction within a few percent level with the uncoupled case at more than $10\sigma$ when the complete survey, covering $8500$ sq. deg., is considered. We found that the inclusion of weak lensing measurements will not help to further constrain the coupling parameter. For completeness, we compare to forecasts for DESI and Euclid, which provide similar discriminating power.Comment: 34 pages, 17 figures, added some clarifications and discussions, matches published versio

The miniJPAS survey quasar selection IV: Classification and redshift estimation with SQUEzE

We present a list of quasar candidates including photometric redshift estimates from the miniJPAS Data Release constructed using SQUEzE. This work is based on machine-learning classification of photometric data of quasar candidates using SQUEzE. It has the advantage that its classification procedure can be explained to some extent, making it less of a `black box' when compared with other classifiers. Another key advantage is that using user-defined metrics means the user has more control over the classification. While SQUEzE was designed for spectroscopic data, here we adapt it for multi-band photometric data, i.e. we treat multiple narrow-band filters as very low-resolution spectra. We train our models using specialized mocks from Queiroz et al. (2022). We estimate our redshift precision using the normalized median absolute deviation, $\sigma_{\rm NMAD}$ applied to our test sample. Our test sample returns an $f_1$ score (effectively the purity and completeness) of 0.49 for quasars down to magnitude $r=24.3$ with $z\geq2.1$ and 0.24 for quasars with $z<2.1$. For high-z quasars, this goes up to 0.9 for $r<21.0$. We present two catalogues of quasar candidates including redshift estimates: 301 from point-like sources and 1049 when also including extended sources. We discuss the impact of including extended sources in our predictions (they are not included in the mocks), as well as the impact of changing the noise model of the mocks. We also give an explanation of SQUEzE reasoning. Our estimates for the redshift precision using the test sample indicate a $\sigma_{NMAD}=0.92\%$ for the entire sample, reduced to 0.81\% for $r<22.5$ and 0.74\% for $r<21.3$. Spectroscopic follow-up of the candidates is required in order to confirm the validity of our findings.Comment: Accepted in A&A 24 pages, 24 figures, 7 table

The miniJPAS & J-NEP surveys: Identification and characterization of the Lyα\alpha Emitter population and the Lyα\alpha Luminosity Function

We present the Lyman-$a$ (Lya) Luminosity Function (LF) at $2.05<z<3.75$, estimated from a sample of 67 Lya-emitter (LAE) candidates in the J-PAS Pathfinder surveys: miniJPAS and J-NEP. These two surveys cover a total effective area of $\sim 1.14$ deg$^2$ with 54 Narrow Band (NB) filters across the optical range, with typical limiting magnitudes of $\sim 23$. This set of NBs allows to probe Lya emission in a wide and continuous range of redshifts. We develop a method for detecting Lya emission for the estimation of the Lya LF using the whole J-PAS filter set. We test this method by applying it to the miniJPAS and J-NEP data. In order to compute the corrections needed to estimate the Lya LF and to test the performance of the candidates selection method, we build mock catalogs. These include representative populations of Lya Emitters at $1.9<z<4.5$ as well as their expected contaminants, namely low-$z$ galaxies and $z<2$ QSOs. We show that our method is able to provide the Lya LF at the intermediate-bright range of luminosity ($\rm 10^{43.5} erg\,s^{-1} \lesssim L_{Lya} \lesssim 10^{44.5} erg\,s^{-1}$). The photometric information provided by these surveys suggests that our samples are dominated by bright, Lya-emitting Active Galactic Nuclei. At $L_{{\rm Ly}a}<10^{44.5}$ erg\,s$^{-1}$, we fit our Lya LF to a power-law with slope $A=0.70\pm0.25$. We also fit a Schechter function to our data, obtaining: Log(\Phi^* / \text{Mpc^{-3}})=-6.30^{+0.48}_{-0.70}, Log$(L^*/ \rm erg\,s^{-1})=44.85^{+0.50}_{-0.32}$, $a=-1.65^{+0.29}_{-0.27}$. Overall, our results confirm the presence of an AGN component at the bright-end of the Lya LF. In particular, we find no significant contribution of star-forming LAEs to the Lya LF at Log$(L_{\rm Lya}$ / erg\,s$^{-1}$)>43.5. This work serves as a proof-of-concept for the results that can be obtained with the upcoming data releases of the J-PAS survey.Comment: 25 pages, 15 figures, submitted to A&

Campus accesible, campus igualitario

El Proyecto “Campus Accesible, Campus Igualitario” del Vicerrectorado de Campus y Sostenibilidad, la Unidad de Igualdad y el Vicerrectorado de Estudiantes, articulado sobre el trípode que lo vincula a la innovación docente, la investigación y la acción transformadora, en su segundo año de andadura, ha trabajado en tres líneas: por un lado, dando continuidad (y, con ella, sentido) a las acciones emprendidas el curso pasado; por otro, revisando con espíritu crítico tanto los datos como las experiencias recabadas para reinterpretarlos a la luz de nuevos contextos y nuevas posibilidades; y, finalmente, asumiendo el reto que se lanza al Secretariado de Desarrollo de Campus desde el 2ª Plan de Igualdad de Oportunidades entre Mujeres y Hombres de la Universidad de Alicante, 2014-2016, en el Objetivo 2, Incorporar la perspectiva de género en los procesos de planificación y gestión de la actividad deportiva ofertada por la UA, Acción 14, Introducir la perspectiva de género en el diseño y uso de espacios en las instalaciones deportivas. Con este fin, se ha diagnosticado tanto el espacio del Campus en su conjunto como su zona deportiva y se han sentado las bases teóricas para la confección de un sondeo de opinión entre la comunidad universitaria