Reynolds-stress and dissipation rate budgets in a turbulent channel flow

The budgets for the Reynolds stresses and for the dissipation rate of the turbulence kinetic energy are computed using direct simulation data of a turbulent channel flow. The budget data reveal that all the terms in the budget become important close to the wall. For inhomogeneous pressure boundary conditions, the pressure-strain term is split into a return term, a rapid term, and a Stokes term. The Stokes term is important close to the wall. The rapid and return terms play different roles depending on the component of the term. A split of the velocity pressure-gradient term into a redistributive term and a diffusion term is proposed, which should be simpler to model. The budget data is used to test existing closure models for the pressure-strain term, the dissipation rate, and the transport rate. In general, further work is needed to improve the models

Computation of turbulent flows over backward-facing step

A numerical method for computing incompressible turbulent flows is presented. The method is tested by calculating laminar recirculating flows and is applied in conjunction with a modified Kappa-epsilon model to compute the flow over a backward-facing step. In the laminar regime, the computational results are in good agreement with the experimental data. The turbulent flow study shows that the reattachment length is underpredicted by the standard Kappa-epsilon model. The addition of a term to the standard model that accounts for the effects of rotation on turbulent flow improves the results in the recirculation region and increases the computed reattachment length

Non-local modulation of the energy cascade in broad-band forced turbulence

Classically, large-scale forced turbulence is characterized by a transfer of energy from large to small scales via nonlinear interactions. We have investigated the changes in this energy transfer process in broad-band forced turbulence where an additional perturbation of flow at smaller scales is introduced. The modulation of the energy dynamics via the introduction of forcing at smaller scales occurs not only in the forced region but also in a broad range of length-scales outside the forced bands due to non-local triad interactions. Broad-band forcing changes the energy distribution and energy transfer function in a characteristic manner leading to a significant modulation of the turbulence. We studied the changes in this transfer of energy when changing the strength and location of the small-scale forcing support. The energy content in the larger scales was observed to decrease, while the energy transport power for scales in between the large and small scale forcing regions was enhanced. This was investigated further in terms of the detailed transfer function between the triad contributions and observing the long-time statistics of the flow. The energy is transferred toward smaller scales not only by wavenumbers of similar size as in the case of large-scale forced turbulence, but by a much wider extent of scales that can be externally controlled.Comment: submitted to Phys. Rev. E, 15 pages, 18 figures, uses revtex4.cl

Immune-Mediated Inflammation May Contribute to the Pathogenesis of Cardiovascular Disease in Mucopolysaccharidosis Type I.

BackgroundCardiovascular disease, a progressive manifestation of α-L-iduronidase deficiency or mucopolysaccharidosis type I, continues in patients both untreated and treated with hematopoietic stem cell transplantation or intravenous enzyme replacement. Few studies have examined the effects of α-L-iduronidase deficiency and subsequent glycosaminoglycan storage upon arterial gene expression to understand the pathogenesis of cardiovascular disease.MethodsGene expression in carotid artery, ascending, and descending aortas from four non-tolerized, non-enzyme treated 19 month-old mucopolysaccharidosis type I dogs was compared with expression in corresponding vascular segments from three normal, age-matched dogs. Data were analyzed using R and whole genome network correlation analysis, a bias-free method of categorizing expression level and significance into discrete modules. Genes were further categorized based on module-trait relationships. Expression of clusterin, a protein implicated in other etiologies of cardiovascular disease, was assessed in canine and murine mucopolysaccharidosis type I aortas via Western blot and in situ immunohistochemistry.ResultsGene families with more than two-fold, significant increased expression involved lysosomal function, proteasome function, and immune regulation. Significantly downregulated genes were related to cellular adhesion, cytoskeletal elements, and calcium regulation. Clusterin gene overexpression (9-fold) and protein overexpression (1.3 to 1.62-fold) was confirmed and located specifically in arterial plaques of mucopolysaccharidosis-affected dogs and mice.ConclusionsOverexpression of lysosomal and proteasomal-related genes are expected responses to cellular stress induced by lysosomal storage in mucopolysaccharidosis type I. Upregulation of immunity-related genes implicates the potential involvement of glycosaminoglycan-induced inflammation in the pathogenesis of mucopolysaccharidosis-related arterial disease, for which clusterin represents a potential biomarker

Two-qubit parametric amplifier: large amplification of weak signals

Using numerical simulations, we show that two coupled qubits can amplify a weak signal about hundredfold. This can be achieved if the two qubits are biased simultaneously by this weak signal and a strong pump signal, both of which having frequencies close to the inter-level transitions in the system. The weak signal strongly affects the spectrum generated by the strong pumping drive by producing and controlling mixed harmonics with amplitudes of the order of the main harmonic of the strong drive. We show that the amplification is robust with respect to noise, with an intensity of the order of the weak signal. When deviating from the optimal regime (corresponding to strong qubit coupling and a weak-signal frequency equal to the inter-level transition frequency) the proposed amplifier becomes less efficient, but it can still considerably enhance a weak signal (by several tens). We therefore propose to use coupled qubits as a combined parametric amplifier and frequency shifter.Comment: 6 figure

The first resolved imaging of milliarcsecond-scale jets in Circinus X-1

We present the first resolved imaging of the milliarcsecond-scale jets in the neutron star X-ray binary Circinus X-1, made using the Australian Long Baseline Array. The angular extent of the resolved jets is ~20 milliarcseconds, corresponding to a physical scale of ~150 au at the assumed distance of 7.8 kpc. The jet position angle is relatively consistent with previous arcsecond-scale imaging with the Australia Telescope Compact Array. The radio emission is symmetric about the peak, and is unresolved along the minor axis, constraining the opening angle to be less than 20 degrees. We observe evidence for outward motion of the components between the two halves of the observation. Constraints on the proper motion of the radio-emitting components suggest that they are only mildly relativistic, although we cannot definitively rule out the presence of the unseen, ultra-relativistic (Lorentz factor >15) flow previously inferred to exist in this system.Comment: Accepted for publication in MNRAS Letters. 6 pages, 4 figure

Large-eddy simulation of spectral coherence in a wind turbine wake

This work is mainly dedicated to the study of the characteristics of spectral coherence of turbulence fluctuations in wind turbine wakes. A computational fluid dynamics (CFD) code has been implemented using a large-eddy simulation (LES) approach, which is thought to be conceptually more suitable for studying the turbulence evolution in a wind turbine wake. Comparisons with experimental data from the Nørrekær Enge II Windfarm, in Denmark, and with an analytical model proposed by Panofsky and Dutton have been performed, and the results are found to be in reasonable agreement with both

A complete X-ray spectral coverage of the 2010 May-June outbursts of Circinus X-1

Circinus X-1 is a neutron-star-accreting X-ray binary in a wide (P$_{\rm orb}$ = 16.6 d), eccentric orbit. After two years of relatively low X-ray luminosity, in May 2010 Circinus X-1 went into outburst, reaching 0.4 Crab flux. This outburst lasted for about two orbital cycles and was followed by another shorter and fainter outburst in June. We focus here on the broadband X-ray spectral evolution of the source as it spans about three order of magnitudes in flux. We attempt to relate luminosity, spectral shape, local absorption, and orbital phase. We use multiple Rossi-XTE/PCA (3.0--25 keV) and Swift/XRT (1.0--9.0 keV) observations and a 20 ks long Chandra/HETGS observation (1.0--9.0 keV), to comprehensively track the spectral evolution of the source during all the outbursting phases. These observations were taken every two/three days and cover about four orbital cycles. The PCA data mostly cover the major outburst, the XRT data monitor the declining phase of the major outburst and all the phases of the minor outburst, and Chandra data provide an essential snapshot of the end of this overall outbursting phase. The X-ray spectrum can be satisfactorily described by a thermal Comptonization model with variable neutral local absorption in all phases of the outburst. No other additive component is statistically required. The first outburst decays linearly, with an ankle in the light curve as the flux decreases below $\sim$\,5 $\times$ 10$^{-10}$ erg cm$^{-2}$ s$^{-1}$. At the same time, the source shows a clear spectral state transition from an optically thick to an optically thin state. While the characteristics of the first, bright, outburst can be interpreted within the disk-instability scenario, the following, minor, outburst shows peculiarities that cannot be easily reconciled in this framework.Comment: Accepted for publication in Astronomy and Astrophysic