Association of Family History of Epilepsy with Earlier Age Onset of Juvenile Myoclonic Epilepsy

How to Cite This Article: Najafi MR, Najafi MA, Safaei A. Association of Family History of Epilepsy with Earlier Age Onset of Juvenile Myoclonic Epilepsy. Iran J Child Neurol. Spring 2016; 10(2):10-15.AbstractObjectiveJuvenile myoclonic epilepsy (JME) is supposedly the most frequent subtype of idiopathic generalized epilepsies (IGE). The aim of this study was to determine the prevalence of JME and comparison of patients’ demographics as well as timeline of the disease between positive family history epileptic patients (PFHE) and negative family history epileptic patients (NFHE) among sample of Iranian epileptic patients.Materials & MethodsFrom Feb. 2006 to Oct. 2009, 1915 definite epileptic patients (873 females) referred to epilepsy clinics in Isfahan, central Iran, were surveyed and among them, 194 JME patients were diagnosed. JME was diagnosed by its specific clinical and EEG criteria. Patients were divided into two groups as PFHE and NFHE and data were compared between them.ResultsJME was responsible for 10% (194 patients) of all types of epilepsies. Of JME patients, 53% were female. In terms of family history of epilepsy, 40% were positive. No significant differences was found between PFHE and NFHE groups as for gender (P>0.05). Age of epilepsy onset was significantly earlier in PFHE patients (15 vs. 22 yr, P<0.001). Occurrence of JME before 18 yr old among PFHE patients was significantly higher (OR=2.356, P=0.007).ConclusionA family history of epilepsy might be associated with an earlier age of onset in patients with JME. References1. Banerjee PN, Filippi D, Allen Hauser W. The descriptive epidemiology of epilepsy—a review. Epilepsy Res 2009;85(1):31-45.2. Khedr EM, Shawky OA, Ahmed MA, Elfetoh NA, Al Attar G, Ali AM, et al. A community based epidemiological study of epilepsy in Assiut Governorate/Egypt. Epilepsy Res 2013;103(2):294-302.3. Rektor I, Schachter SC, Arzy S, Baloyannis SJ, Bazil C, Brázdil M, et al. Epilepsy, behavior, and art (Epilepsy, Brain, and Mind, part 1). Epilepsy Behav 2013;28(2):261-82.4. Steinlein OK. Genetics and epilepsy. Dialogues Clin Neurosci 2008;10(1):29-38.5. Engel Jr J. ILAE classification of epilepsy syndromes. Epilepsy Res 2006;70:5-10.6. Janz D. Epilepsy with impulsive petit mal (juvenile myoclonic epilepsy). Acta Neurol Scandinavica 1985;72(5):449-59.7. Alfradique I, Vasconcelos MM. Juvenile myoclonic epilepsy. Arquivos de Neuro-Psiquiatria 2007;65(4B):1266-71.8. Vijai J, Cherian P, Sylaja P, Anand A, Radhakrishnan K. Clinical characteristics of a South Indian cohort of juvenile myoclonic epilepsy probands. Seizure 2003;12(7):490-6.9. Babtain FA. Impact of a family history of epilepsy on the diagnosis of epilepsy in southern Saudi Arabia. Seizure 2013;22(7):542-7.10. Montenegro MA, Guerreiro MM, Lopes-Cendes I, Guerreiro CA, Li LM, Cendes F, editors. Association of family history of epilepsy with earlier age at seizure onset in patients with focal cortical dysplasia. Mayo Clinic Proceedings 2002;77(12): 1291–94.11. Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, Cross JH, Van Emde Boas W, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005–2009. Epilepsia 2010;51(4):676-85.12. Janz D. Juvenile myoclonic epilepsy. Epilepsy with impulsive petit mal. Cleveland Clin J Med 1989;56 Suppl Pt 1:S23-33; discussion S40-2. Epub 1989/01/01.13. Najafi MR, Sonbolestan F, Sonbolestan SA, Zare M, Mehvari J, Meshkati SN. The course and outcome of pregnancy and neonatal situation in epileptic women. Adv Biomed Res 2012;1:4. Epub 2012/12/05. 14. Bittles AH. Consanguinity and its relevance to clinical genetics. Clin Genetics 2001;60(2):89-98.15. Johnston MV. Nelson’s Textbook of Pediatrics. 17th ed. Seizures in childhood. Vol. 2. Philadelphia: Saunders; 2004 p. 1993–2005.16. Sinha S, Pramod M, Dilipkumar S, Satishchandra P. Idiopathic generalized epilepsy: Phenotypic and electroencephalographic observations in a large cohort from South India. Ann Indian Academy Neurol 2013;16(2):163.17. Jallon P, Loiseau P, Loiseau J. Newly diagnosed unprovoked epileptic seizures: presentation at diagnosis in CAROLE study. Epilepsia 2001;42(4):464-75.18. Oka E, Ishida S, Ohtsuka Y, Ohtahara S. Neuroepidemiological study of childhood epilepsy by application of international classification of epilepsies and epileptic syndromes (ILAE, 1989). Epilepsia 1995;36(7):658-61.19. Murthy J, Yangala R, Srinivas M. The Syndromic Classification of the International League Against Epilepsy: A Hospital-Based Study from South India. Epilepsia 1998;39(1):48-54.20. Fittipaldi F, Curra A, Fusco L, Ruggieri S, Manfredi M. EEG discharges on awakening: a marker of idiopathic generalized epilepsy. Neurol 2001;56(1):123-6.21. Jallon P, Latour P. Epidemiology of idiopathic generalized epilepsies. Epilepsia 2005;46(s9):10-4.22. Classification Co, Epilepsy TotILA. Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia 1989;30:389-99.23. Berkovic, S. F. Genetics of epilepsy syndromes. In: Epilepsy: A Comprehensive Textbook (Eds J. Engel and T. A. Pedley). Lippincott-Raven Publ., 1997: pp. 217–224.24. Camfield CS, Striano P, Camfield PR. Epidemiology of juvenile myoclonic epilepsy. Epilepsy Behav 2013;28:S15-S7.25. Camfield CS, Camfield PR. Juvenile myoclonic epilepsy 25 years after seizure onset A population-based study. Neurol 2009;73(13):1041-5.26. Jayalakshmi SS, Mohandas S, Sailaja S, Borgohain R. Clinical and electroencephalographic study of first-degree relatives and probands with juvenile myoclonic epilepsy. Seizure 2006;15(3):177-83.27. Sozmen V, Baybas S, Dirican A, Koksal A, Ozturk M. Frequency of epilepsies in family members of patients with different epileptic syndromes. European Neurol 2010;65(1):4-9.28. Mullins G, O’sullivan S, Neligan A, McCarthy A, McNamara B, Galvin R, et al. A study of idiopathic generalised epilepsy in an Irish population. Seizure 2007;16(3):204-10.29. Shahnaz KS, Sattar RA. Clinical and EEG characteristics of Juvenile Myoclonic Epilepsy. Pak J Med Sci 2014;30(1):12.30. Liu A, Delgado-Escueta A, Gee M, Serratosa J, Zhang Q, Alonso M, et al. Juvenile myoclonic epilepsy in chromosome 6p12-p11: Locus heterogeneity and recombinations. Am J Medi Genetics 1996;63(3):438-46. 31. Figueredo R, Trevisol-Bittencourt PC, Ferro JBdM. Estudo clínico-epidemiológico de pacientes com epilepsia mioclônica juvenil em Santa Catarina. Arq Neuropsiquiatr 1999;57(2-B):401-4.32. Obeid T, Panayiotopoulos C. Juvenile myoclonic epilepsy: a study in Saudi Arabia. Epilepsia 1988;29(3):280-2.33. Nair RR, Thomas SV. Genetic liability to epilepsy in Kerala State, India. Epilepsy Res 2004;62(2):163-70. 34. Ottman R, Lee JH, Risch N, Hauser WA, Susser M. Clinical indicators of genetic susceptibility to epilepsy. Epilepsia 1996;37(4):353-61.35. Bianchi A, Viaggi S, Chiossi E. Family study of epilepsy in first degree relatives: data from the Italian Episcreen Study. Seizure 2003;12(4):203-10.36. Manganotti P, Bongiovanni LG, Fuggetta G, Zanette G, Fiaschi A. Effects of sleep deprivation on cortical excitability in patients affected by juvenile myoclonic epilepsy: a combined transcranial magnetic stimulation and EEG study. J Neurol Neurosurg Psychiatr 2006;77(1):56-60. Epub 2005/12/20.37. Roebling R, Scheerer N, Uttner I, Gruber O, Kraft E, Lerche H. Evaluation of cognition, structural, and functional MRI in juvenile myoclonic epilepsy. Epilepsia 2009;50(11):2456-65. Epub 2009/06/06.38. Edwards T, Scott AG, Munyoki G, Odera VMa, Chengo E, Bauni E, et al. Active convulsive epilepsy in a rural district of Kenya: a study of prevalence and possible risk factors. The Lancet Neurol 2008;7(1):50-6.

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