131 research outputs found
Association of Family History of Epilepsy with Earlier Age Onset of Juvenile Myoclonic Epilepsy
How to Cite This Article: Najafi MR, Najafi MA, Safaei A. Association of Family History of Epilepsy with Earlier Age Onset of Juvenile Myoclonic Epilepsy. Iran J Child Neurol. Spring 2016; 10(2):10-15.AbstractObjectiveJuvenile myoclonic epilepsy (JME) is supposedly the most frequent subtype of idiopathic generalized epilepsies (IGE). The aim of this study was to determine the prevalence of JME and comparison of patientsâ demographics as well as timeline of the disease between positive family history epileptic patients (PFHE) and negative family history epileptic patients (NFHE) among sample of Iranian epileptic patients.Materials & MethodsFrom Feb. 2006 to Oct. 2009, 1915 definite epileptic patients (873 females) referred to epilepsy clinics in Isfahan, central Iran, were surveyed and among them, 194 JME patients were diagnosed. JME was diagnosed by its specific clinical and EEG criteria. Patients were divided into two groups as PFHE and NFHE and data were compared between them.ResultsJME was responsible for 10% (194 patients) of all types of epilepsies. Of JME patients, 53% were female. In terms of family history of epilepsy, 40% were positive. No significant differences was found between PFHE and NFHE groups as for gender (P>0.05). Age of epilepsy onset was significantly earlier in PFHE patients (15 vs. 22 yr, P<0.001). Occurrence of JME before 18 yr old among PFHE patients was significantly higher (OR=2.356, P=0.007).ConclusionA family history of epilepsy might be associated with an earlier age of onset in patients with JME. References1. Banerjee PN, Filippi D, Allen Hauser W. The descriptive epidemiology of epilepsyâa review. Epilepsy Res 2009;85(1):31-45.2. Khedr EM, Shawky OA, Ahmed MA, Elfetoh NA, Al Attar G, Ali AM, et al. A community based epidemiological study of epilepsy in Assiut Governorate/Egypt. Epilepsy Res 2013;103(2):294-302.3. Rektor I, Schachter SC, Arzy S, Baloyannis SJ, Bazil C, BrĂĄzdil M, et al. Epilepsy, behavior, and art (Epilepsy, Brain, and Mind, part 1). Epilepsy Behav 2013;28(2):261-82.4. Steinlein OK. Genetics and epilepsy. Dialogues Clin Neurosci 2008;10(1):29-38.5. Engel Jr J. ILAE classification of epilepsy syndromes. Epilepsy Res 2006;70:5-10.6. Janz D. Epilepsy with impulsive petit mal (juvenile myoclonic epilepsy). Acta Neurol Scandinavica 1985;72(5):449-59.7. Alfradique I, Vasconcelos MM. Juvenile myoclonic epilepsy. Arquivos de Neuro-Psiquiatria 2007;65(4B):1266-71.8. Vijai J, Cherian P, Sylaja P, Anand A, Radhakrishnan K. Clinical characteristics of a South Indian cohort of juvenile myoclonic epilepsy probands. Seizure 2003;12(7):490-6.9. Babtain FA. Impact of a family history of epilepsy on the diagnosis of epilepsy in southern Saudi Arabia. Seizure 2013;22(7):542-7.10. Montenegro MA, Guerreiro MM, Lopes-Cendes I, Guerreiro CA, Li LM, Cendes F, editors. Association of family history of epilepsy with earlier age at seizure onset in patients with focal cortical dysplasia. Mayo Clinic Proceedings 2002;77(12): 1291â94.11. Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, Cross JH, Van Emde Boas W, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005â2009. Epilepsia 2010;51(4):676-85.12. Janz D. Juvenile myoclonic epilepsy. Epilepsy with impulsive petit mal. Cleveland Clin J Med 1989;56 Suppl Pt 1:S23-33; discussion S40-2. Epub 1989/01/01.13. Najafi MR, Sonbolestan F, Sonbolestan SA, Zare M, Mehvari J, Meshkati SN. The course and outcome of pregnancy and neonatal situation in epileptic women. Adv Biomed Res 2012;1:4. Epub 2012/12/05. 14. Bittles AH. Consanguinity and its relevance to clinical genetics. Clin Genetics 2001;60(2):89-98.15. Johnston MV. Nelsonâs Textbook of Pediatrics. 17th ed. Seizures in childhood. Vol. 2. Philadelphia: Saunders; 2004 p. 1993â2005.16. Sinha S, Pramod M, Dilipkumar S, Satishchandra P. Idiopathic generalized epilepsy: Phenotypic and electroencephalographic observations in a large cohort from South India. Ann Indian Academy Neurol 2013;16(2):163.17. Jallon P, Loiseau P, Loiseau J. Newly diagnosed unprovoked epileptic seizures: presentation at diagnosis in CAROLE study. Epilepsia 2001;42(4):464-75.18. Oka E, Ishida S, Ohtsuka Y, Ohtahara S. Neuroepidemiological study of childhood epilepsy by application of international classification of epilepsies and epileptic syndromes (ILAE, 1989). Epilepsia 1995;36(7):658-61.19. Murthy J, Yangala R, Srinivas M. The Syndromic Classification of the International League Against Epilepsy: A Hospital-Based Study from South India. Epilepsia 1998;39(1):48-54.20. Fittipaldi F, Curra A, Fusco L, Ruggieri S, Manfredi M. EEG discharges on awakening: a marker of idiopathic generalized epilepsy. Neurol 2001;56(1):123-6.21. Jallon P, Latour P. Epidemiology of idiopathic generalized epilepsies. Epilepsia 2005;46(s9):10-4.22. Classification Co, Epilepsy TotILA. Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia 1989;30:389-99.23. Berkovic, S. F. Genetics of epilepsy syndromes. In: Epilepsy: A Comprehensive Textbook (Eds J. Engel and T. A. Pedley). Lippincott-Raven Publ., 1997: pp. 217â224.24. Camfield CS, Striano P, Camfield PR. Epidemiology of juvenile myoclonic epilepsy. Epilepsy Behav 2013;28:S15-S7.25. Camfield CS, Camfield PR. Juvenile myoclonic epilepsy 25 years after seizure onset A population-based study. Neurol 2009;73(13):1041-5.26. Jayalakshmi SS, Mohandas S, Sailaja S, Borgohain R. Clinical and electroencephalographic study of first-degree relatives and probands with juvenile myoclonic epilepsy. Seizure 2006;15(3):177-83.27. Sozmen V, Baybas S, Dirican A, Koksal A, Ozturk M. Frequency of epilepsies in family members of patients with different epileptic syndromes. European Neurol 2010;65(1):4-9.28. Mullins G, Oâsullivan S, Neligan A, McCarthy A, McNamara B, Galvin R, et al. A study of idiopathic generalised epilepsy in an Irish population. Seizure 2007;16(3):204-10.29. Shahnaz KS, Sattar RA. Clinical and EEG characteristics of Juvenile Myoclonic Epilepsy. Pak J Med Sci 2014;30(1):12.30. Liu A, Delgado-Escueta A, Gee M, Serratosa J, Zhang Q, Alonso M, et al. Juvenile myoclonic epilepsy in chromosome 6p12-p11: Locus heterogeneity and recombinations. Am J Medi Genetics 1996;63(3):438-46. 31. Figueredo R, Trevisol-Bittencourt PC, Ferro JBdM. Estudo clĂnico-epidemiolĂłgico de pacientes com epilepsia mioclĂŽnica juvenil em Santa Catarina. Arq Neuropsiquiatr 1999;57(2-B):401-4.32. Obeid T, Panayiotopoulos C. Juvenile myoclonic epilepsy: a study in Saudi Arabia. Epilepsia 1988;29(3):280-2.33. Nair RR, Thomas SV. Genetic liability to epilepsy in Kerala State, India. Epilepsy Res 2004;62(2):163-70. 34. Ottman R, Lee JH, Risch N, Hauser WA, Susser M. Clinical indicators of genetic susceptibility to epilepsy. Epilepsia 1996;37(4):353-61.35. Bianchi A, Viaggi S, Chiossi E. Family study of epilepsy in first degree relatives: data from the Italian Episcreen Study. Seizure 2003;12(4):203-10.36. Manganotti P, Bongiovanni LG, Fuggetta G, Zanette G, Fiaschi A. Effects of sleep deprivation on cortical excitability in patients affected by juvenile myoclonic epilepsy: a combined transcranial magnetic stimulation and EEG study. J Neurol Neurosurg Psychiatr 2006;77(1):56-60. Epub 2005/12/20.37. Roebling R, Scheerer N, Uttner I, Gruber O, Kraft E, Lerche H. Evaluation of cognition, structural, and functional MRI in juvenile myoclonic epilepsy. Epilepsia 2009;50(11):2456-65. Epub 2009/06/06.38. Edwards T, Scott AG, Munyoki G, Odera VMa, Chengo E, Bauni E, et al. Active convulsive epilepsy in a rural district of Kenya: a study of prevalence and possible risk factors. The Lancet Neurol 2008;7(1):50-6.
Numerical performance of thermal conductivity in Bioconvection flow of cross nanofluid containing swimming microorganisms over a cylinder with melting phenomenon
This study investigates the effects of melting phenomena and non-linear thermal radiation in Cross nanofluid bioconvection flow with motile microorganisms with a convective boundary over a cylinder. Brownian motion and thermophoresis diffusion are also taken into account in this mathematical model. A governing partial differential equation is used to represent the given flow phenomena. The proper dimensionless transformation is then employed to convert the PDE controlling system into an ordinary one. Bvp4c numerically solves redesigned ODE problems using a shooting strategy in the computational tool MATLAB. Figures versus velocity, temperature distribution, nanoparticle concentration, and microbe concentration profiles are used to analyze and expound on the notably involved aspects thoroughly. It has been demonstrated that increasing the estimates of a mixed convection parameter can enhance velocity. By increasing the Prandtl number, the temperature and concentration of nanoparticles decrease. A high Peclet value lowers the microorganism\u27s profile
Performance Evaluation of Nanofluids in an Inclined Ribbed Microchannel for Electronic Cooling Applications
Nanofluids are liquid/solid suspensions with higher thermal conductivity, compared to common working fluids. In recent years, the application of these fluids in electronic cooling systems seems prospective. In the present study, the laminar mixed convection heat transfer of different waterâcopper nanofluids through an inclined ribbed microchannelââas a common electronic cooling system in industryââwas investigated numerically, using a finite volume method. The middle section of microchannelâs right wall was ribbed, and at a higher temperature compared to entrance fluid. The modeling was carried out for Reynolds number of 50, Richardson numbers from 0.1 to 10, inclination angles ranging from 0° to 90°, and nanoparticlesâ volume fractions of 0.0â0.04. The influences of nanoparticle volume concentration, inclination angle, buoyancy and shear forces, and ribâs shape on the hydraulics and thermal behavior of nanofluid flow were studied. The results were portrayed in terms of pressure, temperature, coefficient of friction, and Nusselt number profiles as well as streamlines and isotherm contours. The model validation was found to be in excellent accords with experimental and numerical results from other previous studies
MILD AND EFFICIENT METHOD FOR OXIDATION OF ALCOHOLS IN IONIC LIQUID MEDIA
In this study the strong oxidative agent, potassium permanganate, has been moderated with using under ionic liquid media for selective oxidation of some benzylic and aliphatic alcohols to their corresponding carbonyl compounds under mild and green conditions. 1-Butyl-3-methylimidazoliumbromide ([bmim]Br) (BMIM) associated with acetonitrile has been employed as modified media for oxidation of benzylic alcohols. This chemoselective and efficient process produced aldehydes and ketones with higher purity and yields and shorter reaction period in [bmim]Br as ionic liquid than conventional solvents
Role of cardiac hypoxia in the pathogenesis of sudden death syndrome in broiler chickens. A metabolic and molecular study
Analytical study concerning foundations of social constructionism
This study is aimed to achieve the foundations of social constructionism by using analytical method. Using analytical method, dissection of the social constructionismâs foundations will be the main aim of this study. To achieve social constructionismâs foundations, after preparing a definition, its differences with constructivism, its types, features, and roots were examined. The results showed that despite being realistic with regards to ontology, as soon as talking about the reality, social constructivism changes to a constructed phenomenon, which adopts a critical and pluralistic stand. Knowledge, in this perspective, is the product of social interactions. Furthermore, constructionism, regarding ethics and values, treats with respect to the values of other cultures and believes in toleration. Thus, social constructionism is based on a relative and pluralistic ontology, epistemology, and axiology. Viewing from an anthropological point of view, social constructionists, are also known as anti-essentialism and anti-individualism and the human is considered as a social animal. Finally, they assign both individual and society as the origin of effect
Mathematical Modeling for Nanofluids Simulation: A Review of the Latest Works
Exploiting nanofluids in thermal systems is growing day by day. Nanofluids having ultrafine solid particles promise new working fluids for application in energy devices. Many studies have been conducted on thermophysical properties as well as heat and fluid flow characteristics of nanofluids in various systems to discover their advantages compared to conventional working fluids. The main aim of this study is to present the latest developments and progress in the mathematical modeling of nanofluids flow. For this purpose, a comprehensive review of different nanofluid computational fluid dynamics (CFD) approaches is carried out. This study provides detailed information about the commonly used formulations as well as techniques for mathematical modeling of nanofluids. In addition, advantages and disadvantages of each method are rendered to find the most appropriate approach, which can give valid results
A Randomized Triple-Blind Clinical Trial of the Effect of Low-Level Laser Therapy on Infiltration Injection Pain in the Anterior Maxilla
Objective: To evaluate the level of pain experienced during infiltration anesthesia of the anterior maxilla following low-level laser therapy (LLLT) with 810-980 nm wavelengths. Material and Methods: In the current triple-blind clinical trial, 84 patients received a total of 168 infiltration anesthesia injections (1.8 mL of 2% lidocaine plus 1:100,000 epinephrine) in the anterior maxilla. Each patient received two injections into the buccal mucosa of the right and left central incisors with a two-week interval. One injection was performed after LLLT, while the other injection was administered conventionally without laser. The pain level was measured immediately after injection using a visual analog scale (VAS). Results: There was a significant difference in the pain level experienced with and without LLLT, such that the mean pain score following LLLT was significantly lower than that without LLLT (p<0.05). No significant difference was found in the pain level between laser and no laser groups in males, but the difference in this regard was significant in females (p<0.05) and female patients experienced a significantly lower level of pain following LLLT. Conclusion: The low-level laser therapy can be successfully used to decrease the level of pain experienced during infiltration anesthesia of the anterior maxilla
Numerical Investigation of Heat Transfer Enhancement in a Rectangular Heated Pipe for Turbulent Nanofluid
Thermal characteristics of turbulent nanofluid flow in a rectangular pipe have been investigated numerically. The continuity, momentum, and energy equations were solved by means of a finite volume method (FVM). The symmetrical rectangular channel is heated at the top and bottom at a constant heat flux while the sides walls are insulated. Four different types of nanoparticles Al2O3, ZnO, CuO, and SiO2 at different volume fractions of nanofluids in the range of 1% to 5% are considered in the present investigation. In this paper, effect of different Reynolds numbers in the range of 5000 < Re < 25000 on heat transfer characteristics of nanofluids flowing through the channel is investigated. The numerical results indicate that SiO2-water has the highest Nusselt number compared to other nanofluids while it has the lowest heat transfer coefficient due to low thermal conductivity. The Nusselt number increases with the increase of the Reynolds number and the volume fraction of nanoparticles. The results of simulation show a good agreement with the existing experimental correlations
A Review on biomedical application of polysaccharide-based hydrogels with a focus on drug delivery systems
Over the last years of research on drug delivery systems (DDSs), natural polymer-based 18 hydrogels have shown many scientific advances due to their intrinsic properties and a wide variety 19 of potential applications. While drug efficacy and cytotoxicity play a key role, adopting a proper 20 DDS is crucial to preserve the drug along the route of administration and possess desired therapeu-21 tic effect at the targeted site. Thus, drug delivery technology can be used to overcome the difficulties 22 of maintaining drugs at a physiologically related serum concentration for prolonged periods. Due 23 to their outstanding biocompatibility, polysaccharides have been thoroughly researched as a bio-24 logical material for DDS advancement. To formulate a modified DDS, polysaccharides can cross-25 link with different molecules, resulting in hydrogels. According to our recent findings, targeted 26 drug delivery at a certain spot occurs due to external stimulation like temperature, pH, glucose, or 27 light. As an adjustable biomedical device, the hydrogel has tremendous potential for nanotech ap-28 plications in the involved health area like pharmaceutical and biomedical engineering. An overview 29 of hydrogel characteristics and functionalities is provided in this review. We focus on discussing 30 the various kinds of hydrogel-based on their potential for effectively delivering drugs that are made 31 of polysaccharides
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