NOSTROMO - D1.2 - Final Project Results Report

The main objective of the NOSTROMO project has been to develop, demonstrate and evaluate an innovative modelling approach for the rigorous and comprehensive assessment of the performance impact of future ATM concepts and solutions at ECAC network level. This approach brings together the ability of bottom-up microscopic models to capture emergent behaviour and interdependencies between different solutions with the level of tractability and interpretability required to effectively support decision-making. This report provides a summary of NOSTROMO accomplishments and contributions to the SESAR Programme. It gathers technical lessons learned and concludes proposing further developments to facilitate the use of the NOSTROMO methodology in the future SESAR 3 Programme

Towards an in-plane methodology to track breast lesions using mammograms and patient-specific finite-element simulations

In breast cancer screening or diagnosis, it is usual to combine different images in order to locate a lesion as accurately as possible. These images are generated using a single or several imaging techniques. As x-ray-based mammography is widely used, a breast lesion is located in the same plane of the image (mammogram), but tracking it across mammograms corresponding to different views is a challenging task for medical physicians. Accordingly, simulation tools and methodologies that use patient-specific numerical models can facilitate the task of fusing information from different images. Additionally, these tools need to be as straightforward as possible to facilitate their translation to the clinical area. This paper presents a patient-specific, finite-element-based and semi-automated simulation methodology to track breast lesions across mammograms. A realistic three-dimensional computer model of a patient''s breast was generated from magnetic resonance imaging to simulate mammographic compressions in cranio-caudal (CC, head-to-toe) and medio-lateral oblique (MLO, shoulder-to-opposite hip) directions. For each compression being simulated, a virtual mammogram was obtained and posteriorly superimposed to the corresponding real mammogram, by sharing the nipple as a common feature. Two-dimensional rigid-body transformations were applied, and the error distance measured between the centroids of the tumors previously located on each image was 3.84 mm and 2.41 mm for CC and MLO compression, respectively. Considering that the scope of this work is to conceive a methodology translatable to clinical practice, the results indicate that it could be helpful in supporting the tracking of breast lesions

Correlations between Background Radiation inside a Multilayer Interleaving Structure, Geomagnetic Activity, and Cosmic Radiation: A Fourth Order Cumulant-based Correlation Analysis

In this work, we analyzed time-series of background radiation inside a multilayer interleaving structure, geomagnetic activity and cosmic-ray activity using the Pearson correlation coefficient and a new correlation measure based on the one-dimensional component of the fourth order cumulant. The new method is proposed based on the fact that the cumulant of a random process is zero if it is of Gaussian nature. The results show that this methodology is useful for detecting correlations between the analyzed variables.Comment: 8 pages, 2 figures and 4 table

Relationship Between the Xylem Anatomy of Grapevine Rootstocks and Their Susceptibility to Phaeoacremonium minimum and Phaeomoniella chlamydospora

[EN] Fungal grapevine trunk diseases (GTDs) are some of the most pressing threats to grape production worldwide. While these diseases are associated with several fungal pathogens, Phaeomoniella chlamydospora and Phaeoacremonium minimum are important contributors to esca and Petri diseases. Recent research has linked grapevine xylem diameter with tolerance to Pa. chlamydospora in commercial rootstocks. In this study, we screen over 25 rootstocks for xylem characteristics and tolerance to both Pa. chlamydospora and Pm. minimum. Tolerance was measured by fungal incidence and DNA concentration (quantified via qPCR), while histological analyses were used to measure xylem characteristics, including xylem vessels diameter, density, and the proportion of the stem surface area covered by xylem vessels. Rootstocks were grouped into different classes based on xylem characteristics to assess the potential association between vasculature traits and pathogen tolerance. Our results revealed significant differences in all the analyzed xylem traits, and also in DNA concentration for both pathogens among the tested rootstocks. They corroborate the link between xylem vessels diameter and tolerance to Pa. chlamydospora. In Pm. minimum, the rootstocks with the widest xylem diameter proved the most susceptible. This relationship between vasculature development and pathogen tolerance has the potential to inform both cultivar choice and future rootstock breeding to reduce the detrimental impact of GTDs worldwide.Funding This research was founded by FEDER funding through a State Program of I + D + i oriented to the Challenges of Society (RTA2015-00015-C02-00), supported by The National Institute for Agricultural and Food Research and Technology (INIA). DG was supported by the Ramon y Cajal program, Spanish Government (RyC-2017-23098). This research has been developed as a result of a mobility stay funded by the Erasmus+ KA1 Erasmus Mundus Joint Master Degrees Programme of the European Commission under the PLANT HEALTH Project.Ramsing, CK.; Gramaje, D.; Mocholí, S.; Agusti, J.; Cabello Sáenz De Santa María, F.; Armengol Fortí, J.; Berbegal Martinez, M. (2021). Relationship Between the Xylem Anatomy of Grapevine Rootstocks and Their Susceptibility to Phaeoacremonium minimum and Phaeomoniella chlamydospora. Frontiers in Plant Science. 12:1-13. https://doi.org/10.3389/fpls.2021.726461S1131

Bibliografía histórica sobre la Ciencia y la Técnica en España. 1997

Repertori de bibliografia històrica sobre la ciència i la tècnica a Espanya editada en 1994. //.Repertorio de bibliografía histórica sobre la ciencia y la técnica en España editada en 1994

Ship-to-shore training for active deep-sea capacity development

Sailing on scientific expeditions as an early career researcher (ECR) offers the beneficial opportunity to gain field experience and training. However, the number of available berths to achieve the scientific goals of an expedition limits the number of onboard participants. Telepresence and remote learning can be utilized to increase the number of active participants, broadening the reach of capacity development. The 2021 iMirabilis2 expedition on board the Spanish Research Vessel Sarmiento de Gamboa used telepresence to virtually involve ECRs from several countries in deep-sea science. One year post-expedition, a survey of onshore participants was conducted to assess and quantify the effectiveness of the peer-to-peer ECR ship-to-shore scheme. During the expedition, live, interactive training via WhatsApp and Zoom was utilized by onshore ECRs more than traditional static, unidirectional methods of blog posts and pre-recorded videos. All respondents either agreed or strongly agreed that the scheme provided an inclusive and accessible platform to share deep-sea science. These results suggest similar schemes could be used to supplement shorter-duration at-sea-training, used prior to a seagoing experience to better prepare ECRs, or to allow members of the science community unable to join an expedition in person to actively participate remotely, increasing inclusivity

RhoE Deficiency Produces Postnatal Lethality, Profound Motor Deficits and Neurodevelopmental Delay in Mice

Rnd proteins are a subfamily of Rho GTPases involved in the control of actin cytoskeleton dynamics and other cell functions such as motility, proliferation and survival. Unlike other members of the Rho family, Rnd proteins lack GTPase activity and therefore remain constitutively active. We have recently described that RhoE/Rnd3 is expressed in the Central Nervous System and that it has a role in promoting neurite formation. Despite their possible relevance during development, the role of Rnd proteins in vivo is not known. To get insight into the in vivo function of RhoE we have generated mice lacking RhoE expression by an exon trapping cassette. RhoE null mice (RhoE gt/gt) are smaller at birth, display growth retardation and early postnatal death since only half of RhoE gt/gt mice survive beyond postnatal day (PD) 15 and 100% are dead by PD 29. RhoE gt/gt mice show an abnormal body position with profound motor impairment and impaired performance in most neurobehavioral tests. Null mutant mice are hypoactive, show an immature locomotor pattern and display a significant delay in the appearance of the hindlimb mature responses. Moreover, they perform worse than the control littermates in the wire suspension, vertical climbing and clinging, righting reflex and negative geotaxis tests. Also, RhoE ablation results in a delay of neuromuscular maturation and in a reduction in the number of spinal motor neurons. Finally, RhoE gt/gt mice lack the common peroneal nerve and, consequently, show a complete atrophy of the target muscles. This is the first model to study the in vivo functions of a member of the Rnd subfamily of proteins, revealing the important role of Rnd3/RhoE in the normal development and suggesting the possible involvement of this protein in neurological disorders