A Measurement of the Cosmic Microwave Background Gravitational Lensing Potential and its Power Spectrum from 500 Square Degrees of SPTpol Data

Weak gravitational lensing by large-scale structure in the universe causes deflections in the paths of cosmic microwave background (CMB) photons. This effect introduces statistical anisotropy in the observed CMB temperature and polarization fields. The signature of lensing can be used to reconstruct the projected gravitational lensing potential with a quadratic estimator technique; this provides a measure of the integrated mass distribution out to the surface of last scattering, sourced primarily from redshifts between 0.1 and 5. The power spectrum of the lensing potential encodes information about the geometry of the universe and the growth of structure and can be used to place constraints on the sum of neutrino masses and dark energy. High signal-to-noise mass maps from CMB lensing are also powerful for cross-correlating with other tracers of large-scale structure and for delensing the CMB in search for primordial gravitational waves. This thesis describes a high signal-to-noise reconstruction of the CMB gravitational lensing potential and a measurement of its power spectrum using data from 500 \sqdeg of sky observed between 2012 and 2015 with the polarization-sensitive receiver SPTpol, installed on the South Pole Telescope (SPT). We find the ratio of the lensing spectrum to a theoretical $\Lambda$CDM model to be A_{\rm \mv}=0.94 \pm 0.05 {\rm\, (stat.)} \pm 0.04 {\rm\, (sys.)}. This measurement represents a $17.1 \sigma$ constraint on the lensing amplitude and a $41 \sigma$ detection of lensing effects

Mesenchymal Stem Cell-Derived Exosomes Modulate Angiogenesis in Gastric Cancer

Individualized gastric cancer (GC) treatment aims at providing targeted therapies that translate the latest research into improved management strategies. Extracellular vesicle microRNAs have been proposed as biomarkers for GC prognosis. Helicobacter pylori infection influences the therapeutic response to and the drivers of malignant changes in chronic gastritis. The successful use of transplanted mesenchymal stem cells (MSCs) for gastric ulcer healing has raised interest in studying their effects on tumor neovascularization and in potential antiangiogenic therapies that could use mesenchymal stem cell secretion into extracellular vesicles—such as exosomes—in GC cells. The use of MSCs isolated from bone marrow in order to achieve angiogenic modulation in the tumor microenvironment could exploit the inherent migration of MSCs into GC tissues. Bone marrow-derived MSCs naturally present in the stomach have been reported to carry a malignancy risk, but their effect in GC is still being researched. The pro- and antiangiogenic effects of MSCs derived from various sources complement their role in immune regulation and tissue regeneration and provide further understanding into the heterogeneous biology of GC, the aberrant morphology of tumor vasculature and the mechanisms of resistance to antiangiogenic drugs

A Measurement of the Cosmic Microwave Background Lensing Potential and Power Spectrum from 500 deg2 of SPTpol Temperature and Polarization Data

We present a measurement of the cosmic microwave background lensing potential using 500 deg2 of 150 GHz data from the SPTpol receiver on the South Pole Telescope. The lensing potential is reconstructed with signal-to-noise per mode greater than unity at lensing multipoles L lesssim 250, using a quadratic estimator on a combination of cosmic microwave background temperature and polarization maps. We report measurements of the lensing potential power spectrum in the multipole range of 100 < L < 2000 from sets of temperature-only (T), polarization-only (POL), and minimum-variance (MV) estimators. We measure the lensing amplitude by taking the ratio of the measured spectrum to the expected spectrum from the best-fit Λ cold dark matter model to the Planck 2015 TT + low P + lensing data set. For the minimum-variance estimator, we find ${A}_{\mathrm{MV}}=0.944\pm 0.058(\mathrm{Stat}.)\pm 0.025\ (\mathrm{Sys}.);$ restricting to only polarization data, we find ${A}_{\mathrm{POL}}=0.906\pm 0.090\ (\mathrm{Stat}.)\pm 0.040\ (\mathrm{Sys}.)$. Considering statistical uncertainties alone, this is the most precise polarization-only lensing amplitude constraint to date (10.1σ) and is more precise than our temperature-only constraint. We perform null tests and consistency checks and find no evidence for significant contamination

A demonstration of improved constraints on primordial gravitational waves with delensing

We present a constraint on the tensor-to-scalar ratio, r, derived from measurements of cosmic microwave background (CMB) polarization B-modes with “delensing,” whereby the uncertainty on r contributed by the sample variance of the gravitational lensing B-modes is reduced by cross-correlating against a lensing B-mode template. This template is constructed by combining an estimate of the polarized CMB with a tracer of the projected large-scale structure. The large-scale-structure tracer used is a map of the cosmic infrared background derived from Planck satellite data, while the polarized CMB map comes from a combination of South Pole Telescope, bicep/Keck, and Planck data. We expand the bicep/Keck likelihood analysis framework to accept a lensing template and apply it to the bicep/Keck dataset collected through 2014 using the same parametric foreground modeling as in the previous analysis. From simulations, we find that the uncertainty on r is reduced by ∼10%, from σ(r)=0.024 to 0.022, which can be compared with a ∼26% reduction obtained when using a perfect lensing template or if there were zero lensing B-modes. Applying the technique to the real data, the constraint on r is improved from r0.05<0.090 to r0.05<0.082 (95% C.L.). This is the first demonstration of improvement in an r constraint through delensing

Diminishing benefits of urban living for children and adolescents’ growth and development

Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1–6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis of rural and urban place of residence in 200 countries and territories from 1990 to 2020. In 1990, children and adolescents residing in cities were taller than their rural counterparts in all but a few high-income countries. By 2020, the urban height advantage became smaller in most countries, and in many high-income western countries it reversed into a small urban-based disadvantage. The exception was for boys in most countries in sub-Saharan Africa and in some countries in Oceania, south Asia and the region of central Asia, Middle East and north Africa. In these countries, successive cohorts of boys from rural places either did not gain height or possibly became shorter, and hence fell further behind their urban peers. The difference between the age-standardized mean BMI of children in urban and rural areas was <1.1 kg m–2 in the vast majority of countries. Within this small range, BMI increased slightly more in cities than in rural areas, except in south Asia, sub-Saharan Africa and some countries in central and eastern Europe. Our results show that in much of the world, the growth and developmental advantages of living in cities have diminished in the twenty-first century, whereas in much of sub-Saharan Africa they have amplified

Low incidence of SARS-CoV-2, risk factors of mortality and the course of illness in the French national cohort of dialysis patients

International audienceThe aim of this study was to estimate the incidence of COVID-19 disease in the French national population of dialysis patients, their course of illness and to identify the risk factors associated with mortality. Our study included all patients on dialysis recorded in the French REIN Registry in April 2020. Clinical characteristics at last follow-up and the evolution of COVID-19 illness severity over time were recorded for diagnosed cases (either suspicious clinical symptoms, characteristic signs on the chest scan or a positive reverse transcription polymerase chain reaction) for SARS-CoV-2. A total of 1,621 infected patients were reported on the REIN registry from March 16th, 2020 to May 4th, 2020. Of these, 344 died. The prevalence of COVID-19 patients varied from less than 1% to 10% between regions. The probability of being a case was higher in males, patients with diabetes, those in need of assistance for transfer or treated at a self-care unit. Dialysis at home was associated with a lower probability of being infected as was being a smoker, a former smoker, having an active malignancy, or peripheral vascular disease. Mortality in diagnosed cases (21%) was associated with the same causes as in the general population. Higher age, hypoalbuminemia and the presence of an ischemic heart disease were statistically independently associated with a higher risk of death. Being treated at a selfcare unit was associated with a lower risk. Thus, our study showed a relatively low frequency of COVID-19 among dialysis patients contrary to what might have been assumed