Proximal Corpus Cavernosum Tear Presenting as Scrotal Hematoma

We present the case of a penile fracture involving the proximal corpus cavernosum, presenting as a hematoma extending into the scrotum. The presentation, diagnosis, and surgical approach, which differ from the more typical penile shaft fracture, are delineated

The diagnosis of male infertility:an analysis of the evidence to support the developments of global WHO guidance. Challenges and future research opportunities

Background: Herein, we describe the consensus guideline methodology, summarize the evidence-based recommendations we provided to the World Health Organization (WHO) for their consideration in the development of global guidance and present a narrative review of the diagnosis of male infertility as related to the eight prioritized (problem or population (P), intervention (I), comparison (C) and outcome(s) (O) (PICO)) questions. Additionally, we discuss the challenges and research gaps identified during the synthesis of this evidence.Objective and Rationale: The aim of this paper is to present an evidence-based approach for the diagnosis of male infertility as related to the eight prioritized PICO questions.Search Methods: Collating the evidence to support providing recommendations involved a collaborative process as developed by WHO, namely: identification of priority questions and critical outcomes; retrieval of up-to-date evidence and existing guidelines; assessment and synthesis of the evidence; and the formulation of draft recommendations to be used for reaching consensus with a wide range of global stakeholders. For each draft recommendation the quality of the supporting evidence was then graded and assessed for consideration during a WHO consensus.Outcomes: Evidence was synthesized and recommendations were drafted to address the diagnosis of male infertility specifically encompassing the following: What is the prevalence of male infertility and what proportion of infertility is attributable to the male? Is it necessary for all infertile men to undergo a thorough evaluation? What is the clinical (ART/non ART) value of traditional semen parameters? What key male lifestyle factors impact on fertility (focusing on obesity, heat and tobacco smoking)? Do supplementary oral antioxidants or herbal therapies significantly influence fertility outcomes for infertile men? What are the evidence-based criteria for genetic screening of infertile men? How does a history of neoplasia and related treatments in the male impact on (his and his partner’s) reproductive health and fertility options? And lastly, what is the impact of varicocele on male fertility and does correction of varicocele improve semen parameters and/or fertility?Wider Implications: This evidence synthesis analysis has been conducted in a manner to be considered for global applicability for the diagnosis of male infertility

Motile sperm organelle morphology examination (MSOME): intervariation study of normal sperm and sperm with large nuclear vacuoles

<p>Abstract</p> <p>Background</p> <p>Although the motile sperm organelle morphology examination (MSOME) was developed only as a selection criterion, its application as a method for classifying sperm morphology may represent an improvement in evaluation of semen quality, with potential clinical repercussions. The present study aimed to evaluate individual variations in the motile sperm organelle morphology examination (MSOME) analysis after a time interval.</p> <p>Methods</p> <p>Two semen samples were obtained from 240 men from an unselected group of couples undergoing infertility investigation and treatment. Mean time interval between the two semen evaluations was 119 +/- 102 days. No clinical or surgical treatment was realized between the two observations. Spermatozoa were analyzed at greater than or equal to 8400× magnification by inverted microscope equipped with DIC/Nomarski differential interference contrast optics. At least 200 motile spermatozoa per semen sample were evaluated and percentages of normal spermatozoa and spermatozoa with large nuclear vacuoles (LNV/one or more vacuoles occupying >50% of the sperm nuclear area) were determined. A spermatozoon was classified as morphologically normal when it exhibited a normal nucleus (smooth, symmetric and oval nucleus, width 3.28 +/- 0.20 μm, length 4.75 +/- 0.20 μm/absence of vacuoles occupying >4% of nuclear area) as well as acrosome, post-acrosomal lamina, neck and tail, besides not presenting cytoplasm around the head. One examiner, blinded to subject identity, performed the entire study.</p> <p>Results</p> <p>Mean percentages of morphologically normal and LNV spermatozoa were identical in the two MSOME analyses (1.6 +/- 2.2% vs. 1.6 +/- 2.1% <it>P </it>= 0.83 and 25.2 +/- 19.2% vs. 26.1 +/- 19.0% <it>P </it>= 0.31, respectively). Regression analysis between the two samples revealed significant positive correlation for morphologically normal and for LNV spermatozoa (r = 0.57 95% CI:0.47-0.65 <it>P </it>< 0.0001 and r = 0.50 95% CI:0.38-0.58 <it>P </it>< 0.0001, respectively).</p> <p>Conclusions</p> <p>The significant positive correlation and absence of differences between two sperm samples evaluated after a time interval with respect to normal morphology and LNV spermatozoa indicated that MSOME seems reliable (at least for these two specific sperm forms) for analyzing semen. The present result supports the future use of MSOME as a routine method for semen analysis.</p

Россия и Монголия близки

В статье дается обзор презентации монографий российских, монгольских ученых о Монголии и ее культуре, которая состоялась в г. Улабаатор (Монголия)

Multiplex Waves in the Planning of Innovation Processes in Business Systems

This chapter aims to outline the methodologies for solving the most important challenges in the field of innovation management – assessment of innovative events and activities and selection of optimal calendar periods for carrying them out. A transdisciplinary approach is used as a way of solving this problem. Basic principles of this approach, principles of building transdisciplinary models of informational and temporal order units will be covered, thereby making it possible to represent development as a multiplex or a totality of M-waves. Use of such models allows to offer special methodologies - an innovative chart of business system development. Results of a retrospective analysis of several enterprises are shown, which confirm the effectiveness of this methodical technique, and an example of building an innovative chart of development is presented, including the calculation of schedule periods for development and implementation of investment, as well as mandatory critical points and control points in the future development of business systems. </jats:p

Actual problems of Eurasianism

Reader’s note on: Eurasianism: theoretical potential and practical application: materials of Sixth All-Russian Science and Practice conference (with international participants) Barnaul, June 25–26, 2012: in 2 v. / ed. by V.Ya. Barkalov, A.V. Ivanov, Barnaul: IG "Si-press”, 2012

Recent advancements in PARP inhibitors-based targeted cancer therapy

Abstract Poly(ADP-ribose) polymerase inhibitors (PARPi) are a new class of agents with unparalleled clinical achievement for driving synthetic lethality in BRCA-deficient cancers. Recent FDA approval of PARPi has motivated clinical trials centered around the optimization of PARPi-associated therapies in a variety of BRCA-deficient cancers. This review highlights recent advancements in understanding the molecular mechanisms of PARP ‘trapping’ and synthetic lethality. Particular attention is placed on the potential extension of PARPi therapies from BRCA-deficient patients to populations with other homologous recombination-deficient backgrounds, and common characteristics of PARPi and non-homologous end-joining have been elucidated. The synergistic antitumor effect of combining PARPi with various immune checkpoint blockades has been explored to evaluate the potential of combination therapy in attaining greater therapeutic outcome. This has shed light onto the differing classifications of PARPi as well as the factors that result in altered PARPi activity. Lastly, acquired chemoresistance is a crucial issue for clinical application of PARPi. The molecular mechanisms underlying PARPi resistance and potential overcoming strategies are discussed.</jats:p

Hallmark of Dentistry: The Evolution and Benefits of the Dental Magnifying Loupe

ABSTRACTBackground Dental education has increasingly recognized magnification as an integral part of dentistry and based on the advantages and benefits recommends its use as early as in the first year of dental school. Dental students and practitioners have become aware of their enhanced quality of work, while preventing eye fatigue and strain. Thanks to proper ergonomics, long-term bodily afflictions such as MSDs can be prevented and increase the dental students and practitioners’ ability to enhance career longevity.Case Description This review aims to present the evolution and benefits of dental magnifying loupes used to improve diagnosis and treatment outcomes through enhancement of the visual acuity, thus preventing musculoskeletal disorders and improving ergonomics. An overview of the type of magnification is presented discussing single lens loupes, Galilean loupes and prism loupes. Furthermore, visual acuity, working distance and depth of field, declination angle and working angle, field of view and convergence angle, magnification and illumination are explained.Practical Implications Loupes offer the dental profession enhanced visualization of the operating field, while at the same time they reduce eyestrain providing ergonomic advantages, and preventing long-term complications such as musculoskeletal disorders (MSDs). When dental students and practitioners wear dental loupes in an ergonomically correct neutral position, significantly more benefits have been reported compared to operators that do not use magnification. Dental magnifying loupes are becoming the expected hallmark of dentistry; thus, they are considered a new identity and icon of the dental profession