13 research outputs found

    Kosmetika onkologikoa: kimioterapiak eta erradioterapiak larruazalean eragindako efektu desiragaitzak eta horiek tratatzeko konposatu naturaletan oinarritutako formulazio berriak

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    Sarritan, tratamendu onkologikoek pazientearen bizi-kalitatea baldintzatu dezaketen efektu desiragaitzak sortzen dituzte, minbizi-zelulak kaltetzeaz gain, bes-telako ehun osasuntsuak suntsitzen baitituzte. Lan honetan tratamendu onkologikoen ondorioz larruazalean sortutako gaitzak aztertuko dira (hala nola pruritoa, ezkatatzea edota ultzerazioa kasu larrienetan) eta baita arazo horiei aurre egiteko formulatu diren produktu berrien konposizioa ere. Orain arte erabili diren kortikoide, antihistaminiko edo lidokainadun kremak alde batera uzteko helburuarekin, laborategi dermokosmeti-koek paziente onkologikoen larruazala tratatzeko bestelako produktu-lerroak merka-turatu dituzte, horien bizi-kalitatea hobetu eta eragin desiragaitz berantiarren agerpena oztopatzeko asmoz. Antzinatik erabili izan diren landare-estraktuez baliatuz, larruaza-laren erreparaketa-prozesua bultzatzea helburu duten formulazioak diseinatu dituzte, Maria D’uol edota OnCosmetics laborategien produktu-lerroak bezala. Beste kasu ba-tzuetan, landare-jatorriko konposatuez gain, bestelako molekula aktiboak erabili dituzte; hala nola, BEACON Biomedicine laborategien kasuan, hazkuntza-faktoreak eta Tectum 11 izeneko proteina-konplexuak erabiltzen dituzte, edota IFC laborategian, Cryptomphalus aspersa barraskilotik lortutako jariakinaz baliatzen dira tratamendu on-kologikoen ondorioz sortutako larruazaleko gaitzak erreparatzeko.; Often, cancer treatments create undesirable effects that may compromise the patient’s quality of life, given that besides killing cancer cells, they also destroy other healthy tissues. The present work discusses the skin diseases caused by cancer treatments, such as pruritus, flaking and/or ulceration in the most severe cases, as well as new products that are formulated to address these issues. With the aim of leaving aside the so far used corticoids, anti-histaminic drugs or lidocaine creams, dermo-cos-metic laboratories are now releasing alternative product lines for the skin treatment of patients with oncologic disorders. This is intended to improve their quality of life, hin-dering the unwanted late onset effects. By using plant extracts that have been used since ancient times, different formulations have been designed to promote the skin re-generation process. Product lines from laboratories such as Maria D’uol and OnCos-metics represent good examples of this. In other cases, besides plant origin compounds, other active molecules are also included. This is the case of BEACON Biomedicine laboratories, working with growth factors and a complex protein called Tectum 1; or IFC, where the fluids obtained from Cryptomphalus aspersa snails are used for the treatment of skin disorders caused by cancer

    Present-Day Greenland Ice Sheet Climate and Surface Mass Balance in CESM2

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    The response of the Greenland Ice Sheet (GrIS) to a warmer climate is uncertain on long time scales. Climate models, such as those participating in the Coupled Model Intercomparison Project phase 6 (CMIP6), are used to assess this uncertainty. The Community Earth System Model version 2.1 (CESM2) is a CMIP6 model capable of running climate simulations with either one-way coupling (fixed ice sheet geometry) or two-way coupling (dynamic geometry) to the GrIS. The model features prognostic snow albedo, online downscaling using elevation classes, and a firn pack to refreeze percolating melt water. Here we evaluate the representation of the GrIS surface energy balance and surface mass balance in CESM2 at 1° resolution with fixed GrIS geometry. CESM2 agrees closely with ERA-Interim reanalysis data for key controls on GrIS SMB: surface pressure, sea ice extent, 500 hPa geopotential height, wind speed, and 700 hPa air temperature. Cloudsat-CALIPSO data show that supercooled liquid-containing clouds are adequately represented, whereas comparisons to Moderate Resolution Imaging Spectroradiometer and CM SAF Cloud, Albedo, and Surface Radiation data set from Advanced Very High Resolution Radiometer data second edition data suggest that CESM2 underestimates surface albedo. The seasonal cycle and spatial patterns of surface energy balance and surface mass balance components in CESM2 agree well with regional climate model RACMO2.3p2, with GrIS-integrated melt, refreezing, and runoff bracketed by RACMO2 counterparts at 11 and 1 km. Time series of melt, runoff, and SMB show a break point around 1990, similar to RACMO2. These results suggest that GrIS SMB is realistic in CESM2, which adds confidence to coupled ice sheet-climate experiments that aim to assess the GrIS contribution to future sea level rise

    Present-Day Greenland Ice Sheet Climate and Surface Mass Balance in CESM2

    No full text
    The response of the Greenland Ice Sheet (GrIS) to a warmer climate is uncertain on long time scales. Climate models, such as those participating in the Coupled Model Intercomparison Project phase 6 (CMIP6), are used to assess this uncertainty. The Community Earth System Model version 2.1 (CESM2) is a CMIP6 model capable of running climate simulations with either one-way coupling (fixed ice sheet geometry) or two-way coupling (dynamic geometry) to the GrIS. The model features prognostic snow albedo, online downscaling using elevation classes, and a firn pack to refreeze percolating melt water. Here we evaluate the representation of the GrIS surface energy balance and surface mass balance in CESM2 at 1° resolution with fixed GrIS geometry. CESM2 agrees closely with ERA-Interim reanalysis data for key controls on GrIS SMB: surface pressure, sea ice extent, 500 hPa geopotential height, wind speed, and 700 hPa air temperature. Cloudsat-CALIPSO data show that supercooled liquid-containing clouds are adequately represented, whereas comparisons to Moderate Resolution Imaging Spectroradiometer and CM SAF Cloud, Albedo, and Surface Radiation data set from Advanced Very High Resolution Radiometer data second edition data suggest that CESM2 underestimates surface albedo. The seasonal cycle and spatial patterns of surface energy balance and surface mass balance components in CESM2 agree well with regional climate model RACMO2.3p2, with GrIS-integrated melt, refreezing, and runoff bracketed by RACMO2 counterparts at 11 and 1 km. Time series of melt, runoff, and SMB show a break point around 1990, similar to RACMO2. These results suggest that GrIS SMB is realistic in CESM2, which adds confidence to coupled ice sheet-climate experiments that aim to assess the GrIS contribution to future sea level rise
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