On multifractals: a non-linear study of actigraphy data

This work aimed, to determine the characteristics of activity series from fractal geometry concepts application, in addition to evaluate the possibility of identifying individuals with fibromyalgia. Activity level data were collected from 27 healthy subjects and 27 fibromyalgia patients, with the use of clock-like devices equipped with accelerometers, for about four weeks, all day long. The activity series were evaluated through fractal and multifractal methods. Hurst exponent analysis exhibited values according to other studies ($H>0.5$) for both groups ($H=0.98\pm0.04$ for healthy subjects and $H=0.97\pm0.03$ for fibromyalgia patients), however, it is not possible to distinguish between the two groups by such analysis. Activity time series also exhibited a multifractal pattern. A paired analysis of the spectra indices for the sleep and awake states revealed differences between healthy subjects and fibromyalgia patients. The individuals feature differences between awake and sleep states, having statistically significant differences for $\alpha_{q-} - \alpha_{0}$ in healthy subjects ($p = 0.014$) and $D_{0}$ for patients with fibromyalgia ($p = 0.013$). The approach has proven to be an option on the characterisation of such kind of signals and was able to differ between both healthy and fibromyalgia groups. This outcome suggests changes in the physiologic mechanisms of movement control.Comment: Preprint accepted for publication at Physica A: Statistical Mechanics and its Application

Relatório de estágio profissional

O seguinte relatório de estágio profissional está dividido em três capítulos, no entanto antes dos capítulos serem iniciados irá ser apresentada uma breve introdução a este trabalho no qual estarão identificados uma série de elementos, tais como, a identificação do local de estágio, a descrição da estrutura deste relatório, a identificação do grupo de estágio, a metodologia utilizada, a pertinência do estágio e ainda a duração e cronologia do mesmo. No capítulo 1 serão apresentadas sete secções referentes às diferentes salas por onde passei durante o tempo de estágio, em cada secção irei fazer relatos diários seguidos de inferências fundamentadas segundo as práticas observadas. O capítulo 2 destina-se com as planificações de algumas aulas dadas no Ensino do pré-escolar contendo os diferentes domínios que lecionei, bem como estratégias e as devidas inferências fundamentadas cientificamente. Posteriormente, o capítulo 3 abordará os dispositivos de avaliação utilizados no Ensino do 1.º ciclo do Ensino Básico ao longo do estágio englobando as três áreas. A última parte deste relatório refere-se à reflexão sobre o mesmo e o futuro. 4 Este relatório possui ainda uma lista de referências bibliográficas utilizadas na sua elaboração, sendo que todos os documentos utilizados para elaborar a fundamentação estarão presentes neste espaço

A mixed integer programming approach for multi-action planning for threat management

Planning for management actions that address threats to biodiversity is important for securing its long term persistence. However, systematic conservation planning (SCP) has traditionally overlooked this aspect and just focused on identiying priority areas without any recommendation on actions needed. This paper develops a mixed integer mathematical programming (MIP) approach for the multi-action management planning problem (MAMP), where the goal is to find an optimal combination of management actions that abate threats, in an efficent way while accounting for connectiivty. An extended version of the MAMP model (MAMP-E) is also proposed that adds an expression for minimizing fragmentation between different actions. To evaluate the efficiency of the two models, they were applied to a case study corresponding to a large area of the Mitchell River in Northern Asutralia, where 45 species of freshwater fish are exposed to the presence of four threats. The evaluation compares our exact MIP approach with the conservation planning software Marxan and the heuristic approach developed in Cattarino et al. (2015). The results obtained show that our MIP models have three advantages over their heuristic counterparts: shorter execution times, higher solutions quality, and a solution quality guarantee. Hence, the proposed MIP methodology provides a more effective framework for addressing the multi-action conservation problem.Peer ReviewedPostprint (published version

Architectural design of classroom to stimulate learning in higher education: an approach connected with neuroeducation and neuroarchitecture

The architectural design of learning spaces in higher education has undergone profound changes with the new educational perspectives that break with traditional pedagogical practice supported by control, hierarchy, and information dissemination. Educational institutions are gradually seeking disruptive models that enhance new learning experiences. This article presents references of innovative projects of learning and interaction spaces, that have been added to the principles of Neuroeducation and Neuroarchitecture for the development of architectural strategies for a new classroom proposal for the Bahia State University. As a result, the project brings preliminary studies to the Learning Environment Model for Higher Education (LEMHE). A flexible model, divided into three learning areas: flexible zone (active); introspection zone, and relaxing zone. This zoning aims to provide diverse experiences of pedagogical practices, added to respect the physiological needs of its users to enhance well-being and learning in higher education.info:eu-repo/semantics/publishedVersio

Reconstrucción mandibular mediante colgajo miocutáneo de pectoral mayor en carcinoma epidermoide, reporte de caso clínico y revisión de la literatura.

Squamous cell carcinoma arises from the epithelium of the oral mucosa, common in the fifth and sixth decades of life and is typically associated with risk factors such as smoking and alcohol consumption. Worldwide, the incidence of oral cancer is higher among men than women. The increase in the incidence of cancer in Mexico requires proper management and the use of vascularized flaps to repair defects generated by a hemimandibulectomy with safety margins. Despite the advent of vascularized free tissue grafts, the myocutaneous pectoralis major flap remains a pedunculated flap widely used for the reconstruction of soft tissue defects in the oral and maxillofacial region. The surgical protocol carried out at the ISSSTE “General Ignacio Zaragoza” Regional Hospital for the treatment of mandibular squamous cell carcinoma is shown.El carcinoma epidermoide surge del epitelio de la mucosa oral, es frecuente en la quinta y sexta décadas de la vida y está típicamente asociado con factores de riesgo como tabaquismo y el consumo de alcohol. En todo el mundo, la incidencia de cáncer oral es más alta en hombres que en mujeres. El incremento en la incidencia del cáncer en México requiere de un manejo adecuado, como colgajos vascularizados para reparar defectos generados por una hemimandibulectomía con márgenes de seguridad. A pesar de la llegada de injertos de tejido libres vascularizados, el colgajo pectoral mayor miocutáneo sigue siendo un colgajo pediculado ampliamente utilizado para la reconstrucción de defectos de tejidos blandos en la región oral y maxilofacial. Se muestra el protocolo quirúrgico realizado en el Hospital Regional “General Ignacio Zaragoza” ISSSTE para el tratamiento de un carcinoma epidermoide mandibular

Origin of the asymmetric magnetization reversal behavior in exchange-biased systems : competing anisotropies

The magnetization reversal in exchange-biased ferromagnetic-antiferromagnetic (FM-AFM) bilayers is investigated. Different reversal pathways on each branch of the hysteresis loop, i.e., asymmetry, are obtained both experimentally and theoretically when the magnetic field is applied at certain angles from the anisotropy direction. The range of angles and the magnitude of this asymmetry are determined by the ratio between the FM anisotropy and the interfacial FM-AFM exchange anisotropy. The occurrence of asymmetry is linked with the appearance of irreversibility, i.e., finite coercivity, as well as with the maximum of exchange bias, increasing for larger anisotropy ratios. Our results indicate that asymmetric hysteresis loops are intrinsic to exchange-biased systems and the competition between anisotropies determines the asymmetric behavior of the magnetization reversal

Analgesia multidimensional para los pacientes en estadio terminal por cáncer de páncreas

Introduction: cancer is the second leading cause of death in the world; the tumors of the digestive system occupy the second place and according to itslocation, those in the pancreas have the lowest survival rate.Objective: to assess the effectiveness of multidimensional analgesia for patients in terminal stage due to pancreatic cancer.Methods: a quasi-experimental, comparative, prospective and longitudinal study was conducted in patients with pain due to pancreatic tumor in terminal stage at Abel Santamaria Cuadrado General Teaching Hospital from November 2016 to July 2019; all patients with pain due topancreatictumor were included. In the terminal stage of pancreatic cancer, three (3) groups were completed according to the analgesia method applied; Group I (n = 10) multimodal analgesia, Group II (n = 10) multidimensional analgesia and Group III (n = 3) following WHO analgesia scheme, analgesia quality, and the need for rescue dose and application of morphine, the methods were compared and survival rate was determined.Results: the quality of analgesia was higher in patients from group II, in the same group the application of morphine was not required until the 7th month and in only two patients (p = 0.00), there were no differences in the rates of survival.Conclusions: the multidimensional approach to analgesia, where the individual is included as a biopsychosocial being and the family achieves greater quality of analgesia, the method applied for pain relief does not influence on survival.Introducción: el cáncer es la segunda causa de muerte en el mundo; los tumores del sistema digestivo ocupan el segundo lugar y según localización los de páncreas poseen la menor tasa de supervivencia.Objetivo: evaluar la efectividad de la analgesia multidimensional para los pacientes en estadio terminal por cáncer de páncreas.Métodos: se realizó un estudio cuasiexperimental, comparativo, prospectivo y longitudinal en pacientes con dolor por tumor de páncreas en etapa final de su enfermedad, en el Hospital Abel Santamaria Cuadrado desde noviembre 2016 a julio 2019. Se incluyeron todos los pacientes con dolor por tumor de páncreas en estadio terminal, se conformaron tres grupos de acuerdo con el método de analgesia empleado; Grupo I (n=10) analgesia multimodal, Grupo II (n=10) analgesia multidimensional y Grupo III (n=3) esquema de analgesia de la Organización Mundial de la Salud, se evaluó calidad de la analgesia, la necesidad de dosis de rescate y uso de morfina, se compararon los métodos y se determinó la supervivencia.Resultados: la calidad de la analgesia fue mayor en los pacientes del grupo II, en igual grupo no fue necesario el uso de morfina hasta el 7mo mes y en solo dos pacientes, (p=0,00) no hubo diferencias en las tasas de supervivencia.Conclusiones: el enfoque multidimensional de la analgesia, donde se incluya al individuo como ser biopsicosocial y a la familia, logra mayor calidad de la analgesia. El método empleado para el alivio del dolor no influye en la supervivencia

Analgesia multidimensional para los pacientes en estadio terminal por cáncer de páncreas

Introduction: cancer is the second leading cause of death in the world; the tumors of the digestive system occupy the second place and according to itslocation, those in the pancreas have the lowest survival rate.Objective: to assess the effectiveness of multidimensional analgesia for patients in terminal stage due to pancreatic cancer.Methods: a quasi-experimental, comparative, prospective and longitudinal study was conducted in patients with pain due to pancreatic tumor in terminal stage at Abel Santamaria Cuadrado General Teaching Hospital from November 2016 to July 2019; all patients with pain due topancreatictumor were included. In the terminal stage of pancreatic cancer, three (3) groups were completed according to the analgesia method applied; Group I (n = 10) multimodal analgesia, Group II (n = 10) multidimensional analgesia and Group III (n = 3) following WHO analgesia scheme, analgesia quality, and the need for rescue dose and application of morphine, the methods were compared and survival rate was determined.Results: the quality of analgesia was higher in patients from group II, in the same group the application of morphine was not required until the 7th month and in only two patients (p = 0.00), there were no differences in the rates of survival.Conclusions: the multidimensional approach to analgesia, where the individual is included as a biopsychosocial being and the family achieves greater quality of analgesia, the method applied for pain relief does not influence on survival.Introducción: el cáncer es la segunda causa de muerte en el mundo; los tumores del sistema digestivo ocupan el segundo lugar y según localización los de páncreas poseen la menor tasa de supervivencia.Objetivo: evaluar la efectividad de la analgesia multidimensional para los pacientes en estadio terminal por cáncer de páncreas.Métodos: se realizó un estudio cuasiexperimental, comparativo, prospectivo y longitudinal en pacientes con dolor por tumor de páncreas en etapa final de su enfermedad, en el Hospital Abel Santamaria Cuadrado desde noviembre 2016 a julio 2019. Se incluyeron todos los pacientes con dolor por tumor de páncreas en estadio terminal, se conformaron tres grupos de acuerdo con el método de analgesia empleado; Grupo I (n=10) analgesia multimodal, Grupo II (n=10) analgesia multidimensional y Grupo III (n=3) esquema de analgesia de la Organización Mundial de la Salud, se evaluó calidad de la analgesia, la necesidad de dosis de rescate y uso de morfina, se compararon los métodos y se determinó la supervivencia.Resultados: la calidad de la analgesia fue mayor en los pacientes del grupo II, en igual grupo no fue necesario el uso de morfina hasta el 7mo mes y en solo dos pacientes, (p=0,00) no hubo diferencias en las tasas de supervivencia.Conclusiones: el enfoque multidimensional de la analgesia, donde se incluya al individuo como ser biopsicosocial y a la familia, logra mayor calidad de la analgesia. El método empleado para el alivio del dolor no influye en la supervivencia

Gender and functional CYP2C and NAT2 polymorphisms determine the metabolic profile of metamizole

Metamizole is a pain-killer drug that has been banned in some countries because of its toxicity, but it is still used in many countries due to its effective analgesic and antispasmodic properties. Although large variability in the biodisposition and adverse effects of metamizole are known, factors underlying this variability are poorly understood. We analyzed the urinary recovery of metabolites, as well as the association of these profiles with genetic and non-genetic factors, in a group of 362 healthy individuals. Gender and functional polymorphisms are strongly related to metabolic profiles. N-demethylation of the active metabolite MAA is diminished in carriers of the CYP2C19*2 allele and in NAT2-slow acetylators. Acetylation of the secondary metabolite AA is decreased in men, in drinkers and in NAT2-slow acetylators with a differential effect of NAT2*5 and NAT2*6 alleles. The formylation of MAA is diminished in older subjects and in carriers of defect CYP2C9 and CYP2C19 alleles. Two novel arachidonoyl metabolites were identified for the first time in humans. Women and NAT2-slow acetylators show higher concentrations, whereas the presence of the rapid CYP2C19*17 allele is associated with lower concentrations of these metabolites. All genetic associations show a gene-dose effect. We identified for the first time genetic and non-genetic factors related to the oxidative metabolism of analgesic drug metamizole, as well as new active metabolites in humans. The phenotypic and genetic factors identified in this study have a potential application as biomarkers of metamizole biotransformation and toxicity.We are grateful to Prof. James McCue for assistance in language editing. Financed by grants PS09/00943, PS09/00469, PI12/00241, PI12/00324 and RETICS RD07/0064/0016 and RD12/0013/0002 and RD12/0013/0009 from Fondo de Investigacion Sanitaria, Instituto de Salud Carlos III, Madrid, Spain; GR10068 from Junta de Extremadura, Spain. Financed in part with FEDER funds from the European Union. I.A. is supported by a Servet Contract CP11/00154.Martínez, C.; Andreu Ros, MI.; Amo, G.; Miranda Alonso, MÁ.; Esguevillas, G.; Torres, MJ.; Blanca López, N.... (2014). Gender and functional CYP2C and NAT2 polymorphisms determine the metabolic profile of metamizole. Biochemical Pharmacology. 92(3):457-466. https://doi.org/10.1016/j.bcp.2014.09.005S45746692

Boraginales Juss. ex Bercht. & J.Presl em uma área de Caatinga na Microrregião do Curimataú Ocidental, Estado da Paraíba, Nordeste do Brasil

Boraginales comprises approximately 125 genera and 2,700 species distributed worldwide. In Brazil, it is represented by 14 genera and 148 species grouped in four families. In this paper, we present the taxonomic survey of Boraginales in a Caatinga area located in the Curimataú Microrregion, where 10 species, two genera and two families were recorded: Cordiaceae, with two genera Cordia (one species) and Varronia (four species) and Heliotropiaceae, with three genera Euploca (one species), Heliotropium (two species) and Myriopus (two species). A key to the recognition of the families and species, as well as descriptions, illustrations, taxonomic comments and geographic distribution data to the species are provided.Boraginales compreende aproximadamente 125 gêneros e 2.700 espécies distribuídas em todo o mundo. No Brasil está representada por 14 gêneros e 148 espécies agrupadas em quatro famílias. Neste estudo, nós apresentamos o levantamento taxonômico de Boraginales em uma área de Caatinga localizada na Microrregião do Curimataú Paraibano, onde 10 espécies, cinco gêneros e duas famílias foram registradas: Cordiaceae, com dois gêneros, Cordia (uma espécie) e Varronia (quatro espécies); e Heliotropiaceae, com três gêneros, Euploca (uma espécie), Heliotropium (duas espécies) e Myriopus (duas espécies). Chave para o reconhecimento das famílias e espécies, além de descrições, ilustrações, comentários taxonômicos e dados sobre distribuição geográfica dos taxa são fornecidos