Late-glacial Coleoptera fauna from Lismore, Nova Scotia

Fossil Coleoptera from a late-glacial site near Lismore, Nova Scotia record paleoclimatic and paleoecological conditions prior to the Younger Dryas in eastern Canada. A buried peat deposit dated 11,900 years B.P. near the base and 10,500 years B.P. at the top contains a small insect fauna that includes both boreal species, such as Olophrum consimile, and subarctic beetle species like Elaphrus lapponicus. Although a palynological study of the Lismore site shows evidence of the Younger Dryas, the beetle fauna is poorly preserved in sandy peat deposits dated younger than 10.600 years B.P. RÉSUMÉ Les coléopteres fossiles provenant d'une site tardi-glaciaire près de Lismore, Nouvelle-Écosse, témoignent des conditions paléoclimatiques et paléoécologiques antérieures au Dryas tardif de Test du Canada. Un dépôt de tourbe, datant de 11,900 B.P. à la base et de 10,500 B.P. au sommet, contient une faune de petits insectes qui inclut autant des espèces boréales, comme Olophrum consimile, que des espèces subarctiques, telle Elaphrus lapponicus. Bien que l'étude palynologique du site de Lismore montre des évidences du Dryas tardif, la faune de coédoptères est mal préservée dans les dépôts de tourbière sablonneux plus jeunes que 10,600 B.P. [Traduit par le journal

Impact of solar photovoltaics on the low-voltage distribution network in New Zealand

Residential rooftop-mounted solar photovoltaic (PV) panels are being installed at an increasing rate, both in New Zealand and globally. There have been concerns over possible issues such as overvoltage and overcurrent. These PV systems are mostly connected at low voltage (LV). This study presents a case study of simulating the entire LV network from a single utility, comprising 10,558 11 kV–415 V transformers and their associated distribution feeders. These results are also presented by network type. Various solar PV penetration levels are added to the model and the power-flow results are presented. From these results, possible maximum limits of solar PV penetration are investigated and measures to alleviate overvoltage problems are simulated. The effect of using PV inverters with voltage regulation is simulated. Results show that some minor overvoltage problems can be expected in the future, particularly in urban areas. However, in most cases the overvoltage would not be much higher than the statutory limit of 1.06 p.u

Total plasma magnesium, zinc, copper and selenium concentrations in obese patients before and after bariatric surgery

Funding: This work was supported by the British Heart Foundation (grant code: FS/20/3/34956).Obesity enhances the risk of type-2 diabetes, cardiovascular disease and inflammatory conditions and often leads to metal dyshomeostasis, which contributes to the negative health aspects associated with the disease. In severe cases, bariatric surgery can be recommended to achieve sustained weight loss and improvement in health. Here, magnesium, zinc, copper and selenium concentrations were examined in 24 obese patients (7 males; 17 females) before and 9 months after undergoing Roux-en-Y gastric bypass surgery. All patients lost weight over this period, with the mean BMI reducing from 51.2±7.1 kg/m2 to 37.2±5.5 kg/m2. Moreover, whole-blood glycated haemoglobin (HbA1c), as a marker of average glycaemia, was also measured and a correlative analysis of this parameter with metal concentrations performed. Significant alterations in the plasma concentrations of magnesium, zinc (both increased by 13.2% and 25.2% respectively) and copper (decreased by 7.9%) were observed over this period (plasma selenium concentration was unchanged), with BMI values correlating with plasma magnesium (p=0.004) and zinc (p=0.022) concentrations. At 9 months post-surgery, an increase in mean zinc/copper ratio was observed (0.86±0.29 compared to 0.63±0.14 pre-surgery). Comparison of whole-blood HbA1c concentrations pre- and post-surgery revealed a reduction from 6.50±1.28% pre-surgery to 5.51±0.49% post-surgery. Differences in plasma HbA1c and magnesium at either pre- and post-surgery correlated significantly, as did HbA1c and magnesium levels when pre- and post-surgery values were analysed together. Collectively, this work reveals that bariatric surgery, in conjunction with lifestyle/dietary changes, lead to improvements in the nutritional status of magnesium, zinc and copper. Furthermore, the observed improvements in magnesium and zinc were associated with weight loss and in the case of magnesium, to better glycaemic control.Publisher PDFPeer reviewe

Identification of a Phosphorylation Site for Calcium/Calmodulindependent Protein Kinase II in the NR2B Subunit of the N-Methyl-D-aspartate Receptor

The N-methyl-D-aspartate (NMDA) subtype of excitatory glutamate receptors plays critical roles in embryonic and adult synaptic plasticity in the central nervous system. The receptor is a heteromultimer of core subunits, NR1, and one or more regulatory subunits, NR2A-D. Protein phosphorylation can regulate NMDA receptor function (Lieberman, D. N., and Mody, I. (1994) Nature 369, 235-239; Wang, Y. T., and Salter, M. W. (1994) Nature 369, 233-235; Wang, L.-Y., Orser, B. A., Brautigan, D. L., and MacDonald, J. F. (1994) Nature 369, 230-232). Here we identify a major phosphorylation site on subunit NR2B that is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (CaM kinase II), an abundant protein kinase located at postsynaptic sites in glutamatergic synapses. For the initial identification of the site, we constructed a recombinant fusion protein containing 334 amino acids of the C terminus of the NR2B subunit and phosphorylated it with CaM kinase II in vitro. By peptide mapping, automated sequencing, and mass spectrometry, we identified the major site of phosphorylation on the fusion protein as Ser-383, corresponding to Ser-1303 of full-length NR2B. The Km for phosphorylation of this site in the fusion protein was ~50 nM, much lower than that of other known substrates for CaM kinase II, suggesting that the receptor is a high affinity substrate. We show that serine 1303 in the full-length NR2B and/or the cognate site in NR2A is a major site of phosphorylation of the receptor both in the postsynaptic density fraction and in living hippocampal neurons

Supersymmetry and a Time-Dependent Landau System

A general technique is outlined for investigating supersymmetry properties of a charged spin-\half quantum particle in time-varying electromagnetic fields. The case of a time-varying uniform magnetic induction is examined and shown to provide a physical realization of a supersymmetric quantum-mechanical system. Group-theoretic methods are used to factorize the relevant Schr\"odinger equations and obtain eigensolutions. The supercoherent states for this system are constructed.Comment: 47 pages, submitted to Phys. Rev. A, LaTeX, IUHET 243 and LA-UR-93-20

TERMS Photometry of Known Transiting Exoplanets

The Transit Ephemeris Refinement and Monitoring Survey (TERMS) conducts radial velocity and photometric monitoring of known exoplanets in order to refine planetary orbits and predictions of possible transit times. This effort is primarily directed towards planets not known to transit, but a small sample of our targets consist of known transiting systems. Here we present precision photometry for 6 WASP planets acquired during their transit windows. We perform a Markov Chain Monte Carlo (MCMC) analysis for each planet and combine these data with previous measurements to redetermine the period and ephemerides for these planets. These observations provide recent mid-transit times which are useful for scheduling future observations. Our results improve the ephemerides of WASP-4b, WASP-5b and WASP-6b and reduce the uncertainties on the mid-transit time for WASP-29b. We also confirm the orbital, stellar and planetary parameters of all 6 systems.Comment: 12 pages; 6 figures; 9 tables; accepted for publication in AJ; two references updated and minor improvements made to match the version to be publishe

Correction to: HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction induced injury

Following publication of the original article [1], the authors flagged that there is a discrepancy with the Availability of data and materials statement on page 12 of the article

HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury

BACKGROUND: In muscular dystrophy and old age, skeletal muscle repair is compromised leading to fibrosis and fatty tissue accumulation. Therefore, therapies that protect skeletal muscle or enhance repair would be valuable medical treatments. Hypoxia-inducible factors (HIFs) regulate gene transcription under conditions of low oxygen, and HIF target genes EPO and VEGF have been associated with muscle protection and repair. We tested the importance of HIF activation following skeletal muscle injury, in both a murine model and human volunteers, using prolyl hydroxylase inhibitors that stabilize and activate HIF. METHODS: Using a mouse eccentric limb injury model, we characterized the protective effects of prolyl hydroxylase inhibitor, GSK1120360A. We then extended these studies to examine the impact of EPO modulation and infiltrating immune cell populations on muscle protection. Finally, we extended this study with an experimental medicine approach using eccentric arm exercise in untrained volunteers to measure the muscle-protective effects of a clinical prolyl hydroxylase inhibitor, daprodustat. RESULTS: GSK1120360A dramatically prevented functional deficits and histological damage, while accelerating recovery after eccentric limb injury in mice. Surprisingly, this effect was independent of EPO, but required myeloid HIF1α-mediated iNOS activity. Treatment of healthy human volunteers with high-dose daprodustat reduced accumulation of circulating damage markers following eccentric arm exercise, although we did not observe any diminution of functional deficits with compound treatment. CONCLUSION: The results of these experiments highlight a novel skeletal muscle protective effect of prolyl hydroxylase inhibition via HIF-mediated expression of iNOS in macrophages. Partial recapitulation of these findings in healthy volunteers suggests elements of consistent pharmacology compared to responses in mice although there are clear differences between these two systems

Composition with Target Constraints

It is known that the composition of schema mappings, each specified by source-to-target tgds (st-tgds), can be specified by a second-order tgd (SO tgd). We consider the question of what happens when target constraints are allowed. Specifically, we consider the question of specifying the composition of standard schema mappings (those specified by st-tgds, target egds, and a weakly acyclic set of target tgds). We show that SO tgds, even with the assistance of arbitrary source constraints and target constraints, cannot specify in general the composition of two standard schema mappings. Therefore, we introduce source-to-target second-order dependencies (st-SO dependencies), which are similar to SO tgds, but allow equations in the conclusion. We show that st-SO dependencies (along with target egds and target tgds) are sufficient to express the composition of every finite sequence of standard schema mappings, and further, every st-SO dependency specifies such a composition. In addition to this expressive power, we show that st-SO dependencies enjoy other desirable properties. In particular, they have a polynomial-time chase that generates a universal solution. This universal solution can be used to find the certain answers to unions of conjunctive queries in polynomial time. It is easy to show that the composition of an arbitrary number of standard schema mappings is equivalent to the composition of only two standard schema mappings. We show that surprisingly, the analogous result holds also for schema mappings specified by just st-tgds (no target constraints). This is proven by showing that every SO tgd is equivalent to an unnested SO tgd (one where there is no nesting of function symbols). Similarly, we prove unnesting results for st-SO dependencies, with the same types of consequences.Comment: This paper is an extended version of: M. Arenas, R. Fagin, and A. Nash. Composition with Target Constraints. In 13th International Conference on Database Theory (ICDT), pages 129-142, 201