Hybrid Dorsal Preservation Rhinoplasty: How We Do It

Background: A difficult to correct dorsal K-area is a frequent cause of residual and/or recurrent dorsal hump in preservation rhinoplasty. Fragile osseocartilaginous elastic connections essential in static stability of nasal pyramid structure should be at least respected. A bulging of Upper Lateral Cartilage (ULC) caudally to this area are principal cause of cartilaginous hump, difficult to correct without damaging the stability. Aim: A hybrid method of a combination of structural surgery with preservation attitude was suggested. Methods and Material: Osseocartilaginous interconnection of DKA area (Dorsal K-Area) can be totally preserved with structural correction of the same area. An incision below of DKA interconnections, with high auto-spreader grafts instead of trimming the deformity was suggested. Conclusion: Septal T-segment could be freely excised as needed, sutured with high and low autospreader graft, as well with septum in desired position, without jeopardizing static stability of nasal pyramid. In our patients, no residual and/or recurrent hump was registered in immediate and as well in long term resultsinfo:eu-repo/semantics/publishedVersio

Deviated Nose: Partial Lateral Osteotomies in a New Preservation Rhinoplasty Concept

Background: A deviated nose continues to be a problem to solve in Rhinoplasty. Various techniques were presented as a possible solution of this aesthetic and functional nasal deformation. In the light of current trend of preservation of structures and function, a modification of osteotomies was presented. Goals: The goal of this paper is to present partial lateral osteotomies surgical technique performed with piezo-electric instruments. Methods and Results: Partial and incomplete osteotomies were introduced as method to avoid disinsertion of nasal pyramid of glabellar area and to avoid bony step in areas of osteotomy cut. Rhinosculpture in its extended mode was promoted for modulation of bony structure with obtaining immediate aesthetic and structural results, minoring a surgical trauma. Conclusion: An incomplete oblique transverse, lateral and intermediate osteotomies, facilitates the "slide-down" positioning of the bone edges, without the need of bone dessinsertion in glabellar region.info:eu-repo/semantics/publishedVersio

Extended Dorsal Preservation in a New Concept of Preservational Rhinoplasty

Background: A dorsal preservation rhinoplasty concept was discussed and the benefits vs. contraindications and limitations were presented. In specific cases of severe nasal septal deformations associated with necessity of major septoplasty, focused on perpendicular plate, a New Concept of Extended Dorsal Preservation Rhinoplasty is presented (New Extended PR-D). PR-D is based on septoplasty, rhinosculpture and partial osteotomies. Goals: The objective of this paper is to present a new approach in some cases of rhinoplasty named as extended dorsal preservation rhinoplasty. Methods and Results: Partial and incomplete osteotomies were introduced as method to avoid disinsertion of nasal pyramid of glabellar area and to avoid bony step in areas off osteotomy cut. Rhinosculpture in its extended mode was promoted for modulation of bony structure with obtaining immediate aesthetic and structural results, minoring a surgical trauma. Conclusion: The principles of Preservation Concept were respected in this New Extended PR-D Concept.info:eu-repo/semantics/publishedVersio

El trabajo de la fuerza de fricción en libros de texto universitarios

Considerando una revisión de la literatura relacionada con la enseñanza de la física, estamos desarrollando una investigación que analiza cómo se presenta el trabajo de las fuerzas de roce y sus relaciones con el teorema de trabajo y energía, en libros de texto de nivel universitario básico. Si bien algunos artículos ampliamente citados destacan aspectos relevantes que deberían ser considerados en el tratamiento del tema y han sido publicados hace más de dos décadas, encontramos textos que no se han hecho eco de los mismos, otros que introducen modificaciones parciales y pocos que reflejan explícitamente los cambios sugeridos. Las tendencias mencionadas se ilustran considerando tres textos de uso muy difundido en nuestro ámbito

El trabajo de la fuerza de fricción en libros de texto universitarios

Considerando una revisión de la literatura relacionada con la enseñanza de la física, estamos desarrollando una investigación que analiza cómo se presenta el trabajo de las fuerzas de roce y sus relaciones con el teorema de trabajo y energía, en libros de texto de nivel universitario básico. Si bien algunos artículos ampliamente citados destacan aspectos relevantes que deberían ser considerados en el tratamiento del tema y han sido publicados hace más de dos décadas, encontramos textos que no se han hecho eco de los mismos, otros que introducen modificaciones parciales y pocos que reflejan explícitamente los cambios sugeridos. Las tendencias mencionadas se ilustran considerando tres textos de uso muy difundido en nuestro ámbito

Active Cage Mechanism of Chaperonin-Assisted Protein Folding Demonstrated at Single-Molecule Level

The cylindrical chaperonin GroEL and its lid-shaped cofactor GroES of Escherichia coil have an essential role in assisting protein folding by transiently encapsulating non-native substrate in an ATP-regulated mechanism. It remains controversial whether the chaperonin system functions solely as an infinite dilution chamber, preventing off-pathway aggregation, or actively enhances folding kinetics by modulating the folding energy landscape. Here we developed single-molecule approaches to distinguish between passive and active chaperonin mechanisms. Using low protein concentrations (100 pM) to exclude aggregation, we measured the spontaneous and GroEL/ES-assisted folding of double-mutant maltose binding protein (DM-MBP) by single-pair fluorescence resonance energy transfer and fluorescence correlation spectroscopy. We find that GroEL/ES accelerates folding of DM-MBP up to 8-fold over the spontaneous folding rate. Accelerated folding is achieved by encapsulation of folding intermediate in the GroEL/ES cage, independent of repetitive cycles of protein binding and release from GroEL. Moreover, photoinduced electron transfer experiments provided direct physical evidence that the confining environment of the chaperonin restricts polypeptide chain dynamics. This effect is mediated by the net-negatively charged wall of the GroEL/ES cavity, as shown using the GroEL mutant EL(KKK2) in which the net-negative charge is removed. EL(KKK2)/ES functions as a passive cage in which folding occurs at the slow spontaneous rate. Taken together our findings suggest that protein encapsulation can accelerate folding by entropically destabilizing folding intermediates, in strong support of an active chaperonin mechanism in the folding of some proteins. Accelerated folding is biologically significant as it adjusts folding rates relative to the speed of protein synthesis. (C) 2014 The Authors. Published by Elsevier Ltd

Phytophagous hoverflies (Diptera Syrphidae) as indicators of changing landscapes

Spatial and temporal differences in landscape patterns are of considerable interest for understanding ecological processes. In this study, we assessed habitat quality by using the Syrph The Net database and data on decreasing species richness over a 25-year period for the two largest phytophagous hoverfly genera (Merodon and Cheilosia). Furthermore, within this time frame, we explored congruence between ecological responses (species richness and Biodiversity Maintenance Function for these two genera) and landscape structural changes through correlation analysis. Our results indicate that landscapes have experienced changes in aggregation, isolation/connectivity and landscape diversity, with these parameters being significantly correlated with Cheilosia species richness loss and habitat quality. We conclude that the genus Cheilosia is a good bioindicator that can highlight not only the current quality of an area but also temporal changes in landscape patterns.Peer reviewe

Adjustment of Insulin Pump Settings in Type 1 Diabetes Management: Advisor Pro Device Compared to Physicians’ Recommendations

Aims: To compare insulin dose adjustments made by physicians to those made by an artificial intelligence-based decision support system, the Advisor Pro, in people with type 1 diabetes (T1D) using an insulin pump and self-monitoring blood glucose (SMBG). Methods: This was a multinational, non-interventional study surveying 17 physicians from 11 countries. Each physician was asked to provide insulin dose adjustments for the settings of the pump including basal rate, carbohydrate-to-insulin ratios (CRs), and correction factors (CFs) for 15 data sets of pumps and SMBG of people with T1D (mean age 18.4 ± 4.8 years; eight females; mean glycated hemoglobin 8.2% ± 1.4% [66 ± 11mmol/mol]). The recommendations were compared among the physicians and between the physicians and the Advisor Pro. The study endpoint was the percentage of comparison points for which there was an agreement on the direction of insulin dose adjustments. Results: The percentage (mean ± SD) of agreement among the physicians on the direction of insulin pump dose adjustments was 51.8% ± 9.2%, 54.2% ± 6.4%, and 49.8% ± 11.6% for the basal, CR, and CF, respectively. The automated recommendations of the Advisor Pro on the direction of insulin dose adjustments were comparable)49.5% ± 6.4%, 55.3% ± 8.7%, and 47.6% ± 14.4% for the basal rate, CR, and CF, respectively(and noninferior to those provided by physicians. The mean absolute difference in magnitude of change between physicians was 17.1% ± 13.1%, 14.6% ± 8.4%, and 23.9% ± 18.6% for the basal, CR, and CF, respectively, and comparable to the Advisor Pro 11.7% ± 9.7%, 10.1% ± 4.5%, and 25.5% ± 19.5%, respectively, significant for basal and CR. Conclusions: Considerable differences in the recommendations for changes in insulin dosing were observed among physicians. Since automated recommendations by the Advisor Pro were similar to those given by physicians, it could be considered a useful tool to manage T1D