16 research outputs found
Tertiary development of the Polish and eastern Slovak parts of the Carpathian accretionary wedge : insights from balanced cross-sections
During Eocene-Sarmatian, a Polish-eastern Slovak portion of the Outer West Carpathian accretionary wedge was deformed in front of the ALCAPA terrane. This portion advanced into the area of the subducting remnant Carpathian Flysch Basin, a large oceanic tract left in front of the Alpine orogen. Western parts of the wedge were characterized by a noticeable lack of involvement of thick-skin thrusting and by a predominant development of fault-propagation folds. Eastern parts of the wedge were characterized by the involvement of thick-skin thrusting, triangle zones and back-thrusts. The frontal portion of the wedge was characterized by a dĂŠcollement formed along the shale and gypsum formations of the Badenian molasse sediments, which resulted in the increased width of the thrust sheets. Forelandward thinning of foreland basin sediments indicates that the portion of the European Platform attached to the subducting oceanic lithosphere flexed underneath the advancing Carpathians as early as the Eocene. Oligocene sediments record syn-depositional thrusting by abrupt thickness changes over short distances. Younger periods of the thrusting are documented by the Eggenburgian-Karpatian piggy-back basin carried by thrust sheets in the frontal portion of the ALCAPA terrane, the Early Miocene age of the youngest sediments in the central portion of the wedge and involvement of the middle Badenian molasse sediments in the frontal portion of the wedge. The end of the shortening is documented by the lower Sarmatian end of the strike-slip
fault activity behind the wedge, by the middle Sarmatian transgression over the deformed wedge in the Orava-Nowy Targ Basin, which is located in the rear portion of the wedge, and by the Sarmatian undeformed sediments sealing the wedge front. The existence of the forebulge in front of the advancing Carpathians is documented by local Eocene, Oligocene and Lower Miocene unconformities in the frontal portion of the wedge
Seasonal variability of the warm Atlantic Water layer in the vicinity of the Greenland shelf break
The warmest water reaching the east and west coast of Greenland is found between 200?m and 600?m. Whilst important for melting Greenland's outlet glaciers, limited winter observations of this layer prohibit determination of its seasonality. To address this, temperature data from Argo profiling floats, a range of sources within the World Ocean Database and unprecedented coverage from marine-mammal borne sensors have been analysed for the period 2002-2011. A significant seasonal range in temperature (~1-2?°C) is found in the warm layer, in contrast to most of the surrounding ocean. The phase of the seasonal cycle exhibits considerable spatial variability, with the warmest water found near the eastern and southwestern shelf-break towards the end of the calendar year. High-resolution ocean model trajectory analysis suggest the timing of the arrival of the year's warmest water is a function of advection time from the subduction site in the Irminger Basin
Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial.
BACKGROUND: Remote ischaemic conditioning with transient ischaemia and reperfusion applied to the arm has been shown to reduce myocardial infarct size in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). We investigated whether remote ischaemic conditioning could reduce the incidence of cardiac death and hospitalisation for heart failure at 12 months. METHODS: We did an international investigator-initiated, prospective, single-blind, randomised controlled trial (CONDI-2/ERIC-PPCI) at 33 centres across the UK, Denmark, Spain, and Serbia. Patients (age >18 years) with suspected STEMI and who were eligible for PPCI were randomly allocated (1:1, stratified by centre with a permuted block method) to receive standard treatment (including a sham simulated remote ischaemic conditioning intervention at UK sites only) or remote ischaemic conditioning treatment (intermittent ischaemia and reperfusion applied to the arm through four cycles of 5-min inflation and 5-min deflation of an automated cuff device) before PPCI. Investigators responsible for data collection and outcome assessment were masked to treatment allocation. The primary combined endpoint was cardiac death or hospitalisation for heart failure at 12 months in the intention-to-treat population. This trial is registered with ClinicalTrials.gov (NCT02342522) and is completed. FINDINGS: Between Nov 6, 2013, and March 31, 2018, 5401 patients were randomly allocated to either the control group (n=2701) or the remote ischaemic conditioning group (n=2700). After exclusion of patients upon hospital arrival or loss to follow-up, 2569 patients in the control group and 2546 in the intervention group were included in the intention-to-treat analysis. At 12 months post-PPCI, the Kaplan-Meier-estimated frequencies of cardiac death or hospitalisation for heart failure (the primary endpoint) were 220 (8¡6%) patients in the control group and 239 (9¡4%) in the remote ischaemic conditioning group (hazard ratio 1¡10 [95% CI 0¡91-1¡32], p=0¡32 for intervention versus control). No important unexpected adverse events or side effects of remote ischaemic conditioning were observed. INTERPRETATION: Remote ischaemic conditioning does not improve clinical outcomes (cardiac death or hospitalisation for heart failure) at 12 months in patients with STEMI undergoing PPCI. FUNDING: British Heart Foundation, University College London Hospitals/University College London Biomedical Research Centre, Danish Innovation Foundation, Novo Nordisk Foundation, TrygFonden
Tian-ren-he-yi strategy: An Eastern perspective
Research on the business-environment dilemma has traditionally focused on strategies based on isolated, either/or mindsets, such as economically-oriented and environmentally-oriented strategies. Drawing on the cultural, philosophical, and intellectual traditions of China, we sketch the contours of a new holism-based strategic mindset, which results in a tian-ren-he-yi strategy. As an Eastern perspective, tian-ren-he-yi means ânature and mankind combined as oneâ or ânature-human harmony.â We leverage both qualitative and quantitative investigations to first identify the underlying mechanisms connecting tian-ren-he-yi strategy and firm performance, and then to compare the performance-enhancing potential of tian-ren-he-yi strategy with the two strategies based on the isolated mindset. Our analysis shows that when managing the business-environment dilemma, tian-ren-he-yi strategy has stronger performance-enhancing potential than either economically-oriented or environmentally-oriented strategies