Immunoreactive GnRH type I receptors in the mouse and sheep brain

International audienceGonadotropin Releasing Hormone-I (GnRH) has been implicated in an array of functions outside the neuroendocrine reproductive axis. Previous investigations have reported extensive GnRH binding in numerous sites and this has been supported by in situ hybridization studies reporting GnRH receptor mRNA distribution. The present study on mice and sheep supports and extends these earlier investigations by revealing the distribution of cells immunoreactive for the GnRH receptor. In addition to sites previously shown to express GnRH receptors such as the hippocampus, amygdala and the arcuate nucleus, the improved resolution afforded by immunocytochemistry detected cells in the mitral cell lay of the olfactory bulb as well as the central grey of the mesencephalon. In addition, GnRH receptor immunoreactive neurons in the hippocampus and mesencephalon of the sheep were shown to colocalize with estrogen receptor beta. Although GnRH may act at some of these sites to regulate reproductive processes, evidence is accumulating to support an extra-reproductive role for this hypothalamic decapeptide

Reverse Phenotyping in Patients with Skin Capillary Malformations and Mosaic GNAQ or GNA11 Mutations Defines a Clinical Spectrum with Genotype-Phenotype Correlation

International audienceNo abstract availabl

La ville dans tous les sens

Le dossier de Communication & Organisation que nous avons intitulé « La ville dans tous les sens » s’intéresse à un espace urbain dont nous avons voulu saisir à la fois l’importance (plus de 80 % de la population française vit en ville ; c’est aussi vrai ailleurs), la mutation (métropolisation, globalisation) et la complexité. Sous l’angle de la communication, nous avons souhaité que soit posée la question de la limite, à un moment de notre société de nouvelles technologies où les frontières sont invisibles, sans cesse repoussées plus loin, aussi loin que les communications le permettent, apportant un possible infini. Dans ce contexte, sans vouloir la dramatiser, la ville apparaît aujourd’hui comme un théâtre passionnant d’expressions multiples, métissées, contradictoires, qui interrogent notre société en mutation accélérée. C’est donc une ville multiple, à la fois hétérogène et sectorisée, traversée par des réseaux de fonctionnalité, des réseaux affectifs, habillée par une complexité de messages contradictoires, qui est analysée dans ce dossier consacré aux « nouvelles écritures de la ville »

Developmental and symptom profiles in early-onset psychosis

International audienc

National records of 3000 European bee and hoverfly species: A contribution to pollinator conservation

Pollinators play a crucial role in ecosystems globally, ensuring the seed production of most flowering plants. They are threatened by global changes and knowledge of their distribution at the national and continental levels is needed to implement efficient conservation actions, but this knowledge is still fragmented and/or difficult to access. As a step forward, we provide an updated list of around 3000 European bee and hoverfly species, reflecting their current distributional status at the national level (in the form of present, absent, regionally extinct, possibly extinct or non-native). This work was attainable by incorporating both published and unpublished data, as well as knowledge from a large set of taxonomists and ecologists in both groups. After providing the first National species lists for bees and hoverflies for many countries, we examine the current distributional patterns of these species and designate the countries with highest levels of species richness. We also show that many species are recorded in a single European country, highlighting the importance of articulating European and national conservation strategies. Finally, we discuss how the data provided here can be combined with future trait and Red List data to implement research that will further advance pollinator conservation