Survivin expression at the mRNA level in tumors and the protein concentration in the serum and peritoneal fluid in patients with serous ovarian tumors

Objectives: Ovarian cancer is one of the gynecological cancers that have the worst prognosis. The expression of the proteins from the IAP family (inhibitor of apoptosis protein), including survivin, is observed in many types of cancer. The aim of the study was to evaluate survivin at the mRNA level in tumors and the protein concentration in the serum and peritoneal fluid of patients with serous ovarian cancer in order to assess the relationship between the concentration of survivin and the histological subtypes of cancer. Material and methods: The study group consisted of 55 women, including patients with serous ovarian cancer (n = 30, nine low-grade serous carcinoma LGSC, 21 high-grade serous carcinoma HGSC), serous cysts (n = 10) and the control group (n = 15). The concentration of protein in the peritoneal fluid and serum was assessed using ELISA tests. The expression of survivin gene BIRC5 in the tumors was assessed using the RT-qPCR method. Results: The data that was obtained indicated that the concentration of survivin was higher in the serum of the women with serous ovarian cancer compared those that had benign tumors (p < 0.05) and the control group (p < 0.001). The survivin concentration was also higher in both the serum and peritoneal fluid in the HGSC group compared to the LGSC group (p < 0.001). The mRNA level was highest in the HGSC group, and there was a statistically significant difference compared to those in the benign tumor group and HGSC group ( p < 0.05). Conclusions: The observed changes prove that the expression level increases significantly in HGSC in both the protein and mRNA levels. Based on these findings, it can be assumed that assessing this parameter could be a useful additional indicator of the progression and differentiation of this type of cancer. However, this requires further research in a larger group of patients and possibly in other types of ovarian cancer

Safety and efficacy of embolic protection devices in saphenous vein graft interventions : a propensity score analysis-multicenter SVG PCI PROTECTA study

Background: Evidence concerning the efficacy of the embolic protection devices (EPDs) in saphenous vein graft (SVG) percutaneous coronary intervention (PCI) is sparse. The study was designed to compare major cardiovascular events of all-comer population of SVG PCI with and without EPDs at one year of follow-up. Methods and results: A multi-center registry comparing PCI with and without EPDs in consecutive patients undergoing PCI of SVG. The group comprised 792 patients, among which 266 (33.6%) had myocardial infarction (MI). The primary composite endpoint was major adverse cardiac and cerebrovascular event (MACCE) defined as death, MI, target vessel revascularization (TVR), and stroke assessed at one year. After propensity score analysis, there were no differences in MACCE (21.9% vs. 23.9%; HR 0.91, 95% CI 0.57–1.45, p = 0.681, respectively) nor in secondary endpoints of death, MI, TVR, target lesion revascularization (TLR) and stroke at one year in EPDs PCI group vs. no-EPDs PCI group. Similarly, there were no differences between groups in the study endpoints at 30 days follow-up. Conclusions: There were no clinical benefit for routine use of EPDs during SVG PCI in short and long-term follow-up. Further studies are warranted to explore the effect of individual types of EPDs on clinical outcomes

Pro Libris: Lubuskie Pismo Literacko-Kulturalne, nr 3 (2008)

152 s. : il.

EXAMPLES OF MEDICAL SOFTWARE AND HARDWARE EXPERT SYSTEMS FOR DYSFUNCTION ANALYSIS AND TREATMENT

Paper present the recent research in DMCS. The medical and biometric research projects are presented. One of the key element is an image acquisition and processing. The paper presents research of diagnostic application of voice analysis for stroke patients with speech dysfunction, as well as the method for diagnosing and monitoring the effectiveness of medical rehabilitation of patients with dysfunction of the cervical spine. Then the method for sudden cardiac death risk stratification is elaborated

Pro Libris: Lubuskie Pismo Literacko-Kulturalne, nr 4 (2008)

172 s. : il

RECENT RESEARCH IN VLSI, MEMS AND POWER DEVICES WITH PRACTICAL APPLICATION TO THE ITER AND DREAM PROJECTS

Several MEMS (Micro Electro-Mechanical Systems) devices have been analysed and simulated. The new proposed model of SiC MPS (Merged PIN-Schottky) diodes is in full agreement with the real MPS devices. The real size DLL (Dynamic Lattice Liquid) simulator as well as the research on modelling and simulation of modern VLSI devices with practical applications have been presented. In the basis of experience in the field of ATCA (Advanced Telecommunications Computing Architecture) based systems a proof-of-concept DAQ (data acquisition) system for ITER (International Thermonuclear Experimental Reactor) have been proposed

The 42nd Symposium Chromatographic Methods of Investigating Organic Compounds : Book of abstracts

The 42nd Symposium Chromatographic Methods of Investigating Organic Compounds : Book of abstracts. June 4-7, 2019, Szczyrk, Polan

Cardiopoietic cell therapy for advanced ischemic heart failure: results at 39 weeks of the prospective, randomized, double blind, sham-controlled CHART-1 clinical trial

Cardiopoietic cells, produced through cardiogenic conditioning of patients' mesenchymal stem cells, have shown preliminary efficacy. The Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART-1) trial aimed to validate cardiopoiesis-based biotherapy in a larger heart failure cohort

Wielopoziomowy system komunikacyjny oparty na łączu RS-232 i 4-portowych przełącznikach

The multiport, hierarchical communication system based on RS-232 and MCOM 4-channel switches is presented in the paper. The switches were designed in the Institute of Informatics, Silesian University of Technology.W artykule przedstawiono koncepcję i przykład wykorzystania wie­lo­portowego, hierarchicznego systemu komunikacyjnego opartego na łączu RS­-232 i 4-kanałowych przełącznikach MCOM 4-port switch opracowanych w Zakładzie Urządzeń Informatyki Politechniki Śląskiej

Wpływ metody autorozluźniania mięśniowo-powięziowego na zmianę elastyczności taśmy powierzchownej tylnej

Background. The aim of the study was to assess the effect of self myofascial release (SMR) using foam rolling on elasticity of (SMR) using rolling superficial back line (SBL) in young physically active adults. Material and methods. The sample included 40 students (man age 4.91 years). Tissue flexibility was assessed before and after rolling using one of EUROFIT motor ability tests of flexibility. The subjects performed a maximal forward flexion. 9-minute long rolling was performed in the following areas of the body: rear surface of the feet, rear surface of the shanks. rear surface of the thighs. paraspinal muscles of the sacrolumbar spine. The values corresponding to flexion depth prior to and following rolling were compared. Student’s t-test was applied for statistical analysis and significance level was set at p<0.05. Results Depth of flexion significantly increased after rolling (p<0.001). on average by 3.24 cm (31%). It was also found that gender had no effect on the differences in the values corresponding to the depth of superficial back line . In 65 % of the sample improvement of well-being was noted after rolling. Conclusions. The results indicate that the release using a roller is an easy accessible approach to prophylactic measures aimed at improvement of body elasticity.Wstęp. Celem pracy było zbadanie wpływu autorozluźniania mięśniowo-powięziowego/ self-myofascial release (SMR) z wykorzystaniem rolera (foam rolling) na elastyczność taśmy powierzchownej tylnej (TPT) u młodych dorosłych aktywnych fizycznie. Materiał i metody. Badanie przeprowadzono na 40. studentach, średnia wieku 22,36±4,91 lat. Elastyczność tkanek oceniano bezpośrednio przed i po zakończeniu rolowania, wykorzystując jedną z prób sprawności motorycznej Europejskiego Testu Sprawności Fizycznej „EUROFIT” sprawdzającą gibkość. Badani w siadzie wykonywali maksymalny skłon dosiężny w przód. Rolowaniu trwającemu 9 minut, zostały poddane następujące obszary ciała: tylna powierzchnia stóp, tylna powierzchnia goleni, tylna powierzchnia ud, mięśnie przykręgosłupowe odcinka piersiowo-lędźwiowego kręgosłupa. Porównano wyniki głębokości skłonu wykonanego przed i po rolowaniu. Do analizy statystycznej wykorzystano test t-Studenta, za poziom istotności przyjęto p<0,05. Wyniki. Głębokość skłonu po rolowaniu zwiększyła się istotnie statystycznie (p<0,001), średnio o 3,24 cm (31%). Stwierdzono również, że płeć nie różnicuje wyników elastyczności taśmy powierzchownej tylnej. U 65% badanych zaobserwowano poprawę samopoczucia po rolowaniu. Wnioski. Otrzymane wyniki pozwalają wnioskować, iż metoda SMR za pomocą rolera jest szybką, ekonomiczną, łatwo dostępną metodą fizjoprofilaktyki w poprawie elastyczności i gibkości ciała