210 research outputs found
Teams, HRM and innovation:an organisation-level analysis
For organizations to survive and prosper they have to develop new and improved products, services and ways of working. Innovation is vital for organizational survival. Much research and managerial attention is therefore devoted to understanding the factors that predict innovation in organizations. This paper describes a research study of product innovation in manufacturing organizations and explores the extent to which team based working and team working effectiveness in these organizations predict product innovation. It also considers whether combinations of good HRM systems and practices, extensive team based working and effective team working are associated with product innovation
Personal, social, health and economic (PSHE) education: A mapping study of the prevalent models of delivery and their effectiveness
In October 2008, then Schools Minister Ji, Knight announced that Personal, Social, Health and Economic (PSHE) education would become compulsory (for Key Stages 1-4). Following this, In November 2009, Sheffield Hallam University was contracted by DCSF (now DfE) to conduct a mapping exercise of PSHE education in primary and secondary schools in England. This resulted from a recommendation in the Macdonald Review, whcih identified the need for research to establish and report on the prevalent models of delivery for PSHE education and their effectiveness in improving outcomes for children and young people (Macdonald, 2009:8)
Uniformity and Diversity in Handaxe Shape at the End of the Acheulean in Southwest Asia
This study examines parameters, causes, and spatio-temporal patterns of handaxe shape variation from Tabun cave in the Levant, and Khall Amayshan 4B and Khabb Musayyib in northern Arabia. These assemblages span the range of most pointy to most rounded handaxes found anywhere during the Acheulean. The AGMT3D program is used to conduct high resolution geometric morphometric analysis of handaxe form from 3D models. Shape variation is tested against blank type, allometry, and reduction intensity. None of these factors appears to be a strong influence, but there are significant assemblage-wise differences in form, suggesting the different shapes were intentionally produced. The analysis quantifies a pattern of high diversity in the assemblages from Tabun versus low diversity in the shorter occupations at the Arabian sites. We suggest possible explanations of emerging specificity in utilitarian functions, as well as the manifestation of social identities in artefacts at the end of the Acheulean
Plant, pigment, and bone processing in the Neolithic of northern Arabia-New evidence from Use-wear analysis of grinding tools at Jebel Oraf
Archaeological sites with surface hearths are a ubiquitous feature across the arid zones of the Arabian interior. At Jebel Oraf, in the Jubbah basin of the Nefud Desert of northern Arabia, numerous grinding stone fragments were found in association with hearths, though the original purpose of these stones was unclear owing to the poor preservation of faunal and botanic remains. Here we describe results from use-wear analysis on five grinding tools at Jebel Oraf, demonstrating that such artefacts were used during the Neolithic for plant processing, bone processing, and pigment production. Grinding stones were often broken up after initial use and fragments were subsequently re-used for alternative purposes, before finally being placed on hearths or discarded. More specifically, plants were ground or prepared and possibly cooked in the hearths, and bones were processed as well. The analyses also highlight the importance of pigment processing at Neolithic sites and provide a link to painted rock art. The frequent use of pigment in the archaeological record suggests that pigment was widely used, and that Neolithic painted art may have been more common than the surviving images suggest
Left-right dissociation of hippocampal memory processes in mice.
Left-right asymmetries have likely evolved to make optimal use of bilaterian nervous systems; however, little is known about the synaptic and circuit mechanisms that support divergence of function between equivalent structures in each hemisphere. Here we examined whether lateralized hippocampal memory processing is present in mice, where hemispheric asymmetry at the CA3-CA1 pyramidal neuron synapse has recently been demonstrated, with different spine morphology, glutamate receptor content, and synaptic plasticity, depending on whether afferents originate in the left or right CA3. To address this question, we used optogenetics to acutely silence CA3 pyramidal neurons in either the left or right dorsal hippocampus while mice performed hippocampus-dependent memory tasks. We found that unilateral silencing of either the left or right CA3 was sufficient to impair short-term memory. However, a striking asymmetry emerged in long-term memory, wherein only left CA3 silencing impaired performance on an associative spatial long-term memory task, whereas right CA3 silencing had no effect. To explore whether synaptic properties intrinsic to the hippocampus might contribute to this left-right behavioral asymmetry, we investigated the expression of hippocampal long-term potentiation. Following the induction of long-term potentiation by high-frequency electrical stimulation, synapses between CA3 and CA1 pyramidal neurons were strengthened only when presynaptic input originated in the left CA3, confirming an asymmetry in synaptic properties. The dissociation of hippocampal long-term memory function between hemispheres suggests that memory is routed via distinct left-right pathways within the mouse hippocampus, and provides a promising approach to help elucidate the synaptic basis of long-term memory.http://dx.doi.org/10.1073/pnas.1405648111This is the author's accepted manuscript. It will be under embargo for 6 months from the date of publication. The final version is available from PNAS at http://www.pnas.org/content/early/2014/09/16/1405648111.abstract
Evidence that binding to the S2-subsite of papain may be coupled with catalytically relevant structural change involving the cysteine-25âhistidine-159 diad. Kinetics of the reaction of papain with a two-protonic-state reactivity probe containing a hydrophobic side chain
Haemoglobin and Hematinic Status Before and After Bariatric Surgery over 4 years of Follow-Up
From Springer Nature via Jisc Publications RouterHistory: received 2020-03-02, rev-recd 2020-08-17, accepted 2020-08-18, registration 2020-08-19, pub-electronic 2020-09-01, online 2020-09-01, pub-print 2021-02Publication status: PublishedFunder: University of ManchesterAbstract: Purpose: Bariatric surgery is associated with deficiencies of vitamins and minerals, and patients are routinely advised supplements postoperatively. We studied prevalence of vitamin B12, folate and iron deficiencies and anaemia before and after bariatric surgery over 4 years of follow-up. Materials and Methods: We performed a retrospective cohort analysis of 353 people with obesity, including 257 (72.8%) women, who underwent gastric bypass (252, 71.4%) or sleeve gastrectomy (101, 28.6%) at our National Health Service bariatric centre in Northwest England. Results: At baseline, mean (standard error) age was 46.0 (0.6) years, body mass index 53.1 (0.4) kg/m2, serum vitamin B12 400.2 (16.4) pg/L, folate 7.7 (0.2) ÎŒg/L, iron 12.0 (0.3) ÎŒmol/L, ferritin 118.3 (8.4) ÎŒg/L and haemoglobin 137.9 (0.8) g/L. Frequency of low vitamin B12 levels reduced from 7.5% preoperatively to 2.3% at 48 months (P < 0.038). Mean folate levels increased from baseline to 48 months by 5.3 ÎŒg/L (P < 0.001) but frequency of low folate levels increased from 4.7% preoperatively to 10.3% (P < 0.048). Ferritin levels increased from baseline to 48 months by 51.3 ÎŒg/L (P < 0.009). Frequency of low ferritin levels was greater in women (39.1%) than in men (8.9%) at baseline (P < 0.001) and throughout the study period. Haemoglobin was low in 4.6% of all patients at baseline with no significant change over the study period. Conclusion: There were notable rates of haematinic insufficiencies in bariatric surgical candidates preoperatively. Our study lends further support to regular supplementation with vitamin B12, folic acid, and iron in people undergoing bariatric surgery
Characterizing the Potential for Injection-Induced Fault Reactivation Through Subsurface Structural Mapping and Stress Field Analysis, Wellington Field, Sumner County, Kansas
Kansas, like other parts of the central U.S., has experienced a recent increase in seismicity. Correlation of these events with brine disposal operations suggests pore fluid pressure increases are reactivating preexisting faults, but rigorous evaluation at injection sites is lacking. Here we determine the suitability of CO2 injection into the CambrianâOrdovician Arbuckle Group for longâterm storage and into a Mississippian reservoir for enhanced oil recovery in Wellington Field, Sumner County, Kansas. To determine the potential for injectionâinduced earthquakes, we map subsurface faults and estimate in situ stresses, perform slip and dilation tendency analyses to identify wellâoriented faults relative to the estimated stress field, and determine the pressure changes required to induce slip at reservoir and basement depths. Threeâdimensional seismic reflection data reveal 12 nearâvertical faults, mostly striking NNE, consistent with nodal planes from moment tensor solutions from recent earthquakes in the region. Most of the faults cut both reservoirs and several clearly penetrate the Precambrian basement. Drillingâinduced fractures (N = 40) identified from image logs and inversion of earthquake moment tensor solutions (N = 65) indicate that the maximum horizontal stress is approximately EW. Slip tendency analysis indicates that faults striking <020° are stable under current reservoir conditions, whereas faults striking 020°â049° may be prone to reactivation with increasing pore fluid pressure. Although the proposed injection volume (40,000 t) is unlikely to reactive faults at reservoir depths, highârate injection operations could reach pressures beyond the critical threshold for slip within the basement, as demonstrated by the large number of injectionâinduced earthquakes west of the study area
Human occupation of northern India spans the Toba super-eruption ~74,000 years ago
Abstract: India is located at a critical geographic crossroads for understanding the dispersal of Homo sapiens out of Africa and into Asia and Oceania. Here we report evidence for long-term human occupation, spanning the last ~80 thousand years, at the site of Dhaba in the Middle Son River Valley of Central India. An unchanging stone tool industry is found at Dhaba spanning the Toba eruption of ~74 ka (i.e., the Youngest Toba Tuff, YTT) bracketed between ages of 79.6 ± 3.2 and 65.2 ± 3.1 ka, with the introduction of microlithic technology ~48 ka. The lithic industry from Dhaba strongly resembles stone tool assemblages from the African Middle Stone Age (MSA) and Arabia, and the earliest artefacts from Australia, suggesting that it is likely the product of Homo sapiens as they dispersed eastward out of Africa
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