Modeling the Distribution of Organic Coffee Supply Chain from Junín Region, Peru

This research uses Supply Chain (SC) data gathered during the distribution and transportation activities of organic coffee. The purpose of this research is to analyze different ways in which crop-chain solutions are adopted in the region of Junn, Peru. The disintegration of the SC is revealed, as each cooperative member works uncoordinatedly on his own leading to different results standards with high costs and low returns. The study focused on different entities from farmers to the port of Callao of an organic coffee supply chain where disintegration is constant. The paper describes a misaligned supply chain including poorly collaboration. All problems found will be an opportunity to develop a distribution model in the organic coffee supply chain of Junn region

Sesgos cognitivos en las sentencias por los procesos de violación sexual en el juzgado penal colegiado de Tarapoto; 2021

La investigación tuvo como objetivo general analizar de qué manera los sesgos cognitivos se presentan en las sentencias por los procesos violación sexual en el Juzgado Penal Colegiado de Tarapoto; 2021. La existencia de los sesgos frente a una decisión del operador jurídica se ve reflejada en el proceso de presentación de la prueba, esto como contenido esencial del derecho a la presentación de la prueba analizado a través del delito de violación sexual. La metodología fue de tipo básica con diseño en teoría fundamentada, el enfoque aplicado en la investigación fue cualitativa, los instrumentos de recolección de datos fueron la guía de análisis documental y entrevista a expertos. El resultado principal indicó que el alcance de los sesgos cognitivos dentro del delito de violación sexual es sorpresivo, los operadores jurídicos se encuentran sesgados en demasía con estos atajos mentales que nublan el buen juicio, llegando a actuar y valorar incorrectamente medios probatorios y actos procesales de toda índole. Llegando a concluir que los sesgos cognitivos se presentan de forma encriptada dentro de las sentencias por los procesos en los delitos de violación sexual, hay que lograr identificarlas, esto lográndolo desde el análisis exhaustivo y el conocimiento de los sesgos

Estudio de prefactibilidad para la instalación de una planta procesadora de ensaladas en frascos para ser comercializadas por máquinas expendedoras

El presente estudio tiene como objetivo determinar la factibilidad tecnológica, económica y financiera de la instalación de una planta procesadora de ensaladas en frascos que serán comercializadas a través de máquinas expendedoras. En el primer capítulo se definen los aspectos generales del trabajo tales como: objetivos, alcance, justificaciones, hipótesis, marco referencial y conceptual. Por otro lado, en el segundo nos centramos en el estudio del mercado investigando en la Universidad de Lima tanto la demanda potencial como la del proyecto y analizando las estrategias de marketing a realizar, como ofrecer tres variedades del producto. En el tercer capítulo se realiza el estudio de localización de planta en distritos de Lima cercanos a la universidad, seleccionando a Santa Anita. En el cuarto capítulo se selecciona el tamaño de planta analizando las restricciones de demanda, disponibilidad de recursos, tecnología y punto de equilibrio. Estableciendo el tamaño por la demanda del proyecto de 79.045,00 ensaladas al año. En el quinto capítulo se explica las características técnicas del producto, la tecnología necesaria para su elaboración, los procesos de producción y requerimientos de materia prima. Asimismo, se toman en cuenta diversos aspectos de seguridad, calidad, entre otros necesarios en la planta. Determinando una capacidad instalada de 81.299,00 envases al año que asegura la producción durante los cinco años proyectados. En el sexto capítulo se muestran los pasos para la formación de la organización, los requisitos de personal y la estructura organizacional. En el séptimo capítulo se calculan los costos de producción y presupuestos de ingresos y egresos para determinar la viabilidad económica y financiera del proyecto, resultando en VAN mayores a 0 y TIR mayores al COK. En el último capítulo se realiza la evaluación social del proyecto donde se aprecia los beneficios de este hacia el país, generando un Valor Agregado de S/ 1.859.675,97.The objective of this study is to determine the technological, economic and financial feasibility of the installation of a salad processing plant in jars that will be sold through vending machines. In the first chapter the general aspects of the work are defined such as: objectives, reach, justifications, hypotheses, referential and conceptual framework. On the other hand, in the second we focus on the market study, investigating both the potential and project demand at the University of Lima and analyzing the marketing strategies to be carried out, such as offering three varieties of the product. In the third chapter, the study of plant location is carried out in districts of Lima near the university, selecting Santa Anita. In the fourth chapter, the size of the plant is selected by analyzing the restrictions of demand, availability of resources, technology and balance point. Establishing the project demand size of 79,045.00 salads per year. In the fifth chapter the technical characteristics of the product, the technology necessary for its elaboration, the production processes and raw material requirements are explained. Likewise, various aspects of safety, quality, among others necessary in the plant, are considered. Determining an installed capacity of 81,299.00 containers per year that ensures production during the five projected years. The sixth chapter shows the steps for organization formation, personnel requirements, and organizational structure. In the seventh chapter, production costs and income and expenditure budgets are calculated to determine the economic and financial viability of the project, resulting in NPV greater than 0 and IRR greater than COK. In the last chapter, the social evaluation of the project is carried out, where the benefits of this to the country can be seen, generating an Added Value of S / 1,859,675.97

Gal-1 Expression Analysis in the GLIOCAT Multicenter Study: Role as a Prognostic Factor and an Immune-Suppressive Biomarker

Glioblastoma (GBM) is the most frequent primary malignant brain tumor and has a dismal prognosis. Unfortunately, despite the recent revolution of immune checkpoint inhibitors in many solid tumors, these have not shown a benefit in overall survival in GBM patients. Therefore, new potential treatment targets as well as diagnostic, prognostic, and/or predictive biomarkers are needed to improve outcomes in this population. The beta-galactoside binding protein Galectin-1 (Gal-1) is a protein with a wide range of pro-tumor functions such as proliferation, invasion, angiogenesis, and immune suppression. Here, we evaluated Gal-1 expression by immunohistochemistry in a homogenously treated cohort of GBM (the GLIOCAT project) and correlated its expression with clinical and molecular data. We observed that Gal-1 is a negative prognostic factor in GBM. Interestingly, we observed higher levels of Gal-1 expression in the mesenchymal/classical subtypes compared to the less aggressive proneural subtype. We also observed a Gal-1 expression correlation with immune suppressive signatures of CD4 T-cells and macrophages, as well as with several GBM established biomarkers, including SHC1, PD-L1, PAX2, MEOX2, YKL-40, TCIRG1, YWHAG, OLIG2, SOX2, Ki-67, and SOX11. Moreover, Gal-1 levels were significantly lower in grade 4 IDH-1 mutant astrocytomas, which have a better prognosis. Our results confirm the role of Gal-1 as a prognostic factor and also suggest its value as an immune-suppressive biomarker in GBM

In silico validation of RNA-Seq results can identify gene fusions with oncogenic potential in glioblastoma

RNA-Sequencing (RNA-Seq) can identify gene fusions in tumors, but not all these fusions have functional consequences. Using multiple data bases, we have performed an in silico analysis of fusions detected by RNA-Seq in tumor samples from 139 newly diagnosed glioblastoma patients to identify in-frame fusions with predictable oncogenic potential. Among 61 samples with fusions, there were 103 different fusions, involving 167 different genes, including 20 known oncogenes or tumor suppressor genes (TSGs), 16 associated with cancer but not oncogenes or TSGs, and 32 not associated with cancer but previously shown to be involved in fusions in gliomas. After selecting in-frame fusions able to produce a protein product and running Oncofuse, we identified 30 fusions with predictable oncogenic potential and classified them into four non-overlapping categories: six previously described in cancer; six involving an oncogene or TSG; four predicted by Oncofuse to have oncogenic potential; and 14 other in-frame fusions. Only 24 patients harbored one or more of these 30 fusions, and only two fusions were present in more than one patient: FGFR3::TACC3 and EGFR::SEPTIN14. This in silico study provides a good starting point for the identification of gene fusions with functional consequences in the pathogenesis or treatment of glioblastoma

Ten golden rules for optimal antibiotic use in hospital settings: the WARNING call to action

Antibiotics are recognized widely for their benefits when used appropriately. However, they are often used inappropriately despite the importance of responsible use within good clinical practice. Effective antibiotic treatment is an essential component of universal healthcare, and it is a global responsibility to ensure appropriate use. Currently, pharmaceutical companies have little incentive to develop new antibiotics due to scientific, regulatory, and financial barriers, further emphasizing the importance of appropriate antibiotic use. To address this issue, the Global Alliance for Infections in Surgery established an international multidisciplinary task force of 295 experts from 115 countries with different backgrounds. The task force developed a position statement called WARNING (Worldwide Antimicrobial Resistance National/International Network Group) aimed at raising awareness of antimicrobial resistance and improving antibiotic prescribing practices worldwide. The statement outlined is 10 axioms, or “golden rules,” for the appropriate use of antibiotics that all healthcare workers should consistently adhere in clinical practice

Delito de peculado cometido por los alcaldes en el ejercicio de sus funciones

TesisLa presente Tesis Titulada “DELITO DE PECULADO COMETIDO POR LOS ALCALDES EN EL EJERCICIO DE SUS FUNCIONES”, ha sido realizada con el aporte de diferentes fuentes bibliográficas que han servido de base para cumplir con todos los objetivos que nos hemos planteado, el cual ha sido contrastado con un trabajo de campo mediante un cuestionario que se ha realizado a los Administrados y Abogados, ya que se ha podido observar desconocimiento y no aplicación de diferentes planteamientos teóricos, legislación comparada y normas de nuestro ordenamiento jurídico en los referente al Delito de de Peculado cometido por los Alcaldes en Ejercicio de sus Funciones

Modeling the distribution of organic coffee Supply Chain from Junín region, Peru

El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.This research uses Supply Chain (SC) data gathered during the distribution and transportation activities of organic coffee. The purpose of this research is to analyze different ways in which crop-chain solutions are adopted in the region of Junín, Peru. The disintegration of the SC is revealed, as each cooperative member works uncoordinatedly on his own leading to different results standards with high costs and low returns. The study focused on different entities from farmers to the port of Callao of an organic coffee supply chain where disintegration is constant. The paper describes a misaligned supply chain including poorly collaboration. All problems found will be an opportunity to develop a distribution model in the organic coffee supply chain of Junín region.Revisión por pare

Bevacizumab for the Treatment of Glioblastoma

Glioblastoma (GBM) or grade IV glioma is the most common primary brain tumor in adults. Standard treatment median overall survival (OS) is only 14–15 months and less than 10% of patients will survive 5 years after diagnosis. There is no standard treatment in recurrent GBM and OS ranges from 3 to 9 months. GBM is 1 of the most vascularized human tumors and GBM cells produce vascular endothelial growth factor (VEGF). Bevacizumab, a humanized monoclonal antibody against VEGF, has demonstrated activity in vitro and in phase II trials in relapse, as well as in 1 phase III trial as first line therapy. Bevacizumab also improves quality of life for patients suffering GBM. This paper reviews the mechanism of action of bevacizumab, its metabolism and pharmacokinetic profile. It summarizes the clinical studies in recurrent and newly diagnosed GBM, its potential side effects and complications and its place in therapy