Spatially resolved LMC star formation history: I. Outside in evolution of the outer LMC disk

We study the evolution of three fields in the outer LMC disk Rgc=3.5-6.2 Kpc. Their star formation history indicates a stellar populations gradient such that younger stellar populations are more centrally concentrated. We identify two main star forming epochs, separated by a period of lower activity between ~7 and ~4 Gyr ago. Their relative importance varies from a similar amount of stars formed in the two epochs in the innermost field, to only 40% of the stars formed in the more recent epoch in the outermost field. The young star forming epoch continues to the present time in the innermost field, but lasted only till ~0.8 and 1.3 Gyr ago at Rgc=5.5 degrees and 7.1 degrees, respectively. This gradient is correlated with the measured HI column density and implies an outside-in quenching of the star formation, possibly related to a variation of the size of the HI disk. This could either result from gas depletion due to star formation or ram-pressure stripping, or from to the compression of the gas disk as ram-pressure from the Milky Way halo acted on the LMC interstellar medium. The latter two situations may have occurred when the LMC first approached the Milky Way.Comment: 15 pages, 13 figures, 4 tables. MNRAS, in pres

Three classical Cepheid variable stars in the nuclear bulge of the Milky Way

The nuclear bulge is a region with a radius of about 200 parsecs around the centre of the Milky Way. It contains stars with ages ranging from a few million years to over a billion years, yet its star-formation history and the triggering process for star formation remain to be resolved. Recently, episodic star formation, powered by changes in the gas content, has been suggested. Classical Cepheid variable stars have pulsation periods that decrease with increasing age, so it is possible to probe the star-formation history on the basis of the distribution of their periods. Here we report the presence of three classical Cepheids in the nuclear bulge with pulsation periods of approximately 20 days, within 40 parsecs (projected distance) of the central black hole. No Cepheids with longer or shorter periods were found. We infer that there was a period about 25 million years ago, and possibly lasting until recently, in which star formation increased relative to the period of 30-70 million years ago.Comment: 19 pages, 5 figures, 1 table (including main paper and supplemantary information

CEPHEID VARIABLE STARS IN THE PEGASUS DWARF IRREGULAR GALAXY: CONSTRAINTS ON THE STAR FORMATION HISTORY

Observations of the resolved stars obtained over a period of 11 years in the Local Group dwarf irregular galaxy Pegasus have been used to search for Cepheid variable stars. Images were obtained in 55 epochs in the V band and in 24 epochs in the I band. We have identified 26 Cepheids and have obtained their light curves and periods. On the basis of their position in the period-luminosity (PL) diagram, we have classified them as 18 fundamental modes and eight first overtone Cepheids. Two PL relations for Cepheids have been used to derive the distance, resulting in 1.07 ± 0.05 Mpc. We present the VARFINDER code which finds the variable stars and their predicted periods in a given synthetic color-magnitude diagram computed with IAC-star and we propose the use of the Cepheid population as a constraint of the star formation history of Pegasus

The Star Formation History of the Magellanic Clouds: Latest Results

We present new results of a long-term investigation of the stellar content of the Large and the Small Magellanic Cloud. The main aim of the project is to obtain a comprehensive knowledge of the star formation history of these two nearby galaxies. Here we discuss the latest findings obtained using new data and a variety of different observational approaches, based on wide-field ground-based photometry and low-resolution CaT spectra. We find evidence of two main star formation events across the LMC disk. We also found evidence that the young and intermediate age population (8 Gyr). In particular, the young (<2 Gyr) component seems to extend to 8 degrees from the center, distance at which it decreases abruptly. At larger distance, the old population dominates, extending to at least 13.5 kpc. We also report the discovery of a population of stars located across the Magellanic Bridge, compatible with the old population of the LMC

Clinical relevance of 8q23, 15q13 and 18q21 SNP genotyping to evaluate colorectal cancer risk.

To determine if the at-risk single-nucleotide polymorphism (SNP) alleles for colorectal cancer (CRC) could contribute to clinical situations suggestive of an increased genetic risk for CRC, we performed a prospective national case-control study based on highly selected patients (CRC in two first-degree relatives, one before 61 years of age; or CRC diagnosed before 51 years of age; or multiple primary CRCs, the first before 61 years of age; exclusion of Lynch syndrome and polyposes) and controls without personal or familial history of CRC. SNPs were genotyped using SNaPshot, and statistical analyses were performed using Pearson's χ(2) test, Cochran-Armitage test of trend and logistic regression. We included 1029 patients and 350 controls. We confirmed the association of CRC risk with four SNPs, with odds ratio (OR) higher than previously reported: rs16892766 on 8q23.3 (OR: 1.88, 95% confidence interval (CI): 1.30-2.72; P=0.0007); rs4779584 on 15q13.3 (OR: 1.42, CI: 1.11-1.83; P=0.0061) and rs4939827 and rs58920878/Novel 1 on 18q21.1 (OR: 1.49, CI: 1.13-1.98; P=0.007 and OR: 1.49, CI: 1.14-1.95; P=0.0035). We found a significant (P<0.0001) cumulative effect of the at-risk alleles or genotypes with OR at 1.62 (CI: 1.10-2.37), 2.09 (CI: 1.43-3.07), 2.87 (CI: 1.76-4.70) and 3.88 (CI: 1.72-8.76) for 1, 2, 3 and at least 4 at-risk alleles, respectively, and OR at 1.71 (CI: 1.18-2.46), 2.29 (CI: 1.55-3.38) and 6.21 (CI: 2.67-14.42) for 1, 2 and 3 at-risk genotypes, respectively. Combination of SNPs may therefore explain a fraction of clinical situations suggestive of an increased risk for CRC

Oral contraceptive use and ovarian cancer risk for BRCA1/2 mutation carriers: an international cohort study

International audienceBackground: Ovarian cancer risk in BRCA1 and BRCA2 mutation carriers has been shown to decrease with longer duration of oral contraceptive use. Although the effects of using oral contraceptives in the general population are well established (approximately 50% risk reduction in ovarian cancer), the estimated risk reduction in mutation carriers is much less precise because of potential bias and small sample sizes. In addition, only a few studies on oral contraceptive use have examined the associations of duration of use, time since last use, starting age, and calendar year of start with risk of ovarian cancer.Objective: This study aimed to investigate in more detail the associations of various characteristics of oral contraceptive use and risk of ovarian cancer, to provide healthcare providers and carriers with better risk estimates.Study design: In this international retrospective study, ovarian cancer risk associations were assessed using oral contraceptives data on 3989 BRCA1 and 2445 BRCA2 mutation carriers. Age-dependent-weighted Cox regression analyses were stratified by study and birth cohort and included breast cancer diagnosis as a covariate. To minimize survival bias, analyses were left truncated at 5 years before baseline questionnaire. Separate analyses were conducted for each aspect of oral contraceptive use and in a multivariate analysis, including all these aspects. In addition, the analysis of duration of oral contraceptive use was stratified by recency of use.Results: Oral contraceptives were less often used by mutation carriers who were diagnosed with ovarian cancer (ever use: 58.6% for BRCA1 and 53.5% BRCA2) than by unaffected carriers (ever use: 88.9% for BRCA1 and 80.7% for BRCA2). The median duration of use was 7 years for both BRCA1 and BRCA2 carriers who developed ovarian cancer and 9 and 8 years for unaffected BRCA1 and BRCA2 carriers with ovarian cancer, respectively. For BRCA1 mutation carriers, univariate analyses have shown that both a longer duration of oral contraceptive use and more recent oral contraceptive use were associated with a reduction in the risk of ovarian cancer. However, in multivariate analyses, including duration of use, age at first use, and time since last use, duration of oral contraceptive use proved to be the prominent protective factor (compared with 10 years [hazard ratio, 0.37; 95% confidence interval, 0.19-0.73]; Ptrend=.008). The inverse association between duration of use and ovarian cancer risk persisted for more than 15 years (duration of ≥10 years; BRCA1 15 years since last use [hazard ratio, 0.56; 95% confidence interval, 0.18-0.59]). Univariate results for BRCA2 mutation carriers were similar but were inconclusive because of limited sample size.Conclusion: For BRCA1 mutation carriers, longer duration of oral contraceptive use is associated with a greater reduction in ovarian cancer risk, and the protection is long term

Search for single productio no vector-like quarks decaying to a Z boson and a top or a bottom quark in proton-proton collisions at root s=13 TeV

A search for single production of vector-like quarks, T and B, decaying into a Z boson and a top or a bottom quark, respectively, is presented. The search is performed using data collected by the CMS experiment at the LHC in proton-proton collisions at root s = 13TeV, corresponding to an integrated luminosity of 2.3 fb(-1). An exotic T quark production mode through the decay of a heavy Z' resonance is also considered. The search is performed in events with a Z boson decaying leptonically, accompanied by a bottom or a top quark decaying hadronically. No excess of events is observed over the standard model background expectation. Products of production cross section and branching fraction for T and B quarks from 1.26 and 0.13 pb are excluded at 95% confidence level for the range of resonance mass considered, which is between 0.7 and 1.7TeV. Limits on the product of the Z 0 boson production cross section and branching fraction, with the Z' boson decaying to the Tt final state, are set between 0.31 and 0.13 pb, for Z' boson masses in the range from 1.5 to 2.5 TeV. This is the first search at 13TeV for single production of vector-like quarks in events with a Z boson decaying leptonically accompanied by boosted jets