National spatial development planning in South Africa 1930-2010: An introductory comparative analysis

This article reviews the various attempts at national spatial development planning that have been introduced in South Africa over the past eighty years. It demonstrates that, despite the ostensible support for national planning during this period, such plans and proposals rarely had a direct impact on the conduct of government business. Using both the authors’ personal experiences with the most recent such ‘plan’ – the National Spatial Development Perspective – they seek to explain why such planning initiatives are so difficult to introduce and implement. Key in this regard, they argue, is that while most national planning initiatives are formulated in a control paradigm common to more local planning contexts, the plans have to function within a complex and tightly interwoven national, provincial and local system that is essentially incompatible with such a paradigm. The historical overview, they argue, suggests that such a national spatial planning intervention would require a far harder-edged form of governance leaning more in the direction of intervention and control and less so in the direction of the current softer forms of dialogue, facilitation and guidance premised by the 1996 Constitution

Yeast cell wall extracts from Saccharomyces cerevisiae varying in structure and composition differentially shape the innate immunity and mucosal tissue responses of the intestine of zebrafish (Danio rerio)

With the rising awareness of antimicrobial resistance, the development and use of functional feed additives (FFAs) as an alternative prophylactic approach to improve animal health and performance is increasing. Although the FFAs from yeasts are widely used in animal and human pharma applications already, the success of future candidates resides in linking their structural functional properties to their efficacy in vivo. Herein, this study aimed to characterise the biochemical and molecular properties of four proprietary yeast cell wall extracts from S. cerevisiae in relation to their potential effect on the intestinal immune responses when given orally. Dietary supplementation of the YCW fractions identified that the α-mannan content was a potent driver of mucus cell and intraepithelial lymphocyte hyperplasia within the intestinal mucosal tissue. Furthermore, the differences in α-mannan and β-1,3-glucans chain lengths of each YCW fraction affected their capacity to be recognised by different PRRs. As a result, this affected the downstream signalling and shaping of the innate cytokine milieu to elicit the preferential mobilisation of effector T-helper cell subsets namely Th17, Th1, Tr1 and FoxP3+-Tregs. Together these findings demonstrate the importance of characterising the molecular and biochemical properties of YCW fractions when assessing and concluding their immune potential. Additionally, this study offers novel perspectives in the development specific YCW fractions derived from S. cerievisae for use in precision animal feeds

Tool condition monitoring of diamond-coated burrs with acoustic emission utilising machine learning methods

Within manufacturing there is a growing need for autonomous Tool Condition Monitoring (TCM) systems, with the ability to predict tool wear and failure. This need is increased, when using specialised tools such as Diamond-Coated Burrs (DCBs), in which the random nature of the tool and inconsistent manufacturing methods create large variance in tool life. This unpredictable nature leads to a significant fraction of a DCB tool’s life being underutilised due to premature replacement. Acoustic Emission (AE) in conjunction with Machine Learning (ML) models presents a possible on-machine monitoring technique which could be used as a prediction method for DCB wear. Four wear life tests were conducted with a ∅1.3 mm #1000 DCB until failure, in which AE was continuously acquired during grinding passes, followed by surface measurements of the DCB. Three ML model architectures were trained on AE features to predict DCB mean radius, an indicator of overall tool wear. All architectures showed potential of learning from the dataset, with Long Short-Term Memory (LSTM) models performing the best, resulting in prediction error of MSE = 0.559 μm2 after optimisation. Additionally, links between AE kurtosis and the tool’s run-out/form error were identified during an initial review of the data, showing potential for future work to focus on grinding effectiveness as well as overall wear. This paper has shown that AE contains sufficient information to enable on-machine monitoring of DCBs during the grinding process. ML models have been shown to be sufficiently precise in predicting overall DCB wear and have the potential of interpreting grinding condition

Local stability of self-gravitating fluid disks made of two components in relative motion

Context. We consider a simple self-gravitating disk, made of two fluid components characterized by different effective thermal speeds and interacting with one another only through gravity; two-component models of this type have often been considered in order to estimate the impact of the cold interstellar medium on gravitational instabilities in star-dominated galaxy disks. Aims. This simple model allows us to produce a unified description of instabilities in non-viscous self-gravitating disks, some originating from Jeans collapse, and others from the relative motion between the two components. In particular, the model suggests that the small streaming velocity between the two components associated with the so-called asymmetric drift may be the origin of instability for suitable non-axisymmetric perturbations. Methods. The result is obtained by examining the properties of a local, linear dispersion relation for tightly wound density waves in such two-component model. The parameters characterizing the equilibrium model and the related dispersion relation allow us to recover as natural limits the cases, known in the literature, in which the relative drift between the two components is ignored. Results. Dynamically, the instability is similar to (although gentler than) that known to affect counter-rotating disks. However, in contrast to the instability induced by counter-rotation, which is a relatively rare phenomenon, the mechanism discussed in this paper is likely to be rather common in nature. Conclusions. We briefly indicate some consequences of the instability on the evolution of galaxy disks and possible applications to other astrophysical systems, in particular to protostellar disks and accretion disks.Comment: 9 pages, 5 figures, Astronomy & Astrophysics, in pres

Near-island biological hotspots in barren ocean basins

Phytoplankton production drives marine ecosystem trophic-structure and global fisheries yields. Phytoplankton biomass is particularly influential near coral reef islands and atolls that span the oligotrophic tropical oceans. The paradoxical enhancement in phytoplankton near an island-reef ecosystem—Island Mass Effect (IME)—was first documented 60 years ago, yet much remains unknown about the prevalence and drivers of this ecologically important phenomenon. Here we provide the first basin-scale investigation of IME. We show that IME is a near-ubiquitous feature among a majority (91%) of coral reef ecosystems surveyed, creating near-island ‘hotspots' of phytoplankton biomass throughout the upper water column. Variations in IME strength are governed by geomorphic type (atoll vs island), bathymetric slope, reef area and local human impacts (for example, human-derived nutrient input). These ocean oases increase nearshore phytoplankton biomass by up to 86% over oceanic conditions, providing basal energetic resources to higher trophic levels that support subsistence-based human populations

Simulations of the grand design galaxy M51: a case study for analysing tidally induced spiral structure

We present hydrodynamical models of the grand design spiral M51 (NGC 5194), and its interaction with its companion NGC 5195. Despite the simplicity of our models, our simulations capture the present day spiral structure of M51 remarkably well, and even reproduce details such as a kink along one spiral arm, and spiral arm bifurcations. We investigate the offset between the stellar and gaseous spiral arms, and find at most times (including the present day) there is no offset between the stars and gas to within our error bars. We also compare our simulations with recent observational analysis of M51. We compute the pattern speed versus radius, and like the observations, find no single global pattern speed. We also show that the spiral arms cannot be fitted well by logarithmic spirals. We interpret these findings as evidence that M51 does not exhibit a quasi-steady density wave, as would be predicted by density wave theory. The internal structure of M51 derives from the complicated and dynamical interaction with its companion, resulting in spiral arms showing considerable structure in the form of short-lived kinks and bifurcations. Rather than trying to model such galaxies in terms of global spiral modes with fixed pattern speeds, it is more realistic to start from a picture in which the spiral arms, while not being simple material arms, are the result of tidally induced kinematic density `waves' or density patterns, which wind up slowly over time.Comment: 23 pages, 20 figures, accepted for publication in MNRA

Myosin 1E interacts with synaptojanin-1 and dynamin and is involved in endocytosis

AbstractMyosin 1E is one of two “long-tailed” human Class I myosins that contain an SH3 domain within the tail region. SH3 domains of yeast and amoeboid myosins I interact with activators of the Arp2/3 complex, an important regulator of actin polymerization. No binding partners for the SH3 domains of myosins I have been identified in higher eukaryotes. In the current study, we show that two proteins with prominent functions in endocytosis, synaptojanin-1 and dynamin, bind to the SH3 domain of human Myo1E. Myosin 1E co-localizes with clathrin- and dynamin-containing puncta at the plasma membrane and this co-localization requires an intact SH3 domain. Expression of Myo1E tail, which acts in a dominant-negative manner, inhibits endocytosis of transferrin. Our findings suggest that myosin 1E may contribute to receptor-mediated endocytosis