Valoración de la calidad de vida en los pacientes crónicos pluripatológicos

Actualmente, la sociedad se caracteriza por un aumento progresivo de la población envejecida, entre cuyas características sanitarias se encuentra la pluripatología. Por ello, en Castilla y León se implanta una estrategia de atención al paciente crónico pluripatológico en situación de complejidad, también llamado G3. Para tratarlos holísticamente se decide investigar sobre la percepción de su calidad de vida, específicamente en las zonas básicas de salud de La Victoria y de Magdalena de Valladolid Este. Objetivo: Valorar la calidad de vida de los pacientes pluripatológicos catalogados como G3 en la plataforma Medora en un momento aleatorio de su vida. Método: A través de un estudio transversal observacional se evalúan cuantitativamente distintas variables empleando el cuestionario de calidad de vida SF-36, la escala EVA, el índice de Barthel y el examen MiniMental. Resultado: Los pacientes G3 refieren peor estado en la esfera física que en la psíquica, existiendo diferencias entre las zonas básicas de salud analizadas. Discusión: El colectivo estudiado presenta mejor estado de salud mental que los valores de referencia normales de la población española y se encuentra dentro de los intervalos normales de salud física.Grado en Enfermerí

The complete HEFT Lagragian after the LHC Run I

The complete effective chiral Lagrangian for a dynamical Higgs is presented and constrained by means of a global analysis including electroweak precision data together with Higgs and triple gauge-boson coupling data from the LHC Run I. The operators' basis up to next-to-leading order in the expansion consists of 148 (188 considering right-handed neutrinos) flavour universal terms and it is presented here making explicit the custodial nature of the operators. This effective Lagrangian provides the most general description of the physical Higgs couplings once the electroweak symmetry is assumed, and it allows for deviations from the SU(2)L doublet nature of the Standard Model Higgs. The comparison with the effective linear Lagrangian constructed with an exact SU(2)L doublet Higgs and considering operators with at most canonical dimension six is presented. A promising strategy to disentangle the two descriptions consists in analysing (i) anomalous signals present only in the chiral Lagrangian and not expected in the linear one, that are potentially relevant for LHC searches, and (ii) decorrelation effects between observables that are predicted to be correlated in the linear case and not in the chiral one. The global analysis presented here, which includes several kinematic distributions, is crucial for reducing the allowed parameter space and for controlling the correlations between parameters. This improves previous studies aimed at investigating the Higgs Nature and the origin of the electroweak symmetry breaking

A New bound on CP Violation in the τ\tau Lepton Yukawa Coupling and electroweak baryogenesis

The origin of the matter-antimatter asymmetry in the Universe is a fundamental question of physics. Electroweak baryogenesis is a compelling scenario for explaining it but it requires beyond the Standard Model sources of the CP symmetry violation. The simplest possibility is CP violation in the third generation fermion Higgs couplings, widely investigated theoretically and searched for experimentally. It has been found that the experimental bounds on the CP violation in the quark Yukawa couplings exclude their significant role in the electroweak baryogenesis, but it can be still played by the $\tau$ lepton Yukawa coupling. It is shown in this paper that, within the context of the Standard Model Effective Field Theory and assuming an underlying flavour symmetry of the Wilson coefficients, the electron dipole moment bound on the $\tau$ lepton Yukawa coupling is two orders of magnitude stronger than previously reported. This sheds strong doubts on its role in the electroweak baryogenesis, further stimulates the interest in its experimental verification and makes electroweak baryogenesis even more difficult to explain.Comment: V2: references added; minor changes on the text; results unchanged; version accepted for publication on JHE

Estudio de la función suprarrenal en el embarazo y en el parto mediante el test de Thorn

Tesis inédita, presentada en la Universidad de Madrid, Facultad de Medicina, 1955.Fac. de MedicinaTRUEProQuestpu

Exotic vertolike quark phenomenology in the minimal linear σ model

Extensions of the Standard Model that include vectorlike quarks commonly also include additional particles that may mediate new production or decay modes. Using the minimal linear σ model as an example, which reduces to the minimal SO (5)/SO (4) composite Higgs model in a specific limit, we consider the phenomenology of vectorlike quarks when a scalar singlet σ is present. This new particle may be produced in the decays T → tσ, B → bσ, where T and B are vectorlike quarks of charges 2/3 and −1/3, respectively, with the subsequent decay σ → W+W−, ZZ, hh. By scanning over the allowed parameter space we find that these decays may be dominant. In addition, we find that the presence of several new particles allows for single T production cross sections larger than those expected in minimal models. We discuss the observability of these new signatures in existing searchesThe authors acknowledge partial financial support by the Spanish MINECO through the Centro de excelencia Severo Ochoa Program under Grant No. SEV2016-0597. J. A. G., L. M. and J. A. A. S. acknowledge partial financial support by the Spanish “Agencia Estatal de Investigación” (AEI) and the EU “Fondo Europeo de Desarrollo Regional” (FEDER) through the Projects No. FPA2016-78645-P and No. FPA2016-78220-C3-1-P. L. M. acknowledges partial financial support by the Spanish MINECO through the “Ramón y Cajal” programme (RYC-2015-17173). J. M. N. acknowledges support from the Ramón y Cajal Fellowship Contract No. RYC-2017-22986 and from the Spanish Proyectos de I + D de Generación de Conocimiento via Grant No. PGC2018-096646-A-I00. L. M. and J. M. N. also acknowledge support from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie Grant agreements No. 690575 (RISE InvisiblesPlus) and No. 674896 (ITN ELUSIVES

Comportamiento clínico-epidemiológico de la artritis séptica en pacientes ingresados en el servicio de pediatría en el Hospital Fernando Vélez Páiz 2018-2020

Con el objetivo de evaluar a pacientes en el Servicio de pediatría del Hospital Fernando Vélez Páiz, con diagnóstico de artritis séptica en el periodo 2018 a 2020, se realizó un estudio descriptivo, correlacional y observacional. Las principales variables analizadas fueron características sociodemográficas, estado nutricional, patologías causantes, estudios de laboratorio e imagen y complicaciones médicas. Los análisis estadísticos efectuados fueron: descriptivos, Chi cuadrado. Del análisis y discusión de los resultados obtenidos, se alcanzaron las siguientes conclusiones: Los pacientes en estudio se caracterizan por ser masculinos, menores de 4 años de edad, sin escolaridad, de procedencia urbana, eutróficos. En los antecedentes patológicos, la mayoría de los pacientes, tuvo antecedentes de trauma, el síntoma principal fue el dolor, los estudios de laboratorio se realizó PCR a todos los pacientes al ingreso, la BHC dio una media de leucocitos mayor de 14 mil, y media de neutrófilos mayor de 9mil, la procalcitonina solo se realizó a 5 pacientes en todo el estudio, los cultivos positivos fueron 14, de los cuales reportaron aislamiento principalmente de estafilococo aureus, con mayor sensibilidad a la clindamicina y mayor resistencia a oxacilina. Los estudios de imagen se realizó ultrasonido a 43 pacientes de los cuales colección articular y bursitis fueron los que más se reportaron. Las complicaciones más comunes fueron sepsis y osteomielitis, acudieron en menos de 3 días desde el inicio de los síntomas en su mayoría, presentando estancia intrahospitalaria entre 8 a 15 días, egresando vivo

Testable axion-like particles in the minimal linear σ model

Axion and axion-like particle models are typically affected by a strong fine-tuning problem in conceiving the electroweak and the Peccei-Quinn breaking scales. Within the context of the Minimal Linear σ Model, axion-like particle constructions are identified where this hierarchy problem is solved, accounting for a TeV Peccei-Quinn breaking scale and a pseudoscalar particle with a mass larger than 10 MeV. Potential signatures at colliders and B-factories are discussedThe authors acknowledge partial financial support by the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreements No.690575 and No. 674896. J.A.G and L.M. acknowledge partial financial support by the Spanish Agencia Estatal de Investigación (AEI) and the EU Fondo Europeo de Desarrollo Regional(FEDER) through the project FPA2016-78645-P, and through the Centro de excelencia Severo Ochoa Program under grant SEV-2016-0597. L. M. acknowledges partial financial support by the Spanish MINECO through the “Ramón y Cajal” programme (RYC-2015-17173).J.A.G. and L.M. thank the Physics and Astronomy department “Galileo Galilei” of the Padua University for hospitality during the development of this project. Furthermore, L.M. thanks the Kavli Institute for the Physics and Mathematics of the Universe for hospitality during the development of this projec

Evolutionary Dynamics of Multigene Families in Triportheus (Characiformes, Triportheidae): A Transposon Mediated Mechanism?

Triportheus (Characiformes, Triportheidae) is a freshwater fish genus with 18 valid species. These fishes are widely distributed in the major river drainages of South America, having commercial importance in the fishing market, mainly in the Amazon basin. This genus has diverged recently in a complex process of speciation carried out in different river basins. The use of repetitive sequences is suitable to trace the genomic reorganizations occured along the speciation process. In this work, the 5S rDNA multigene family has been characterized at molecular and phylogenetic level. The results showed that other multigene family has been found within the non-transcribed spacer (NTS): the U1 snRNA gene. Double-FISH with 5S and U1 probes were also performed, confirming the close linkage between these two multigene families. Moreover, evidences of different transposable elements (TE) were detected within the spacer, thus suggesting a transposon-mediated mechanism of 5S-U1 evolutionary pathway in this genus. Phylogenetic analysis demonstrated a species-specific grouping, except for Triportheus pantanensis, Triportheus aff. rotundatus and Triportheus trifurcatus. The evolutionary model of the 5S rDNA in Triportheus species has been discussed. In addition, the results suggest new clues for the speciation and evolutionary trend in these species, which could be suitable to use in other Characiformes species

Endometrial study in patients with postmenopausal metrorrhagia

Introduction: The aim of the study was to devise a strategy to diagnose malign endometrial pathologies (adenocarcinoma or atypical hyperplasia) that minimizes the number of invasive tests done (hysteroscopy, aspiration biopsy or curettage) with no loss of its detection efficiency. Material and methods: We retrospectively studied the clinical histories of 779 postmenopausal women at the University Hospital Complex of Albacete, for whom an endometrial study had been done (hysteroscopy, aspiration biopsy or curettage) with a 1-year follow-up between 1 March 2006 and 31 March 2008. Results: There were 77 cases of a malignant pathology (66 adenocarcinomas and 11 hyperplasias with atypia); 96.1% had metrorrhagia, and there were only 3 cases of asymptomatic patients (all 3 presented endometrial thickness of > 5 mm: 10, 12 and 15 mm). The sensitivity and specificity of the transvaginal ultrasound, with a 5 mm cut-off point to diagnose a malignant pathology, were 98.4% and 30.1%, respectively; 89.1% and 99.6%, respectively, for aspiration biopsy; 83.9% and 99.1%, respectively, for hysteroscopy without biopsy; and both were 100% for biopsy. Statistical significance was considered at p < 0.05 and confidence intervals were calculated at 95%. Conclusions: In postmenopausal women with metrorrhagia, the first action to take is to do a transvaginal ultrasound, followed by en endometrial study, but only if the endometrium is irregular or endometrial thickness is > 5 mm; in asymptomatic women, the cut-off point should be set at 10 mm. The immediate method of choice is an ambulatory biopsy