The \u3ci\u3eDrosophila\u3c/i\u3e T-box Transcription Factor Midline Functions Within the Notch-Delta Signaling Pathway To Specify Sensory Organ Precursor Cell Fates and Regulates Cell Survival Within the Eye Imaginal Disc

We report that the T-box transcription factor Midline (Mid), an evolutionary conserved homolog of the vertebrate Tbx20 protein, functions within the Notch-Delta signaling pathway essential for specifying the fates of sensory organ precursor (SOP) cells. These findings complement an established history of research showing that Mid regulates the cell-fate specification of diverse cell types within the developing heart, epidermis and central nervous system. Tbx20 has been detected in unique neuronal and epithelial cells of embryonic eye tissues in both mice and humans. However, the mechanisms by which either Mid or Tbx20 function to regulate cell-fate specification or other critical aspects of eye development including cell survival have not yet been elucidated. We have also gathered preliminary evidence suggesting that Mid may play an indirect, but vital role in selecting SOP cells within the third-instar larval eye disc by regulating the expression of the proneural gene atonal. During subsequent pupal stages, Mid specifies SOP cell fates as a member of the Notch-Delta signaling hierarchy and is essential for maintaining cell viability by inhibiting apoptotic pathways. We present several new hypotheses that seek to understand the role of Mid in regulating developmental processes downstream of the Notch receptor that are critical for specifying unique cell fates, patterning the adult eye and maintaining cellular homeostasis during eye disc morphogenesis. © 2013 Elsevier Ireland Ltd

Interferometric measurements of the [lambda] 7319 A doublet emissions of OII

Fabry-Perot interferometer observations of the OII 7319 A line made from College, Alaska are presented. Significant Doppler shifts corresponding to the ion drift motion, caused by the convection electric fields, were observed under special conditions, but no steady observations were possible due to the sporadic nature of this emission. Very preliminary results of the observed doublet separation ([approximate]0.836 A) are also presented.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/22389/1/0000838.pd

Noncontrast MRI with advanced diffusion weighted imaging for breast cancer detection in a lactating woman.

Magnetic resonance imaging (MRI) is used for preoperative evaluation, high-risk screening, and other select indications for breast cancer. However, the interpretation of breast MR images in pregnant and lactating women is complicated by physiologic changes of the breast that may result in marked background enhancement. Breast MRI with contrast administration is contraindicated in pregnancy. Restriction spectrum imaging (RSI) is an advanced diffusion-weighted (DW)-MRI method that theoretically reflects signal from cells with high nuclear-to-cytoplasm ratio without gadolinium-based contrast. This report describes a case in which RSI notably increased tumor conspicuity in a lactating woman, compared to contrast-enhanced (CE)-MRI and conventional DW-MRI

Storm-time response of the mid-latitude thermosphere: Observations from a network of Fabry-Perot interferometers

Observations of thermospheric neutral winds and temperatures obtained from a network of five Fabry-Perot interferometers deployed in the midwest United States during a geomagnetic storm on 2 October 2013 showed that coincident with the commencement of the storm, the horizontal wind was observed to surge westward and southward (towards the equator). Simultaneous with this surge in the horizontal winds, an apparent downward wind of approximately 100 m/s lasting for 6 hours was also observed. The neutral temperature was observed to increase by approximately 400 K over all of the sites. Similar results of downward vertical winds and sustained heating have been seen in other geomagnetic storm events. The large sustained apparent downward winds are interpreted as arising from the contamination of the nominal spectral profile of the 630.0-nm population distribution, which is thermalized within the thermosphere region, by fast O related to the infusion of low-energy O+ ions that are generated by charge exchange and momentum transfer collisions. This interpretation is supported through simultaneous observations made by the Helium, Oxygen, Proton, and Electron spectrometer instruments on the twin Van Allen Probes spacecrafts, which show an influx of low-energy ions well correlated with the period of apparent downward winds. These results emphasize the importance of distributed networks of instruments in understanding the complex dynamics that occur in the upper atmosphere during disturbed conditions and represent an example of magnetosphere-ionosphere coupling

Exercise Professionals with Advanced Clinical Training Should be Afforded Greater Responsibility in Pre-Participation Exercise Screening: A New Collaborative Model between Exercise Professionals and Physicians

© 2018 The Author(s) Regular exercise improves health but can also induce adverse responses. Although such episodes are rare, many guidelines for pre-participation exercise screening have historically had a low threshold for recommending medical clearance prior to the commencement of exercise, placing the responsibility for decision making about exercise participation on physicians. The ‘clearance to exercise’ model still occurs widely in practice, but creates cost burdens and barriers to the uptake of exercise. Moreover, many physicians are not provided the training, nor time in a standard consultation, to be able to effectively perform this role. We present a model for pre-participation exercise screening and the initial assessment of clients wishing to commence an exercise programme. It is designed to guide professional practice for the referral, assessment and prescription of exercise for people across the health spectrum, from individuals who are apparently healthy, through to clients with pre-existing or occult chronic conditions. The model removes the request that physicians provide a ‘clearance’ for patients to engage in exercise programmes. Instead the role of physicians is identified as providing relevant clinical guidance to suitably qualified exercise professionals to allow them to use their knowledge, skills and expertise in exercise prescription to assess and manage any risks related to the prescription and delivery of appropriate exercise programmes. It is anticipated that removing unjustified barriers to exercise participation, such as mandated medical review, will improve the uptake of exercise by the unacceptably high proportion of the population who do not undertake sufficient physical activity for health benefit

Addressing childhood obesity through increased physical activity

Obesity is affecting an increasing proportion of children globally. Despite an appreciation that physical activity is essential for the normal growth and development of children and prevents obesity and obesity-related health problems, too few children are physically active. A concurrent problem is that today’s young people spend more time than previous generations did in sedentary pursuits, including watching television and engaging in screen-based games. Active behavior has been displaced by these inactive recreational choices, which has contributed to reductions in activity-related energy expenditure. Implementation of multifactorial solutions considered to offer the best chance of combating these trends is urgently required to redress the energy imbalance that characterizes obesity. The counterproductive ‘shame and blame’ mentality that apportions responsibility for the childhood obesity problem to sufferers, their parents, teachers or health-care providers needs to be changed. Instead, these groups should offer constant support and encouragement to promote appropriate physical activity in children. Failure to provide activity opportunities will increase the likelihood that the children of today will live less healthy (and possibly shorter)lives than their parents