Analysis and decision : a framework for estimating capital and operating costs in the urban transportation planning process

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Urban Studies and Planning, 1990.Includes bibliographical references (leaves [326]-[343]).by Aurelio Menéndez.Ph.D

El Derecho Mercantil como categoría dogmática

Ante la confusión que puede generar el Derecho Mercantil como categoría dogmática, El Dr. Menéndez reflexiona sobre las distintas unidades sistemáticas que lo conforman y las explica para sustentar el error que comete la doctrina al centrarse únicamente en el derecho de sociedades, olvidando otros sectores que acentúan mucho más su autonomía

Espacios polivalentes para usuarios diferentes

Distintos usuarios=Distintos servicios/Distintos espaciosComunicación presentada por miembros de la Biblioteca de la Universidad de Oviedo, en las III Jornadas de Bibliotecas G9 sobre buenas prácticas en atención a espacios y usuarios, organizada por el Servicio de Bibliotecas de la UCLM en Almagro (Ciudad Real) los días 3 y 4 de octubre de 2019. La Biblioteca de Ciencias Jurídico-Sociales es un edificio independiente de cuatro plantas ubicado en el Campus del Cristo de la Universidad de Oviedo. Es la depositaria de los fondos bibliográficos de las facultades de Economía y Empresa y Derecho. Hasta ahora nuestra Biblioteca ofrecía cuatro salas de estudio con idéntica función: el estudio y consulta en riguroso silencio (primera y segunda plantas), una sala de referencia y otra de revistas, también para trabajo de consulta en silencio (planta baja) y un Depósito en la planta inferior del edificio al que solo accedía el PDI. En los últimos años y, especialmente, tras la implantación de los grados, percibimos que las demandas de usuarios y usuarias eran diferentes dependiendo del tipo y de la expectativa que cada uno tenía sobre los servicios bibliotecarios y que, en muchas ocasiones, no encontraban su acomodo en la Biblioteca. Así, por ejemplo, detectamos un usuario-estudiante que venía en grupo y que esperaba poder estudiar en grupo, encontramos también un usuario que buscaba tranquilidad y silencio absolutos (algunos docentes, usuarios externos opositores), también aparecieron, según se fueron desarrollando los grados, los usuarios demandantes de información para la elaboración de TFG/TFM, los cada vez más numerosos estudiantes ERASMUS y las personas que pasaban mucho tiempo en la Biblioteca y necesitaban zonas de descanso dentro del edificio, ya que al estar en un extremo del Campus, se emplea cierto tiempo en llegar a la zona de cafeterías. Asimismo, el auge de los estudios de género y del feminismo propició una creciente demanda de información sobre el tema y amplió el número de usuarias que utilizaban la sección de feminismo de nuestra colección. Lo que antes solo interesaba especialmente a estudiantes de Sociología o de Filosofía del Derecho se convirtió en una demanda transversal que atrajo a nuestra Biblioteca estudiantes de otros grados y otros Campus. Teniendo esto en cuenta y aprovechando una serie de cambios organizativos que se produjeron en la Biblioteca, se han venido acometiendo desde 2018 una serie de innovaciones en el uso de sus espacios con el objetivo de ampliar los servicios que se ofrecen y de habilitar zonas más acogedoras y personalizadas, al gusto de las nuevas demandas de los usuarios y usuarias. Se han establecido de esta manera una serie de zonas en función del grado de silencio que el usuario necesita en cada momento y unas zonas de descanso donde tomarse un respiro. Se ha habilitado también un espacio para formación y otro para extensión cultural, en el cual se ha incluido una gran parte de la colección de temática feminista que anteriormente se encontraba en el Depósito. El hashtag #bcjsigualdad que utilizamos en nuestras publicaciones de Facebook relacionadas con la temática de género, nos sirve también para dar publicidad a este espacio.Communication presented by members of the Library of the University of Oviedo, in the III Conference of G9 Libraries on good practices in attention to spaces and users, organized by the UCLM Library Service in Almagro (Ciudad Real) on days 3 and 4 October 2019.    The Library of Legal and Social Sciences is an independent four-storey building located on the Campus del Cristo of the University of Oviedo. It is the depository of the bibliographic funds of the faculties of Economics and Business and Law.    Until now our Library offered four study rooms with the same function: the study and consultation in strict silence (first and second floors), a reference room and another magazine, also for silent consultation work (ground floor) and a Depository on the lower floor of the building accessed by the POI only.    In recent years and, especially, after the implementation of the degrees, we perceive that the demands of users were different depending on the type and expectation that each one had about library services and that, on many occasions, they did not find their Accommodation in the Library. Thus, for example, we detected a user-student who came in a group and who hoped to study in a group, we also found a user who sought absolute tranquility and silence (some teachers, opposing external users), also appeared, as the grades were developed , the users demanding information for the development of TFG / TFM, the increasingly numerous ERASMUS students and people who spent a lot of time in the Library and needed rest areas inside the building, since being at one end of the Campus, It takes some time to reach the coffee shop area. Likewise, the rise of gender and feminism studies led to a growing demand for information on the subject and expanded the number of users who used the feminism section of our collection. What previously only interested students of Sociology or Philosophy of Law in particular became a transversal demand that attracted students from other grades and other campuses to our Library.  Taking this into account and taking advantage of a series of organizational changes that occurred in the Library, a series of innovations in the use of its spaces have been undertaken since 2018 with the aim of expanding the services offered and enabling more welcoming areas and personalized, to the taste of the new demands of the users. In this way, a series of zones have been established depending on the degree of silence that the user needs at all times and resting areas where to take a break. It has also enabled a space for training and another for cultural extension, which has included a large part of the feminist theme collection that was previously in the Depot. The hashtag #bcjsigualdad that we use in our Facebook publications related to gender issues, also serves to publicize this space

Fluorescence multi-scale endoscopy and its applications in the study and diagnosis of gastro-intestinal diseases: set-up design and software implementation

Proceedings of: IPA 2015 / SPIE Biophotonics South America. Rio de Janeiro, Brazil, 22-26 May, 2015Endoscopy is frequently used in the diagnosis of several gastro-intestinal pathologies as Crohn disease, ulcerative colitis or colorectal cancer. It has great potential as a non-invasive screening technique capable of detecting suspicious alterations in the intestinal mucosa, such as inflammatory processes. However, these early lesions usually cannot be detected with conventional endoscopes, due to lack of cellular detail and the absence of specific markers. Due to this lack of specificity, the development of new endoscopy technologies, which are able to show microscopic changes in the mucosa structure, are necessary. We here present a confocal endomicroscope, which in combination with a wide field fluorescence endoscope offers fast and specific macroscopic information through the use of activatable probes and a detailed analysis at cellular level of the possible altered tissue areas. This multi-modal and multi-scale imaging module, compatible with commercial endoscopes, combines near-infrared fluorescence (NIRF) measurements (enabling specific imaging of markers of disease and prognosis) and confocal endomicroscopy making use of a fiber bundle, providing a cellular level resolution. The system will be used in animal models exhibiting gastro-intestinal diseases in order to analyze the use of potential diagnostic markers in colorectal cancer. In this work, we present in detail the set-up design and the software implementation in order to obtain simultaneous RGB/NIRF measurements and short confocal scanning times.The authors acknowledge support from EC FP7 IMI project PREDICT-TB, the EC FP7 CIG grant HIGH-THROUGHPUT TOMO, the Spanish MINECO project grant FIS2013-41802-R MESO-IMAGING, and TOPUS S2013/MIT-3024 project from the regional government of MadridPublicad

Circulating prolactin and in situ breast cancer risk in the European EPIC cohort: a case-control study

Introduction: The relationship between circulating prolactin and invasive breast cancer has been investigated previously, but the association between prolactin levels and in situ breast cancer risk has received less attention. Methods: We analysed the relationship between pre-diagnostic prolactin levels and the risk of in situ breast cancer overall, and by menopausal status and use of postmenopausal hormone therapy (HT) at blood donation. Conditional logistic regression was used to assess this association in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, including 307 in situ breast cancer cases and their matched control subjects. Results: We found a significant positive association between higher circulating prolactin levels and risk of in situ breast cancer among all women [pre-and postmenopausal combined, ORlog2 = 1.35 (95% CI 1.04-1.76), P-trend = 0.03]. No statistically significant heterogeneity was found between prolactin levels and in situ cancer risk by menopausal status (P-het = 0.98) or baseline HT use (P-het = 0.20), although the observed association was more pronounced among postmenopausal women using HT compared to non-users (P-trend = 0.06 vs P-trend = 0.35). In subgroup analyses, the observed positive association was strongest in women diagnosed with in situ breast tumors = 4 years after blood donation (P-trend = 0.01 vs P-trend = 0.63; P-het = 0.04) and among nulliparous women compared to parous women (P-trend = 0.03 vs P-trend = 0.15; P-het = 0.07). Conclusions: Our data extends prior research linking prolactin and invasive breast cancer to the outcome of in situ breast tumours and shows that higher circulating prolactin is associated with increased risk of in situ breast cancer. The relationship between circulating prolactin and invasive breast cancer has been investigated previously, but the association between prolactin levels and in situ breast cancer risk has received less attention

Dietary intakes and food sources of phenolic acids in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Phenolic acids are secondary plant metabolites that may have protective effects against oxidative stress, inflammation and cancer in experimental studies. To date, limited data exist on the quantitative intake of phenolic acids. We estimated the intake of phenolic acids and their food sources and associated lifestyle factors in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Phenolic acid intakes were estimated for 36 037 subjects aged 35-74 years and recruited between 1992 and 2000 in ten European countries using a standardised 24 h recall software (EPIC-Soft), and their food sources were identified. Dietary data were linked to the Phenol-Explorer database, which contains data on forty-five aglycones of phenolic acids in 452 foods. The total phenolic acid intake was highest in Aarhus, Denmark (1265·5 and 980·7 mg/d in men and women, respectively), while the intake was lowest in Greece (213·2 and 158·6 mg/d in men and women, respectively). The hydroxycinnamic acid subclass was the main contributor to the total phenolic acid intake, accounting for 84·6-95·3 % of intake depending on the region. Hydroxybenzoic acids accounted for 4·6-14·4 %, hydroxyphenylacetic acids 0·1-0·8 % and hydroxyphenylpropanoic acids ≤ 0·1 % for all regions. An increasing south-north gradient of consumption was also found. Coffee was the main food source of phenolic acids and accounted for 55·3-80·7 % of the total phenolic acid intake, followed by fruits, vegetables and nuts. A high heterogeneity in phenolic acid intake was observed across the European countries in the EPIC cohort, which will allow further exploration of the associations with the risk of diseases

Menstrual factors, reproductive history, hormone use, and Urothelial carcinoma risk: A prospective study in the EPIC cohort

Background: Urothelial carcinoma (UC) is the predominant (95%) bladder cancer subtype in industrialised nations. Animal and epidemiological human studies suggest that hormonal factors may influence UC risk. Methods: We used an analytic cohort of 333,919 women from the European Prospective Investigation into Cancer and Nutrition Cohort (EPIC). Associations between hormonal factors and incident UC (overall and by tumour grade, by tumour aggressiveness, and by non-muscle invasive UC) risk were evaluated using Cox proportional hazards models. All models were stratified by age at recruitment and study centre, and adjusted for smoking status and intensity, and fruit and vegetable intakes. Results: During a mean of 15 years of follow-up, 529 women developed UC. In a model including number of full-term pregnancies (FTP), menopausal status, and menopausal hormone therapy (MHT) showed an inverse association between, number of FTP was inversely associated with UC risk (HR≥5vs1=0.48, 0.25-0.90; P-trend in parous women=0.010) and MHT-use (compared to non-use) was positively associated with UC risk (HR=1.27, 1.03-1.57), but no dose-response by years of MHT-use was observed. No modification of HRs by smoking status was observed. Finally, sensitivity analysis in never-smokers showed similar HR patterns for number of FTP and no association between MHT-use and UC risk. Association between MHT-use and UC risk only remained significant in current-smokers. No heterogeneity of the risk estimations in the final model was observed by tumour aggressiveness or by tumour grade. A positive association between the MTH-use and non-muscle invasive UC risk was observed. Conclusion: Increasing number of FTP may reduce UC risk. Our results provided limited evidence for a role of MHT-use in UC risk due to residual confounding by tobacco. Impact: More detailed studies on parity are needed to understand the possible effects of perinatal hormone changes in urothelial cells

Mecanismos de coordinación docente en la Facultad de Derecho

El trabajo de esta Red docente ha consistido en recopilar y proponer nuevos mecanismos de coordinación docente aplicables a las cuatro titulaciones de Grado de la Facultad de Derecho. Los resultados de los Informes de Seguimiento de cada titulación de la Facultad, muestran la necesidad de establecer instrumentos de coordinación del profesorado de cada titulación para unificar y armonizar criterios en lo relativo al volumen total del trabajo exigido al estudiante, la distribución temporal adecuada del mismo y el trabajo colectivo de todos los profesores para conseguir los objetivos plasmados en la Memoria Verificada por ANECA para cada título. El objetivo de esta Red ha sido recopilar los mecanismos de coordinación ya existentes y proponer otros nuevos que puedan plantearse en las correspondientes Comisiones de titulación y aplicarse en cursos sucesivos en nuestra Facultad