348 research outputs found
Thermoresponsive poly(N-vinylcaprolactam) as stationary phase for aqueous and green liquid chromatography
Poly(N-vinylcaprolactam) (PVCL) connected to aminopropyl silica is a new stationary phase for temperature responsive liquid chromatography (TR-LC). PVCL shows a transition from hydrophilic to hydrophobic interaction between 30 and 40 degrees C. The synthesis is described in detail. The temperature responsive characteristic of the phase is illustrated with a mixture of steroids using pure water as mobile phase. An increase in retention is observed when raising the temperature. H-u plots at different temperatures were constructed. Below the lower critical solution temperature (LCST), no optimal velocity could be measured because of substantial resistance to mass transfer. Above the LCST, u (opt) was ca. 0.3 mm s(-1) with reduced plate heights from 4 at 45 degrees C to 3 at 65 degrees C. The temperature responsive nature of the polymer is lost in green chromatography with ethanol as modifier in concentrations above 5%
Pharmacological management of acute bronchiolitis
This article reviews the current knowledge base related to the pharmacological treatments for acute bronchiolitis. Bronchiolitis is a common lower respiratory illness affecting infants worldwide. The mainstays of therapy include airway support, supplemental oxygen, and support of fluids and nutrition. Frequently tried pharmacological interventions, such as ribavirin, nebulized bronchodilators, and systemic corticosteroids, have not been proven to benefit patients with bronchiolitis. Antibiotics do not improve the clinical course of patients with bronchiolitis, and should be used only in those patients with proven concurrent bacterial infection. Exogenous surfactant and heliox therapy also cannot be recommended for routine use, but surfactant replacement holds promise and should be further studied
Performance of 24-inch supersonic axial-flow compressor in air II : performance of compressor rotor at equivalent tip speeds from 800 to 1765 feet per second
An equatorial wind from the massive young stellar object S140 IRS 1
The discovery of the second equatorial ionized stellar wind from a massive
young stellar object is reported. High resolution radio continuum maps of S140
IRS 1 reveal a highly elongated source that is perpendicular to the larger
scale bipolar molecular outflow. This picture is confirmed by location of a
small scale monopolar near-IR reflection nebula at the base of the blueshifted
lobe. A second epoch of observations over a five year baseline show little
ordered outward proper motion of clumps as would have been expected for a jet.
A third epoch, taken only 50 days after the second, did show significant
changes in the radio morphology. These radio properties can all be understood
in the context of an equatorial wind driven by radiation pressure from the
central star and inner disc acting on the gas in the surface layers of the disc
as proposed by Drew et al. (1998). This equatorial wind system is briefly
compared with the one in S106IR, and contrasted with other massive young
stellar objects that drive ionized jets.Comment: 19 pages, 5 figures, accepted by ApJ, minor changes in light of
referees repor
Site-Selective Excitation And Polarized Absorption Spectra Of Nd3+ In Sr-5(Po4)(3)F And Ca-5(Po4)(3)F
Polarized absorption and fluorescence spectra were analyzed to establish individual energy (Stark) levels of Nd3+ ions in host crystals of Sr-5(PO4)(3)F (SFAP) and Ca-5(PO4)(3)F (FAP). Site-selective excitation and fluorescence facilitated differentiation between Nd3+ ions in emitting sites-associated with 1.06 mu m stimulated emission, and nonemitting Nd3+ ions in other sites. Measurements were made on samples containing different concentrations of Nd3+ at 4 K and higher temperatures. Substitution of Nd3+ for Sr2+ or Ca2+ was accompanied by passive charge compensation during crystal growth. Crystal-field splitting calculations were performed according to site for Stark levels of Nd3+ ions identified spectroscopically. We obtained a final set of crystal-field parameters B-nm for Nd3+ ions in fluorescing sites with a rms, deviation of 7 cm(-1) (52 levels in Nd:SFAP) and 8 cm(-1) (59 levels in Nd:FAP). For one of the nonemitting sites in Nd:FAP we obtained a final set of B-nm parameters which gave a rms deviation of 6 cm(-1) between 46 experimental and calculated levels
The Allen Telescope Array: The First Widefield, Panchromatic, Snapshot Radio Camera for Radio Astronomy and SETI
The first 42 elements of the Allen Telescope Array (ATA-42) are beginning to
deliver data at the Hat Creek Radio Observatory in Northern California.
Scientists and engineers are actively exploiting all of the flexibility
designed into this innovative instrument for simultaneously conducting surveys
of the astrophysical sky and conducting searches for distant technological
civilizations. This paper summarizes the design elements of the ATA, the cost
savings made possible by the use of COTS components, and the cost/performance
trades that eventually enabled this first snapshot radio camera. The
fundamental scientific program of this new telescope is varied and exciting;
some of the first astronomical results will be discussed.Comment: Special Issue of Proceedings of the IEEE: "Advances in Radio
Telescopes", Baars,J. Thompson,R., D'Addario, L., eds, 2009, in pres
New Crayfish Species Records from the Sipsey Fork Drainage, Including Lewis Smith Reservoir (Alabama, USA): Native or Introduced Species?
As part of a study of aquatic faunal community changes along riverine-lacustrine transition zones upstream of Lewis Smith Reservoir in northwest Alabama, USA, we collected crayfish from 60 sites in the Sipsey Fork, Brushy Creek, and selected tributaries (Black Warrior River system). After finding two unexpected and possibly-introduced crayfish species, we expanded our investigation of crayfish distributions to include crayfish obtained from stomachs of black bass ( Micropterus spp.) caught at seven sites in the reservoir. To explore what crayfish species were in the drainage historically, we examined museum databases as well as stomach and intestinal contents of a variety of preserved fishes that were caught in the Sipsey Fork and Brushy Creek drainages upstream of the reservoir in the early 1990’s. Of the seven crayfish species collected, one, Orconectes ( Procericambarus ) sp. nr ronaldi , was not previously reported from Alabama, and another, O. lancifer , was not reported from the Black Warrior River system prior to the study. Three are known or possibly introduced species. Upstream of the reservoir, the native species Cambarus obstipus, C. striatus , and O. validus were common. The same three species were found in fish collected in the 1990’s. Orconectes perfectus was found only in the reservoir but may be native to the drainage. Orconectes lancifer was in the reservoir and in stream reaches influenced by the reservoir. Evidence points to O. lancifer being introduced in the drainage, but this is uncertain. Orconectes sp. nr ronaldi was found in a relatively small portion of Brushy Creek and its tributaries, in both flowing and impounded habitats, and may be introduced. Orconectes virilis is introduced in Alabama and was found only in stomachs of fish collected in the reservoir
Galaxy Zoo: CANDELS barred discs and bar fractions
The formation of bars in disc galaxies is a tracer of the dynamical maturity of the population. Previous studies have found that the incidence of bars in discs decreases from the local Universe to z ~ 1, and by z > 1 simulations predict that bar features in dynamically mature discs should be extremely rare. Here, we report the discovery of strong barred structures in massive disc galaxies at z ~ 1.5 in deep rest-frame optical images from the Cosmic Assembly Near-Infrared Deep Extragalactic Legacy Survey. From within a sample of 876 disc galaxies identified by visual classification in Galaxy Zoo, we identify 123 barred galaxies. Selecting a subsample within the same region of the evolving galaxy luminosity function (brighter than L*), we find that the bar fraction across the redshift range 0.5 ≤ z ≤ 2 (fbar = 10.7+6.3 -3.5 per cent after correcting for incompleteness) does not significantly evolve.We discuss the implications of this discovery in the context of existing simulations and our current understanding of the way disc galaxies have evolved over the last 11 billion yearsPeer reviewedFinal Accepted Versio
Expression of OATP Family Members in Hormone-Related Cancers: Potential Markers of Progression
The organic anion transporting polypeptide (OATP) family of transporters has been implicated in prostate cancer disease progression probably by transporting hormones or drugs. In this study, we aimed to elucidate the expression, frequency, and relevance of OATPs as a biomarker in hormone-dependent cancers. We completed a study examining SLCO1B3, SLCO1B1 and SLCO2B1 mRNA expression in 381 primary, independent patient samples representing 21 cancers and normal tissues. From a separate cohort, protein expression of OATP1B3 was examined in prostate, colon, and bladder tissue. Based on expression frequency, SLCO2B1 was lower in liver cancer (P = 0.04) which also trended lower with decreasing differentiation (P = 0.004) and lower magnitude in pancreatic cancer (P = 0.05). SLCO2B1 also had a higher frequency in thyroid cancer (67%) than normal (0%) and expression increased with stage (P = 0.04). SLCO1B3 was expressed in 52% of cancerous prostate samples and increased SLCO1B3 expression trended with higher Gleason score (P = 0.03). SLCO1B3 expression was also higher in testicular cancer (P = 0.02). SLCO1B1 expression was lower in liver cancer (P = 0.04) which trended lower with liver cancer grade (P = 0.0004) and higher with colon cancer grade (P = 0.05). Protein expression of OATP1B3 was examined in normal and cancerous prostate, colon, and bladder tissue samples from an independent cohort. The results were similar to the transcription data, but showed distinct localization. OATPs correlate to differentiation in certain hormone-dependent cancers, thus may be useful as biomarkers for assessing clinical treatment and stage of disease
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