40 research outputs found
The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma
- Author
- Abdel-Rahman Mohamed H.
- Abeshouse Adam
- Adebamowo Clement
- Adebamowo Sally N.
- Agnew Kathy
- Ahn Keunsoo
- Ajani Jaffer A.
- Akbani Rehan
- Akbani Rehan
- Akeredolu Teniola
- Al-Ahmadie Hikmat
- Albert Monique
- Alexopoulou Iakovina
- Ally Adrian
- Alvaro Domenico
- Anderson Matthew L.
- Andry Chris
- Antenucci Anna
- Anur Pavana
- Appelbaum Elizabeth L.
- Aredes Natália D.
- Armenia Joshua
- Arnaout Angel
- Asa Sylvia L.
- Auman J. Todd
- Aymerich Marta
- Aziz Dina
- Bailey Matthew
- Balasundaram Miruna
- Balu Saianand
- Barnett Gene
- Barnholtz-Sloan Jill S.
- Barrett Wendi
- Bartlett John
- Bathe Oliver
- Baudin Eric
- Baylin Stephen
- Becker Karl-Friedrich
- Beer David
- Behera Madhusmita
- Behrens Carmen
- Bell Debra
- Bell Sue
- Bellair Michelle
- Bennett Joseph
- Benz Christopher
- Berchuck Andrew
- Berger Ashton C.
- Bergeron Alain
- Berkowitz Ross
- Bernard Brady
- Beroukhim Rameen
- Beroukhim Rameen
- Beuschlein Felix
- Bifulco Carlo
- Bigner Darell
- Birrer Michael
- Birsoy Kivanc
- Bocklage Therese
- Bodenheimer Tom
- Bondaruk Jolanta
- Bootwalla Moiz S.
- Borad Mitesh
- Borgia Jeffrey A.
- Bossler Aaron
- Botnariuc Natalia
- Bottaro Donald P.
- Boussioutas Alex
- Bowen Jay
- Bowlby Reanne
- Bowlby Reanne
- Bowman Rayleen
- Bradford Carol
- Bragazzi Maria Consiglia
- Brat Daniel J.
- Breggia Anne
- Brewer Cathy
- Brimo Fadi
- Broaddus Russell
- Brooks Denise
- Broom Bradley M.
- Broudy Thomas
- Bryce Alan H.
- Bubley Glenn
- Bueno Raphael
- Burnette Andrew
- Caesar-Johnson Samantha J.
- Calatozzolo Chiara
- Campo Elias
- Campos Benito
- Caraman Irina
- Cardinale Vincenzo
- Carey Francis
- Carey Thomas
- Carlotti Carlos Gilberto
- Carlsen Rebecca
- Carney Michael
- Carpino Guido
- Carroll Peter R.
- Carter Candace
- Carvalho Andre L.
- Castle Erik
- Castro Patricia D.
- Catto James
- Cebulla Colleen M.
- Cernat Mircea
- Chabot John
- Chakravarty Debyani
- Chambwe Nyasha
- Chan June M.
- Chan Timothy A.
- Chandan Vishal
- Chang Kyle
- Chatila Walid K.
- Chemencedji Inga
- Chen Amy
- Chen Chu
- Cheng Feixiong
- Cherniack Andrew D.
- Chesla David
- Chevalier Simone
- Cheville John
- Cho Juok
- Choueiri Toni K.
- Chuah Eric
- Chudamani Sudha
- Chung Ki
- Cibulskis Carrie
- Clipca Adrian
- Colman Howard
- Cope Leslie
- Copland John A.
- Corcoran Niall
- Cordes Matthew G.
- Costello Tony
- Cottingham Sandra
- Couce Marta
- Covington Kyle
- Crain Daniel
- Cramer Daniel
- Creaney Jenette
- Creighton Chad J.
- Cuppini Lucia
- Curley Erin
- Cuzzubbo Stefania
- Czerniak Bogdan
- Danilova Ludmila
- Davis Amy
- de Bruijn Ino
- de Carvalho Ana C.
- De Cubas Aguirre A.
- de Krijger Ronald
- De Rienzo Assunta
- De Rose Agostino
- Defreitas Timothy
- Delman Keith
- Demchok John A.
- Desjardins Laurence
- Devine Karen
- Deyarmin Brenda
- Dhalla Noreen
- Dhanasekaran Renumathy
- Dhankani Varsha
- Dhir Rajiv
- Dimeco Francesco
- Ding Li
- Dinh Huyen
- Dinkin Mikhail
- Dipersio John
- Disaia Philip
- Doddapaneni Harshavardhan
- Donehower Lawrence A.
- Doruc Serghei
- Dos Santos Jose Sebastião
- Dottino Peter R.
- Drake Bettina
- Drummond Jennifer
- Drwiega Paul
- Dubina Michael
- Duell Rebecca
- Duffy Elizabeth R.
- Eckman John
- Edenfield W. Jeffrey
- Eijckenboom Wil
- Elder J. Bradley
- Engel Jay
- Eschbacher Jennifer
- Esmaeli Bita
- Evason Kimberley
- Facciolo Francesco
- Fan Cheng
- Fan Huihui
- Fan Huihui
- Fantacone-Campbell J. Leigh
- Farnell Michael
- Farver Carol
- Fassnacht Martin
- Fehrenbach Ashley
- Felau Ina
- Feldman Michael
- Feltmate Colleen
- Ferguson Martin L.
- Finocchiaro Gaetano
- Flotte Thomas
- Fong Kwun M.
- Force Seth
- Forgie Ian
- Frazer Scott
- Fregnani José H.
- Fronick Catrina C.
- Fujimoto Junya
- Fulop Jordonna
- Fulton Lucinda A.
- Fulton Robert S.
- Gabra Hani
- Gabriel Stacey B.
- Galbraith Joseph
- Gao Galen F.
- Gao Jianjiong
- Gardner Johanna
- Gastier-Foster Julie M.
- Gaudio Eugenio
- Gehlenborg Nils
- Gerken Mark
- Gershenwald Jeffrey
- Getz Gad
- Ghossein Ronald
- Giama Nasra
- Gibb Ewan A.
- Gibbs Richard A.
- Gibbs Richard A.
- Gilbert Sebastien
- Gillis Ad
- Gimenez-Roqueplo Anne-Paule
- Giné Eva
- Giordano Thomas
- Girard Nicolas
- Giuliante Felice
- Glenn Pat
- Glenn Robert
- Godwin Andrew K.
- Godwin Andrew K.
- Godwin Eryn M.
- Gonzalez Ana Maria Angulo
- Goodman Marc
- Gopalan Anuradha
- Goparaju Chandra
- Gorincioi Ghenadie
- Govindan Ramaswamy
- Graefen Markus
- Grazi Gianluca
- Grizzle William E.
- Gross Benjamin E.
- Guillermo Armando López
- Guo Charles
- Ha Gavin
- Haake Scott
- Haddad Andrea
- Hagedorn Curt H.
- Hakimi A. Ari
- Hale Walker
- Han Yi
- Hanh Phan Thi
- Hansen Paul
- Harr Jodi
- Hartmann Arndt
- Haydu Lauren
- Hayes D. Neil
- Hayward Nicholas
- Heath Sharon
- Hegde Apurva M.
- Heiman David I.
- Heins Zachary J.
- Henderson Joel
- Henske Elizabeth P.
- Hermes Beth
- Hernandez Brenda
- Herold-Mende Christel
- Hersey Peter
- Hess Julian
- Hibshoosh Hanina
- Hilty Joe
- Hinoue Toshinori
- Ho Thai
- Ho Thai H.
- Hoadley Katherine A.
- Holt Robert
- Hooke Jeffrey A.
- Hoon Dave
- Horowitz Neil
- Houck John
- Hovens Christopher
- Hoyle Alan P.
- Hsieh James J.
- Hu Hai
- Hu Jianhong
- Huland Hartwig
- Hung Nguyen Phi
- Huntsman David
- Hutter Carolyn M.
- Iacocca Mary
- Ittmann Michael
- Jacobus Laura
- Jakrot Valerie
- Janssen Klaus-Peter
- Jefferys Stuart R.
- Jimeno Antonio
- Jones Corbin D.
- Jones Steven J. M.
- Ju Zhenlin
- Juhl Hartmut
- Jungk Christin
- Junker Kerstin
- Kakavand Hojabr
- Kalkanis Steven
- Kanchi Rupa S.
- Kanchi Rupa S.
- Kandoth Cyriac
- Kang Koo Jeong
- Karlan Beth Y.
- Kasaian Katayoon
- Kasapi Melpomeni
- Kastl Alison
- Kebebew Electron
- Kefford Richard
- Kelley Robin K.
- Kemp Rafael
- Kendall Sara
- Kendler Ady
- Kendrick Michael
- Khuri Fadlo
- Kibel Adam
- Kim Jaegil
- Kim William T.
- Knijnenburg Theo
- Knudson Michael
- Knutson Tina
- Kocher Jean-Pierre
- Kohl Bernard
- Kopp Karla
- Korchina Viktoriya
- Korkut Anil
- Korpershoek Esther
- Korst Robert
- Kovatich Albert J.
- Kramer Roger
- Krishnan Bhavani
- Kucherlapati Melanie H.
- Kucherlapati Raju S.
- Kumar Bahavna
- Kundra Ritika
- Kvecher Leonid
- Kwaitkowski David J.
- Kycler Witold
- La Konnor
- Lacombe Louis
- Ladanyi Marc
- Lai Phillip H.
- Laird Peter W.
- Landen Charles N.
- Landrum Lisa
- Lang James
- Lang Martin
- Larson Caroline
- Latour Mathieu
- Lau Kevin
- Lawrence Michael S.
- Lazar Alexander J.
- Le Xuan
- Lechan Ronald
- Lee Darlene
- Lee Jung Il
- Lee Kenneth
- Lee Sandra
- Lehman Norman L.
- Leinonen Kalle
- Leraas Kristen M.
- Levine Douglas A.
- Lewis Lora
- Ley Timothy
- Li Jun
- Li Wei
- Liang Han
- Lichtenberg Tara M.
- Lin Pei
- Linehan W. Marston
- Linehan W. Marston
- Ling Shiyun
- Lipp Eric
- Liptay Michael J.
- Liu Jia
- Liu Wenbin
- Liu Xiuping
- Liu Yuexin
- Logothetis Christopher
- Lohavanichbutr Pawadee
- Lolla Laxmi
- Long Georgina
- Longatto-Filho Adhemar
- Looijenga Leendert
- Lu Yiling
- Lui Wembin
- Luketich James
- Luna Augustin
- Lyadov Vladimir
- Ma Deqin
- Ma Yussanne
- Madan Rashna
- Maglinte Dennis T.
- Magliocca Kelly
- Maithel Shishir
- Mallery David
- Malykh Andrei
- Mandt Randy
- Manikhas George
- Mann Graham
- Mannel Robert
- Mannelli Massimo
- Mardis Elaine R.
- Mariamidze Armaz
- Mariani Odette
- Marino Mirella
- Marks Jeffrey
- Marra Marco A.
- Martignetti John A.
- Martin Julie
- Mattei Luca
- Mayo Michael
- Mccall Shannon
- Mcgraw Mary
- Mckercher Ginette
- Mclellan Michael D.
- Mclendon Roger
- Mcpherson Christopher
- Meier Sam
- Melamed Jonathan
- Meng Shaowu
- Meric-Bernstam Funda
- Merino Maria J.
- Merola Roberta
- Mes-Masson Anne-Marie
- Metwalli Adam R.
- Meyerson Matthew
- Mieczkowski Piotr A.
- Mikkelsen Tom
- Milhem Mohammed
- Miller Christopher A.
- Miller Judy
- Miller Michael
- Mills Gordon B.
- Mills Gordon B.
- Mirsaidi Cyrus
- Moiseenko Fedor
- Moncrieff Marc
- Moore Kathleen
- Moore Richard A.
- Moran Cesar
- Morgan Margaret
- Morris Scott
- Morrison Carl
- Morton Donna
- Mose Lisle E.
- Moser Catherine
- Moxley Katherine
- Moyer Jeffey
- Mungall Andrew J.
- Mungall Karen
- Mura Sergiu
- Mural Richard J.
- Murawa Dawid
- Muto Michael
- Muzny Donna
- Myers Jerome
- Myers Jerome
- Nagorney David
- Nair Praveen
- Naresh Rashi
- Naska Theresa
- Nelson Mark
- Ng Kwok-Shing
- Nguyen Phuong
- Nickerson Michael L.
- Nissan Moriah G.
- Noble Michael S.
- Noss Ardene
- Noushmehr Houtan
- O'Brien Daniel
- O'Neill Brian Patrick
- Ochoa Angelica
- Olabode Oluwole
- Olson Jeffrey J.
- Omberg Larsson
- Oosterhuis Wolter
- Ostrom Quinn T.
- Owonikoko Taofeek
- Pacak Karel
- Paklina Oxana
- Parfitt Jeremy
- Park Joong-Won
- Parker Joel S.
- Pass Harvey
- Patel Tushar
- Paulauskis Joseph
- Pennell Nathan A.
- Penny Robert
- Perin Alessandro
- Perou Amy H.
- Perou Charles M.
- Petersen Gloria
- Peterson Lisa
- Peto Myron
- Phillips Joanna
- Phillips Sarah M.
- Phu Bui Duc
- Piché Alain
- Pickens Alan
- Pihl Todd
- Pilarski Robert
- Pinero Edna M. Mora
- Pinto Peter A.
- Pirtac Maria
- Pollo Bianca
- Pool Mark
- Porten Sima
- Postier Russel
- Potapova Olga
- Powers James
- Prados Michael
- Prince Mark
- Que Florencia
- Quinn Michael
- Quintero-Aguilo Mario
- Rabeno Brenda
- Rai Karan
- Ramalingam Suresh
- Ramirez Nilsa C.
- Ramondetta Lois
- Rao Arvind
- Rassl Doris M.
- Rathmell W. Kimryn
- Rathmell W. Kimryn
- Raut Chandrajit P.
- Raymond Daniel
- Reis Rui M.
- Reuter Victor
- Reuter Victor E.
- Reynolds Sheila
- Reznik Ed
- Reznik Ed
- Rice David
- Richards William G.
- Ricketts Christopher J.
- Rintoul Robert C.
- Rivera Michael
- Roach Jeffrey
- Roberts Lewis
- Robertson A. Gordon
- Robertson A. Gordon
- Robinson Bruce
- Roggin Kevin
- Roman-Roman Sergio
- Rosenthal Howard G.
- Rozek Laura
- Rubin Mark A.
- Ryan Michael
- Saad Fred
- Sadeghi Sara
- Saksena Gordon
- Sanchez-Vega Francisco
- Sander Chris
- Sankarankuty Ajith
- Santibanez Jireh
- Sastre Xavier
- Sauter Guido
- Saw Robyn
- Scapulatempo-Neto Cristovam
- Scarpace Lisa
- Schadendorf Dirk
- Schein Jacqueline E.
- Schiffman Mark
- Schilero Cathy
- Schlomm Thorsten
- Schmidt Heather K.
- Schmidt Laura S.
- Schmidt Laura S.
- Schoenfield Lynn
- Schultz Nikolaus
- Schumacher Steven E.
- Scolyer Richard
- Secord Angeles
- Seder Christopher W.
- Sekhon Harman
- Senecal Kelly
- Sepulveda Antonia
- Setdikova Galiya
- Sexton Katherine C.
- Shabunin Alexey
- Shannon Kerwin
- Sharp Alexis
- Shelley C. Simon
- Shelley Carl Simon
- Shelton Candace
- Shelton Troy
- Shen Hui
- Shen Hui
- Sheridan Robert
- Sherman Mark
- Sheth Margi
- Shi Yan
- Shih Juliann
- Shimmel Kristen
- Shin Dong M.
- Shinbrot Eve
- Shipman Cassaundra
- Shmulevich Ilya
- Shriver Craig D.
- Shuch Brian
- Sica Gabriel
- Sifri Suzanne
- Sigmund Rita
- Signoretti Sabina
- Signoretti Sabina
- Silveira Henrique C. S.
- Simko Jeffry
- Simon Ronald
- Simons Janae V.
- Singer Samuel
- Singh Bhuvanesh
- Singh Rosy
- Sipahimalani Payal
- Skelly Tara
- Sloan Andrew E.
- Slotta-Huspenina Julia
- Smallridge Robert
- Smith Christof C.
- Smith Jennifer
- Smith-McCune Karen
- Smolenski Kathy
- Smyrk Thomas
- Sofia Heidi J.
- Soloway Matthew G.
- Somiari Stella
- Sood Anil
- Spellman Paul
- Spellman Paul T.
- Spillane Andrew
- Srinivasan Ramaprasad
- Stancul Irina
- Stanton Melissa
- Staugaitis Susan M.
- Steele Ruth
- Stepa Serghei
- Stern Marc-Henri
- Stoehr Christine
- Stoehr Robert
- Stoop Hans
- Stretch Onathan
- Stuart Joshua M.
- Su Tao
- Sumer S. Onur
- Sun Qiang
- Sun Yichao
- Swanson Patricia
- Swisher Elizabeth
- Synott Maria
- Tam Angela
- Tamakawa Raina
- Tamboli Pheroze
- Tamboli Pheroze
- Tan Donghui
- Tang Yufang
- Tarnuzzer Roy
- Taubert Helge
- Tavobilov Mikhail
- Taylor Barry S.
- Tcaciuc Diana
- Tennstedt Pierre
- Thiessen Nina
- Thomas George
- Thomas George
- Thompson Eric
- Thompson John
- Thompson R. Houston
- Thompson Timothy
- Thorp Richard
- Thorsson Vesteinn
- Tien Nguyen Viet
- Timmers Henri
- Tirapelli Daniela
- Tischler Arthur
- Torbenson Michael
- Troncoso Patricia
- Tsao Anne
- Tse Kane
- Tucker Kelinda
- Têtu Bernard
- Unterberg Andreas
- Urba Walter
- Valdivieso Federico
- Van Bang Nguyen
- Van Den Berg David J.
- van Kessel Kim E.
- Van Meir Erwin G.
- Van Tine Brian
- Vandenberg Scott
- Veluvolu Umadevi
- Vicha Ales
- Vidal Daniel O.
- Vincent Benjamin G.
- Vocke Cathy D.
- Vocke Cathy D.
- Voet Doug
- von Deimling Andreas
- Voronina Olga
- Wach Sven
- Wakely Paul
- Waldmann Jens
- Walker Joan
- Wan Yunhu
- Wang Jing
- Wang Jioajiao
- Wang Linghua
- Wang Min
- Wang Timothy
- Wang Zhining
- Warnick Ronald
- Weinstein John N.
- Weisenberger Daniel J.
- Wentzensen Nicolas
- Westervelt Peter
- Wheeler David A.
- Wheeler David A.
- Wilkerson Matthew D.
- Williams Felicia
- Wilmott James
- Wilson Richard K.
- Wise Lisa
- Wistuba Ignacio
- Wiznerowicz Maciej
- Wolf Gregory
- Wolinsky Yingli
- Wong Christopher K.
- Wong Tina
- Worrell Robert
- Wu Ye
- Wullich Bernd
- Xi Liu
- Yang Hannah
- Yang Ian
- Yang Ju Dong
- Yang Liming
- Yang Lixing
- Yau Christina
- Yena Peggy
- Zach Leigh Anne
- Zaren Howard
- Zelinka Tomas
- Zenklusen Jean C.
- Zhang Hailei
- Zhang Hongxin
- Zhang Hongzheng
- Zhang Jiashan (Julia)
- Zhang Jiexin
- Zhang Lizhi
- Zhang Wei
- Zhao Fengmei
- Zhou Wanding
- Zmuda Erik
- Zuna Rosemary
- Zwarthoff Ellen C.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial
- Author
- Abaterusso Cataldo
- Abdul Kadir Khalid
- Abrahamovych Orest
- Acharya Shamasunder
- Acosta Idalia
- Adam Noor
- Adams Luthando
- Adawi Faiad
- Adolphe Allen
- Ahmad Ghazali
- Ahmed Azazuddin
- Ahmed Ziauddin
- Ahn Kyu Jeung
- Alcantara-Gonzalez Altagracia Aurora
- Aldrete Jorge
- Ali Norhaliza Mohd
- Almirall Jaume
- Alscher Mark
- Alvarado Odilon
- Alvarez German
- Alvarisqueta Andres
- Amin Mohammad
- Amodeo Celso
- Andress Dennis L
- Annand Andrew
- Antunes Ferreira Manuel Anibal
- Anzai Jiichi
- Apostolou Theofanis
- Arauz-Pacheco Carlos
- Arciszewska Malgorzata
- Argoud Georges
- Arif Ahmed
- Aronson Ronnie
- Arrieta Lezama Javier
- Assefi Ali
- Ato Keita
- Atray Naveen
- Awua-Larbi Stella
- Aziz Nor Azizah
- Azuma Nobuyuki
- Bai Liqun
- Bailey Gordon
- Bajaj Harpreet Singh
- Bakdash Wa'El
- Baker John
- Baker Penelope
- Bako Gabriel
- Bakris George
- Bakris George
- Bansal Shweta
- Bar-Dayan Yosefa
- Bardymova Tatiana
- Barendregt Jnm
- Barengolts Elena
- Bartaskova Dagmar
- Bau Cho-Tsan
- Bayliss George
- Beddhu Srinivasan
- Bedros Fadi
- Belledonne Mario
- Belo Diogo
- Bentsianov Marie
- Bhargava Anuj
- Bhorat Qasim
- Bieler Tasso
- Birne Rita
- Blagoveshchenskaya Olga
- Bloom Scott
- Blumenthal Samuel
- Bochicchio-Ricardelli Tomasso
- Bock Andreas
- Bohm Guillermo
- Boiskin Mark
- Bonet Sol Josep
- Borges Joao Lindolfo
- Bowman-Stroud Cynthia
- Brantley Roman
- Bressler Peter
- Brown Eric
- Brunati Chiara
- Brusco Osvaldo
- Bucek Petr
- Budde Klemens
- Burga Nunez Jose
- Burgos-Calderon Rafael
- Busch Robert
- Butt Salman
- Cabrita Antonio
- Calderon Ortiz Ricardo
- Calderon Ticona Jorge
- Calero Gonzalez Francesca
- Cangiano Jose
- Capasso Giovambattista
- Carranza-Madrigal Jaime
- Castillo Alvaro
- Castro-Alonso Cristina
- Cathcart Harold
- Cercato Cintia
- Cha Dae-Ryong
- Chan Doris
- Chatha Rupi
- Chen Ching-Chu
- Chen Jung-Fu
- Chen Nan
- Cheung Siu Fai
- Chevaile-Ramos Jose
- Chew Wong Alfredo
- Chmelickova Hana
- Cho Ho Chan
- Cho Yong-Wook
- Choi Kyung Mook
- Choi Moon-Gi
- Chow Stephen
- Christofides Elena
- Chu Chih-Hsun
- Chuang Peale
- Chung Choon Hee
- Ciechanowski Kazimierz
- Cigarran Guldris Secundino
- Coetzee Kathleen
- Cohen Josef
- Combe Christian
- Comulada-Rivera Angel
- Conte Giuseppe
- Cooke Duncan
- Correa-Rotter Ricardo
- Costa e Forti Adriana
- Cournoyer Serge
- Cruz Lucita
- Cusumano Ana
- D'Avila Domingos
- Dahl Neera
- Danin Vargas Alfredo
- Daoud Deeb
- Davis Tim
- de Arteaga Javier
- De Cosmo Salvatore
- De la Calle Gilda
- de Lourdes Noronha Irene
- de Zeeuw Dick
- Deboni Luciane
- Delgado-Butron Cesar
- Dellanna Frank
- Desai Sachin
- Dextre Espinoza Augusto
- Ding Guohua
- Ding Xiaoqiang
- Distiller Larry
- Dixon Brad
- Doo-Man Kim
- Doshi Ankur
- Draibe Sergio
- Dudar Iryna
- Dulude Emily
- Duma Livia
- Dussol Bertrand
- Egido Jesus
- Egstrup Kenneth
- El-Shahawy Mohamed
- Elbert Alicia
- Elder John
- Eliaschewitz Freddy
- Ellis Graham
- Endre Zoltan
- Esnault Vincent
- Esposito Ciro
- Essaian Ashot
- Eustace Joseph
- Fang Michael
- Farfan-Aspilcueta Julio
- Farias Eduardo
- Fekete Jozef
- Felicio Joao
- Fellstrom Bengt
- Fernandez Fresnedo Gema
- Fernandez Giraldez Elvira
- Fernando Ronald
- Fitz-Patrick David
- Flores Jose
- Foo Marjorie Wai Yin
- Fraenkel Margaret
- Fraige Filho Fadlo
- Frajewicki Victor
- Frias Juan
- Fried Linda
- Fu Ping
- Fu Shuxia
- Fujii Shinya
- Fujita Akira
- Fulopova Alla
- Fung Samuel
- Fung Yin Khet
- Furuya Ryuichi
- Fushtey Ivan
- Galan Antonio
- Galfre Andrea
- Galindo Ramos Eugenia
- Gallagher Martin
- Galphin Claude
- Galushchak Olga
- Gansevoort Ronald
- Gaona Raul
- Garcia Mendez Isabel
- Gesualdo Loreto
- Gilbert John
- Gillard Pieter
- Gnudi Luigi
- Godoy Gonzalo
- Goh Bak Leong
- Goldfarb David
- Golestaneh Laden
- Goluch Richard
- Gonzalez Gonzalez Jose
- Gonzalez Fernando
- Gonzalez-Galvez Guillermo
- Goto Daisuke
- Gouge Steven
- Goumenos Dimitrios
- Graf Ronald
- Greenwood Gregory
- Greloni Gustavo
- Guadiz Ramon
- Guasch Antonio
- Gundroo Aijaz
- Guo Xiaohui
- Gutierrez Vicente
- Halimi Jean-Michel
- Hall Karen
- Hames Melanie
- Hancu Nicolae
- Hanson Lenita
- Hao Chuanming
- Harada Hiroyuki
- Hashiguchi Yasuhiro
- Hassan Wan Hasnul Halimi Wan
- Hasslacher Christoph
- Heerspink Hiddo J L
- Hellberg Olof
- Herman Lee
- Hernandez-Jaras Julio
- Herrada Orue Benjamin
- Herrero Calvo Jose
- Hershon Kenneth
- Hirano Fuminori
- Honova Vaclava
- Horwitz Edward
- Hou Fan-Fan
- Hou Fanfan
- Hougardy Jean
- Huang Chien-Ning
- Hugo Christian
- Hussein Zanariah
- Iehara Noriyuki
- Iitsuka Tadashi
- Ijaz Adeel
- Ikeda Naoko
- Imura Mitsuo
- Inoue Toshihiko
- Ionutiu Lavinia
- Ishikawa Kazuo
- Ishiko Tamayo
- Israel Ezra
- Itabashi Naoki
- Ivanova Svetlana
- Iwaoka Hideaki
- Jabbour Serge
- Jadoul Michel
- Jamal Aamir
- James Sam
- Jang Hak Chul
- Jardula Michael
- Jere Charles
- Ji Linong
- Jia Weiping
- Jiang Ju-Ying
- John Rekha
- Jolly Shivinder
- Jones Audrey
- Joshi Sucharit
- Joshi Sudhir
- Juncos Luis
- Kalender Betul
- Kalirao Paramjit
- Kalra Phillip
- Kanai Hidetoshi
- Kaneko Shizuka
- Kantola Ilkka
- Kantor Samuel
- Karim Shahana
- Karonova Tatiana
- Karpova Irina
- Kashihara Naoki
- Kashine Susumu
- Kayali Zeid
- Keitel Elizete
- Kenis Irina
- Khandwala Hasnain
- Kim Beom Seok
- Kim Byung-Joon
- Kim In-Joo
- Kim Min Seon
- Kim Sang Yong
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- Ueda Shinichiro
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- Vaithilingam Indralingam
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- Vallejos Augusto
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- Varghese Freemu
- Vazquez-Tanus Jose
- Vengadasalam V Paranthaman P
- Vercammen Chris
- Vicks Steven
- Vielhauer Volker
- Vijayasingham Shalini
- Villevalde Svetlana
- Vogel Daniel
- Vogt Liffert
- Wainstein Julio
- Wang Song
- Wanner Christoph
- Warling Xavier
- Watanabe Shuichi
- Weinstein Debra
- Weinstein Talia
- Weiss Robert
- Weng Jian
- Whaley-Connell Adam
- Wiecek Andrzej
- Wigderson Melissa
- Wise Jonathan
- Wong Hin Seng
- Woo Jeong-Taek
- Wruk Michal
- Wu Du-An
- Wu Mai-Szu
- Xiao Guanqing
- Xing Changying
- Xu Gang
- Xu Yan
- Yagil Yoram
- Yalcin Murat
- Yamada Daishiro
- Yamaguchi Yukinari
- Yamamoto Masahiro
- Yamauchi Akira
- Yambe Yuko
- Yang Jinkui
- Yavdosyuk Andrey
- Yeoh Lee Ying
- Yeung Vincent
- Yi Joo Hark
- Yi Tingting
- Yildiz Alaattin
- Yoo Soon-Jib
- Yoon Kun Ho
- Yoon Sun Ae
- Youmbissi Joseph
- Yu Shengqiang
- Yu Tae Yang
- Zahumensky Emil
- Zanella Maria
- Zaoui Philippe
- Zapata-Rincon Luis
- Zea-Nunez Carlos Antonio
- Zeig Steven
- Zhao Hongwen
- Zhao Jiajun
- Zhao Minghui
- Zieve Franklin
- Zolotaikina Viktoriia
- Zrazhevskiy Konstantin
- Zucchini Alfredo
- Zuo Li
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
Background: Short-term treatment for people with type 2 diabetes using a low dose of the selective endothelin A receptor antagonist atrasentan reduces albuminuria without causing significant sodium retention. We report the long-term effects of treatment with atrasentan on major renal outcomes. Methods: We did this double-blind, randomised, placebo-controlled trial at 689 sites in 41 countries. We enrolled adults aged 18–85 years with type 2 diabetes, estimated glomerular filtration rate (eGFR)25–75 mL/min per 1·73 m 2 of body surface area, and a urine albumin-to-creatinine ratio (UACR)of 300–5000 mg/g who had received maximum labelled or tolerated renin–angiotensin system inhibition for at least 4 weeks. Participants were given atrasentan 0·75 mg orally daily during an enrichment period before random group assignment. Those with a UACR decrease of at least 30% with no substantial fluid retention during the enrichment period (responders)were included in the double-blind treatment period. Responders were randomly assigned to receive either atrasentan 0·75 mg orally daily or placebo. All patients and investigators were masked to treatment assignment. The primary endpoint was a composite of doubling of serum creatinine (sustained for ≥30 days)or end-stage kidney disease (eGFR <15 mL/min per 1·73 m 2 sustained for ≥90 days, chronic dialysis for ≥90 days, kidney transplantation, or death from kidney failure)in the intention-to-treat population of all responders. Safety was assessed in all patients who received at least one dose of their assigned study treatment. The study is registered with ClinicalTrials.gov, number NCT01858532. Findings: Between May 17, 2013, and July 13, 2017, 11 087 patients were screened; 5117 entered the enrichment period, and 4711 completed the enrichment period. Of these, 2648 patients were responders and were randomly assigned to the atrasentan group (n=1325)or placebo group (n=1323). Median follow-up was 2·2 years (IQR 1·4–2·9). 79 (6·0%)of 1325 patients in the atrasentan group and 105 (7·9%)of 1323 in the placebo group had a primary composite renal endpoint event (hazard ratio [HR]0·65 [95% CI 0·49–0·88]; p=0·0047). Fluid retention and anaemia adverse events, which have been previously attributed to endothelin receptor antagonists, were more frequent in the atrasentan group than in the placebo group. Hospital admission for heart failure occurred in 47 (3·5%)of 1325 patients in the atrasentan group and 34 (2·6%)of 1323 patients in the placebo group (HR 1·33 [95% CI 0·85–2·07]; p=0·208). 58 (4·4%)patients in the atrasentan group and 52 (3·9%)in the placebo group died (HR 1·09 [95% CI 0·75–1·59]; p=0·65). Interpretation: Atrasentan reduced the risk of renal events in patients with diabetes and chronic kidney disease who were selected to optimise efficacy and safety. These data support a potential role for selective endothelin receptor antagonists in protecting renal function in patients with type 2 diabetes at high risk of developing end-stage kidney disease. Funding: AbbVie
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
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- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
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- Ashcroft Kevin
- Ashurst Jennifer
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- Ashworth Linda K.
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- Asomugha Chinwe O.
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- Egan Amy
- Eichler Evan
- Eichler Evan
- Ejima Fumio
- Elkin Chris
- Ellington Andrew
- Elliot David
- Elliot Glendoria
- Elliot Jeffrey
- Ellwood Matthew
- Emberson Becky
- Emelianenko Natalia
- Emery-Cohen Alexandra J.
- Endrizzi Matthew
- Engh Ger van den
- Engle David
- Erickson Jeffery
- Erler Anne Marie
- Errington Helen
- Escobar Julio
- Escotto Michael
- Eugene Craig S.
- Evans Gareth
- Evans John
- Evans Katie
- Evans Richard
- Eveleth Gerald
- Eyras Eduardo
- Fan Hongyuan
- Fan Keke
- Fang Jianqiu
- Farina Abderrahim
- Faro Susan
- Faulkner Louisa
- Fawcett Joseph J.
- Fechtel Kim
- Fellingham Charlotte
- Felming Claire
- Felsenfeld Adam
- Feltwell Theresa
- Feng Guodong
- Feng Haiyan
- Feng Jie
- Feng Xiaoli
- Fennell Stephen
- Ferguson Alicia
- Fernandez Sonia
- Fernandez-Suarez Xose
- Fernando Pushpa Ranjani
- Ferriera Pat
- Fertitta Anne
- Fey Jim
- Fidel Patrick
- Fields Elizabeth
- Fink Marie
- Finley Maria C.
- Finn Robert
- Fischer Heather
- Fischer Laurice
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- Fitzgerald Mike
- Flack Tina
- Flagg Nicole
- Flanagan J.
- Fleming Kerry
- Flint Jonathan
- Flint Mark
- Flowers Dave
- Floyd Yvonne
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- Folta Peg
- Fong Jonathan
- Fonknechten Núrua
- Footman Simon
- Forbes Lisa D.
- Ford Amanda F.
- Foster Myre J.
- Fotopulos Dea
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- Fowler John
- Fox Jessica
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- Fu Gang
- Fu Qiushi
- Fujioka Michiru
- Fujiyama Asao
- Fukawa Rintaro
- Fuller Liam
- Fuller Sharin
- Fullerton Kathryn
- Fulton Lucinda A.
- Fulton Robert S.
- Furey Terrence S.
- Furuhashi Mie
- Förste Silke
- Gabisi Abdul M.
- Gage Diane
- Gaige Tony
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- Garcia Marvin
- Garcia Ricardo M, III
- Garcia-Martinez Antonio
- Gardner Alison
- Gardner Alison
- Garduno Consuelo
- Gardyna Steph
- Garner Patrick
- Garner Toni T.
- Garnes Jeffrey A.
- Garnett Jane
- Garza Melissa
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- Gatland Leigh
- Gatland Lindsay
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- Geng Jianing
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- Gong Guanghui
- Gong Jinying
- Gonzales Eidelyn
- Gonzalez Guillermo B.
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- Goodstadt Leo
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- Gordon Catherine
- Gordon Laurie A.
- Gordon Seth
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- Gorvad Ann
- Gould Christine
- Goyea Ernest
- Goyette Audra
- Grady Deborah I.
- Grady Michelle L.
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- Grant Michael
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- Griffith Jeffrey K.
- Griffiths Coline
- Griffiths Ed
- Griffiths Mark
- Griffiths-Jones Sam
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- Hamilton Matt
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- Hammon Nancy
- Hammond Martin
- Hammond Sha
- Hammond Sian
- Hamza Khalid
- Han Guiqing
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- Hanak Vincent A.
- Hancock Julie
- Harbes Brandy A.
- Harding Adam
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- Harley Joanne
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- Hawes Alicia C.
- Hawkins Ebere Sylvia Onyirioha
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- Heyen Joshua
- Higgs Douglas
- Hildebrand Carl E.
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- Hillyard Guy
- Hines Sandra
- Hinkins Russell
- Hinrichs Angela S.
- Hitchens Matthew Edward
- Ho Issac
- Ho Sara-Jane
- Hodgson Anne V.
- Hodgson David
- Hoffman Susan M.G.
- Hoffs Michael
- Hogues Marilyn E.
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- Idlebird Devincent G.
- Iliev Ilian
- Imbro Paula
- Imo Kelvin C.
- Inacio Nicole
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- Ince Michael
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- Inoue Shuuji
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- Ishibashi Akiko
- Ishikawa Sabine K.
- Ishizaki Hinako
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- Jia Jia
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- Krawczyk Marie-Claude
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- Kruchowski Scott S.
- Kube Michael
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- Lou Yunian
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- Lowenstein Michael G.
- Lowry Stephen
- Lozado Ryan J.
- Lu Lingfeng
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- Lu Yue
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- Nair Seema R.
- Naka Maho
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- Nwokenkwo Stanley
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- O\u27Donovan Daniel
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- Olson Maynard V.
- Omotosho Bamidele
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- Pasternak Shiran
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- Paul Shelia
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- Perez Lesette M.
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- Peterson Jane
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- Wray Paul
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- Wright Debbie
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- Wright Kristin
- Wright Rita A.
- Wu Chungen
- Wu Dongying
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- Wu Qingfa
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- Wu Xiao
- Wu Xiaojing
- Wu Zaining
- Wyatt Julia
- Wycoff-Montenegro Melissa
- Wylie Kris
- Wyman Dudley
- Wyman Stacia
- Xi Yan
- Xi Yingying
- Xie Fei
- Xie Gary
- Xie Jane
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- Xiong Yuqing
- Xu Alex
- Xu Jing
- Xu Jing
- Xu Ruqin
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- Xu Yuning
- Xu Zhihong
- Xu Zuyuan
- Xuan Yali
- Xuan Zhenyu
- Xue Rui
- Yada Tetsushi
- Yadav Shailendra
- Yakub Syed
- Yamamoto Lynn
- Yamamoto Noriko
- Yamamoto Yuko
- Yamashita Yasue
- Yamazaki Satoru
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- Yang Huanming
- Yang Huanming
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- Yang Shiaw-Pyng
- Yang Shudong
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- Yang Xiaonan
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- Yao Zhijian
- Yao Zhijian
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- Ye Chen
- Yeager Shane
- Yeh Mimi
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- Yun Rui
- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
- Zhan Guoping
- Zhang Bo
- Zhang Caimin
- Zhang Fengmei
- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture
- Author
- Abou-Khalil Bassel
- Adesoji Oluyomi M.
- Afawi Zaid
- Amadori Elisabetta
- Anderson Alison
- Anderson Joseph
- Andrade Danielle M.
- Annesi Grazia
- Auce Pauls
- Avbersek Andreja
- Bahlo Melanie
- Baker Mark D.
- Balagura Ganna
- Balestrini Simona
- Barba Carmen
- Barboza Karen
- Bartolomei Fabrice
- Bast Thomas
- Baum Larry
- Baumgartner Tobias
- Baykan Betül
- Bebek Nerses
- Becker Albert J.
- Becker Felicitas
- Bennett Caitlin A.
- Berghuis Bianca
- Berkovic Samuel F.
- Beydoun Ahmad
- Bianchini Claudia
- Bisulli Francesca
- Blatt Ilan
- Bobbili Dheeraj R.
- Borggraefe Ingo
- Bosselmann Christian
- Braatz Vera
- Bradfield Jonathan P.
- Brockmann Knut
- Brody Lawrence C.
- Buono Russell J.
- Busch Robyn M.
- Caglayan Hande
- Campbell Ciarán
- Campbell Ellen
- Canafoglia Laura
- Canavati Christina
- Cascino Gregory D.
- Castellotti Barbara
- Catarino Claudia B.
- Cavalleri Gianpiero L.
- Cerrato Felecia
- Chassoux Francine
- Chen Siwei
- Cherny Stacey S.
- Cheung Ching-Lung
- Chinthapalli Krishna
- Chou I-Jun
- Chung Seo-Kyung
- Churchhouse Claire
- Clark Peggy O.
- Cole Andrew J.
- Compston Alastair
- Coppola Antonietta
- Cosico Mahgenn
- Cossette Patrick
- Craig John J.
- Cusick Caroline
- Daly Mark J.
- Davis Lea K.
- de Haan Gerrit-Jan
- Delanty Norman
- Depondt Chantal
- Derambure Philippe
- Devinsky Orrin
- Di Vito Lidia
- Dlugos Dennis J.
- Doccini Viola
- Doherty Colin P.
- El-Naggar Hany
- Elger Christian E.
- Ellis Colin A.
- Eriksson Johan G.
- Faucon Annika
- Feng Yen-Chen A.
- Ferguson Lisa
- Ferraro Thomas N.
- Ferri Lorenzo
- Feucht Martha
- Fitzgerald Mark
- Fonferko-Shadrach Beata
- Fortunato Francesco
- Franceschetti Silvana
- Franke Andre
- French Jacqueline A.
- Freri Elena
- Gagliardi Monica
- Gambardella Antonio
- Geller Eric B.
- Giangregorio Tania
- Gjerstad Leif
- Glauser Tracy
- Goldberg Ethan
- Goldman Alicia
- Granata Tiziana
- Greenberg David A.
- Guerrini Renzo
- Gupta Namrata
- Haas Kevin F.
- Hakonarson Hakon
- Hallmann Kerstin
- Hassanin Emadeldin
- Hegde Manu
- Heinzen Erin L.
- Helbig Ingo
- Hengsbach Christian
- Heyne Henrike O.
- Hirose Shinichi
- Hirsch Edouard
- Hjalgrim Helle
- Howrigan Daniel P.
- Hucks Donald
- Hung Po-Cheng
- Iacomino Michele
- Imbach Lukas L.
- Inoue Yushi
- Ishii Atsushi
- Jamnadas-Khoda Jennifer
- Jehi Lara
- Johnson Michael R.
- Kamatani Yoichiro
- Kanaan Moien
- Kanai Masahiro
- Kantanen Anne-Mari
- Kara Bülent
- Kariuki Symon M.
- Kasperavičiūte Dalia
- Kasteleijn-Nolst Trenite Dorothee
- Kato Mitsuhiro
- Kegele Josua
- Kesim Yeşim
- Khoueiry-Zgheib Nathalie
- King Chontelle
- Kirsch Heidi E.
- Klein Karl M.
- Kluger Gerhard
- Knake Susanne
- Knowlton Robert C.
- Koeleman Bobby P. C.
- Korczyn Amos D.
- Koupparis Andreas
- Kousiappa Ioanna
- Krause Roland
- Krenn Martin
- Krestel Heinz
- Krey Ilona
- Kunz Wolfram S.
- Kurki Mitja I.
- Kurlemann Gerhard
- Kuzniecky Ruben
- Kwan Patrick
- Kälviäinen Reetta
- Labate Angelo
- Lacey Austin
- Lal Dennis
- Landoulsi Zied
- Lau Yu-Lung
- Lauxmann Stephen
- Leech Stephanie L.
- Lehesjoki Anna-Elina
- Lemke Johannes R.
- Lerche Holger
- Lesca Gaetan
- Leu Costin
- Lewin Naomi
- Lewis-Smith David
- Li Gloria H.-Y.
- Li Qingqin S.
- Licchetta Laura
- Lin Kuang-Lin
- Lindhout Dick
- Linnankivi Tarja
- Lopes-Cendes Iscia
- Lowenstein Daniel H.
- Lui Colin H. T.
- Madia Francesca
- Magnusson Sigurdur
- Marson Anthony G.
- May Patrick
- McGraw Christopher M.
- Mei Davide
- Mills James L.
- Minardi Raffaella
- Mirza Nasir
- Molloy Anne M.
- Montomoli Martino
- Mostacci Barbara
- Muccioli Lorenzo
- Muhle Hiltrud
- Møller Rikke S.
- Müller-Schlüter Karen
- Najm Imad M.
- Nasreddine Wassim
- Neale Benjamin M.
- Neubauer Bernd
- Newton Charles R. J. C.
- Nothnagel Michael
- Nöthen Markus M.
- Nürnberg Peter
- Okada Yukinori
- Oliver Karen L.
- O’Brien Terence J.
- Palotie Aarno
- Pangilinan Faith
- Papacostas Savvas S.
- Parrini Elena
- Pato Carlos N.
- Pato Michele T.
- Pendziwiat Manuela
- Petrovski Slavé
- Pickrell William O.
- Pinsky Rebecca
- Pippucci Tommaso
- Poduri Annapurna
- Pondrelli Federica
- Powell Rob H. W.
- Privitera Michael
- Rademacher Annika
- Radtke Rodney
- Ragona Francesca
- Rau Sarah
- Rees Mark I.
- Regan Brigid M.
- Reif Philipp S.
- Rhelms Sylvain
- Riva Antonella
- Rosenow Felix
- Ryvlin Philippe
- Saarela Anni
- Sadleir Lynette G.
- Sander Josemir W.
- Sander Thomas
- Scala Marcello
- Scattergood Theresa
- Schachter Steven C.
- Schankin Christoph J.
- Scheffer Ingrid E.
- Schmitz Bettina
- Schoch Susanne
- Schubert-Bast Susanne
- Schulze-Bonhage Andreas
- Scudieri Paolo
- Sham Pak
- Sheidley Beth R.
- Shih Jerry J.
- Sills Graeme J.
- Sisodiya Sanjay M.
- Smith Michael C.
- Smith Philip E.
- Sonsma Anja C. M.
- Speed Doug
- Sperling Michael R.
- Stefansson Hreinn
- Stefansson Kári
- Steinhoff Bernhard J.
- Stephani Ulrich
- Stevelink Remi
- Stewart William C.
- Stipa Carlotta
- Striano Pasquale
- Stroink Hans
- Strzelczyk Adam
- Surges Rainer
- Suzuki Toshimitsu
- Tan K. Meng
- Taneja R. S.
- Tanteles George A.
- Taubøll Erik
- Thio Liu Lin
- Thomas G. Neil
- Thomas Rhys H.
- Timonen Oskari
- Tinuper Paolo
- Todaro Marian
- Topaloğlu Pınar
- Tozzi Rossana
- Tsai Meng-Han
- Tumiene Birute
- Turkdogan Dilsad
- Unnsteinsdóttir Unnur
- Utkus Algirdas
- Vaidiswaran Priya
- Valton Luc
- van Baalen Andreas
- Vetro Annalisa
- Vining Eileen P. G.
- Visscher Frank
- von Brauchitsch Sophie
- von Wrede Randi
- Wagner Ryan G.
- Weber Yvonne G.
- Weckhuysen Sarah
- Weisenberg Judith
- Weller Michael
- Widdess-Walsh Peter
- Wolff Markus
- Wolking Stefan
- Wu David
- Yamakawa Kazuhiro
- Yang Wanling
- Yapıcı Zuhal
- Yücesan Emrah
- Zagaglia Sara
- Zahnert Felix
- Zara Federico
- Zhou Wei
- Zimprich Fritz
- Zsurka Gábor
- Zulfiqar Ali Quratulain
- Ólafsson Elías
- Özkara Çiğdem
- Publication venue
- Nature Research
- Publication date
- 01/01/2023
- Field of study
Epilepsy is a highly heritable disorder affecting over 50 million people worldwide, of which about one-third are resistant to current treatments. Here we report a multi-ancestry genome-wide association study including 29,944 cases, stratified into three broad categories and seven subtypes of epilepsy, and 52,538 controls. We identify 26 genome-wide significant loci, 19 of which are specific to genetic generalized epilepsy (GGE). We implicate 29 likely causal genes underlying these 26 loci. SNP-based heritability analyses show that common variants explain between 39.6% and 90% of genetic risk for GGE and its subtypes. Subtype analysis revealed markedly different genetic architectures between focal and generalized epilepsies. Gene-set analyses of GGE signals implicate synaptic processes in both excitatory and inhibitory neurons in the brain. Prioritized candidate genes overlap with monogenic epilepsy genes and with targets of current antiseizure medications. Finally, we leverage our results to identify alternate drugs with predicted efficacy if repurposed for epilepsy treatment
Abstracts from the Food Allergy and Anaphylaxis Meeting 2016
- Author
- A. Wesley Burks
- Abdulhadi Al-Qahtani
- Abdullah Alfhaid
- Abir Haddi
- Adam T. Fox
- Adam Wawrzeńczyk
- Adnan Custovic
- Adriana Machinena
- Adriana Muntean
- Adriano Mari
- Aeilko Zwinderman
- Afke M. M. Schins
- Agata Michalska
- Agata Szymkiewicz
- Agha Rehan Khaliq
- Agnieszka Lipiec
- Agurtzane Bilbao
- Agustin Madroñero
- Aida del Campo García
- Aida Semic-Jusufagic
- Aideen Byrne
- Aimee Lou Nano
- Aimée Dorkenoo
- Aine Adams
- Akanksha Sharma
- Akila Rekima
- Alba Pablos-Tanarro
- Alejandro Joral
- Aleksandar Bulog
- Alena Berger
- Alessandro Fiocchi
- Alessandro Travaglini
- Alexander Rohrbach
- Alexandra Rodrigues
- Alf Weimann
- Ali Almontasheri
- Alice Coimbra
- Alina Zbróg
- Aline Sprikkelman
- Alkerta Ibranji
- Amaranta Traversa
- Amena Warner
- Amyra Ali Azamar Jácome
- Ana Célia Costa
- Ana Fiandor
- Ana María Plaza
- Ana Miranda
- Ana Molina
- Ana Paula Moschione Castro
- Ana Pereira
- Ana Prieto
- Ana Prieto del Prado
- Ana Reis Ferreira
- Ana Rodolfo
- Ana Rodriguez-Fernandez
- Anastasia Cirisano
- Anastasia Papadopoulou
- Anders Blom Jensen
- Andre Knulst
- Andrea Costanzi
- Andrea Di Rienzo Businco
- Andrea Keiko Gushken
- Andrea Mikkelsen
- Andrea Vereda
- Andrea Wangorsch
- Andreas Frey
- Andreia Forno
- André C. Knulst
- André Moreira
- André Wolterbeek
- Aneta Tomaszewska
- Angela Simpson
- Angelica Ehrenberg
- Ania Carsin
- Anja Jeverica
- Anja Koren Jeverica
- Anna G. Vidarsdottir
- Anna Iliopoulou
- Anna Kaarina Kukkonen
- Anna Kuklinska-Pijanka
- Anna Pelkonen
- Anna Selby
- Anna Sokolova
- Anna Szyc
- Anna Wawrzeńczyk
- Anna-Lena Bramstång Björk
- Anna-Maija Hanni
- Annabelle Capt
- Annamaria Bianchi
- Anne Miles
- Anne Moneret-Vautrin
- Anne-Fleur Schoemaker
- Anne-Marie Kochuyt
- Anne-Marie Oomkes-Pilon
- Anne-Sofie Ballegaard
- Annette Jamin
- Annick Bastiaensen
- Annick Mercenier
- Anouska D. Michelsen-Huisman
- Anthony Dubois
- Anthony E. J. Dubois
- Antima Banerjee
- Antoine Deschildre
- Antoine Magnan
- Anton A. Shekhetov
- Anton Hartmann
- Antonia Rojas
- Antonino Romano
- Antonio Amoroso
- Antonio Carlos Pastorino
- Antonio Fernandez
- Antonio Pastorino
- António Jorge Cabral
- Arianna Dondi
- Arnaldo Porto
- Arne Homann
- Artur Walkiewicz
- Assad M. Butt
- Astrid G. Kruizinga
- Astrid Kruizinga
- Astrid Versluis
- Athina van Gasse
- Attilio Francesco Speciani
- Audrey Dunn Galvin
- Ayelet Rimon
- Barbara Ballmer
- Barbara Ballmer-Weber
- Barbara Majkowska-Wojciechowska
- Barbara Pfitzner
- Barbara Wróblewska
- Beatriz Secades Barbado
- Ben Remington
- Benoît Sterling
- Berber Vlieg-Boerstra
- Bernard Mahon
- Bert Popping
- Bertine M. J. Flokstra-de Blok
- Bertrand Evrard
- Bettina Brix
- Bianca Balbino
- Birgit Kalb
- Birgit Quinting
- Bjorn R. Ludviksson
- Bo Pontoppidan
- Bodo Niggemann
- Boleslaw Samolinski
- Borja Bartalomé
- Borja Bartolomé
- Boudewjin J. Kollen
- Bruna Aquilante
- Bruno Pereira
- Bryan M. Harvey
- Bushra Javed
- Carina Kelleher
- Carl Hamsten
- Carla Camerotto
- Carla Jones
- Carla Mastrorilli
- Carlo Caffarelli
- Carlotta Povesi Dascola
- Carmen Di Scala
- Carmen D’Amelio
- Carmen Ponce
- Carmen Riggioni
- Carmen Saviana Ganea
- Carolina Aranda
- Carolina S. Aranda
- Caroline Klingebiel
- Caroline Thumerelle
- Caroline Zimmermann
- Carsten Bindslev-Jensen
- Catherine Bertholet
- Catherine Nock
- Chantal Agabriel
- Chantal Brossard
- Charlotte Eisenmann
- Charlotte Hands Plovdiv
- Charlotte Madsen
- Charlotte Mortz
- Chia-Chi Wang
- Chiara Fiamingo
- Chiara Pistoletti
- Chiara Rafaiani
- Chris H. Bridts
- Christian Harwanegg
- Christian Radauer
- Christian Schwager
- Christine Breynaert
- Christopher Munro
- Chrystyna Kalicinsky
- Chun-Wei Tung
- Chung-Hsiung Huang
- Claire Claverie
- Claire Mills
- Clara Ippolito
- Claudia Alessandri
- Claudia Pföhler
- Cleonir Lui de Moraes Beck
- Clémence Mordacq
- Colette Larré
- Colin Barber
- Cono Casale
- Constantinos Pitsios
- Corinne Herouet-Guicheney
- Cornelia Bergmayr
- Cornelia Jansen
- Cornelis K. van der Ent
- Cristiane Nunes dos Santos
- Cristiano Caruso
- Cristina Arêde
- Cristina Bueno
- Cristina Deaconu
- Cristina Ornelas
- Cristobalina Mayorga
- Daniel Corbacho
- Daniel Lozano-Ojalvo
- Daniel Sampaio
- Daniela Adriano
- Daniela Manila Bianchi
- Danijela Apostolovic
- Danila Zennaro
- Danilo Villalta
- Dasha Roa-Medellín
- David Alejandro Mendoza Hernández
- David C. A. Candy
- David Endesfelder
- David Gillick
- David Luyt
- Deirdre Galloway
- Denise Borges
- Diana Deleanu
- Diana Pérez Alzate
- Diana Silva
- Dianne Campbell
- Didier Ebo
- Diego Faggian
- Diego G. Peroni
- Diego Peroni
- Dikla Pivko Levy
- Dimitris Mitsias
- Dirceu Solé
- Dirk Verhoeven
- Djamel Saidi
- Djordje Filipovic
- Domingo Barber
- Donatella Bignardi
- Dorien Van Ginkle
- Duncan Brown
- E. N. Clare Mills
- Edward F. Knol
- Edyta Krzych
- Ekaterina Khaleva
- Ekaterini Goudouris
- Ekaterini Papadopoulou
- Elena D. Kuvshinova
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- Elodie Drumez
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- Esben Eller
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- Florence Pineau
- Florin-Adrian Secureanu
- Florin-Dan Popescu
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- Francine C. van Erp
- Francisca Gomez
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- Gabriele Schulz
- Gador Bogas
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- Gary Stiefel
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- Geert Houben
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- Georgios Rentzos
- Gerard H. Koppelman
- Gert van Duijn
- Geunwoong Noh
- Giampaolo Ricci
- Gian Lodovico Rapaccini
- Giorgio Bedogni
- Giovanni Pajno
- Giuseppe Crisafulli
- Giuseppe Pingitore
- Gjustina Loloci
- Glauce Yonamine
- Graham King
- Graham Roberts
- Grzegorz Sergiejko
- Grégory Bouchaud
- Guillaume Pouessel
- Gustavo Soldateli
- H. Kim A. Brand
- H. Mary-Lene de Zeeuw-Brouwer
- Hajime Karasuyama
- Hanan Sharif
- Hanane Kaddouri
- Hannah M. Kansen
- Hanneke van der Kleij
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- Hans-Jørgen Malling
- Harmieke van Os-Medendorp
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- Harry Wichers
- Hassan Al-Dhekri
- Heinz Fehrenbach
- Helen Brown
- Helen Lindqvist
- Helena Larramona
- Helga Magnusdottir
- Henk van Loveren
- Henny Otten
- Henrik Fomsgaard Kjaer
- Hervé Bernard
- Hilde Cnossen
- Huan Rao
- Hub P. J. M. Noteborn
- Hulya Ercan Sarıcoban
- Huub F. J. Savelkoul
- Ifigenia Sfika
- Ignacio García Núñez
- Ileana-Maria Ghiordanescu
- Ilya Vorozhko
- Indre Butiene
- Ine Decuyper
- Ines Mrakovcic-Sutic
- Ines Padua
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- Ingrid Sutic
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- Inmaculada Sánchez-Machín
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- Ioana Maris
- Ioanna Manolaraki
- Irena Nedelea
- Irene Berends
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- Isidor Hutteger
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- Ivana Giangrieco
- Ivana Sutic
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- Ivona Baricevic-Jones
- Iztok Devetak
- J. L. van der Velde
- Jaakko Yrjänä
- Jaap Akkerdaas
- Jacek Borowicz
- Jackeline F. Motta
- Jacqueline J. M. Castenmiller
- Jaime Lozano
- James Hindley
- Jan Knol
- Javier Cuesta-Herranz
- Javier Moreno
- Jean Tratt
- Jean-Louis Mège
- Jean-Luc Fauquert
- Jean-Marie Renaudin
- Jean-Michel Wal
- Jeanette Fisker Trandbohus
- Jelena Mihailovic
- Jennette Higgs
- Jennifer Hammond
- Jennifer Santos
- Jenny Badas
- Jenny van Odijk
- Jia Yin
- Jim Langridge
- Jlenia Fresta
- Joan Bartra
- Joana Caiado
- Joana Vitte
- Joaquín Navarro
- Jochen Behrends
- Joe Baumert
- Johan Garssen
- Johanna P. M. van der Valk
- Johanna Rost
- Johanna van der Valk
- Jolanda van Bilsen
- Jonas Lidholm
- Jonas Östling
- Jonathan Hourihane
- Jonathan O’B. Hourihane
- Joost Westerhout
- Jordi Roca-Ferrer
- Jorge Alvarez
- Jorge Esparza-Gordillo
- Jorge Kalil
- Joris Mens
- Jose Ignacio Larco
- Josefina Cernadas
- Josefina R. Cernadas
- Joseph Baumert
- Jossie Garthoff
- Josué Alejandro Huertas Guzmán
- José Antonio Bácter Martos
- José María Ignacio García
- José Pedro Moreira Silva
- José Plácido
- José Ramón Fernández Lorenzo
- Joyce A. M. Emons
- Joyce Emons
- João Marcelino
- Juan Carlos Daza
- Juan Carlos Julia
- Juan Carlos López-Rodríguez
- Juan Heber Castellanos
- Juan Miguel Garcia
- Juliane Gregersen
- Juliane Schulz
- Julie C. Locklear
- Julie Galand
- Julie Locklear
- Julien Labreuche
- Justine Courtois
- Júlio Oliveira
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- Karen English
- Karin Hoffman-Sommergruber
- Karin Hoffmann-Sommergruber
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- Karine Patient
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- Katrine Lindholm Bøgh
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- Khaled Messaoudi
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- Marina A. Kiseleva
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- Marina Themisb
- Mario Plebani
- Mariola Dietrich
- Mariona Pascal
- Marit Reitsma
- Mariya Ivanovska
- Marjeta Sedmak
- Mark Blankestijn
- Marleen T. J. Van Ampting
- Marta Anda
- Marta Goñi Esarte
- Marta Lomikovska
- Marta Neto
- Marta Vazquez-Ortiz
- Martin D. Chapman
- Martin Karjalainen
- Martinus Lovik
- Marysia Recto
- María José Barasona Villarejo
- María Luisa Baeza
- María Teresa Villalba
- María Ángeles Algaba Mármol
- Mashary Altamimi
- Mathilde Claude
- Mathilde Turfkruyer
- Matt Sperrin
- Matteo Moretti
- Maurits van Maaren
- Maurizio Mennini
- Maurizio Tamburrini
- Mauro Calvani
- Mayra Coutinho Andrade
- Mayra de Barros Dorna
- Melanie Cap
- Melina Makatsori
- Meltem Ugras
- Mercedes Escarrer Jaume
- Merima Bublin
- Meropi Kontogianni
- Meta Accetto
- Michael Clausen
- Michał Przybyszewski
- Michel Neunlist
- Michela Carola Speciani
- Michela Ciancamerla
- Michele Miraglia del Giudice
- Michelle Epstein
- Miguel García Domínguez
- Miguel Vieira
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- Mika Mäkelä
- Mikael Kuitunen
- Mindy Tsai
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- Miren Arteaga
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- Mirjana Zupančič
- Mohammad Al Bahkali
- Moira Austin
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- Monica Maćków
- Monica Piquer
- Montserrat Alvaro
- Montserrat Bosque García
- Montserrat De Prada
- Montserrat Fernandez-Rivas
- Montserrat López Onieva
- Montserrat Álvaro
- Morten Christensen
- Moshe Ben-Shoshan
- Mukul Das
- Muriel Totis
- Mário Morais-Almeida
- Mònica Piquer
- Nandinee Patel
- Nanju Alice Lee
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- Nehad Gomaa
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- Nerea Sarmiento Carrera
- Nesrine Zaabat
- Network for Online Registration of Anaphylaxis (NORA)
- Neusa F. Wandalsen
- Niamh Brosnan
- Nicolas Gaudenzio
- Nicolette Arends
- Nicolette de Jong
- Nicolette J. T. Arends
- Nicolette W. de Jong
- Nicolette W. de Jong
- Niels Röckendorf
- Nikki Edelbroek
- Nikolaos A. Kitsioulis
- Nikolaos Douladiris
- Nikolaos G. Papadopoulos
- Nikolaos Mikos
- Nikolaos Papadopoulos
- Nikos Papadopoulos
- Nino Adamia
- Noe Ontiveros
- Nour Baiz
- Nunzia Maiello
- Oksana Matsyura
- Olga Chernyak
- Olga Dominguez
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- Oscar Asensio
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- Pablo San Segundo-Acosta
- Paloma Campo
- Paloma Poza-Guedes
- Paola Dignetti
- Paola Minale
- Paolo Giordani
- Paolo Maria Matricardi
- Paraskevi Xepapadaki
- Pasquale Comberiati
- Patricia Macchiaverni
- Patricia Padrao
- Patrizia Polverino de Laureto
- Paul J. Turner
- Paul Turner
- Pawel Dubiela
- Pedro Giavina Bianchi
- Pedro Moreira
- Pernille Winther
- Peter Korošec
- Peter Meyer
- Petri Kulmala
- Phil Couch
- Phil Padfield
- Philip Couch
- Philipp Starkl
- Philippe Aubert
- Philippe Delahaut
- Philippe Egenmann
- Pierre Bruhns
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- Rand K. Arnaout
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- Regina Treudler
- Reiko Teshima
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- Sabine Dölle
- Sabine Pfeifer
- Sabine Schnadt
- Sahar Elshorbagi
- Salvatore Tripodi
- Sam Mehr
- Sandra Brandhoff
- Sandra Denery
- Sandra Denery-Papini
- Sandra Lucarelli
- Sara Abián
- Sara Martínez
- Sara Pereiro Fernández
- Sarah Grosche
- Sarah Kuntz
- Sarah Lindsley
- Saskia Albroscheit
- Sean Bennett
- Sebastian Tschirner
- Sebastien Holvoet
- Serena Perna
- Shan Deng
- Shinobu Sakai
- Shira Benor
- Sigrun Lund
- Sigurveig Sigurdardottir
- Silvia Gallina
- Silvia Peveri
- Simon Rosenberg
- Simone Frediani
- Sira Miquel
- Skadi Kull
- Sofia Kostoudi
- Songül Yürek
- Sonia Ricò
- Sonja Posega Devetak
- Sonsoles Intente-Herrero
- Sophia Watts
- Sophie Nutten
- Soraya Ainad Tabet
- Soren Wille
- Srdan Banac
- Sridevi Muralidharan
- Stefan Kabasser
- Stefan Vieths
- Stefania Arasi
- Stefanie Rohwer
- Stefano Luccioli
- Stefano Pattini
- Stephan Scheurer
- Stephane Leteurtre
- Stephanie Claus
- Stephen J. Galli
- Stephen Till
- Steve Taylor
- Stéphanie Lejeune
- Susana Piedade
- Susana Rodrigues
- Susanne Diesner
- Susanne Lau
- Susanne Schwarz
- Svetlan Dermendzhiev
- Svetlana Denisova
- Svitlana Nedelska
- Svitlana Zubchenko
- Sylke Rietz
- Sylvia Osscini
- Tadej Avčin
- Tanja Cirkovic Velickovic
- Tanja Rouhani Rankouhi
- Tatyana Popova
- Tatyana Sentsova
- Teija Dunder
- Teodoríkez Jiménez-Rodríguez
- The Anaphylaxis Working Group of the French Allergology SocietyThe Anaphylaxis Working Group of the French Allergology Society
- Thomas Eiwegger
- Thomas Keil
- Thomas Marichal
- Tiina Kauppila
- Timothy Watts
- Tina Vesel
- Tomaž Poredoš
- Tong-Rong Jan
- Tullio Frediani
- Tushar Banerjee
- Ulf Bengtsson
- Ulrike Lehnigk
- Umberto Pelosi
- Urszula Samolinska-Zawisza
- Uta Jappe
- Valentino Pavisic
- Valery Muhortnich
- Valérie Liabeuf
- Valérie Trendelenburg
- Valérie Verhasselt
- Vasti Iancu
- Vera A. Revyakina
- Vera Elisabeth Assmann
- Vicente Albendiz
- Victor Matheu-Delgado
- Vito Sabato
- Viviana Moschese
- Vladimir Micovic
- Vladyslava Barzylovych
- Véronique Nève
- W. Marty Blom
- Waltraud Suer
- Wentong Xue
- Winfried Leeman
- Wolf-Meinhard Becker
- Xavier Domingo Miró
- Yanne Boloh
- Yin-Hua Cheng
- Yolanda Meijer
- Yolanda Puente
- Youcef Bouferkas
- Younes Belabbas
- Young-Ae Lee
- Yvonne Vergouwe
- Zbigniew Bartuzi
- Zdenka Baricev-Novakovic
- Zerrin Yalvac
- Zizi Cojocariu
- Zorica Zivkovic
- Zsolt Szepfalusi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/03/2017
- Field of study
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Nick
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Adhikari Sheetal
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Enezi Farhan
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderman Meera
- Aldo Bonizzoni Matteo
- Alegria Ana
- Alessandro Carà Gianmarco
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Almeshhedani Hasham
- AlQahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Al Amri Ali
- Al Qasim Eman
- Amatya Sameena
- Ambrosino Richard
- Anderson Thomas
- Andreae Mark
- Aneman Anders
- Angus Derek C.
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Aquino Maia
- Arabi Yaseen M.
- Arachchige Malka
- Aravindan Latha
- Arbane Gill
- Archambault Patrick
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arias Sonia
- Arishi Hatim
- Arnold Donald
- Arnold John
- Arnott Andrew
- Arora Anand
- Aryal Diptesh
- Asghar Adeeba
- Asif Namra
- Aspinwall Angelique
- Attokaran Antony
- Attwood Ben
- Au Carly
- Audry Mathilde
- Austin Karen
- Austin Pauline
- Auvet Adrien
- Avard Bronwyn
- Awan Sidra
- Ayee Robert
- Azaiz Amine
- Azzaui Harun
- Babu Suresh
- Bacon Gina
- Badalamenti Salvatore
- Badie Julio
- Bagavathy Kavitha
- Bagot Catherine
- Bagshaw Sean
- Baig Nadia
- Baikady Ravishankar
- Bailey Lucy
- Baillie Kenneth
- Bain William
- Baker Alice
- Baker Evelyn
- Baker Stuart
- Bakthavatsalam Dhanalakshmi
- Balaie Morteza
- Balls-Burgess Sam
- Bamford Amy
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbash Ian
- Barber Russell
- Barbier François
- Barge Deborah
- Bariola Ryan
- Barker Gareth
- Barker Stephanie
- Barnes Nicky
- Baron Rebecca M.
- Barreau Amelie
- Barreau Amélie
- Bart Robert
- Bartholomew Jazz
- Bartley Shauna
- Barton David
- Barton Frances
- Bashyal Archana
- Basile Kim
- Bass Frances
- Bassford Christopher
- Bastos Joana Margarida Pereira Sousa
- Bates Michelle
- Bates Samantha
- Batista Teresa Margarida Oliveira
- Bauchmuller Kris
- Bayne Madeleine
- Bean Sarah
- Beane Abi
- Beane Abigail
- Beard Gregory
- Beasley Richard
- Beaudoin Rosalie
- Beavis Sarah
- Beddows Seonaid
- Bedford Caroline
- Beer Deborah
- Beer Sally
- Begin Phillipe
- Begum Salma
- Bell Gillian
- Bellemare David
- Belletti Allesandro
- Bendjemar Lynda
- Benettaib Fatna
- Bensen Nicole
- Bentley Andrew
- Benyon Sarah
- Benzekri Dalila
- Beqai Besa
- Berdaguer Fernando
- Beresford Stephanie
- Bergin Colin
- Berry Lindsay R.
- Berry Scott
- Berryman Emily
- Bertel Melanie
- Best-Lane Janis
- Besten Henny
- Bevan Emily
- Bewley Jeremy
- Beyerl Ashley
- Bhagani Sanjay
- Bhandal Khushpreet
- Bharaj Kiranjit
- Bhattarai Bina
- Bhattarai Binita
- Bhonagiri Deepak
- Biddie Simon
- Bigas Judit
- Bihari Shailesh
- Bin Hasan Mohd Shahnaz
- Bindels Manon
- Binnie Alexandra
- Biradar Vishwanath
- Birch Catherine
- Birch Janine
- Birch Sophie
- Birchall Kathrine
- Birkinshaw Isobel
- Black Ethel
- Blackledge Bethany
- Blakemore Hayley
- Blanck Wendy
- Bland Yvonne
- Blank Elisabeth
- Bleasdale John
- Bloomfield Jack
- Bloos Frank
- Board Jasmin
- Boardman Melanie
- Boari Gianluca
- Bocher Simon
- Bociek Aneta
- Boivin Anne-Helene
- Boivin Anne-Hélène
- Bojunga Jörg
- Bomken Charlotte
- Bonaccorso Allesandra
- Bongaerts Katherine
- Bonner Stephen
- Bonten Marc J. M.
- Borgatta Barbara
- Borislavova Borislava
- Borrill Zoe
- Boschert Catherine
- Bossard Isabelle
- Bothma Pieter
- Boudineau Michel
- Boulanger Marie-Claude
- Boumahni Dounia
- Bouman Angela
- Bounab Rania
- Bourgoin Charlotte
- Bourne Michelle
- Bourne Richard
- Boutin Mireille
- Bouvier Elodie
- Bouw-Ruiter Marianne
- Boué Yvonnick
- Bowen James
- Bowler Helen
- Boyd Craig
- Boyles Rebecca
- Bracke Stephanie
- Bradbury Charlotte A.
- Bradley Paul
- Brady Kara
- Brailsford Jane
- Brain Matthew
- Brakké Karen
- Brant Emily
- Brasselet Aurélie
- Breen Patrick
- Bremmer Pamela
- Brend Morwenna
- Brennan Aoife
- Bretagnol Anne
- Brett Stephen
- Brewer Chris
- Brickell Kathy
- Bridges Sarah
- Brieger Klaus-Gerd
- Brightling Chris
- Brimfield Lutece
- Brittain Michael
- Britton Kate
- Brochard Laurent
- Brodbeck Andreas
- Brohi Farooq
- Brooks Nicole
- Brown Cynthia
- Brown Julia
- Brown Louise
- Brown Nerissa
- Brown Zarah
- Brugman Curt
- Brunetta Enrico
- Brunkhorst Frank M.
- Brunskill Nigel
- Bryan-Morris Kayla
- Bryden Emma
- Budd Joanna
- Buehner Ulrike
- Buhay Megan
- Buhr Heidi
- Burbee Dylan
- Burda Dorota
- Burgess Richard
- Burke David
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- Burkey Jason
- Burnish Rachel
- Burns Dean
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- Buscher Hergen
- Butler Amelia
- Butler Magdalena
- Butler Susan
- Buxton Meredith
- Buzgau Adrian
- Byrne Kathleen
- Byrne Rahim
- Cabrelli Louise
- Cabreros Leilani
- Cairns Tom
- Calfee Carolyn
- Callahan Jean-Christophe
- Cambalova Lenka
- Campbell Andrew
- Campbell Bridget
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- Campbell Hilary
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- Campion Alexandra
- Campisi Josie
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- Caplin Cecile
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- Carmichael Samantha
- Carmona Rosario
- Carn Vanessa
- Carpio Lillian
- Carr Zoe
- Carr-Wilkinson Joanne
- Carrier François
- Carrier Marc
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- Carter Brittney
- Carter David
- Carter Jay
- Carter Michael
- Casali Sherry
- Casey Ruth
- Casey Siobhan
- Castelain Vincent
- Castle James
- Cathcart Susanne
- Catorze Nuno José Teodoro Amaro dos Santos
- Cattelan Jessy
- Cavayas Alexandros
- Cawley Kathryn
- Cecconi Maurizio
- Centofanti John
- Chambers Emma
- Champanerkar Shreekant
- Chan Carmen
- Chan Charles
- Chan Peter
- Chapman Rachel
- Chapman Susan
- Charles Bethan
- Charles Walton
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- Charlton Sam
- Charron Cyril
- Chartier Delphine
- Chasse Michael
- Chassé Michaël
- Chen Jonathan
- Chen Lixian
- Chen Yan
- Cheng Allen C.
- Cherian Shiney
- Chhablani Manish
- Chin Teri
- Chudeau Nicolas
- Chukkambotla Sri
- Ciccarelli Michele
- Cirstea Emanuel
- Clair Bernard
- Clark Amy
- Clark Michele
- Clark Richard
- Clark Sarah
- Clarke Frances
- Clarke Jennifer
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- Cleary Joanne
- Clement Ian
- Clere-Jehl Raphael
- Clermont Giles
- Clermont Gilles
- Clinton Alison
- Cloutier Ève
- Cockrell Maeve
- Codreanu Daniel
- Coetzee Samantha
- Coghlan Phoebe
- Cole Jade
- Coles Jennifer
- Colin Gwenhael
- Collier Dawn
- Collins Amy
- Collins Daniel
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- Collins Joanne
- Collins Érin
- Collis Matthew
- Combaux Daniele
- Commons Robert
- Comp Susan
- Concha Pablo
- Connolly Karen
- Constantini Elena
- Constantino-Occhipinti Claudia
- Contou Damien
- Convery Karen
- Conway Robert
- Conzelmann Nadine
- Cook Deborah
- Cook Tim
- Cooke Jill
- Cooke Justin
- Cooper Jamie
- Cooper Josh
- Cooper Lauren
- Cooper Melanie
- Cooper Nichola
- Corbett Sarah
- Corcoran Ele
- Corcoran Kathleen
- Cornell Sarah
- Cornell Thomas
- Cort Jon
- Costerousse Olivier
- Couillard-Chénard Émilie
- Courtin Laura
- Coutts Amanda
- Couture Lourie
- Cove Matthew
- Cowdrey Keri-Anne
- Cowley Nicholas
- Cowton Amanda
- Coyne Mark
- Craddock Richard
- Craner Michelle
- Craven Thomas
- Crawshaw Sarah
- Creagh-Brown Ben
- Creange Vanessa
- Cremer Olaf
- Crisp Nikki
- Croft Maria
- Csabi Peter
- Cudlipp Joanna
- Cuesta Jeronimo
- Cuffaro Raffaele
- Curley Gerard
- Currie Andrew
- Cusack Rebecca
- Cuthbertson Brian
- Cutler Sean
- Cárcel Sheila
- Côté Émilie
- D?Amato Fabiola
- D?Aragon Frédérick
- Daebis Admad
- Daher Rana
- Dale Katie
- Daley Jessica
- Dalton James
- Daly James
- Daly Zoe
- Daneman Nick
- Dark Paul
- Darnell Robert
- Darreau Cedric
- Daugherty Jason
- Davey Miriam
- Davidson Neil
- Davies Ellie
- Davies Gwyneth
- Davies Jennifer
- Davies Louisa
- Davies Michelle
- Davies Rhys
- Dawson Laura Ann
- Dawvda Ashlish
- Day Christopher
- Da Rocha Joana
- De Bus Liesbet
- de Courcy-Golder Kim
- de Groot Klaas
- de Jong Menno
- de Jonge Evert
- De Keulenaer Bart
- de la Torre Cisneros Julian
- de Man Angelique
- De Neef Mark
- De Smeytere Anouska
- Deacon Bethan
- Dean Steven
- Dean Tessa
- Dearden Joy
- Dechert William
- Declercq Pierre-Louis
- Degracia Anna
- del Sorbo Lorenzo
- Dela Rosa Arnold
- Delaney Kirsha
- Dell Abbie
- del Prado Michael
- Demetriou Carrie
- Dempster Debra
- Denham Lynn
- Denmade Craig
- Dent Martin
- Depante Maria
- Depuydt Pieter
- Dequin Pierre-François
- Derde Lennie P. G.
- Deshpande Kush
- Detry Michelle A.
- Deye Nicolas
- de la Fuente Carmen
- De Waele Jan
- Dheke Krishan
- Di Lucca Giuseppe
- Dias Priya
- Dice Julie
- Digby Stephen
- Diridis Kristina
- Distler Michael
- Dobell-Brown Kelsey
- Doble Patricia
- Dobson Jade
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- Doherty Ronan
- Doi Yohei
- Dolman Rozzie
- Domingo-Marco Joana
- Donadee Chenell
- Donaldson Kate
- Dondrop Arjen
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- Donlon Sinead
- Donnelly Adrian
- Donnelly Kieran
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- Doonan Reece
- Doran Peter
- Dore Rachael
- Dormand Natalie
- Dos Santos Filipa
- Douillard Thomas
- Drake Chelsea
- Drapola Debra
- Drayss Maria
- Drummond Andrew
- Drury Kay
- Duan Erick
- Duberley Stephen
- Duffy Eamon
- Duffy Oscar
- Duke Graeme
- Duke Zoe
- Duncan Tracy
- Dunsavage Janice
- Duplaix Mathilde
- Duric Natalie
- Duroux Maree
- Dushianthan Ahilanandan
- Dyas Sarah
- Eapen Beena
- Eastgate Christine
- Ebenezer R
- Edmunds Natasha
- Edwards Alexandra
- Efford Georgia
- Egreteau Pierre
- Ehrmann Stephan
- Eichenauer Dennis
- Eisenbeis Simone
- Ekhérian Jean-Michel
- El-Khawas Khaled
- Elender Corinna
- Elgendy Ahmad
- Elhassan Munzir
- Ellervee Anneli
- Ellis Chiara
- Ellis Christine
- Ellis Yvette
- Elmahi Einas
- Elsefi Tarek
- Eltayeb Ayaa
- Elvira Evangeline
- England Jenna
- Englert Sarah
- English Shane
- Epelman¸ Slava
- Eroglu Ege
- Estcourt Lise J.
- Estensen Kristen
- Evans Amy
- Evans Andrew
- Evans Debra
- Evans Gabrielle
- Everitt Robert
- Evers Mirjam
- Evetts George
- Ewalds Esther
- Ezekowitz Justin
- Fagan Laura
- Fagbodun Elizabeth
- Farahi Neda
- Fareed Komal
- Farnell-Ward Sarah
- Fartoukh Muriel
- Faulkner Beverley
- Faulkner Maria
- Fazla Fathima
- Featherstone Peter
- Felton Tim
- Fennessy Gerard
- Ferguson Niall
- Ferguson Susan
- Fergusson Dean
- Fernandes Edna
- Fernandez Maria
- Fernando Gloria
- Fernández de Pinedo Artaraz Ziortza
- Ferreira Ricardo Manuel Castro
- Ferrier Janet
- Ferringer Cindy
- Fesz Jessica
- Fierens Jan
- Finch Cheryl
- Finn André
- Finn Stephanie
- Finnis Mackenzie
- Fiouni Sofia
- Fischer Roy
- Fitzgerald Mark
- Fitzpatrick Meghan
- Fletcher Simon
- Flint Neil
- Flor Thomas
- Florescu Simin
- Fluher Jure
- Flynn Gordon
- Focà Emanuele
- Folci Marco
- Forbes Andrew
- Ford Megan
- Forster Elliot
- Foster Tracy
- Fottrell-Gould Deirdre
- Foulds Angela
- Fowler Rob
- Fowler Robert
- Fox Claire
- Fox Eleonore
- Fragner Gertrud
- Frakking Thuy
- Franch-LLasat Diego
- Francis Olesya
- Francoeur François
- Francois Bruno
- Frankfurter Claudia
- Franz Christopher
- François Bourgerol
- Fraser Catherine
- Frater Alasdair
- French Craig
- Frey Anna
- Frey Christian
- Frise Matthew
- Frost Victoria
- Fuchs Ralph
- Fujitani Shigeki
- Fysh Ed
- Gachet Alexandre
- Galbiati Carola
- Galea James
- Ganesan Arunkumar
- Ganesan Manisha
- Ganguly Saibal
- Garcia Sara
- Gardiner-Hill Caroline
- Garot Denis
- Garrard Hywel
- Garrard William
- Garrett Peter
- Garrier Ludivine
- Garrod Esther
- Garton Mark
- Garvey James
- Gascoyne Rachel
- Gattas David
- Gauli Basanta
- Gay Alexandra
- Gaylard Jane
- Gellamucho Minerva
- Gemmell Lisa
- Gendall Emma
- Geng Wenli
- Geoghegan Pierce
- Geri Guillaume
- Geurts Heidi
- Ghaffari Mehrdad
- Ghamraoui Ali
- Ghattaoraya Amardeep
- Ghosh Alison
- Giardina Giuseppe
- Gibbins Alexandra
- Gill Mandy
- Gilliam Matthew
- Gilmour Kate
- Girard Timothy
- Girijadevi Dinuraj
- Gladas Kirsty
- Glasby Kathleen
- Gledhill Lisa
- Glister Georgina
- Glynou Loukia
- Goddard Wendy
- Godement Mathieu
- Godoy Lucas C.
- Goebeler M.E.
- Golden David
- Goldman John
- Goligher Ewan
- Gomez Keith
- Gommans Frank
- Goodwin Jayne
- Goossens Herman
- Gopal Shameer
- Gopinath Amitha
- Goralski Patricia
- Gordon Anthony C.
- Gosbell Iain
- Gould Richard
- Grady Bart
- Graham Cheryl
- Graham Libby
- Graniewski Jaroslaw
- Grant Caroline
- GrauNovellas Neus
- Greco Massimiliano
- Grecu Irina
- Green Cameron
- Green Jackie
- Greene Emma
- Greener Danni
- Gregory Jane
- Gresham Rebecca
- Greven Frances
- Grieve Richard
- Grimm Patrick
- Grimmer Lisa
- Groeneveld Erika
- Gross Jamie
- Grünewaldt Achim
- Guanco Mark
- Guerineau Elodie
- Guitton Christophe
- Gummadi Mahitha
- Gupta Abhinav
- Gurung Anita
- Guérin Emmanuelle
- Gómez Francisco
- Göpel Siri
- Habeichi Wadih
- Habraken Hannah
- Hadebe Bernard
- Haffiane Abdelmagid
- Hagel Stefan
- Haghi Theerata
- Haiba Khalid
- Haidar Ghady
- Haider Nafeesah
- Haider Syeda
- Hajdu Bence
- Hakak Sheeba
- Halden Sandra
- Haldeos Anne
- Hall Alistair S
- Hall Amelia
- Hall Andrew
- Hall Kathryn
- Hall Rebecca
- Hamilton David
- Hamilton-Davies Colin
- Hamlyn Vincent
- Hammond Naomi
- Hammonds Fiona
- Hand James
- Haniffa Rashan
- Hanisch Alexis
- Hanley Joanne
- Hansen Dan
- Hanson Helen
- Hanson Jane
- Harden Lesley
- Harding Daniel
- Hardy Chloe
- Harford Rachel
- Harland Cain
- Harper Heather
- Harrington Claire
- Harrington Kate
- Harris Celia
- Harris Jade
- Harris John
- Harrison David A.
- Harrison Susan
- Harrow Kath
- Hartley Melissa
- Harvala-Simmonds Heli
- Harvey Alice
- Harvey Daniel
- Harvey James
- Harward Meg
- Hashmi Madhia
- Hashmi Madiha
- Hassan Noor
- Hausermann Marie-Helene
- Hawcutt Daniel
- Hawes Joanne
- Hawkins Nancy
- Hay Sophie
- Haydon Tim
- Hayes Amber
- Hayes Anne
- Hayes Kati
- Hayes Leanne
- HC Ooi
- Headdon William
- Headlam Evie
- Healey Gail
- Hegazy Ahmed
- Hegazy Mohamed
- Heinonen Jonna
- Helms Julie
- Heming Nicholas
- Henderson Kelly
- Henderson Steven
- Henning Jeremy
- Henri-Lagarrigue Matthieu
- Henry Joanne
- Henry Lavinia
- Hensley Joseph
- Heritier Stephane
- Hernandez Erik
- Hewitt Claire
- Hey Samuel
- Hickey John
- Hierons Sarah
- Higgins Alisa M.
- Hill Claire
- Hill Dianne
- Hill Helen
- Hilldrith Anette
- Hills Thomas
- Hin Lui Lok
- Hindle Grace
- Hinrichs Carl
- Hird Clare
- Hodge Christopher
- Hodgson Carol
- Hodgson Helen
- Hoff Uwe
- Hoiting Oscar
- Holbrook Catherine
- Holland Andrew
- Holland Nicky
- Holland Susan
- Hollos Laszlo
- Homes Jennifer
- Honda Hitoshi
- Hope David
- Hopkins Phil
- Hormis Anil
- Horner Dan
- Hornsby James
- Horton Michelle
- Horvat Christopher M.
- Howcroft Clare
- Howell Alice
- Hower Martin
- Howie Lucy
- Howle Ryan
- Hoxha Elvira
- Huang David T.
- Hughes Debbie
- Hugill Keith
- Huijbens Danique
- Hullegie Sebastiaan
- Hulley Amanda
- Hulme Jonathan
- Hulse Sarah
- Humphrey Charlotte
- Hunt Beverley
- Hunter Stephanie
- Hurford Sally-Anne
- Hussain Mahwish
- Hussain Sajid
- Hutchinson Christina
- Hutton Paula
- Hüning Vanessa
- Ichihara Nao
- Ijaz Nazia
- Ikhena Ikhuemose
- Inskip Deborah
- Irving Ben
- Isgro Graziella
- Isguzar Agah
- Ishani Pramodya
- Ivatt Helen
- Jackson Carolyn
- Jackson Shane
- Jackson Susan
- Jacob Reni
- Jacquier Sophie
- Jafarzadeh Mina
- Jagannathan Vijay
- Jain Susan
- James Augustian
- James Christie
- Jan Hassing Robert
- Janin Pierre
- Jarczak Dominik
- Jarman Claire
- Jayakumar Deva
- Jayakumar Devachandran
- Jean-Pierre Eraldi
- Jeblaoui Asma
- Jenkins Samuel
- Jenkins Sarah
- Jenkins Steve
- Jennings Stacey
- Jepson Eleanor
- Jerenec Katja
- Jesty Robert
- Jha Avinash
- Jha Rajeev
- Jhanji Shaman
- Jin Xia
- Jindai Kazuaki
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- Johns Magaret
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- Johnson Paul
- Johnson Rebekah
- Johnson Toby
- Johnston Brian
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- Jones Cathy
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- Jongebloed Katherine
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- Juhaz Vera
- Kadam Umesh
- Kalamar ?iga
- Kalchko-Veyssal Selver
- Kalchthaler Kyle
- Kaliappan Agilan
- Kalla Ismail
- Kalogirou Michael
- Kamata Kazuhiro
- Kamel Toufik
- Kampschreur Linda
- Kamra Maneesha
- Kandeepan Revathi
- Kannan Santhana
- Kannan Thogulava
- Kanwal Darakhshan
- Karachi Tim
- Karim Hina
- Karki Rakshya
- Karlikowski Michal
- Karlsson Sari
- Kasipandian Vidya
- Kassir Sandy
- Katary Amro
- Kato Hideaki
- Kavanagh Lisa
- Kayani Abdul
- Kayastha Srijana
- Kaye Callum
- Kazi Aayesha
- KC Shirish
- KC Shirsh
- Keating Liza
- Keatley Claire
- Keeler Sheryl
- Keen Alexandra
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- Wiles Matt
- Wiley Daisy
- Wilhelmsen Elva
- Wilkinson Dean
- Willams Felicity
- Williams Alexandra
- Williams Angharad
- Williams Anna
- Williams Erin
- Williams Gemma
- Williams Hannah
- Williams Karen
- Williams Marie
- Williams Patricia
- Williams Penny
- Williams Tony
- Williams Virginie
- Williamson Dawn
- Williamson James D
- Willis Joanna
- Willson Jayne
- Wilson Anna
- Wilson Craig
- Wilson Jean
- Wilson Maggie
- Winters James
- Winters Lauren
- Wise Matt
- Wisniewski Mary
- Wittekamp Bastiaan
- Wittenberg Wendy
- Wnuk Chris
- Woelke Amy
- Wong Jenny
- Wong Onyee
- Wood Erica
- Wood Hannah
- Wood Tracy
- Woods Jane
- Woods Lindsey
- Woodward Robert
- Woolett Melissa
- Worner Ruth
- Wren Jess
- Wren Lynn
- Wrey Brown Caroline
- Wright Chris
- Wright Kim
- Wunderley Renee
- Wyatt Rachel
- Wylie Katharine
- Xavier Kugan
- Yamagishi Yoshiaki
- Yamashita Chizuru
- Yang Yang
- Yarad Elizabeth
- Yates Bryan
- Yates David
- Yealy Donald
- Young Ian
- Young Meredith
- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
Enhancing Order and Porosity in a Highly Robust Tin(IV) Triphosphonate Framework
- Publication venue
- Publication date
- Field of study
Metal organic frameworks
(MOFs) are noted for crystallinity, stability, and porosity. For many
industrial challenges though, beyond stability to pore activation,
porous materials require high thermal and moisture stability. Here,
we report a Sn(IV) triphosphonate framework, CALF-28, that is highly
robust and porous. CALF-28 was designed based on the known structure
of a divalent metal phosphonate that was 2-fold interpenetrated. It
has strong sustaining interactions but consequently rapidly precipitates,
compromising crystallinity. Using methods to enhance order, and by
analogy to the M(II) analogue, insights to the structure are ascertained
and corroborated by PXRD and gas sorption analysis. CALF-28 has a
surface area >500 m<sup>2</sup>/g and is stable in water
Engaging dual donor sites within an N-heterocyclic olefin phosphine ligand
- Author
- Publication venue
- Publication date
- 01/01/2017
- Field of study
By investigating the coordination chemistry of a neutral N-heterocyclic olefin phosphine ligand, a new digold(I) chloride complex was discovered, demonstrating that mixed element (P/C) donor sites can be accessed at the same time. However attempts to extend this strategy for the preparation of heterobimetallic complexes featuring copper(I) and gold(I) centers with this mixed donor ligand were unsuccessful. The related monometallic copper(I) and gold(I) iodide complexes were discovered to be emissive in the solid state
Contrasting Reactivities of Silicon and Germanium Complexes Supported by an <i>N</i>‑Heterocyclic Guanidine Ligand
- Author
- Publication venue
- Publication date
- Field of study
We
report the synthesis of an acyclic two-coordinate germylene supported
by two bulky and electron donating <i>N</i>-heterocyclic
guanidine [IPrN]<sup>−</sup> ligands (IPr = [(HCNDipp)<sub>2</sub>C:]; Dipp = [2,6-<sup>i</sup>Pr<sub>2</sub>C<sub>6</sub>H<sub>3</sub>]), and its reactivity with molecular hydrogen to form IPrNH,
which presumably proceeds via the unstable intermediate [H<sub>2</sub>Ge(NIPr)<sub>2</sub>]. Our attempts to isolate the corresponding
silylene [:Si(NIPr)<sub>2</sub>] led
to an unexpected ligand activation/rearrangement process involving
N–C(aryl) bond cleavage within the <i>N</i>-heterocyclic
guanidine ligand; this transformation was also studied by computational
methods
In pursuit of delay-related brain activity for anticipatory eye movements
- Author
- A Murthy
- A Schmid
- B Gaymard
- BR Postle
- BR Riggall AC Postle
- C Pierrot-Deseilligny
- D Schluppeck
- DJ Mitchell
- DK Bowman
- E Poliakoff
- G Campana
- GA O'Driscoll
- GH Recanzone
- GR Barnes
- GR Barnes
- GR Barnes
- Graham R. Barnes
- H Magen
- J Ding
- J Fukushima
- J Maunsell
- JHR Maunsell
- JT Serences
- JW Bisley
- JW Brascamp
- K Fukushima
- KH Britten
- LL Lui
- M Kawasaki
- M Missal
- M Missal
- M Nagel
- M Nagel
- Melanie R. Burke
- MJ Mustari
- MR Burke
- MR Burke
- MR Burke
- MW Greenlee
- Natasha M. Maurits
- P Thier
- PW Dicke
- R Lencer
- R Lencer
- RA Andersen
- RA Berman
- RJ Krauzlis
- RJ Perry
- RL Buckner
- S Kurkin
- SA Brandt
- SA Harrison
- SJ Bennett
- SJ Heinen
- SR Chakraborti
- UJ Ilg
- VP Ferrera
- W Becker
- WF McDaniel
- WS Ong
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 09/09/2013
- Field of study
How the brain stores motion information and subsequently uses it to follow a moving target is largely unknown. This is mainly due to previous fMRI studies using paradigms in which the eye movements cannot be segregated from the storage of this motion information. To avoid this problem we used a novel paradigm designed in our lab in which we interlaced a delay (2, 4 or 6 seconds) between the 1st and 2nd presentation of a moving stimulus. Using this design we could examine brain activity during a delay period using fMRI and have subsequently found a number of brain areas that reveal sustained activity during predictive pursuit. These areas include, the V5 complex and superior parietal lobe. This study provides new evidence for the network involved in the storage of visual information to generate early motor responses in pursuit