Nonlinear temperature response of lake ice breakup

A uniquely comprehensive set of four decades of ice breakup data from 196 Swedish lakes covering 13degrees of latitude (55.7degrees N to 68.4degrees N) shows the relationship between the timing of lake ice breakup and air temperature to be an arc cosine function. The nonlinearity inherent in this relationship results in marked differences in the response of the timing of lake ice breakup to changes in air temperature between colder and warmer geographical regions, and between colder and warmer time periods. The spatial and temporal patterns are mutually consistent, suggesting that climate change impacts on the timing of lake ice breakup will vary along a temperature gradient. This has potentially important ramifications for the employment of lake ice phenologies as climate indicators and for the future behavior of lacustrine ecosystem

The Influence of Nutrition Counseling on the Knowledge and Intake of Macro Nutrient Wus Kek in Region Work Puskesmas Sawah Lebar Bengkulu

Women of Childbearing Age (WUS) are a population that are of particular interest inthe prevention of nutritional problems, especially in addressing their Lack of Chronic Energy (KEK). KEK in WUS is very likely to result in a difficult childbirth and post partum hemorrhage as well as an increased risk death of the mother and of low birth weight babies. Data WUS SEZ in Indonesia in 2010 (30,9%) increased in 2013 (46,4%). Sixteen provinces with the prevalence of the risk of SEZ above the national province, namely the Bengkulu Province (15%). The purpose of this study is to determine the effect of nutrition counseling on the knowledge and intake of macro nutrient on WUS SEZ in the working area of Health Center of Sawah Lebar the Width of the City of Bengkulu the Year 2018. The results of this study there was significant influence of nutritional counseling (p = 0.000) on the intake of macro nutrient (p = 0.000). On WUS KEK in the working area of Health Center of Sawah Lebar the width of the city of Bengkulu the year 2018.The Design of this Research is Pre Experimental Design with design One Group Pretest-Posttest. Nutrition counseling on WUS KEK performed 3 times during 3 weeks. The number of samples as many as 23 people. Statistical analysis using dependent t-test and wilcoxon tes

Futterbewertung im Umbruch? Beziehung zwischen dem Alter von Rindern und Ochsen aus einem Weidemastverfahren und Merkmalen der Fleischtextur (Zartheit)

Die Zartheit ist eines der wichtigsten Merkmale für den Genusswert von Fleisch und speziell für Labelfleischprogramme, aufgrund der Erkennbarkeit der Produkte, sicherlich von entscheidender Bedeutung für den wiederholten Kaufentscheid der Konsumierenden (Koohmaraie und Geesink, 2006). Ziel der vorliegenden Untersuchung war daher zu prüfen, inwieweit sich das Alter von Rindern und Ochsen, die auf der Basis von Gras und Graskonserven extensiv ausgemästet wurden, auf die Eigenschaften des Bindegewebes und die Textur von zwei Muskeln, die sich im Kollagengehalt unterscheiden, auswirkt

A framework for digital sunken relief generation based on 3D geometric models

Sunken relief is a special art form of sculpture whereby the depicted shapes are sunk into a given surface. This is traditionally created by laboriously carving materials such as stone. Sunken reliefs often utilize the engraved lines or strokes to strengthen the impressions of a 3D presence and to highlight the features which otherwise are unrevealed. In other types of reliefs, smooth surfaces and their shadows convey such information in a coherent manner. Existing methods for relief generation are focused on forming a smooth surface with a shallow depth which provides the presence of 3D figures. Such methods unfortunately do not help the art form of sunken reliefs as they omit the presence of feature lines. We propose a framework to produce sunken reliefs from a known 3D geometry, which transforms the 3D objects into three layers of input to incorporate the contour lines seamlessly with the smooth surfaces. The three input layers take the advantages of the geometric information and the visual cues to assist the relief generation. This framework alters existing techniques in line drawings and relief generation, and then combines them organically for this particular purpose

Interferon alpha-2a Plus Ribavirin 1,000/1,200 mg versus Interferon alpha-2a Plus Ribavirin 600 mg for Chronic Hepatitis C Infection in Patients on Opiate Maintenance Treatment: An Open-Label Randomized Multicenter Trial

Abstract : Background: : Many intravenous opiate users are infected with hepatitis C virus (HCV) but few are treated. Although this complies with various guidelines, virtually no published evidence supports such a recommendation. Patients and Methods: : In a multicenter study, HCV-infected patients in opiate maintenance treatment programs received interferon plus high- or low-dose ribavirin (1,000/1,200 mg or 600 mg). HIV-coinfected patients were not included. Endpoints were feasibility, efficacy, side effects, and reasons for dropout. Results: : Of the 420 patients who tested positive for HCV, 27 (6%) were enrolled; 393 (94%) either failed to meet the inclusion criteria or refused treatment. Virologic end-of-treatment response was achieved in 12/27 patients, and sustained response in 13/27 (48%). Response depended on viral genotype, not ribavirin dose. The two doses of ribavirin did not differ in their side effects. Conclusion: : In a small fraction of HCV-infected intravenous drug users in an opiate maintenance treatment program, antiviral therapy was feasible, safe, and effective. The success rate was comparable to that achieved in controlled studies that excluded drug user

A multiscale hybrid model for pro-angiogenic calcium signals in a vascular endothelial cell

Cytosolic calcium machinery is one of the principal signaling mechanisms by which endothelial cells (ECs) respond to external stimuli during several biological processes, including vascular progression in both physiological and pathological conditions. Low concentrations of angiogenic factors (such as VEGF) activate in fact complex pathways involving, among others, second messengers arachidonic acid (AA) and nitric oxide (NO), which in turn control the activity of plasma membrane calcium channels. The subsequent increase in the intracellular level of the ion regulates fundamental biophysical properties of ECs (such as elasticity, intrinsic motility, and chemical strength), enhancing their migratory capacity. Previously, a number of continuous models have represented cytosolic calcium dynamics, while EC migration in angiogenesis has been separately approached with discrete, lattice-based techniques. These two components are here integrated and interfaced to provide a multiscale and hybrid Cellular Potts Model (CPM), where the phenomenology of a motile EC is realistically mediated by its calcium-dependent subcellular events. The model, based on a realistic 3-D cell morphology with a nuclear and a cytosolic region, is set with known biochemical and electrophysiological data. In particular, the resulting simulations are able to reproduce and describe the polarization process, typical of stimulated vascular cells, in various experimental conditions.Moreover, by analyzing the mutual interactions between multilevel biochemical and biomechanical aspects, our study investigates ways to inhibit cell migration: such strategies have in fact the potential to result in pharmacological interventions useful to disrupt malignant vascular progressio

Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium. 15-18 March 2016.

[This corrects the article DOI: 10.1186/s13054-016-1208-6.]

Alu-Alu Recombination Underlying the First Large Genomic Deletion in GlcNAc-Phosphotransferase Alpha/Beta (GNPTAB) Gene in a MLII Alpha/Beta Patient

Mucolipidosis type II α/β is a severe, autosomal recessive lysosomal storage disorder, caused by a defect in the GNPTAB gene that codes for the α/β subunits of the GlcNAc-phosphotransferase. To date, over 100 different mutations have been identified in MLII α/β patients, but no large deletions have been reported. Here we present the first case of a large homozygous intragenic GNPTAB gene deletion (c.3435-386_3602 + 343del897) encompassing exon 19, identified in a ML II α/β patient. Long-range PCR and sequencing methodologies were used to refine the characterization of this rearrangement, leading to the identification of a 21 bp repetitive motif in introns 18 and 19. Further analysis revealed that both the 5' and 3' breakpoints were located within highly homologous Alu elements (Alu-Sz in intron 18 and Alu-Sq2, in intron 19), suggesting that this deletion has probably resulted from Alu-Alu unequal homologous recombination. RT-PCR methods were used to further evaluate the consequences of the alteration for the processing of the mutant pre mRNA GNPTAB, revealing the production of three abnormal transcripts: one without exon 19 (p.Lys1146_Trp1201del); another with an additional loss of exon 20 (p.Arg1145Serfs*2), and a third in which exon 19 was substituted by a pseudoexon inclusion consisting of a 62 bp fragment from intron 18 (p.Arg1145Serfs*16). Interestingly, this 62 bp fragment corresponds to the Alu-Sz element integrated in intron 18.This represents the first description of a large deletion identified in the GNPTAB gene and contributes to enrich the knowledge on the molecular mechanisms underlying causative mutations in ML II.This work was supported by FCT - project PIC/IC/83252/2007 (http://alfa.fct.mctes.pt/). Coutinho MF and Quental S received grants from the FCT (SFRH/BD/48103/2008; SFRH/BPD/64025/2009)

Digital relief generation from 3D models

It is difficult to extend image-based relief generation to high-relief generation, as the images contain insufficient height information. To generate reliefs from three-dimensional (3D) models, it is necessary to extract the height fields from the model, but this can only generate bas-reliefs. To overcome this problem, an efficient method is proposed to generate bas-reliefs and high-reliefs directly from 3D meshes. To produce relief features that are visually appropriate, the 3D meshes are first scaled. 3D unsharp masking is used to enhance the visual features in the 3D mesh, and average smoothing and Laplacian smoothing are implemented to achieve better smoothing results. A nonlinear variable scaling scheme is then employed to generate the final bas-reliefs and high-reliefs. Using the proposed method, relief models can be generated from arbitrary viewing positions with different gestures and combinations of multiple 3D models. The generated relief models can be printed by 3D printers. The proposed method provides a means of generating both high-reliefs and bas-reliefs in an efficient and effective way under the appropriate scaling factors

PELATIHAN PENULISAN ARTIKEL ILMIAH SEBAGAI UPAYA PENINGKATAN KOMPETENSI GURU

Berdasarkan Permenpan dan RB nomor 16 tentang Jabatan Fungsional Guru dan Angka Kreditnya, guru berkewajiban mempublikasikan karya ilmiah sebagai salah satu syarat pengajuan kenaikan pangkat. Pengabdian kepada masyarakat ini dengan tema pelatihan penulisan artikel ilmiah diangkat sebagai upaya untuk meningkatkan kompetensi guru menulis karya ilmiah dan mempublikasikannya pada jurnal ilmiah. Kegiatan ini dilaksanakan bekerjasama dengan guru SMP Negeri 2 Majene. Metode pelaksanaan pengabdian dilakukan dalam bentuk workshop, dimana pemateri menyajikan materi dan peserta workshop melakukan unjuk kerja mandiri dengan membuat artikel sesuai dengan template yang disediakan pemateri. Kelebihan dari template yang disediakan adalah template tersebut memuat banyak jenis cara untuk menuliskan bagian-bagian artikel sehingga guru-guru tidak perlu khawatir tentang potensi plagiarisme yang mungkin akan terjadi. Pelatihan penulisan artikel ilmiah yang dilaksanakan dapat meningkatkan pemahaman dan kemampuan peserta dalam menulis artikel ilmiah. Melalui serangkaian materi, peserta memperoleh pemahaman yang lebih mendalam mengenai struktur, gaya, dan teknik penulisan artikel ilmiah yang berkualita