The effect of Corona Anxiety on Academic Well-Being with Respect to the Mediating Role of Academic Hope

The spread of Corona disease and Corona anxiety has affected students' academic and educational lives by closing schools and rapidly changing teaching methods. The aim of this study was to investigate the relationship between Corona anxiety and students' academic well-being with respect to the mediating role of academic hope. The method of the present study was correlational method. The statistical population of the study was first and second high school students in Urmia. The research sample consisted of 400 people who were selected by the available sampling method. Research tools included method anxiety, academic well-being and academic hope, which were prepared online for students. SPSS and LISREL software were used for data analysis. The results showed that Corona anxiety affects students 'academic hope and academic well-being and academic hope has a mediating role between Corona anxiety and students' academic well-being. Based on the results, it is necessary for schools and the education system to take the necessary tools and counseling to improve coronary anxiety, academic well-being and students' academic hope after the end of Covid 19 disease and the reopening of schools

Study of three common ApoB gene mutations in possible familial hypercholesterolemia patients in Cheharmahal va Bakhtiari province, Iran, 2003

Background and aim: Familial hypercholesterolemia (FH) is an autosomal dominant disorder caused mainly by mutations in the low-density lipoprotein receptor (LDLR) and apolipoprotein B (ApoB).Until now, the molecular basis of FH has been demonstrated in detail in many populations , but there is still very limited molecular data concerning FH in Iran . The aim of this study was to investigate frequency of 3 common Apo-B100 gene mutations in an Iranian population. Method: In this descriptive –lab based study a total of 30 non-related possible FH subjects from Cheharmahal va Bakhtiari were studies. All samples were tested for 3 common Apo-B100 gene mutations including R3500Q, R3500W and R3531C using PCR-RFLP procedure. Result: None of the common Apo-B100 mutations R3500Q, R3500W and R3531C were detected in samples examined using PCR-RFLP. Conclusion: Our data indicated that Apo-B100 gene mutations have not contribution to FH in samples studied here. However, we examined 3 common Apo-B100 mutations in only 30 patients, and to determine the role of mutations of this gene in developing FH in Cheharmahal va Bakhtiari province, more FH samples/populations needed to be investigated

Study of LDL receptor gene mutations in patients with familial hypercholesterolemia in Chaharmahal va Bakhtiari province.

چکیده: زمینه و هدف: هایپرکلسترولمی فامیلی (FH) بیماری غالب اتوزومال است که عمدتاً بدلیل جهش در ژن گیرنده لیپوپروتئین با دانسیته کم (LDLR) ایجاد می شود. این مطالعه با هدف بررسی تغییرات ژن LDLR بیماران مبتلا به کلسترول بالای خانوادگی در استان چهارمحال و بختیاری انجام شد. روش بررسی: در این مطالعه توصیفی- آزمایشگاهی، 57 بیمار مشکوک به FH غربالگری و با استفاده از روش PCR-SSCP جهش در پروموتر و اگزون های 1، 3، 5، 11، 13، 15، 16، 17 و 18 ژن LDLR بررسی شد. یافته ها: در این مطالعه دو تغییر در ژن LDLR شناسایی شد، جهش هتروزیگوت 283T>A و پلی مورفیسم 1959T>C که به ترتیب در 1 و 9 فرد مبتلا به FH شناسایی گردید. نتیجه گیری: نتایج این تحقیق نشان داد نقش ژن LDLR در ایجاد FH در جمعیت مورد مطالعه ضعیف است و احتمالا ژن یا لوکوس های دیگری در ایجاد FH در این منطقه نقش دارن

dy of P53 gene mutations in promoter and exons 2-4 and 9-11 in patient with gastric cancer by PCR-SSCP in Chaharmahal Va Bakhtiari province

Background: Gastric cancer is one of the most important diseases and after lung cancer, is the second cause of cancer death worldwide. Genetic factors including oncogenes and tumor suppressor genes are always contributed in progression of this cancer. The P53 tumor suppressor gene has a broad role in genomic stability and DNA repair. The aim of this study was to determine the P53 gene mutations in gastric cancer specimens in Chaharmahal Va Bakhtiari Province. Methods: In this descriptive-lab based study, we investigated the promoter, exons 2-4 and 9-11 of P53 gene mutations in 38 paraffin embedded gastric cancer specimens. DNA was extracted following the standard phenol chloroform protocol. The P53 gene mutations were determined using PCR-SSCP procedure. Results: Our study revealed no P53 gene mutation in promoter and exons 2-4 and 9-11 in the gastric cancer subjects studied. Conclusion: While P53 gene mutations have been reported as the most frequent genetic alterations and are found in about 50% of the human malignancies, no mutation was detected in this study. The reason may be due to small sample size or mutations on other genes or epigenetic factors

Detection of mutations in exons 5-8 of the P53 gene in gastric cancer samples using PCR-SSCP in Chaharmahal va Bakhtiari province 2006-2007

زمینه و هدف: سرطان معده دومین سرطان شایع در جهان است. فاکتورهای ژنتیکی مانند انکوژن ها و ژن های سرکوبگر تومور، همواره از جمله مهمترین عوامل در بروز این سرطان هستند. ژن P53 یک ژن سرکوبگر تومور است و نقش بسیار مهمی در فرآیند مرگ برنامه ریزی شده سلول ایفا می کند. جهش در ژن P53 موجب از بین رفتن عملکرد محافظتی آن شده که یکی ازعوامل اصلی بروز سرطان معده در انسان است. این مطالعه با هدف بررسی جهش های ژن P53 در بیماران مبتلا به سرطان معده در استان چهارمحال و بختیاری انجام شده است. روش بررسی: در این مطالعه توصیفی آزمایشگاهی به بررسی جهش ها در اگزون های شماره 8-5 ژن P53 در 38 نمونه پارافینه سرطان معده پرداخته ایم. ابتدا DNA به روش استاندارد فنل کلروفرم استخراج شد، سپس با استفاده از تکنیک PCR-SSCP جهش های این ژن بررسی شدند. یافته ها: تفاوت های آشکاری در همه نمونه های کنترل مثبت مشاهده شد. با این وجود در سایر نمونه های مربوط به بیماران هیچ تفاوت و تغییری در حرکت باندها تشخیص داده نشد. نتیجه گیری: در استان چهارمحال و بختیاری ارتباط بین سرطان معده با جهش های ژن P53 بسیار ضعیف است. البته این مطالعه فقط بر روی 38 نمونه بیمار انجام شده و مطالعات بیشتری نیاز است تا ارتباط واقعی جهش بر روی ژن P53 با سرطان معده در این استان مشخص شود

DFNB59 Gene Mutation Screening Using PCR-SSCP/HA Technique in Non-syndromic Genetic Hearing Loss in Bushehr Province

Background: Hearing impairment (HI) is the most prevalent Neurosensory disorder which is heterogenous and can also occur due to environmental causes. The majority of hearing deficiencies are of genetic origin affecting about 60% of the HI cases. A novel gene DFNB59 encodes pejvakin has been recently shown to cause deafness. This study aims to determine the frequency of DFNB59 gene mutations in coding region the gene in Bushehr province. Methods: In this descriptive experimental study, we investigated the presence of DFNB59

Study of two common P53 gene mutations in gastric cancer using PCR-RFLP in Chaharmahal va Bakhtiari province, Iran, 2003

Background and aim: Gastric cancer is the most common cause of cancer death world wide after lung cancer. Genetic factors including oncogenes and tumor suppressor genes are always involved in progression of this cancer. The P53 tumor suppressor gene is believed to have a broad role in the cell such as programmed cell death and stop cell replicating damaged DNA which has been summarized as the guardian of the genome. This study aims to determine the frequency of two common P53 gene mutations using PCR-RFLP in gastric cancer in Chaharmahal va Bakhtiari province. Methods: This descriptive – lab based study describes the mutation analysis of paraffin embedded gastric samples from 38 patients in Chaharmahal va Bakhtiari province. We have investigated the frequency of P53 gene mutation in exons 7 and 8 by PCR-RFLP to detect alteration in two common hot spots in codon 248 and 282. Results: We determined no mutation in P53 gene hot spots in codon 248 and 282. Conclusion: We conclude that association of P53 gene mutations with gastric cancer is very low in Chaharmahal va Bakhtiari province. However we have examined only 38 gastric samples and more samples need to be investigated to reveal the contribution of P53 gene mutation in causing gastric cancer in this province. Also it is necessary to study the entire coding region and promoter of the gene in patients from different population and ethnic groups

Contribution à la commande tolérante aux défauts pour génératrices asynchrones hexaphasées

Les machines triphasés tant en mode générateur que moteur n’ont aucune capacité de continuité d’opération lors de l’ouverture d’une phase. En effet, avec un onduleur à point neutre isolé, les deux phases restantes sont dépendantes et forcent l’arrêt de la machine. A contrario, les machines multiphasées ont plus de trois phases et peuvent fonctionner lors de la perte de l’une d’entre elles sans trop de perte de capacité. Cependant, la puissance extraite est alors polluée par des harmoniques comme les variables du contrôle.L’objectif de cette thèse est de concevoir le contrôle d’un générateur hexaphasé asynchrone tant en mode sain qu’en défaut. L’idée de base tient en dix sous-systèmes de contrôle représentant l’ensemble des coupures de phases possibles jusqu’à trois. Ces systèmes sont conçus pour éliminer les oscillations sur la puissance. Ensuite, un algorithme de détection est introduit pour commuter entre les contrôleurs et s’adapter à la nouvelle situation en ligne. Cependant, une commutation brutale s’accompagne toujours d’un transitoire. Un système d’initialisation du nouveau contrôleur est proposé pour adoucir la transition. La stratégie globale est mise en œuvre et prouve les performances de la méthode sur une SC6PIG de 90WThree-phase induction machines are limited to operate in open-phase conditions in both motor and generator operating modes. Indeed, after losing one of the machine’s phases with an isolated neutral point, the two remaining phases cannot be controlled independently and the machine has to be stopped. Contrary to three-phase machines, the multiphase ones use more than three phase in the stator and thus they can operate even in phase missing conditions with a minimum de-rating. Nevertheless, for a multiphase generator, the extracted power from the machine is associated with oscillations due to the open-phase creation. In addition, the used variables in control system oscillate in these conditions as well. The goal of this thesis is therefore to design a general control system for a squirrel cage six-phase induction generator (SC6PIG) in both healthy and faulty operations. The general control system consists of ten sub control systems which are designed for all possible open-phase faults of the SC6PIG up to three-opened phases. They have been designed regarding the faulty model of the SC6PIG to eliminate the power oscillations in faulted mode. An open-phase detection and operating decider system have been introduced to switch a control system to a new one during the motion. It has been shown that the switching between two different control systems creates a transient voltage in switching instant. In order to minimize the transient voltages, on-line initial condition setting has been proposed for the ten control systems. The proposed strategy has been checked by simulation and experimentation tests on a SC6PIG rated at 90 W. They have confirmed the capacities of the proposed strateg

High Voltage Generators,

Abstract � high voltage synchronous generators known as powerformers, by changing stator configuration and their winding compared to conventional generator could generate fit voltage for connecting to transmission lines directly. Because of the innovation in their configuration and complication, fields and consequently reactances calculations would be so difficult by analytical formulas. In this article, numerical method based on finite element method has been used to calculate leakage, d axis and q axis reactances of a sample high voltage generator. Finally a comparison has been made between the results calculated by numerical analysis as well as analytical formulas. 1