Background: Hearing impairment (HI) is the most prevalent Neurosensory disorder which is
heterogenous and can also occur due to environmental causes. The majority of hearing
deficiencies are of genetic origin affecting about 60% of the HI cases. A novel gene DFNB59
encodes pejvakin has been recently shown to cause deafness. This study aims to determine
the frequency of DFNB59 gene mutations in coding region the gene in Bushehr province.
Methods: In this descriptive experimental study, we investigated the presence of DFNB59