Analiza regionalne osjetljivosti modela nastanka kelata primijenjenog u proizvodnji siderofora

Regional sensitivity analysis is a part of global sensitivity analysis methods. In this study, a multivariate sensitivity analysis was conducted on a qualitative-phenomenological model. Study results allowed us to pinpoint the most influential parameters. Moreover, important measures or ranking gave more insight into factors ordering according to their relative influence and permitted them to follow parameter sensitivities over time. Lastly, a confirmatory procedure using extensive parameter randomisation that covered a broad range of the parameters space allowed more insight into and certainty of each input parameters’ relative importance. This work is licensed under a Creative Commons Attribution 4.0 International License.Regionalna analiza osjetljivosti dio je metoda globalne analize osjetljivosti. U ovom je istraživanju provedena multivarijantna analiza osjetljivosti na kvalitativno-fenomenološkom modelu. Rezultati istraživanja omogućili su određivanje najutjecajnijih parametara. Dan je poredak čimbenika prema njihovu relativnom utjecaju na parametre i omogućeno praćenje osjetljivosti parametara tijekom vremena. Konačna potvrda važnosti ulaznih parametara modela dobivena je nasumičnim odabirom u širokom rasponu njihovih vrijednosti. Ovo djelo je dano na korištenje pod licencom Creative Commons Imenovanje 4.0 međunarodna

Bayoud disease of date palm in Algeria: History, epidemiology and integrated disease management

The bayoud is transmitted by the fungus Fusarium oxysporum f. sp. albedinis, which causes drying and rapid die back. To date, the disease has destroyed more than 12 million date palms in Morocco, or two-thirds of the producers of the best dates trees in this country, and three million of palm trees in Algeria with the threat of the spread of this disease to oasis southeast of Algeria. The research on this disease is very few in Algeria, in this case, this work had objective to study the growth and spread of the disease bayoud on the Algerian palm. is based on the observation of symptoms on palms, it showed that all regions with palm in Bechar (Saoura) and in Adrar (Touat), affected with some palm of Ghardaïa. Prophylactic measures are taken to protect and preserve our date resources (including 'Deglet Nour') in free palm (Zibans and Oued Righ in southeast of Algeria) by improving irrigation methods and the use of free releases, and determination date palm cultivars resistant to the fungus as Takarboucht in oasis of Ghardaïa and Adrar, Hmira and Hartan for Bechar’s date palms.Keywords: Date palm, bayoud disease, saoura, resistance, IPM

Predictive factors for the progression of early inflammatory arthritis to rheumatoid arthritis

Objective: To identify factors predicting the progression of Early Inflammatory Arthritis (EIA) to Rheumatoid Arthritis (RA). Design: This was a prospective longitudinal study. Methods: Inflammatory rheumatism that could not be classified according to defined rheumatism criteria. Demographic, biological, immunological and radiographic data were collected at the time of inclusion in the study. Disease activity as determined by the Disease Activity Score 28-CPR (DAS28- CPR: 4 variables), functional handicap as calculated by Heath Assessment Score (HAQ), and bone and joint damage as evaluated by Sharp-Van der Heijde (SVDH) score. Ultrasound joint imaging were evaluated at the beginning of the study and then 1 year later. Logistic regression was performed to identify predictive factors for progression to RA. Results: One hundred and seventy two patients were included (24 men, 148 women), with a mean age 43.13±14.07 years and a mean time to  diagnosis 10.24±6.84 months. The mean ESR was 46.81±31.16 mm/1st hour, and the mean CRP level was 22.84±39.8 mg/l. Rheumatoid Factors (RFs) and Anti-Citrullinated Protein Antibodies (ACPAs) were present in 48.8% and 53% of patients, respectively. The erosion, joint space narrowing, and total SVDH scores were 3.38±3.48, 5.08±3.32, and 5.95±4.94, respectively. One hundred and sixty one patients were followed up for 12 months. Multivariate regression analysis showed that a DAS28-CRP level >5.2 (OR=28.6; CI 95% 8.7-94.5), an RF level >60 IU/L (OR=11.2; CI 95% 4.3-87.5), and an ACPA level >60 IU/L (OR=5.4; CI 95% 1.9-15.3) were predictive for progression to RA. Conclusion: Our study suggests that clinical evaluation of EIA by DAS28- CRP from the time of diagnosis, as well as evaluating the presence of RA autoantibodies, can predict progression to RA. Key words: Early inflammatory arthritis, Rheumatoid arthritis, Predictive factor