Oral Myxoma in a Steer

Background: Myxoma is a benign neoplasm of mesenchymal cells producing a myxomatous matrix rich in mucopolysaccharides. This tumor occasionally has been described in older dogs and cats, and rarely occurs in other species. In ruminants myxomas can be found in the rumen and omasum, but there are no reports of these neoplasms involving the oral cavity of cattle. Only one case of myxoma was diagnosed in a 40-year study of 606 neoplasms in cattle in South Africa. Similar retrospective studies done in cattle from southern and northeastern Brazil also detected a single case of cutaneous myxoma. The current study reports the clinical and pathological findings of a rare occurrence of bovine oral myxoma.Case: A 22-month-old male crossbreed steer (Bosindicus) from the municipality of Rio Verde, GO (17°44′42″S 50°55′00″W), Brazil, presented a history of sialorrhea. There is no another affected animal in the herd. Clinical evaluation revealed mild swelling in the lower incisive gum. Treatment with flumetasone IM for three consecutive days was performed. Two months after this procedure, there was a considerable increase in the size to a flat, firm mass of 16x13x9 cm. Other clinical signs included emaciation and severe difficulty in feeding and drinking water. After surgical excision, fragments of the tumor were collected for histopathology. There is no local recurrence within approximately one year of the surgery. Microscopically, the lamina propria was found to be expanded and replaced by a nonencapsulated, moderately cellular, poorly demarcated, neoplastic proliferation. The lesion was composed of numerous loosely arranged bundles of cells in an abundant myxoid matrix. The bulk of the tumor parenchyma was formed by spindle or stellate cells with poorly demarcated borders and scant, eosinophilic cytoplasm. The nuclei were oval and hyperchromatic. Mild anisocytosis and anisokaryosis were present, along with rare mitotic figures. The myxoid matrix presented strong positive labeling to mucin by the Alcian blue staining. Based on the anatomopathological and histochemical findings, a diagnosis of myxoma was established.Discussion: Neoplasms of connective tissue originate from poorly differentiated fibroblasts and can produce collagenous (fibroma/fibrosarcoma) or mucinous (myxoma/myxosarcoma) stroma. In some cases, it is difficult to establish a histopathological classification and to distinguish between benign and malignant neoplasms, for which assessment of cell morphology, mitotic index, and biologic behavior are required. Very few cases of myxoma have been previously reported in cattle, this neoplasm and it was never diagnosed in the oral cavity of this species. Thre majority of neoplasms diagnosed in the oral cavity of cattle are squamous cell carcinomas and papillomas, although sporadic cases of lingual fibroma, lingual mastocytoma, odontoma and ameloblastic fibroma have been described. In the current case, the steer presented weight loss and difficulty in feeding and drinking water, probably due to the large volume of the neoplasm. Similar clinical signs can occur in cattle affected by other types of large neoplasms in the oral cavity. After surgical excision, the animal of the current report presented general improvement and considerable weight gain. The myxoma-related pathologic findings observed in the present case are similar to those described in other studies. Because myxoma is considered an infiltrative neoplasm, postoperative recurrence can occur; however, this was not noted in the current case and reports of myxoma in other species. The main differential diagnosis for myxoma is fibroma; the presence of mucin (Alcian blue positive) in the intercellular matrix as seen in the current case confirms the diagnosis of myxoma

Caderno de histologia: texto e atlas

Esta obra é mérito do trabalho conjunto de professores e monitores da disciplina Histologia, do Departamento de Morfologia da UFRN, e surge como um recurso didático com o objetivo de enriquecer o estudo prático do aluno durante as aulas de Histologia e nos momentos extraclasse, servindo como um guia para orientar e direcionar os fundamentos teóricos aplicados às atividades práticas

Síndrome de Prune Belly em paciente escolar: relato de caso

Prune Belly Syndrome (SPB) is a rare congenital disease (1: 40,000 live births) characterized by a triad of anomalies: absence, deficiency or hypoplasia of the abdominal wall, bilateral cryptorchidism, and urinary tract abnormalities. The diagnosis can be made even during prenatal care; however, it has a high perinatal mortality rate. Thus, the present study aimed to describe a case report about SPB in a school patient. VSSB, male, diagnosed with SPB. 2nd trimester US showed a polyhydramnio fetus with morphological alterations. At 38 weeks of gestation, cesarean section was performed due to evidence of severe oligoamnion and fetal malformation. At birth, plum abdomen and bilateral cryptorchidism were observed, suggesting SPB; Diagnostic suspicion was confirmed on the 13th day of life. The patient followed up with a multidisciplinary team. Due to the clinical condition, she required several hospitalizations throughout her life, dying in the last, at 7 years and 11 months. Therefore, it is undoubted to report the importance of quality prenatal care in the early diagnosis of congenital diseases and multidisciplinary follow-up. In addition, the longitudinality and comprehensiveness of care are crucial for increasing quality patient survival. Keywords: Syndrome. Prune Belly. Case reports.A síndrome de Prune Belly (SPB) é uma doença congênita rara (1:40.000 nascidos vivos) caracterizada por uma tríade de anomalias: ausência, deficiência ou hipoplasia da parede abdominal, criptorquidia bilateral e anormalidades do trato urinário. O diagnóstico pode ser realizado ainda no pré-natal, todavia, apresenta alta taxa de mortalidade perinatal. Assim, o presente estudo objetivou descrever um relato de caso sobre SPB em paciente escolar. VSSB, sexo masculino, diagnosticado com SPB. USG de 2º trimestre evidenciou feto polidrâmnio com alterações morfológicas. Com 38 semanas de gestação foi realizado parto cesáreo por evidência de oligoâmnio severo e má formação fetal. Ao nascimento, foi observado abdome em ameixa e criptorquidia bilateral, sugerindo SPB; a suspeita diagnóstica foi confirmada no 13º dia de vida. O paciente seguiu acompanhamento por equipe multiprofissional. Pelo quadro clínico, necessitou de várias internações ao longo da vida, falecendo na última, com 7 anos e 11 meses. Por conseguinte, é indubitável relatar a importância do pré-natal de qualidade no diagnóstico precoce das doenças congênitas e do acompanhamento multiprofissional. Ademais, a longitudinalidade e integralidade do cuidado se mostram como cruciais no aumento da sobrevida do paciente com qualidade. Palavras-chave: Síndrome. Prune Belly. Relatos de casos

Wild dogs at stake: deforestation threatens the only Amazon endemic canid, the short-eared dog (Atelocynus microtis)

The persistent high deforestation rate and fragmentation of the Amazon forests are the main threats to their biodiversity. To anticipate and mitigate these threats, it is important to understand and predict how species respond to the rapidly changing landscape. The short-eared dog Atelocynus microtis is the only Amazon-endemic canid and one of the most understudied wild dogs worldwide. We investigated short-eared dog habitat associations on two spatial scales. First, we used the largest record database ever compiled for short-eared dogs in combination with species distribution models to map species habitat suitability, estimate its distribution range and predict shifts in species distribution in response to predicted deforestation across the entire Amazon (regional scale). Second, we used systematic camera trap surveys and occupancy models to investigate how forest cover and forest fragmentation affect the space use of this species in the Southern Brazilian Amazon (local scale). Species distribution models suggested that the short-eared dog potentially occurs over an extensive and continuous area, through most of the Amazon region south of the Amazon River. However, approximately 30% of the short-eared dog's current distribution is expected to be lost or suffer sharp declines in habitat suitability by 2027 (within three generations) due to forest loss. This proportion might reach 40% of the species distribution in unprotected areas and exceed 60% in some interfluves (i.e. portions of land separated by large rivers) of the Amazon basin. Our local-scale analysis indicated that the presence of forest positively affected short-eared dog space use, while the density of forest edges had a negative effect. Beyond shedding light on the ecology of the short-eared dog and refining its distribution range, our results stress that forest loss poses a serious threat to the conservation of the species in a short time frame. Hence, we propose a re-assessment of the short-eared dog's current IUCN Red List status (Near Threatened) based on findings presented here. Our study exemplifies how data can be integrated across sources and modelling procedures to improve our knowledge of relatively understudied species

ANÁLISE DO USO DO SLEEVE GÁSTRICO NO TRATAMENTO DA OBESIDADE MÓRBIDA

The present study aims to analyze the effectiveness and safety of Sleeve Gastrectomy as a surgical technique for treating morbid obesity, comparing its outcomes with other bariatric methods and evaluating its impact on patients' quality of life. This research utilized a comprehensive literature review, encompassing studies published between 2000 and 2024 in English, Portuguese, and Spanish. Databases such as PubMed, Google Scholar, SciELO, as well as specialized scientific journals and academic repositories were consulted. The results indicate that Sleeve Gastrectomy is an effective technique for weight loss, showing outcomes comparable to other bariatric surgeries such as Roux-en-Y Gastric Bypass. Literature analysis revealed that Sleeve Gastrectomy provides significant short-term and long-term weight loss with lower incidence of postoperative complications compared to other techniques. Furthermore, patients' quality of life improved considerably after surgery, covering physical, psychological, and social aspects. It is concluded that Sleeve Gastrectomy is a viable and safe surgical option for treating morbid obesity, offering significant advantages in terms of weight loss and patient quality of life. However, further long-term studies are needed to fully compare this technique with other bariatric treatment modalities and assess the maintenance of weight loss and improvement of associated comorbidities.O presente estudo visa analisar a eficácia e a segurança do Sleeve Gástrico como técnica cirúrgica no tratamento da obesidade mórbida, comparando seus resultados com outros métodos bariátricos e avaliando seu impacto na qualidade de vida dos pacientes. Esta pesquisa utilizou uma revisão da literatura abrangente, incluindo estudos publicados entre 2000 e 2024 em inglês, português e espanhol. Foram consultadas bases de dados como PubMed, Google Acadêmico, SciELO, além de revistas científicas especializadas e repositórios acadêmicos. Os resultados indicam que o Sleeve Gástrico é uma técnica eficaz para a perda de peso, apresentando resultados comparáveis a outras cirurgias bariátricas como o Bypass Gástrico em Y de Roux. A análise da literatura revelou que o Sleeve Gástrico proporciona uma perda de peso significativa a curto e longo prazo, com menor incidência de complicações pós-operatórias em comparação com outras técnicas. Além disso, a qualidade de vida dos pacientes melhorou consideravelmente após a cirurgia, abrangendo aspectos físicos, psicológicos e sociais. Conclui-se que o Sleeve Gástrico é uma opção cirúrgica viável e segura para o tratamento da obesidade mórbida, oferecendo vantagens significativas em termos de perda de peso e qualidade de vida dos pacientes. No entanto, é necessário mais estudo de longo prazo para comparar plenamente esta técnica com outras modalidades de tratamento bariátrico e avaliar a manutenção da perda de peso e a melhoria das comorbidades associadas

Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): Study protocol for a randomized controlled trial

Background: Acute respiratory distress syndrome (ARDS) is associated with high in-hospital mortality. Alveolar recruitment followed by ventilation at optimal titrated PEEP may reduce ventilator-induced lung injury and improve oxygenation in patients with ARDS, but the effects on mortality and other clinical outcomes remain unknown. This article reports the rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART). Methods/Design: ART is a pragmatic, multicenter, randomized (concealed), controlled trial, which aims to determine if maximum stepwise alveolar recruitment associated with PEEP titration is able to increase 28-day survival in patients with ARDS compared to conventional treatment (ARDSNet strategy). We will enroll adult patients with ARDS of less than 72 h duration. The intervention group will receive an alveolar recruitment maneuver, with stepwise increases of PEEP achieving 45 cmH(2)O and peak pressure of 60 cmH2O, followed by ventilation with optimal PEEP titrated according to the static compliance of the respiratory system. In the control group, mechanical ventilation will follow a conventional protocol (ARDSNet). In both groups, we will use controlled volume mode with low tidal volumes (4 to 6 mL/kg of predicted body weight) and targeting plateau pressure <= 30 cmH2O. The primary outcome is 28-day survival, and the secondary outcomes are: length of ICU stay; length of hospital stay; pneumothorax requiring chest tube during first 7 days; barotrauma during first 7 days; mechanical ventilation-free days from days 1 to 28; ICU, in-hospital, and 6-month survival. ART is an event-guided trial planned to last until 520 events (deaths within 28 days) are observed. These events allow detection of a hazard ratio of 0.75, with 90% power and two-tailed type I error of 5%. All analysis will follow the intention-to-treat principle. Discussion: If the ART strategy with maximum recruitment and PEEP titration improves 28-day survival, this will represent a notable advance to the care of ARDS patients. Conversely, if the ART strategy is similar or inferior to the current evidence-based strategy (ARDSNet), this should also change current practice as many institutions routinely employ recruitment maneuvers and set PEEP levels according to some titration method.Hospital do Coracao (HCor) as part of the Program 'Hospitais de Excelencia a Servico do SUS (PROADI-SUS)'Brazilian Ministry of Healt

Uso das Tecnologias de Informação e Comunicação no Curso de Medicina da UFRN

RESUMO Está claro na literatura que as Tecnologias de Informação e Comunicação (TICs) oferecem um ambiente acadêmico virtual que melhora a interação entre docentes e alunos. Baseado nisto, nosso trabalho descreveu de que modo o estudante de Medicina da Universidade Federal do Rio Grande do Norte utiliza as TICs. Também investigou quais dessas ferramentas são utilizadas e a interferência da língua inglesa emseu uso. Esta pesquisa éum estudo descritivo de delineamento transversal, cujo instrumento de coleta de dados foi um questionário autoaplicável, padronizado e anônimo.Ao final do estudo, obteve-se uma taxa geral de respostas de 82% (n = 489). Verificou-se que as redes sociais são utilizadas por quase a totalidade dos estudantes (97,3%), que há um uso mais frequente de artigos científicos para o aprendizado ao longo dos períodos e que o uso majoritário da língua inglesa nessas ferramentas não constitui uma barreira para a maior parte da amostra (72%)

Prevalência para tuberculose caprina no semi-árido paraibano Prevalence for caprine tuberculosis in semi-arid of Paraíba

A tuberculose é uma enfermidade infecciosa, de distribuição mundial, provocada por micobactérias patogênicas, que afeta o homem e diversas espécies de mamíferos. Visando determinar a prevalência da Tuberculose Caprina e identificar fatores de risco associados à infecção foram tuberculinizados, através do Teste Tuberculínico Comparado (TCC), 1.866 caprinos de diferentes raças e idades, oriundas de 84 propriedades localizadas na microrregião de Monteiro, Estado da Paraíba, Brasil. A interpretação do TCC foi aferida pelo cálculo da diferença obtida entre as cutimetrias correspondentes às respectivas tuberculinas, antes e 72 horas após a inoculação: negativa, quando PPD bovina for menor que a aviária ou maior em até 1,8mm; suspeita ou inconclusiva, reação à PPD bovina maior que a aviária entre 1,9 e 2,4mm; positiva, reação à PPD bovina maior ou igual a aviária em 2,5mm. Das cabras submetidas ao TCC, 0,47% (9/1866), reagiram positivamente (IC 95% = 0,23-0,94%). A prevalência de propriedades positivas para a Tuberculose Caprina foi de 10,71% (IC 95% = 5,02-19,37%). Quando submetido à necropsia e exame histopatológico, um caprino positivo ao teste tuberculínico apresentou lesões compatíveis com tuberculose; também foi detectada a presença de Bacilos Álcool Ácidos Resistentes (BAAR) através da bacterioscopia direta; em relação ao tamanho do rebanho, as propriedades que possuíam um número maior de animais ( >25), apresentaram maior ocorrência da doença e a presença de infecção foi evidenciada nas propriedades que criavam bovinos em associação com caprinos e que não realizavam testes tuberculínicos nos bovinos.Tuberculosis is an infectious disease of world wide distribution caused by pathogenic mycobacteria that affect humans and several mammals species. In order to determine the prevalence of tuberculosis in goats and to identify risk factors associated with infection, 1,866 goats of different breeds and ages from 84 herds in the microregion of Monteiro, State of Paraíba, Northeast Brazil, were tuberculinized by the Comparative Cervical Test (CCT). Interpretation of the CCT was checked by calculation of the difference obtained between skin measures correspondent to respective tuberculins, before and 72 hours after inoculation: negative, when bovine PPD is smaller than avian PPD or larger in up to 1.8mm; suspicious or inconclusive, reaction to bovine PPD larger than avian PPD between 1.9 and 2.4mm; positive, reaction to bovine PPD larger than or equal to avian PPD in 2.5mm. From goats submitted to CCT, 0.47% (9/1866) reacted positively (95% CI = 0.23%-0.94%). The prevalence of positive herds to caprine tuberculosis was 10.71% (95% CI = 5.02-19.37%). When submitted to necropsy and histopathologic examination, a positive goat at tuberculin test presented tuberculosis-like lesions. The presence of Acid-Alcohol Resistant Bacilli (BAAR) was also detected by direct bacterioscopy; in relation to herd size, herds with larger number of animals ( >25) with high incidence of the disease, and presence of the infection was evidenced in properties that raised cattle in association with goats and did not carry out tuberculin tests in cattle