Examining Effective Teaching Practices in Higher Education

Contingent faculty represent the largest instructional group in higher education today yet few receive any andragogic training prior to teaching. Does this impact their effectiveness in the classroom

Immunohistochemistry in pre-invasive vulvar lesions: observations, concerns and an algorithmic approach

The aim of the study was to investigate the presence of immunohistochemical markers p16, p53 and Ki67 and their diagnostic and prognostic value in women with pre-invasive vulvar lesions such as vulvar high-grade squamous intraepithelial lesions (VHSIL) and differentiated vulvar intraepithelial neoplasia (dVIN). Materials and methods. The results of immunohistochemical (IHC) examination of samples obtained from 253 women diagnosed with HSIL or dVIN who asked for medical care at the National Cancer Institute (Kyiv, Ukraine) in 2017-2023 were analysed. 155 of all women examined were diagnosed with dVIN and 98 with VHSIL. All patients underwent a vulvar biopsy. Histological typing of biopsy samples was performed using routine haematoxylin and eosin staining and immunohistochemical (IHC) examination. The IHC study was performed using monoclonal mouse antibody p16 (Monoclonal Mouse Antibody p16 (Mob575-01)) using the Thermo scientific PA1-16662 system, monoclonal mouse antibody Ki-67 (Monoclonal Mouse Anti-Human Ki-67 Antigen Clone MIB-1 (Dako IR-626)) and monoclonal mouse antibody p53 (Monoclonal Mouse Anti-Human p53 Protein Clone DO-7 (Dako IS-616)) using the EnVisionTM FLEX detection system (Dako, Denmark). Results.The average age of patients with dVIN was 58.26±10.17 years old, and the average age of patients with VHSIL was 39.65±10.22 years old. According to the results of the study, all patients with VHSIL (n=98) had positive staining for Ki67 in the middle and upper epithelial sections, and only 72% (n=71) - for p16. Staining for p53 was negative in all cases. That is, 28% (n=27) of the patients with VHSIL  were negative for p16 and positive for Ki67. p53 staining showed the presence of a "wild-type" variant in 65 patients with dVIN (42%) and a "mutant" variant in 90 women (58%). None of the patients showed positive staining for p16. As for VHSIL, the Ki67 marker was detected in 100% of cases and in all situations in the middle and upper parts of the epithelium, while with dVIN patients, such staining was observed in only 45 women (29%). Conclusions. The determination of IHC markers p16, p53 and Ki67 allows to distinguish dVIN from VHSIL, especially in difficult diagnostic cases. In addition, the presence of mutant p53 indicates the possibility of rapid progression to cancer and requires immediate and more aggressive treatment and follow-up

Bridging Pedagogy and Practice: From Coursework to Field Experiences in a Teacher Preparation Program

In this study, two teacher educators, one special education faculty and one mathematics education faculty, examined ways to infuse educational theory into their practice to develop preservice teachers’ ability to meet the demands of the 21st century classroom. The study took place at an urban university in the southeastern United States where the teacher education program prepares future educators for the most diverse classroom settings existing in U.S. public schools today. Results informed the teacher educators of relevant challenges preservice teachers experience with regard to instructional design that addresses the needs of diverse learners. The action research study took place over a 3-semester period during which time the teacher educators learned how structured supports enhanced their students’ abilities to develop effective instruction for diverse learners. ______________________________________________________________ Authors’ note: For the purpose of this study, diverse learners are defined as (a) students with disabilities, (b) Culturally Diverse/English Language Learners, (c) gifted (accelerated) learners, and (d) students with instructional disabilities

Effects of acute and sub-chronic ammonium nitrate exposure on rat liver and blood tissues

Use of fertilizers like ammonium nitrate (NH4NO3) for agricultural purposes has increasingly contaminated the ecosystem with nitrate and/or nitrites. Nitrite is a toxic substance that can cause multiple physiological effects if allowed to build up to high concentrations in animals such as methemoglobinemia. This work is concerned with the study of short term (3 days intoxication) and midterm (over 21 days) NH4NO3 exposure to wistar rats at the dose of 250 mg/Kg. Under these conditions, some hematological and biochemical parameters were affected. Methemoglobinemia, increase in serum nitrates as well as a hepatic cytotoxicity indicated by an increase in bilirubin and transaminases levels were observed

Pengaruh Terapi Musik Klasik Terhadap Tingkat Kecemasan Pada Pasien Hemodialisa Di RS PKU Muhammadiyah Surakarta

Hemodialisa merupakan suatu proses yang digunakan pada pasien dalam keadaan sakit akut dan memerlukan terapi dialisis jangka pendek atau pasien dengan penyakit ginjal stadium akhir. Data yang didapat dari Rumah Sakit PKU Muhammadiyah Surakarta didapat jumlah tindakan program terapi hemodialisa dalam kurung waktu 1 tahun ini (Oktober 2012-Oktober 2013) adalah 472 tindakan hemodialisa, pada bulan Februari 2014 sendiri sebanyak 43 pasien. Mengatasi kecemasan pada pasien hemodialisa ini, perawat perlu memberikan terapi yaitu terapi relaksasi, yang salah satunya dengan menggunakan musik klasik. Musik klasik adalah sebuah terapi kesehatan yang menggunakan musik dimana tujuannya adalah untuk meningkatkan atau memperbaiki kondisi fisik, emosi, kognitif, dan sosial bagi individu dari berbagai kalangan usia. Tujuan penelitian ini adalah untuk mengetahui adakah pengaruh pemberian terapi musik klasik terhadap tingkat kecemasan pasien hemodialisa di Rumah Sakit PKU Muhammadiyah Surakarta. Jenis penelitian ini menggunakan penelitian Quasi eksperimental dengan rancangan penelitian Nonequivalent control group design. Populasi penelitian adalah semua pasien yang menjalani program terapi hemodialisa di RS PKU Muhammadiyah Surakarta yang berjumlah 43 pasien, dan untuk sampel penelitian yaitu 30 responden untuk kedua kelompok, penelitian ini menggunakan teknik sampling accidental sampling. Instrument penelitian berupa Hamilton Rating Scale-Anxeity (HRS-A). Analisis data hasil penelitian menggunakan uji Independent T-Test dan Paired T-Test. Kesimpulan dalam penelitian ini yaitu terdapat pengaruh pemberian terapi musik klasik terhadap tingkat kecemasan pasien hemodialisa di Rumah Sakit PKU Muhammadiyah Surakarta

Hubungan Kualitas Pelayanan Dengan Kepuasan Pasien Rawat Inap Di RSUD Dr. Sayidiman Magetan

Background: The service quality refers to the difference between hope and the fact received by the customers from the service providers. Satisfaction means disappointments or pleasure that someone experienced after comparing the result of a product or perception of performance with hopes. Recent study by Yeni in 2012 about health service quality and hospitalized patient in Sultan Daeng Radja obtained 58,1% respondents weren’t satisfied with comfort they got. Dr. sayidiman general hospital of Magetan always tries their best to improve the service quality in order to achieve the target. The hospital effort to improve the service quality was increasing the specialist number, expansion of hospital buildings, and give some more service facilities. The purpose of this research is to know the association between quality of service with satisfaction of hospitalized patient in dr. Sayidiman General Hospital of Magetan. Methods: This study design was observational analytic with cross sectional method that define the connection between two variables, independent variable (quality of service) and dependent variable (patient satisfaction). The respondents of this study were hospitalized patient in the dr. Sayidiman General Hospital of Magetan taken with accidental sampling method. Total samples were 100 respondents. Data then analyzed with chi-square analysis test. Results: This research conducted with chi-square between service quality variables with patient satisfaction, with the result p < 0,0001. Conclusion: There is significancy relationship of service quality to satisfaction of hospitalized patient in dr. Sayidiman General Hospital of Mageta

Hubungan Antara Pengetahuan Ibu Tentang Diare Dengan Kejadian Diare Pada Balita Usia 2-5 Tahun di Wilayah Kerja Puskesmas Kecamatan Karanganyar Kabupaten Karanganyar

Latar belakang: Apabila balita terserang diare maka tindakan-tindakan yang ibu ambil akan menentukan perjalanan penyakitnya. Tindakan tersebut dipengaruhi berbagai hal, salah satunya adalah pengetahuan. Penyakit diare merupakan penyebab kedua kematian pada anak dibawah lima tahun terutama di Negara berkembang. Sebanyak 1,8 juta orang meninggal setiap tahun karena penyakit diare, 90% adalah anak usia di bawah lima tahun. Dalam urutan penyebab kunjungan puskesmas atau balai pengobatan, diare hampir selalu termasuk dalam kelompok tiga penyebab utama ke puskesmas. Metode: Penelitian ini adalah penelitian observasional analitik dengan pendekatan cross-sectional untuk mengetahui hubungan pengetahuan ibu tentang diare dengan kejadian diare pada balita usia 2-5 tahun. Pengumpulan data dengan menggunakan kuesioner pengetahuan tentang diare, analisis data menggunakan Kolmogorov-Smirnov. Jumlah sampel sebanyak 100 responden. Hasil: Tingkat pengetahuan ibu dibagi menjadi tiga kelompok yaitu, pengetahuan baik 53 orang (53%), pengetahuan cukup 41 orang (41%), dan pengetahuan kurang 6 orang (6%). Dari hasil penelitian, ibu dengan pengetahuan baik (53 orang) sebanyak 18 anak diare dan 35 anak tidak diare. Ibu dengan pengetahuan cukup (41 orang), didapatkan 29 anak diare dan 12 anak tidak diare. Ibu dengan pengetahuan kurang (6 orang) didapatkan 5 anak diare dan 1 anak tidak diare. Hasil analisis didapatkan nilai p = 0,001. Kesimpulan: Terdapat hubungan pengetahuan ibu tentang diare dengan kejadian diare pada balita usia 2-5 tahun di wilayah kerja Puskesmas Kecamatan Karanganyar Kabupaten Karanganyar

Human immunodeficiency virus rebound after suppression to < 400 copies/mL during initial highly active antiretroviral therapy regimens, according to prior nucleoside experience and duration of suppression

This study evaluated 1433 human immunodeficiency virus (HIV)-infected patients starting highly active antiretroviral therapy (HAART), 409 (28%) of whom had prior nucleoside experience and achieved an HIV load of <400 copies/mL by 24 weeks of therapy. Three hundred seven patients experienced virus rebound during a total of 2773.3 person-years of follow-up. There was a higher rate of virus rebound among the patients with pre-HAART nucleoside experience (relative hazard [RH], 2.86; 95% confidence interval, 2.22-3.84; P < .0001) and a decreasing rate of virus rebound with increasing duration of virus suppression (i.e., time since achieving a virus load of <400 HIV RNA copies/mL) among both the nucleoside-experienced and naive patients (P < .0001), but the difference between the groups persisted into the third year of follow-up (P = .0007). Even patients who had experienced <2 months of nucleoside therapy before beginning HAART had an increased risk of virus rebound (RH, 1.95; P = .009). It appears that only a small period of pre-HAART nucleoside therapy is sufficient to confer a disadvantage, in terms of risk of virus rebound, that persists for several years

Hubungan Status Gizi Dengan Kejadian Diare pada Balita Usia 2-5 Tahun di Wilayah Kerja Puskesmas Kecamatan Karanganyar Kabupaten Karanganyar

Latar belakang: Tiap tahunnya diare menjadi salah satu penyakit yang menyebabkan malnutrisi dan mortalitas pada anak, sehingga menjadikan anak mengalami gangguan tumbuh kembang. Secara global setiap tahunnya ada sekitar 2 miliar kasus diare dengan angka kematian 1,5 juta pertahun. Pada negara berkembang, anak-anak usia dibawah 3 tahun rata-rata mengalami 3 episode diare pertahun. Berdasarkan Survei Kesehatan Rumah Tangga (SKRT), Studi Mortalitas dan Riset Kesehatan Dasar dari tahun ke tahun diketahui bahwa diare masih menjadi penyebab utama kematian balita di Indonesia. Metode: Penelitian ini menggunakan metode analitik observasional dengan pendekatan cross-sectional untuk mengetahui hubungan antara status gizi dengan kejadian diare pada balita usia 2-5 tahun. Jumlah sampel sebanyak 100 responden. Pengumpulan data dengan menggunakan kuesioner diare, penimbangan berat badan, dan pengukuran tinggi badan. Analisis data menggunakan Chi square. Hasil: Status gizi pada balita dibagi menjadi 2 kelompok, yaitu baik dan tidak baik. Sebanyak 72 balita memiliki gizi baik, 58% dari balita yang memiliki gizi baik menderita diare, dan 42% dari balita tersebut tidak diare. Balita dengan gizi tidak baik sebanyak 28 balita, dimana sebanyak 36% menderita diare, dan 64% tidak diare. Hasil analisis didapatkan nilai p = 0,042. Kesimpulan: Tidak terdapat hubungan antara status gizi dengan kejadian diare pada balita usia 2-5 tahun di wilayah kerja Puskesmas Kecamatan Karanganyar Kabupaten Karanganyar