311 research outputs found

    Children must be protected from the tobacco industry's marketing tactics.

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    Search for the doubly heavy baryon Ξbc+\it{\Xi}_{bc}^{+} decaying to J/ψΞc+J/\it{\psi} \it{\Xi}_{c}^{+}

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    A first search for the Ξbc+J/ψΞc+\it{\Xi}_{bc}^{+}\to J/\it{\psi}\it{\Xi}_{c}^{+} decay is performed by the LHCb experiment with a data sample of proton-proton collisions, corresponding to an integrated luminosity of 9fb19\,\mathrm{fb}^{-1} recorded at centre-of-mass energies of 7, 8, and 13TeV13\mathrm{\,Te\kern -0.1em V}. Two peaking structures are seen with a local (global) significance of 4.3(2.8)4.3\,(2.8) and 4.1(2.4)4.1\,(2.4) standard deviations at masses of 6571MeV ⁣/c26571\,\mathrm{Me\kern -0.1em V\!/}c^2 and 6694MeV ⁣/c26694\,\mathrm{Me\kern -0.1em V\!/}c^2, respectively. Upper limits are set on the Ξbc+\it{\Xi}_{bc}^{+} baryon production cross-section times the branching fraction relative to that of the Bc+J/ψDs+B_{c}^{+}\to J/\it{\psi} D_{s}^{+} decay at centre-of-mass energies of 8 and 13TeV13\mathrm{\,Te\kern -0.1em V}, in the Ξbc+\it{\Xi}_{bc}^{+} and in the Bc+B_{c}^{+} rapidity and transverse-momentum ranges from 2.0 to 4.5 and 0 to 20GeV ⁣/c20\,\mathrm{Ge\kern -0.1em V\!/}c, respectively. Upper limits are presented as a function of the Ξbc+\it{\Xi}_{bc}^{+} mass and lifetime.Comment: All figures and tables, along with machine-readable versions and any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-005.html (LHCb public pages

    Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status

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    Abstract: Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare inflammatory disease of unknown cause. 30% of patients have anti-neutrophil cytoplasmic antibodies (ANCA) specific for myeloperoxidase (MPO). Here, we describe a genome-wide association study in 676 EGPA cases and 6809 controls, that identifies 4 EGPA-associated loci through conventional case-control analysis, and 4 additional associations through a conditional false discovery rate approach. Many variants are also associated with asthma and six are associated with eosinophil count in the general population. Through Mendelian randomisation, we show that a primary tendency to eosinophilia contributes to EGPA susceptibility. Stratification by ANCA reveals that EGPA comprises two genetically and clinically distinct syndromes. MPO+ ANCA EGPA is an eosinophilic autoimmune disease sharing certain clinical features and an HLA-DQ association with MPO+ ANCA-associated vasculitis, while ANCA-negative EGPA may instead have a mucosal/barrier dysfunction origin. Four candidate genes are targets of therapies in development, supporting their exploration in EGPA

    Luminosity at LHCb in Run 3

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    Evidence for a new structure in the J/ψpJ/\psi p and J/ψpˉJ/\psi \bar{p} systems in Bs0J/ψppˉB_s^0 \to J/\psi p \bar{p} decays

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    International audienceAn amplitude analysis of flavor-untagged Bs0→J/ψpp¯ decays is performed using a sample of 797±31 decays reconstructed with the LHCb detector. The data, collected in proton-proton collisions between 2011 and 2018, correspond to an integrated luminosity of 9  fb-1. Evidence for a new structure in the J/ψp and J/ψp¯ systems with a mass of 4337-4+7 -2+2  MeV and a width of 29-12+26 -14+14  MeV is found, where the first uncertainty is statistical and the second systematic, with a significance in the range of 3.1 to 3.7σ, depending on the assigned JP hypothesis

    Observation of Two New Excited Ξb0\Xi_b^0 States Decaying to Λb0Kπ+\Lambda^0_b K^- \pi^+

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    International audienceTwo narrow resonant states are observed in the Λb0K-π+ mass spectrum using a data sample of proton-proton collisions at a center-of-mass energy of 13 TeV, collected by the LHCb experiment and corresponding to an integrated luminosity of 6  fb-1. The minimal quark content of the Λb0K-π+ system indicates that these are excited Ξb0 baryons. The masses of the Ξb(6327)0 and Ξb(6333)0 states are m[Ξb(6327)0]=6327.28-0.21+0.23±0.12±0.24 and m[Ξb(6333)0]=6332.69-0.18+0.17±0.03±0.22  MeV, respectively, with a mass splitting of Δm=5.41-0.27+0.26±0.12  MeV, where the uncertainties are statistical, systematic, and due to the Λb0 mass measurement. The measured natural widths of these states are consistent with zero, with upper limits of Γ[Ξb(6327)0]<2.20(2.56) and Γ[Ξb(6333)0]<1.60(1.92)  MeV at a 90% (95%) credibility level. The significance of the two-peak hypothesis is larger than nine (five) Gaussian standard deviations compared to the no-peak (one-peak) hypothesis. The masses, widths, and resonant structure of the new states are in good agreement with the expectations for a doublet of 1D Ξb0 resonances

    Precision measurement of forward ZZ boson production in proton-proton collisions at s=13\sqrt{s} = 13 TeV

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    A precision measurement of the ZZ boson production cross-section at s=13\sqrt{s} = 13 TeV in the forward region is presented, using pppp collision data collected by the LHCb detector, corresponding to an integrated luminosity of 5.1 fb1^{-1}. The production cross-section is measured using Zμ+μZ\rightarrow\mu^+\mu^- events within the fiducial region defined as pseudorapidity 2.0202.020 GeV/cc for both muons and dimuon invariant mass 60<Mμμ<12060<M_{\mu\mu}<120 GeV/c2c^2. The integrated cross-section is determined to be \begin{equation*} \sigma(Z\rightarrow\mu^+\mu^-) = 195.3 \pm 0.2 \pm 1.5 \pm 3.9~pb, \end{equation*} where the first uncertainty is statistical, the second is systematic, and the third is due to the luminosity determination. The measured results are in agreement with theoretical predictions, including a prediction at next-to-next-to-leading order in perturbative quantum chromodynamics and a prediction with resummation

    Study of the doubly charmed tetraquark Tcc+T_{cc}^+

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    An exotic narrow state in the D0D0π+D^0D^0\pi^+ mass spectrum just below the D+D0D^{*+}D^0 mass threshold is studied using a data set corresponding to an integrated luminosity of 9 fb1^{-1} acquired with the LHCb detector in proton-proton collisions at centre-of-mass energies of 7, 8 and 13 TeV. The state is consistent with the ground isoscalar Tcc+T^+_{cc} tetraquark with a quark content of ccuˉdˉcc\bar{u}\bar{d} and spin-parity quantum numbers JP=1+\mathrm{J}^{\mathrm{P}}=1^+. Study of the DDDD mass spectra disfavours interpretation of the resonance as the isovector state. The decay structure via intermediate off-shell D+D^{*+} mesons is confirmed by the D0π+D^0\pi^+ mass distribution. The mass of the resonance and its coupling to the DDD^{*}D system are analysed. Resonance parameters including the pole position, scattering length, effective range and compositeness are measured to reveal important information about the nature of the Tcc+T^+_{cc} state. In addition, an unexpected dependence of the production rate on track multiplicity is observed

    Measurement of the lifetimes of promptly produced Ωc0 and Ξc0 baryons

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    International audienceA measurement of the lifetimes of the Ωc0 and Ξc0 baryons is reported using proton–proton collision data at a centre-of-mass energy of 13TeV, corresponding to an integrated luminosity of 5.4fb-1 collected by the LHCb experiment. The Ωc0 and Ξc0 baryons are produced directly from proton interactions and reconstructed in the pK-K-π+ final state. The Ωc0 lifetime is measured to be 276.5±13.4±4.4±0.7fs, and the Ξc0 lifetime is measured to be 148.0±2.3±2.2±0.2fs, where the first uncertainty is statistical, the second systematic, and the third due to the uncertainty on the D0 lifetime. These results confirm previous LHCb measurements based on semileptonic beauty-hadron decays, which disagree with earlier results of a four times shorter Ωc0 lifetime, and provide the single most precise measurement of the Ωc0 lifetime

    Observation of the suppressed Λb0→DpK- decay with D→K+π- and measurement of its CP asymmetry

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    International audienceA study of Λb0 baryon decays to the DpK- final state is presented based on a proton-proton collision data sample corresponding to an integrated luminosity of 9  fb-1 collected with the LHCb detector. Two Λb0 decays are considered, Λb0→DpK- with D→K-π+ and D→K+π-, where D represents a superposition of D0 and D¯0 states. The latter process is expected to be suppressed relative to the former, and is observed for the first time. The ratio of branching fractions of the two decays is measured, and the CP asymmetry of the suppressed mode, which is sensitive to the Cabibbo-Kobayashi-Maskawa angle γ, is also reported
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