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Radiosynthesis of (R,S)-[18 F]GE387: A Potential PET Radiotracer for Imaging Translocator Protein 18 kDa (TSPO) with Low Binding Sensitivity to the Human Gene Polymorphism rs6971.
- Author
- Publication venue
- ChemMedChem
- Publication date
- 06/05/2019
- Field of study
Translocator protein (TSPO) is a biomarker of neuroinflammation, which is a hallmark of many neurodegenerative diseases and has been exploited as a positron emission tomography (PET) target. Carbon-11-labelled PK11195 remains the most applied agent for imaging TSPO, despite its short-lived isotope and low brain permeability. Second-generation radiotracers show variance in affinity amongst subjects (low-, mixed-, and high-affinity binders) caused by the genetic polymorphism (rs6971) of the TSPO gene. To overcome these limitations, a new structural scaffold was explored based on the TSPO pharmacophore, and the analogue with a low-affinity binder/high-affinity binder (LAB/HAB) ratio similar (1.2 vs. 1.3) to that of (R)-[11 C]PK11195 was investigated. The synthesis of the reference compound was accomplished in six steps and 9 % overall yield, and the precursor was prepared in eight steps and 8 % overall yield. The chiral separation of the reference and precursor compounds was performed using supercritical fluid chromatography with >95 % ee. The absolute configuration was determined by circular dichroism. Optimisation of reaction conditions for manual radiolabelling revealed acetonitrile as a preferred solvent at 100 °C. Automation of this radiolabelling method provided R and S enantiomers in respective 21.3±16.7 and 25.6±7.1 % decay-corrected yields and molar activities of 55.8±35.6 and 63.5±39.5 GBq μmol-1 (n=3). Injection of the racemic analogue into a healthy rat confirmed passage through the blood-brain barrier.This work was supported by Medical Research Council (UK) grant awards RG46503 (LM, MH, XZ) and RG70550 (EF), National Institute of Health Research (UK), Cambridge Biomedical Research Unit in Dementia (EF, NKR) and the Herchel Smith Fellowship programme (LQ)
Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial
- Author
- Abbas Jalal
- Abraham Sybil
- Ackert Jessica
- Adams Patricia
- Aggarwala Gaurav
- Aher Nutan
- Ahlqvist Jørn
- Ahn Chul Woo
- Akers Teresa
- Akhras Ronald
- Akhter Faiq
- Aksentyev Sergey
- Al Kawas Firas
- Alexander Karen
- Althouse Denise
- Altobelli Desma
- Alvarisqueta Andres
- Ambrosy Andrew
- Andersen James
- Andersen Ulla
- Anderson Michelle
- Anglade Moise
- Arbañil Hugo
- Arciszewska Malgorzata
- Argoud Georges
- Ariani Mehrdad
- Ashdji Reswan
- Avogaro Angelo
- Avramidis Iakovos
- Axthelm Christoph
- Aye Myint
- Babi Charleen
- Bachus Erasmus
- Baik Sei-Hyun
- Bailey Matt
- Bakhtari Ladan
- Baksi Arun
- Balasubramani Mathangi
- Baldovino Jorge
- Banach Marek
- Banerjee Subhash
- Bartlett Andrew
- Bartone Susan
- Baum Howard
- Bays Harold
- Bazhan Larysa
- Beasley Richard
- Beaudry Yves
- Beaulieu Gail
- Beboso Ronnie
- Bedard Jacques
- Beijerbacht Hugo Peter
- Belfort de Aguiar Renata
- Benjamin Sabrina
- Berger Dirk
- Berlingieri Joseph
- Berndtsson Blom Katarina
- Besada Diego
- Bethel M Angelyn
- Bhagwat Ravi
- Bhargava Anuj
- Bhosale Archana
- Bieler Tasso
- Bijata-Bronisz Renata
- Birkeland Kare
- Birkenfeld Andreas
- Blagden Mark
- Bloomfield Gerald
- Bode Bruce
- Boemi Massimo
- Bonadonna Riccardo
- Bondar Irina
- Bott Jochen
- Bousboulas Stavros
- Boye Alain
- Bratcher Christina
- Breneman Jody
- Briskin Toby
- Bristianou Magdalini
- Brockmyre Andrew
- Broughton Raymond
- Brown Judith
- Brown Kim
- Brychta Tomas
- Brønnum-Schou Jens
- Budhraja Madhusudan
- Bull Georgina
- Bundy Charles
- Burgess Lesley
- Busch Klaus
- Caca Karel
- Cadinot Didier
- Calderon Jorge
- Calella Pedro
- Califf Robert M
- Calvo Gómez Carlos
- Camacho Luis
- Cannon Kevin
- Cano Rodríguez Isidoro
- Cantero Maria Cecilia
- Carr Jewell
- Casson Ed
- Castaño Patricia
- Castro Conde Almudena
- Cathcart Harold
- Cavale Arvind
- Cech Vladimir
- Cequier Fillat Angel
- Cervantes-Escárcega Jose-Luis
- Cha Bong-Soo
- Chau Tuan
- Chaykin Louis
- Chehayeb Raja
- Chen David
- Chen Jung-Fu
- Chertkoff Alejandro
- Cheung Deanna
- Cheung Stephen
- Chevts Julia
- Chiang Chern-En
- Childress Richard
- Christian Tamra
- Chung Choon-Hee
- Coetzee Kathleen
- Cohen Allan
- Coker Rebecca
- Cole Joanna
- Collier Jeannie
- Condit Jonathan
- Consoli Agostino
- Conway James
- Cooksey Erin
- Cookson Tobias
- Cooper John
- Cooper Lauren
- Copland Allan
- Cornel Jan
- Cornett George Mitchell
- Crenier Laurent
- Cuadrado Jesus
- Cuatrecasas Cambra Guillem
- Cusson Jean
- D'Agostino Ralph B
- D'Agostino Ralph B.
- Daga Shruti
- Damyanova Velichka
- Dauber Ira
- Davila William
- Dawood Saleem
- De Armas Luis
- De Cosmo Salvatore
- De Loredo Luis
- De Teresa Parreño Luis
- de Álvaro Moreno Fernando
- Dean Julius
- Debroye Corinne
- Del Prato Stefano
- Del Prato Stefano
- Delgado Lista Javier
- Della Siega Anthony
- DeMets David
- Demidova Irina
- Derezinski Tadeusz
- Deshpande Sameer
- Detweiler Robert
- Devore Adam
- Di Bartolo Paolo
- Di Giovanna Michael
- Diaz Ernesto
- Dimitriadis Georgios
- Dimitrov Stefan
- Distiller Larry
- Dombrowski Keith
- Dominguez Andrea
- Domínguez Escribano José Ramón
- Donaldson Jill
- Donaubauer Torsten
- Dor Isaac
- Dotta Francesco
- Dreval Alexander
- Drummond Waymon
- Dumas Richard
- Dumbre Snehal
- Dungan Kathleen
- Durán García Santiago
- Duyck Francis
- Dvorakova Eva
- Dzongowski Peter
- Eagerton Donald
- Eapen Zubin
- Earl John
- Eaton Charles
- Ebo Geraldine
- Edelsberger Tomas
- Eliasson Bjorn
- Eliasson Ken
- Elisaf Moses
- Ellison Howard
- Elvira González Javier
- Emslie-Smith Alistair
- Endsley Patricia
- Enns Robert
- Erlinger Rudolf
- Ershova Olga
- Español Maria Vanesa
- Espinoza Augusto Dextre
- Farris Neil
- Ferguson Murdo
- Fernandez-Salazar Eva
- Fernández Rodríguez José María
- Fiel Thomas
- Finkelstein Hernan
- Firek Anthony
- First Brian
- Fleming John
- Flota-Cervera Luis Fernando
- Forgosh Les
- Frechtel Gustavo
- French William
- Fretes Jose
- Friedman Daniel
- Frontoni Simona
- Funke Klaus
- Fushtey Ivan
- Gadzinski Waldemar
- Gajek Jacek
- Galatius Søren
- Galetta Marianna
- Galstyan Gagik
- Gambineri Alessandra
- Gandy Winston
- Garcia Ronald
- Garganeeva Alla
- Garrido Santos Natalia
- Garrido Elizabeth
- Garvey Louisa
- Gaudet Daniel
- Gazzaruso Carmine
- Gentry Tracy
- Giaccari Andrea
- Gill Santosh
- Giorgino Francesco
- Goday Arno Alberto
- Godse Rupali
- Gomez Huelgas Ricardo
- Gonzales Rolando Vargas
- Gonzalez Joaquin
- González Juanatey José Ramón
- González-González José Gerardo
- Goodman Shaun
- Gordon Murray
- Gouet Didier
- Grachova Mariya
- Granger Christopher B
- Granger Christopher B.
- Green Fiona
- Green Jennifer B
- Green Jennifer B
- Greene Deb
- Greene Stephen
- Grondin Francois
- Grosskopf Josef
- Groutars Reginald G.E.J.
- Guerci Bruno
- Guice Michael
- Guimaraes Patricia
- Gulseth Hanne
- Gummadi Siva
- Gunstone Anthony
- Gupta Anil
- Gupta Milan
- Gupta Nikita
- Guttormsen Gaute
- Ha JuYoung
- Hackenyos Jonathan
- Haddock Trevorlyn
- Hagenow Andreas
- Hairston Kristen
- Hajdú Csaba
- Halciakova Katarina
- Halperin Frank
- Haluzik Martin
- Hamann Monika
- Hanson Lenita
- Haque Ghazala
- Harcsa Eleonóra
- Harris Tara
- Harrison Lindsay
- Harrison Rob
- Hartard Manfred
- Hartman Israel
- Heitner John
- Hejeebu Srini
- Henry Patrick
- Hereghty Belinda
- Hermany Paul
- Hernandez Mijares Antonio
- Hernandez Adrian F
- Hernandez Adrian F.
- Hernandez-Cassis Carlos
- Heymer Peter
- Hidalgo Horacio
- Higgins Alexander
- Hoek Boudewijn A
- Holman Rury
- Hoogslag Pieter A.M.
- Houle Pierre-Alain
- Hove Jens
- Howell Christina
- Hramiak Irene
- Huppertz Wolfgang
- Hutayanon Pisit
- Ibrahim Hassan
- Illies Gabriele
- Issa Basil
- Izmozherova Nadezhda
- Jackson-Voyzey Ewart
- Jacob Stephan
- Jacobs Shahram
- James Kourtnei
- James Rachel
- Jang Hak Chul
- Janmohamed Salim
- Janmohamed Salim
- Jarosz Marie
- Jenkins Wendy
- Jensen Jan Skov
- Jerjes-Díaz Carlos Sánchez
- Jiménez Díaz Víctor Alfonso
- Jintapakorn Woravut
- Jodar Gimeno Esteban
- Johnson Andrew
- Johnson David
- Johnson Megan
- Jones Michael
- Jones Nigel P
- Jones Nigel P
- Jordan Dedrick
- Joshi Parag
- Jung Thomas
- Kadgaonkar Neha
- Kahrmann Gerd
- Karetnikova Victoria
- Karka Mounika
- Karmalkar Anisha
- Kast Petra
- Kaster Steven
- Katerenchuk Vitaliy
- Kellerer Monika
- Kellum Daniel
- Kelly Aoife
- Kempe Hans-Peter
- Kessler Laurence
- Khandelwal Chaitali
- Kharakhulakh Marina
- Khariouzov Andrei
- Khokhlov Aleksandr
- Kim Chong-Jin
- Kim Christopher
- Kim Ellen
- Kim Hye Soon
- Kim In Joo
- Kirby William
- Klausmann Gerhard
- Klein Christiane
- Kleinecke-Pohl Uwe
- Kleinertz Klaus
- Klodawska Katarzyna
- Knouse Albert
- Kobalava Zhanna
- Kober Lars
- Koch Thorsten
- Kocsis Gyozo
- Kolls Brad
- Kong David
- Konyves Laszlo
- Kooy Adriaan
- Korpachev Vadym
- Kosch Christine
- Koshelskaya Olga
- Kosiborod Mikhail
- Koskinen Pekka
- Kosmacheva Elena
- Kostin Vladimir
- Kotsa Kalliopi
- Kouz Simon
- Kovacheva Snezhina
- Kovacs Christopher
- Koziolova Natalia
- Kragten Johannes A.
- Kravchun Nonna
- Kristiansen Ole Peter
- Krizova Jarmila
- Krzyzagorska Ewa
- Kulback Steven
- Kulkarni Mangesh
- Kumar Mariananda
- Kumar Rakesh
- Kumar Somesh
- Kumari Aditi
- Kuruvanka Tulsidas
- Kuzin Anatoly
- Labroo Ajay
- Lalau Jean-Daniel
- Landry Daniel
- Larin Oleksandr
- Larnefeldt Hans
- Lasswell William
- Lastuvka Jiri
- Lauder Steven
- Lauro Davide
- Lee Eun Young
- Lee Hyoung Woo
- Lee Kwan-Woo
- Lee Moon Kyu
- Leiter Lawrence A
- Leiter Lawrence A.
- Lentz John
- Lenzmeier Thomas
- Lesnov Victor
- Lewis David
- Li Wenyan
- Li Zhaoping
- Lieverse Aloysius G.
- Lif-Tiberg Cornelia
- Lillestol Michael
- Linderfalk Carina
- Lindsay Alistair
- Little Raymond
- Litvak Marcos
- Llamas Edmundo-Alfredo Bayram
- Lokhngina Yuliya
- Lombard Landman
- Longley Troy
- Lonn Eva
- Lopes Renato
- Lopez-Sendon Jose
- Lorimer Jamie
- Lorra Babette
- Lorraine Richard
- Loureyro Juan
- Lozanov Lachezar
- Lucas Morante Tomás
- Luedemann Joerg
- Luna Alejandro
- Lund Gustav
- Lund Per
- Lundman Pia
- Luttermann Matthias
- Lysenko Tatyana
- Maclean Malcolm
- Madej Andrzej
- Maffei Laura
- Makotoko Ellen
- Maldonado Natacha
- Mandal Trisha
- Mandawat Aditya
- Mankovsky Boris
- Manrique Helard
- Marazuela Monica
- Margaritov Viktor
- Markov Valentin
- Marquess Marsha
- Martell Claros Nieves
- Mathews Robin
- Mathieu Chantal
- Mauricio Puente Didac
- Maxeiner Stephan
- Mayorov Alexander
- McGuire Darren
- McKeown-Biagas Cecilia
- McKnight John
- McLaughlin Patricia
- McMurray John J.V.
- McMurray John J.V.
- McNeill Robert
- Mehta Anand
- Mehta Rajendra
- Melchior Thomas
- Melidonis Andreas
- Melloni Chiara
- Mena Ribas Elena
- Merino Torres Juan Francisco
- Mezquita Raya Pedro
- Mhambrey Ankita
- Miekus Pawel
- Migdalis Ilias
- Mihaylova-Shumkova Rositsa
- Milek Karsten
- Miller Alan
- Miller Diane
- Mitrakou Asimina
- Moelle Andrea
- Mohr Gasparini Diego
- Moiseev Sergey
- Moodley Rajendran
- Moon Keon-Woong
- Morales-Palomares Ellen
- Moran Joseph
- Morawski Emily
- Moris Linda
- Mucsi János
- Murphy Karen
- Muzulu Solomon
- Muñoz Ernesto German Cardona
- Myasoedova Svetlana
- Mykhalchyshyn Galyna
- Myshanych Halyna
- Nadar Madhumitha
- Nadar Venkatesh
- Naicker Pallavi
- Namgung June
- Nauck Michael
- Neumann Gerhard
- Nikolaeva Antoaneta
- Nischik Ruth
- Noronha Drusilla
- Nubiola Calonge Andreu
- Nyvad Ole
- O'Connell Ian
- O'Connor Thomas
- O'Mahony William
- Odio Alberto
- Oehrig-Pohl Edith
- Oleksyk Olga
- Olesinska-Mader Martyna
- Olsson Åke
- Oosthuysen Wessels
- Opiela Jaroslaw
- Ordoñez Sánchez Xavier
- Orio Silvia
- Orlenko Valeriia
- Orsi Emanuela
- Overton Robert
- Oyesile Babatunde
- Ozaki Risa
- Pagkalos Emmanouil
- Paolisso Giuseppe
- Papanas Nikolaos
- Pappas Angelos
- Park Kyong Soo
- Parker Reginald
- Pascoe-Gonzalez Sara
- Pascual Izuel Jose Maria
- Pashkovska Nataliia
- Patel Chetan
- Patel Prashant
- Patel Rajesh
- Patel Rajivkumar
- Patel Vickas
- Patil Ashwini P
- Patil Suradnya
- Patterson Catherine
- Pauker Zsolt
- Pearson Ewan
- Pelayo-Orozco Emilia Susana
- Perea Castilla Verónica
- Perez Manghi Federico
- Perez Soto Isabel
- Perez Kathleen
- Perriello Gabriele
- Pertseva Nataliia
- Pesarchick Jean
- Peterson Sean
- Petit Catherine
- Petrosyan Olena
- Petró Gizella
- Petunina Nina
- Philip Sam
- Phillips Lawrence
- Phrommintikul Arintaya
- Piatti Piermarco
- Pinto Miguel
- Piperek Martin
- Plassmann Georg
- Plés Zsolt
- Pohlmeier Lars
- Pontiroli Antonio
- Ponzani Paola
- Pope Connie
- Potnis Omkar
- Povsic Thomas
- Prakash Rahul
- Price Lauren
- Price-Olsen Emma
- Proepper Felix
- Prymkova Vera
- Pérez Pérez Antonio
- Quesada Charneco Miguel
- Quesada Simón Angustias
- Raad George
- Raclavska Lea
- Rahman Aref
- Raikhel Marina
- Raisinghani Ajit
- Rajan Raj
- Ramirez-Diaz Santiago-Paulino
- Raorane Amruta
- Rasouli Neda
- Rauzi Frank
- Rebrov Andrey
- Redón Mas Josep
- Regner Stefan
- Rego Iraeta Antonia
- Reich Dennis
- Rethaford Renee
- Revesz Katalin
- Revoredo Frederick Massucco
- Rich Jenny
- Richards Jackie
- Riddle Matthew
- Rieker Werner
- Rincon Luis Zapata
- Rivellese Angela Albarosa
- Rodriguez Alvarez Maria
- Rodriguez Papini Nelson
- Rodríguez Rodríguez Irene
- Roe Matthew
- Rohr Kathryn
- Romanczuk Piotr
- Rose Ludger
- Roseman Hal
- Rosenberg Anne
- Rosenberg Anne E
- Rosenbloom Alan
- Ross Jorge
- Roush Jennifer
- Rovner Sergio
- Russell Rachael
- Ruyatkina Ludmila
- Saba Fadi
- Sabol Mary Beth
- Sabán Ruiz José
- Sachson Richard
- Sahu Shruti
- Sala Jorgelina
- Saldana-Mendoza Arturo
- Salmonsson Staffan
- Samer Holger
- Samoylova Julia
- Sampanis Christos
- Sandhu Chamandeep
- Sanmartin Berglund Johan
- Sansanayudh Nakarin
- Sarvan Mohamed
- Saswadkar Aarti
- Sauter Joachim
- Sazonova Olga
- Schabauer Alex
- Schaper Frank
- Scheen André
- Schiffer Clemens
- Schleiden Debra
- Schmidt Juergen
- Schneider Ricky
- Scholz Bernd-M.
- Schou Morten
- Schubert Jessica
- Schuchard Timothy
- Schultheis Ron
- Schulze Joerg
- Schuyler Jones William
- Schygiel Pablo
- Sedani Sangeeta
- Segner Alexander
- Sensenbrenner John
- Sesti Giorgio
- Seufert Jochen
- Shaik Fayaz
- Shannon Jennifer
- Sharma Abhinav
- Sharma Richa
- Shavadia Jay
- Shestakova Marina
- Shilkina Natalia
- Shinde Rakesh
- Shitut Aditi
- Shlesinger Yshay
- Siegel Anna
- Sigal Helena
- Sigmon Kristina
- Sigmon Kristina N
- Silhova Elena
- Sinay Isaac
- Singh Narendra
- Sivalingam Kanagaratnam
- Sjöberg Folke
- Skokowska Ewa
- Smirnov Ivan
- Smith Paul
- Smith Peter
- Soffer Joseph
- Sokolova Nadezhda
- Solanki Sheetal
- Somerville Matthew
- Somerville Matthew C
- Soto González Alfonso
- Sowell Margaret
- Sposetti Georgina
- Srimahachota Suphot
- St-Maurice Francois
- Stankiewicz Andrzej
- Stasinska Teresa
- Stead Janet
- Steindorf Joerg
- Stewart Murray
- Stockhausen Juergen
- Stone Allegra
- Stonesifer Larry
- Storey Daniel
- Stoyanova Zhasmina
- Stuebler Petra
- Suh David
- Sukumaran Usha
- Swart Hendrik P.
- Sándor Vangel
- Söderberg Stefan
- Taeschner Heidrun
- Taft Lin
- Tahir Mohammed
- Tan Anjanette
- Tan Choon Beng Kathryn
- Tan Marilyn
- Taylon Alain
- Tentolouris Nikolaos
- Tews Dietrich
- Thakkar Maitreya
- Thomas Betsy
- Thorpe Karl
- Thorpe Karl M
- Thuan Jean-Francois
- Tien Kai Jen
- Tinahones Madueno Francisco
- Tirador Louie
- Tonolo Giancarlo
- Torres-Colores Jose Juan
- Torstensson Ingemar
- Trescoli Serrano Carlos
- Trevisan Roberto
- Tricoci Pierluigi
- Tripathy Devjit
- Trznadel-Morawska Iwona
- Tsapas Apostolos
- Tschoepe Diethelm
- Tseng Shih-Ting
- Tu Shih-Te
- Tugwell Barna
- Tzatzagou Glykeria
- Ulied Armiñana Angels
- Ulla Maria
- Urbanek Robin
- Uwaifo Gabriel
- Van Gaal Luc
- Vandyne Beth
- Vaphare Ashok
- Vasilevskaya Olga
- Vass Viktor
- Vedere Amarnath
- Vemulapalli Sreekanth
- Venugopal Chandra
- Verbovaya Nelli
- Vercammen Chris
- Verra Fernando
- Vidrio-Velázquez Maricela
- Viergever Eric P.
- Villagordoa-Mesa Juan
- Vishneva Elena
- Vizel Saul
- Vlasenko Maryna
- Vo Anthony
- Voinot Christel
- Vorobyev Sergey
- Vorokhobina Natalya
- Vouillarmet Julien
- Vrkoc Jan
- Wang Chih-Yuan
- Wang Ji-Hung
- Watson Anthony
- Watson David
- Welch Michelle
- Welker James
- White Alexander
- Wilhelm Karl
- Willis John
- Wilson Matt
- Wilson Tim
- Witek Robert
- Wium Cecilie
- Womer Terese
- Woo Vincent
- Wraight Ella
- Wynne Alan
- Xing Weibing
- Yamwong Sukit
- Yazdani Shahram
- Ye June
- Yoo Soon Jib
- Yordanov Victor
- Yu Jaemyung
- Zabalua Silvina
- Zaidman Cesar
- Zang Eddie
- Zanozina Olga
- Zeller-Stefan Helga
- Zhdanova Elena
- Zlova Tetiana
- Zubiate Carlos
- Zykova Tatyana
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Background:
Glucagon-like peptide 1 receptor agonists differ in chemical structure, duration of action, and in their effects on clinical outcomes. The cardiovascular effects of once-weekly albiglutide in type 2 diabetes are unknown. We aimed to determine the safety and efficacy of albiglutide in preventing cardiovascular death, myocardial infarction, or stroke.
Methods:
We did a double-blind, randomised, placebo-controlled trial in 610 sites across 28 countries. We randomly assigned patients aged 40 years and older with type 2 diabetes and cardiovascular disease (at a 1:1 ratio) to groups that either received a subcutaneous injection of albiglutide (30–50 mg, based on glycaemic response and tolerability) or of a matched volume of placebo once a week, in addition to their standard care. Investigators used an interactive voice or web response system to obtain treatment assignment, and patients and all study investigators were masked to their treatment allocation. We hypothesised that albiglutide would be non-inferior to placebo for the primary outcome of the first occurrence of cardiovascular death, myocardial infarction, or stroke, which was assessed in the intention-to-treat population. If non-inferiority was confirmed by an upper limit of the 95% CI for a hazard ratio of less than 1·30, closed testing for superiority was prespecified. This study is registered with ClinicalTrials.gov, number NCT02465515.
Findings:
Patients were screened between July 1, 2015, and Nov 24, 2016. 10 793 patients were screened and 9463 participants were enrolled and randomly assigned to groups: 4731 patients were assigned to receive albiglutide and 4732 patients to receive placebo. On Nov 8, 2017, it was determined that 611 primary endpoints and a median follow-up of at least 1·5 years had accrued, and participants returned for a final visit and discontinuation from study treatment; the last patient visit was on March 12, 2018. These 9463 patients, the intention-to-treat population, were evaluated for a median duration of 1·6 years and were assessed for the primary outcome. The primary composite outcome occurred in 338 (7%) of 4731 patients at an incidence rate of 4·6 events per 100 person-years in the albiglutide group and in 428 (9%) of 4732 patients at an incidence rate of 5·9 events per 100 person-years in the placebo group (hazard ratio 0·78, 95% CI 0·68–0·90), which indicated that albiglutide was superior to placebo (p<0·0001 for non-inferiority; p=0·0006 for superiority). The incidence of acute pancreatitis (ten patients in the albiglutide group and seven patients in the placebo group), pancreatic cancer (six patients in the albiglutide group and five patients in the placebo group), medullary thyroid carcinoma (zero patients in both groups), and other serious adverse events did not differ between the two groups. There were three (<1%) deaths in the placebo group that were assessed by investigators, who were masked to study drug assignment, to be treatment-related and two (<1%) deaths in the albiglutide group.
Interpretation:
In patients with type 2 diabetes and cardiovascular disease, albiglutide was superior to placebo with respect to major adverse cardiovascular events. Evidence-based glucagon-like peptide 1 receptor agonists should therefore be considered as part of a comprehensive strategy to reduce the risk of cardiovascular events in patients with type 2 diabetes.
Funding:
GlaxoSmithKline
Baseline characteristics of patients in the reduction of events with darbepoetin alfa in heart failure trial (RED-HF)
- Author
- Adams K.
- Adamson P.
- Adler A.
- Admon D.
- Agarwal D.
- Aggarwal A.
- Agostoni P.
- Aguilar-Romero R.
- Albanese M.
- Albizem Moetaz
- Albuquerque D.
- Almeida D.
- Altenberger J.
- Altschul L.
- Altschuller A.
- Alunni G.
- Amerena J.
- Amirani H.
- Amuchastegui M.
- Anand I.
- Anand Inder S.
- Andreou C.
- Anguita M.
- Anker S.
- Ansari M.
- Antezana G.
- Antonishen M.
- Apetrei E.
- Aroutiounov G.
- Ashok J.
- Aspe y Rosas J.
- Badat A.
- Bagdonas A.
- Bahl V.
- Ballyuzek M.
- Banchs H.
- Banerjee P.
- Banerjee S.
- Banish D.
- Bank A.
- Barbagelata A.
- Barnard D.
- Barsi B.
- Bart B.
- Basart D.
- Bauer F.
- Bayat J.
- Bellinger R.
- Belziti C.
- Benn A.
- Benov H.
- Berk M.
- Berrazueta J.
- Berry B.
- Berukstis E.
- Bethala V.
- Bilazarian S.
- Bini R.
- Bisognano J.
- Bleyer F.
- Bluguermann J.
- Blum M.
- Boccanelli A.
- Bocchi E.
- Boehmer J.
- Bolognese L.
- Bordignon S.
- Bordoloi A.
- Bouchard A.
- Boyle A.
- Bozkurt B.
- Bronnum-Schou J.
- Brown C.
- Bruckner I.
- Bruguera i Cortada J.
- Bugueno C.
- Buijs E.
- Burlew B.
- Burnham K.
- Butler J.
- Caccavo M.
- Call J.
- Camacho A.
- Cambier P.
- Campana C.
- Cappola T.
- Carasca E.
- Carbonieri E.
- Cardona-Muñoz E.
- Carlson R.
- Carpino C.
- Carr-White G.
- Cartasegna L.
- Castro P.
- Castro-Jimenez J.
- Celutkiene J.
- Chandler B.
- Chandra R.
- Chandraratna P.
- Charlier F.
- Chavez-Herrera J.
- Checco L.
- Cheng Sunfa
- Chernick R.
- Chockalingam K.
- Chompalova B.
- Chopda M.
- Chopra V.
- Chuquiure Valenzuela E.
- Churina S.
- Clausell N.
- Cleland J.
- Clemmensen K.
- Cohen Solal A.
- Coisne D.
- Colan D.
- Colfer H.
- Colque R.
- Colucci W.
- Coman I.
- Conejeros C.
- Connelly T.
- Connolly E.
- Cornel J.
- Cosmi F.
- Costantini O.
- Csikasz J.
- Cuneo C.
- Czarnecki W.
- D'Angelo G.
- Dabrowski M.
- Dadkhah S.
- Dambrauskaite A.
- Datcu M.
- Dauber I.
- Davis J.
- Davis S.
- Davy J.
- Dawood S.
- de Ceuninck M.
- De Cristofaro M.
- De Groote P.
- De Keulenaer G.
- De la Pena G.
- de Leeuw M.
- De Looze F.
- de Teresa E.
- Delport E.
- Dendale P.
- Denning S.
- Denny S.
- Dezsi C.
- Diaz Rafael
- Dickstein K.
- Dijkgraaf R.
- Donova T.
- Dos Santos P.
- Dragulescu S.
- Drazner M.
- Dreykluft T.
- Dugal J.
- Dunlap S.
- Dunselman P.
- Dzupina A.
- Ebner C.
- Edes I.
- Egbujiobi L.
- Egstrup K.
- El-Shahawy M.
- Elkayam U.
- Elliott J.
- Ellis G.
- Erglis A.
- Essandoh L.
- Ewald G.
- Fang J.
- Farhoud H.
- Felker G.
- Fernandez A.
- Fernandez J.
- Festin R.
- Fishbein G.
- Flesch M.
- Fletcher P.
- Florea V.
- Flores E.
- Floresta A.
- Floro J.
- Fonseca C.
- Forster T.
- Francis M.
- Freericks M.
- Fucili A.
- Funck F.
- Gabito A.
- Gabris M.
- Galinier M.
- Galvani M.
- Garda R.
- Garg M.
- Gatewood R.
- Geller M.
- Genth-Zotz S.
- Georgiev P.
- Ghaisas N.
- Ghali J.
- Ghosh S.
- Ghumman W.
- Giannetti N.
- Gibbs G.
- Gibelin P.
- Gillespie E.
- Gilmore R.
- Glezer M.
- Gogia H.
- Goicochea R.
- Goldberg L.
- Goloshchekin B.
- Gonzalez M.
- Gonzalez-Maqueda I.
- González Juanatey J.
- Gorosito V.
- Gorski J.
- Gotchev D.
- Goudev A.
- Gradus-Pizlo I.
- Grainger T.
- Grant P.
- Greenbaum R.
- Gregor P.
- Grigorov M.
- Grinfeld L.
- Gudmundsson G.
- Guenova D.
- Gunawardena D.
- Gundersen T.
- Gupta D.
- Gómez Sánchez M.
- Hack T.
- Haddad H.
- Hall S.
- Hambrecht R.
- Hamraoui K.
- Hamroff G.
- Hankins S.
- Hanna M.
- Hare D.
- Hargrove J.
- Harjola V.
- Haught W.
- Hauptman P.
- Hazelrigg M.
- Heath J.
- Hein J.
- Hergeldjieva V.
- Herold M.
- Herrera E.
- Herzog C.
- Heywood J.
- Hill T.
- Hilton T.
- Hiremath S.
- Hirsch H.
- Hole T.
- Hominal M.
- Hranai M.
- Hunter J.
- Huynh T.
- Ibrahim H.
- Imburgia M.
- Ionescu P.
- Iordachescu-Petica D.
- Ireland M.
- Isnard R.
- Iteld B.
- Ivanov D.
- Ivleva A.
- Ivleva A.
- Iyengar S.
- Jackson B.
- Jaffrani N.
- Jagadeesa Subramania B.
- Jain A.
- Jain D.
- Jain P.
- James M.
- Jarasuniene D.
- Jasinkevica I.
- Jensen G.
- Jerabek O.
- Jeserich M.
- Jimenez J.
- Jirmar R.
- John M.
- Johnson E.
- Jordana R.
- Joshi A.
- Kadr H.
- Kaiser S.
- Kakurina N.
- Kale P.
- Kaneshige A.
- Kapadia S.
- Karia D.
- Karlsberg R.
- Karpati P.
- Katholi R.
- Katz A.
- Kerekes C.
- Kerut E.
- Kettunen R.
- Kevorkian R.
- Khan A.
- Khoury W.
- Kipperman R.
- Kis E.
- Kjoller-Hansen L.
- Klainman E.
- Klapholz M.
- Klintberg L.
- Klug E.
- Kmec J.
- Kobalava Z.
- Kober L.
- Korewicki J.
- Kosa I.
- Kosinski E.
- Kostenko V.
- Kostova E.
- Kotila M.
- Kozinn M.
- Kraus D.
- Kreider-Stempfle H.
- Kronvall T.
- Krueger S.
- Krum H.
- Krum H.
- Kuc K.
- Kuchar R.
- Kumar S.
- Lader E.
- Laks T.
- Lattimore J.
- Laufs U.
- Leaes P.
- Lee C.
- Leiva-Pons J.
- Lenderlink T.
- Lenz K.
- Lepage S.
- Levy W.
- Lewis B.
- Lewis E.
- Light-McGroary K.
- Lindsay S.
- Linhart A.
- Linssen G.
- Litvak Bruno M.
- Liu P.
- Llanos J.
- Lodewick P.
- Lodewijks C.
- Loh I.
- Lok D.
- Lombardi W.
- Lonn E.
- Lopatin Y.
- Lopez Alvarado A.
- Luksiene D.
- Lupkovics G.
- Lupon J.
- Lycksell M.
- Ma P.
- Mabin T.
- Machado C.
- Mackinnon I.
- Maggioni Aldo P.
- Maislos F.
- Mancini D.
- Manitiu I.
- Manolova A.
- Manriquez L.
- Manuale O.
- Manyari D.
- Manzano L.
- Marchev S.
- Markenvard J.
- Markus T.
- Marmor A.
- Marra S.
- Martinez D.
- Martins Alves S.
- Martynov A.
- Marwick T.
- Marzetti E.
- Maréchal P.
- Mather P.
- McCants K.
- McGrew F.
- McLaurin B.
- McMillan E.
- McMurray J.
- McMurray John J.V.
- McNamara D.
- Megarry S.
- Memon A.
- Mendez Machado G.
- Meyer T.
- Meymandi S.
- Micko K.
- Miekus P.
- Miller A.
- Minami E.
- Moccetti T.4
- Modi M.
- Mody F.
- Moe G.
- Mohanty P.
- Monteiro P.
- Montera M.
- Moriel M.
- Morner S.
- Moscoso R.
- Moskowitz R.
- Mosseri M.
- Moura L.
- Moustafa M.
- Muellerleile K.
- Mullasari A.
- Mullen M.
- Mullens W.
- Murdoch D.
- Murin J.
- Musca G.
- Musial W.
- Nagy A.
- Naidoo D.
- Naik S.
- Natour M.
- Naz T.
- Neuder Y.
- Niegowska J.
- Nierop P.
- Nikolov F.
- Noonan T.
- Nul D.
- O'Brien T.
- O'Connor Christopher
- Oellerich W.
- Oomman A.
- Oren R.
- Orlov V.
- Pacher R.
- Pai V.
- Pamboukian S.
- Pareppally Gopal R.
- Parikh K.
- Parker J.
- Pascual Figal D.
- Patel T.
- Peccerillo N.
- Pella D.
- Pereira de Castro R.
- Pereira N.
- Perna E.
- Perrone Filardi P.
- Pesant Y.
- Pfeffer Marc A.
- Picchio E.
- Piotrowski W.
- Pitt W.
- Podolec P.
- Podzemska B.
- Poelzl G.
- Polonski L.
- Ponikowski P.
- Pop-Moldovan A.
- Popa V.
- Popov A.
- Porter C.
- Potthoff S.
- Prabhu S.
- Prakash V.
- Preda I.
- Pretorius M.
- Promisloff S.
- Pulpón L.
- Radoi M.
- Raev D.
- Rajda M.
- Ramos-Lopez G.
- Ranjith N.
- Rassi S.
- Ratkovec R.
- Recio J.
- Reis A.
- Ricci J.
- Riccitelli M.
- Richardson R.
- Ridocci Soriano F.
- Rodríguez Lambert J.
- Roig Minguell E.
- Roig Minguell E.
- Rokkedal J.
- Romero J.
- Ronaszeki A.
- Ronner E.
- Ross A.
- Roth S.
- Roul G.
- Rudys A.
- Russo T.
- Rydberg E.
- Rynkiewicz A.
- Sabatier R.
- Sakalyte G.
- Saleh N.
- Saltzberg M.
- Sanchez A.
- Sandri M.
- Santos D.
- Saraiva J.
- Sarkar S.
- Sastry B.
- Sathe S.
- Scarlata Debra
- Scelsi L.
- Schmedtje J.
- Schneider R.
- Schuyler G.
- Schygiel P.
- Schäufele T.
- Semernin E.
- Senior R.
- Senni M.
- Sestier F.
- Shanes J.
- Sharma A.
- Shogenov Z.
- Shotan A.
- Sidorenko B.
- Siegel C.
- Siegel R.
- Silber D.
- Simões M.
- Sindone A.
- Singh J.
- Singh N.
- Singh V.
- Sinha N.
- Skagen K.
- Sklar J.
- Skvortsov A.
- Sliaziene S.
- Sluzar V.
- Small R.
- Smith A.
- Smith E.
- Smith E.
- Smull D.
- Sojka G.
- Solomon Scott D.
- Somsen A.
- Sotolongo R.
- Soucek M.
- Souza Neto J.
- Spac J.
- Spacek R.
- Spisak V.
- Squire I.
- Srikanthan V.
- Stamate S.
- Staniloae C.
- Stapleton D.
- Steele P.
- Stehlik J.
- Stein M.
- Stockins B.
- Storzhakov G.
- Subburamakrishnan P.
- Sulimov V.
- Sussex B.
- Swedberg K.
- Swedberg Karl
- Szelemej R.
- Talibov O.
- Tan L.
- Tang W.
- Tavazzi L.
- Teixeira M.
- Tendera Michal
- Tereshenko S.
- Thacker H.
- Thadani U.
- Thalamus J.
- Thoeng J.
- Thompson P.
- Timberg I.
- Toblli J.
- Tomcsanyi J.
- Tomescu M.
- Torp-Pedersen C.
- Torre-Amoine G.
- Trichon B.
- Trochu J.
- Trusz-Gluza M.
- Tsai C.
- Tse H.
- Tsyrline V.
- Tummala R.
- Tuxen C.
- Tzekova M.
- Ujda M.
- Vahala P.
- Vahula V.
- Valdovinos P.
- Van Bakel A.
- van Dantzig J.
- van der Burgh P.
- van Kempen L.
- van Veldhuisen Dirk J.
- van Vlies B.
- Van Zyl L.
- Vanderheyden M.
- Vanhaecke J.
- Veze I.
- Vicari R.
- Videbak L.
- Vijay N.
- Vijayaraghavan K.
- Vinanska D.
- Vita I.
- Vittorio T.
- Vizel S.
- Vodnansky P.
- Vogel D.
- Volans E.
- von Hodenberg E.
- Voors A.
- Vossler M.
- Vukasovic J.
- Wagoner L.
- Waites J.
- Wallis D.
- Wander G.
- Ward N.
- Wardeh A.
- Weich H.
- Weinstein J.
- Westheim A.
- Weyland K.
- Weytjens C.
- Widmer M.
- Wight J.
- Wikstrom G.
- Wilkins C.
- Willems F.
- Williams C.
- Williams G.
- Winchester M.
- Winkel E.
- Winkelmann B.
- Witte K.
- Wittmer B.
- Wojciechowski D
- Wollaert B.
- Wood D.
- Wormer D.
- Wright R.
- Wysokinski A.
- Xu Z.
- Yan B.
- Yasin M.
- Young James B.
- Zadionchenko V.
- Zamolyi K.
- Zateyshchikov D.
- Zimlichman R.
- Zolty R.
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2013
- Field of study
<p>Aims: This report describes the baseline characteristics of patients in the Reduction of Events with Darbepoetin alfa in Heart Failure trial (RED-HF) which is testing the hypothesis that anaemia correction with darbepoetin alfa will reduce the composite endpoint of death from any cause or hospital admission for worsening heart failure, and improve other outcomes.</p>
<p>Methods and results: Key demographic, clinical, and laboratory findings, along with baseline treatment, are reported and compared with those of patients in other recent clinical trials in heart failure. Compared with other recent trials, RED-HF enrolled more elderly [mean age 70 (SD 11.4) years], female (41%), and black (9%) patients. RED-HF patients more often had diabetes (46%) and renal impairment (72% had an estimated glomerular filtration rate <60 mL/min/1.73 m2). Patients in RED-HF had heart failure of longer duration [5.3 (5.4) years], worse NYHA class (35% II, 63% III, and 2% IV), and more signs of congestion. Mean EF was 30% (6.8%). RED-HF patients were well treated at randomization, and pharmacological therapy at baseline was broadly similar to that of other recent trials, taking account of study-specific inclusion/exclusion criteria. Median (interquartile range) haemoglobin at baseline was 112 (106–117) g/L.</p>
<p>Conclusion: The anaemic patients enrolled in RED-HF were older, moderately to markedly symptomatic, and had extensive co-morbidity.</p>
Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity.
- Author
- Aanensen David M
- Abudahab Khalil
- Acheson Erwan
- Adams Alexander
- Adams Helen
- Adriaenssens Evelien M
- Afifi Safiah
- Aggarwal Dinesh
- Ahmad Shazaad SY
- Alam Mohammad T
- Alcolea-Medina Adela
- Alderton Alex
- Alikhan Nabil-Fareed
- Allan John
- Allara Elias
- Amato Roberto
- Andersson Monique
- Angyal Adrienn
- Aranday-Cortes Elihu
- Ariani Cristina
- Asad Hibo
- Asamaphan Patawee
- Ashworth Jordan
- Atkinson Laura
- Attwood Stephen
- Auckland Cressida
- Awan Ali R
- Aydin Alp
- Baker David J
- Baker Paul
- Balcazar Carlos E
- Ball Jonathan
- Barton Edward
- Bashton Matthew
- Batra Rahul
- Baxter Laura
- Beale Mathew A
- Beaver Charlotte
- Beckett Angela
- Beer Robert
- Beggs Andrew
- Bell Andrew
- Bellis Katherine L
- Berger Duncan J
- Berriman Matt
- Berry Lisa
- Berry Louise
- Betancor Gilberto
- Betteridge Emma
- Bewshea Claire M
- Bibby David
- Bicknell Kelly
- Birchley Alec
- Bird Paul
- Bishop Chloe
- Blane Beth
- Bolt Frances
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Boyd Olivia
- Boyes John
- Bradley Declan T
- Bradshaw Daniel
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgewater Hannah E
- Brooks Tony T
- Broos Alice
- Brown Julianne Rose
- Brown Paul E
- Brown Rebecca
- Brunker Kirstyn
- Bucca Giselda
- Buck David
- Buddenborg Sarah K
- Bull Matthew
- Bull Matthew
- Burton-Fanning Shirelle
- Butcher Ethan
- Caddy Sarah L
- Caller Laura G
- Campbell Sharon
- Carlile Matthew
- Carmichael Stephen N
- Casey Anna
- Castellano Sergi
- Chalker Vicki
- Chand Meera
- Chapman Michael R
- Chappell Joseph G
- Charalampous Themoula
- Charles Ian G
- Chaudhry Yasmin
- Chauhan Anoop J
- Cheng Jeffrey KJ
- Churcher Carol M
- Clark Gemma
- Coll Francesc
- Collins Jennifer
- Colquhoun Rachel
- Colquhoun Rachel M
- Connor Thomas R
- Connor Thomas R
- Constantinidou Chrystala
- Coombes Jason
- Corden Sally
- Cormie Claire
- Cortes Nicholas
- Cortes Nick
- Cottrell Simon
- Coupland Lindsay J
- Cowell Angela
- Cox Alison
- Craine Noel
- Cronin Michelle
- Crooke Derrick
- Curran Martin D
- Curran Tanya
- da Silva Filipe Ana
- da Silva Filipe Ana
- Dabrera Gavin
- Danesh John
- Darby Alistair C
- Davidson Rose K
- Davies Alisha
- Davis Thomas
- de Cesare Mariateresa
- De Lacy Elen
- de Oliveira Martins Leonardo
- de Silva Thushan I
- Debebe Johnny
- Dervisevic Samir
- Dewar Rebecca
- Dias Joana
- Diaz Maria
- Dibling Thomas
- Dorman Matthew J
- Downing Fatima
- Drury Eleanor
- du Plessis Louis
- Duckworth Nichola
- Dyal Patricia L
- Eccles Richard
- Edgeworth Jonathan
- Edwards Sue
- Eldirdiri Sahar
- Ellaby Nicholas
- Ellard Sian
- Elliott Scott
- Eltringham Gary
- Elumogo Ngozi
- Essex Sarah
- Evans Cariad
- Evans Johnathan M
- Eyre David
- Fairley Derek J
- Fallon Karlie
- Farbos Audrey
- Farr Ben
- Feltwell Theresa
- Fina Laia
- Findlay Jacqueline
- Fisher Chloe L
- Fleming Vicki M
- Forrest Leysa M
- Forrest Sally
- Foulser Luke
- Francois Sarah
- Fraser Christophe
- Freeman Timothy M
- Frost Lucy R
- Fuller William
- Gallagher Eileen
- Gallagher Michael D
- Garcia-Casado Maria V
- Gaskin Amy
- Gatica-Wilcox Bree
- Gavriil Artemis
- Geidelberg Lily
- Geidelberg Lily
- Gemmell Matthew
- Georgana Iliana
- George Ryan P
- Gifford Laura
- Gilbert Lauren
- Gill Harmeet K
- Gilroy Rachel AJ
- Girgis Sophia T
- Glaysher Sharon
- Golubchik Tanya
- Goncalves Sonia
- Goodfellow Ian
- Goodfellow Ian G
- Goodwin Scott
- Graham Clive
- Graham Lee
- Grammatopoulos Dimitris
- Green Angie
- Green Luke R
- Greenaway Jane
- Gregory Richard
- Griffith Luke
- Groves Danielle C
- Groves Natalie
- Guest Martyn
- Gulliver Huw
- Gutierrez Ana Victoria
- Hadjirin Nazreen F
- Haldenby Sam T
- Hale Antony D
- Hall Grant
- Halstead Fenella
- Hamilton William L
- Haque Tanzina
- Harper Katherine L
- Harris Kathryn Ann
- Harrison Ewan M
- Harrison Ian
- Harrison James W
- Hartman Hassan
- Hattersley Andrew
- Heaney Judith
- Helmer Thomas
- Hesketh Andrew R
- Heyburn David
- Higginson Ellen E
- Hill Verity
- Hill Verity
- Hilvers Ember
- Hiscox Julian A
- Holden Matthew TG
- Holmes Alison
- Holmes Christopher
- Holmes Nadine
- Hoosdally Sarah
- Hopes Richard
- Hosmillo Myra
- Houldcroft Charlotte J
- Howe Robin
- Howson-Wells Hannah C
- Hubb Jonathan
- Hughes Joseph
- Hughes Margaret
- Hunter Adam D
- Hutchings Stephanie
- Impey Robert
- Irish-Tavares Dianne
- Iturriza-Gomara Miren
- Jackson Ben
- Jackson Ben
- Jackson David A
- Jackson David K
- Jackson Kathryn A
- Jahun Aminu S
- James Keith
- Jamrozy Dorota
- Jarrett Ruth
- Jeffries Aaron R
- Jesudason Natasha
- Jesudason Natasha G
- John Michaela
- Johnson Kate
- Johnson Natasha
- Johnson Rob
- Johnson Robert
- Johnston Ian
- Jones Hannah
- Jones Katie
- Jones Rachel
- Jones Sophie
- Jorgensen David
- Jorgensen David
- Joseph Amelia
- Justice Anita
- Kane Leanne
- Kay Gemma L
- Kay Sally
- Keatley Jon-Paul
- Keeley Alexander J
- Kenyon Anita
- Kermack Leanne M
- Khakh Manjinder
- Khokhar Fahad A
- Kidd Stephen
- Kingsley Robert A
- Kitchen Christine
- Knight Bridget A
- Kolyva Anastasia
- Koshy Cherian
- Kraemer Moritz
- Kristiansen Mark
- Kumziene-Summerhayes Sara
- Kwiatkowski Dominic
- Lackenby Angie
- Langford Cordelia
- Lawniczak Mara
- Le-Viet Thanh
- Lee David
- Lee Jack CD
- Letchford Laura
- Levene Nick
- Levett Lisa J
- Li Kathy
- Li Kathy K
- Liggett Steven
- Lindsey Benjamin B
- Lister Michelle M
- Livett Rich
- Lloyd Allyson
- Lo Stephanie
- Loh Joshua
- Loman Nicholas J
- Loman Nicholas J
- Loose Matthew W
- Loveson Katie F
- Lowe Hannah
- Lucaci Anita O
- Ludden Catherine
- Lynch Jessica
- Lyons Ronan A
- Macfarlane-Smith Louissa R
- Machin Nicholas W
- MacIntyre-Cockett George
- Madona Pinglawathee
- Maes Mailis
- Mahungu Tabitha W
- Mair Daniel
- Maksimovic Joshua
- Manesis Nikos
- Manley Robin
- Manso Carmen
- Marchbank Angela
- Martincorena Inigo
- Martinez-Nunez Rocio T
- Masoli Jane AH
- Mason Jenifer
- Mather Alison E
- Mbisa Tamyo
- McCluggage Kathryn
- McClure Patrick C
- McCrone John T
- McCrone JT
- McGuigan Samantha
- McHugh Martin P
- McKenna James P
- McKerr Caoimhe
- McMinn Liz
- McMurray Claire
- Meader Emma J
- Meadows Lizzie
- Menegazzo Mirko
- Meredith Luke W
- Merrick Ian
- Mestek-Boukhibar Lamia
- Miah Shahjahan
- Michell Stephen L
- Michelsen Michelle L
- Molnar Zoltan
- Monaghan Lynn
- Mookerjee Siddharth
- Moore Catherine
- Moore Catrin
- Moore Christopher
- Moore Nathan
- Morgan Mari
- Morgan Sian
- Mori Matilde
- Moses Samuel
- Muir Peter
- Munn Robert
- Myers Richard
- Nascimento Fabricia F
- Nascimento Fabricia F
- Naydenova Plamena
- Neaverson Alexandra S
- Nebbia Gaia
- Nelson Andrew
- Nelson Charlotte
- Nelson Rachel
- Nicholls Sam
- Nicholls Samuel M
- Nichols Jenna
- Niebel Marc O
- Niola Paola
- Nomikou Kyriaki
- O'Toole Elaine
- O'Toole Áine
- Orton Richard J
- Osman Husam
- Ott Sascha
- O’Grady Justin
- O’Toole Áine
- Pacchiarini Nicole
- Pacchiarini Nicole
- Padgett Debra
- Page Andrew J
- Palmer Sophie
- Palmer Steve
- Panchbhaya Yasmin N
- Pandey Sarojini
- Park Naomi
- Parker Matthew D
- Parmar Surendra
- Parr Yasmin A
- Parsons Paul J
- Partridge David G
- Pascall David J
- Patel Gaurang
- Patel Minal
- Patel Vineet
- Paterson Steve
- Payne Brendan AI
- Peacock Sharon J
- Pearson Clare
- Perry Malorie
- Peto Timothy
- Pinckert Malte L
- Platt Steven
- Plimmer Amy
- Poplawski Radoslaw
- Potter Will
- Prakash Reenesh
- Prestwood Liam
- Price Anna
- Price Anna
- Price James
- Puethe Christoph
- Pybus Oliver
- Pybus Oliver G
- Pymont Hannah M
- Quail Mike
- Quick Joshua
- Raghwani Jayna
- Ragonnet-Cronin Manon
- Rainbow Lucille
- Rajatileka Shavanthi
- Rambaut Andrew
- Rambaut Andrew
- Ramsay Mary
- Randell Paul A
- Raviprakash Veena
- Raza Mohammad
- Resende Silva Paola C
- Rey Sara
- Rey Sara M
- Reynolds Nicola
- Richter Alex
- Robertson David L
- Robertson David L
- Robinson Esther
- Robinson Trevor I
- Robson Samuel C
- Rogers Hazel A
- Rooke Stefan
- Rowan Aileen
- Rowe Will
- Roy Sunando
- Rudder Steven
- Ruis Chris
- Ryan Felicity
- Sambles Christine M
- Sang Fei
- Scarlett Garry P
- Schaefer Ulf
- Scher Emily
- Scott Carol
- Scott Garren
- Sethi Dheeraj K
- Shaaban Sharif
- Shah Divya
- Shah Rajiv
- Shah Rajiv N
- Shankar Giri
- Shaw Robert
- Shepherd James
- Shepherd James G
- Sheriff Nicola
- Shirley Lesley
- Signell Adrian W
- Sillitoe John
- Simpson David A
- Singer Joshua B
- Sivaprakasam Venkat
- Siveroni Igor
- Siveroni Igor
- Sloan Tim J
- Sluga Graciela
- Smith Christen
- Smith Colin P
- Smith Darren L
- Smith Nikki
- Smith Wendy
- Smollett Katherine L
- Snell Luke B
- Souster Emily
- Southgate Joel
- Southgate Joel
- Spellman Karla
- Spencer-Chapman Michael
- Sridhar Sushmita
- Stanley Rachael
- Stanton Thomas D
- Starinskij Igor
- Stark Richard
- Stockton Joanne
- Stuart Claire
- Studholme David J
- Swindells Emma
- Swingler Tracey
- Taha Yusri
- Tang Julian
- Taylor Ben EW
- Taylor Graham P
- Taylor Sarah
- Taylor-Joyce Grace
- Tedim Ana P
- Temperton Ben
- Templeton Kate E
- Thompson Thomas
- Thomson Emma C
- Thomson Emma C
- Thomson Nicholas M
- Thornton Alicia
- Thurston Scott
- Todd John A
- Tong Lily
- Tonkin-Hill Gerry
- Torok M Estee
- Trebes Amy
- Trotter Alexander J
- Tsoleridis Theocharis
- Tucker Rachel M
- Turtle Lance
- Tutill Helena J
- Underwood Anthony P
- Unnikrishnan Meera
- Vamos Edith E
- Vasylyeva Tetyana
- Vattipally Sreenu
- Vipond Ian B
- Volz Erik
- Volz Erik M
- Wain John
- Walsh Sarah
- Wang Dennis
- Wantoch Michelle
- Warne Ben
- Warwick-Dugdale Joanna
- Wastenge Elizabeth
- Watkins Joanne
- Watts Joanne
- Waugh Sheila
- Webber Mark A
- Weeks Sam
- Weldon Danni
- Whitehead Mark
- Williams Charlotte A
- Williams Chris
- Williams David
- Williams Rachel J
- Williams Rebecca
- Williams Thomas
- Williamson Kathleen A
- Willingham Iona
- Wilson Harry D
- Wise Emma
- Workman Trudy
- Wright Victoria
- Wyles Matthew
- Wyllie Sarah
- Yakovleva Anna
- Yasir Muhammad
- Yeats Corin A
- Yew Wen C
- Young Gregory R
- Young Jamie
- Yu Xiaoyu
- Zarebski Alex
- Publication venue
- Cell
- Publication date
- 01/09/2020
- Field of study
Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant
Effect of sitagliptin on cardiovascular outcomes in type 2 diabetes
- Author
- Abdulhakim E
- Abraham P
- Abramov G
- Abu Hassan MR
- Adamson K
- Adawi F
- Adkins K
- Adler A
- Adler A
- Agarwal P
- Ahn KJ
- Akpunonu B
- Albota A
- Albu J
- Alexander K
- Alexandru C
- Alfonsi F
- Alt I
- Alvarisqueta AF
- Alvarsson M
- Alversson M
- Ambos A
- Ambos A
- Ambrosio G
- Ambulkar S
- Anagnostis G
- Anastasi L
- Andersone I
- Arambam P
- Aravind S
- Araz M
- Arciszewska M
- Argoud G
- Arias P
- Armaganijan L
- Armstrong PW
- Armstrong PW
- Aroda V
- Artemiuk E
- Aschner Montoya P
- Aschner P
- Athwal R
- Aziz NA
- Azizad M
- Babenko A
- Badat A
- Badenhoop K
- Bahit M
- Baker J
- Bakiner O
- Balaji V
- Balode A
- Baltramonaitiene K
- Banerji MA
- Barbarash O
- Barros P
- Barsiene L
- Bartkowiak A Jr
- Bashkin A
- Batch B
- Bays H
- Beaven A
- Behn P
- Behnke T
- Beijerbacht H
- Benatar J
- Bender G
- Berdan L
- Bergenstal R
- Bernardez S
- Bernecki G
- Bester F
- Bethel A
- Bethel MA
- Bhargava A
- Bias D
- Binnekamp M
- Birkeland K
- Blach E
- Blagden M
- Blicharski T
- Bobeva R
- Bolster E
- Bondar I
- Borges JL
- Bostandzhieva R
- Botella M
- Botero Lopez R
- Brabec T
- Braun M
- Breedveld R
- Brieger D
- Brito F
- Brychta T
- Buchanan P
- Buganova I
- Bundy C
- Bunster Balocchi LB
- Burgess L
- Busch R
- Buse JB
- Buse JB
- Bushnell C
- Cagide AL
- Calella PR
- Califf RM
- Califf S
- Campbell C
- Canella JP
- Cantero MC
- Carpentier A
- Carroll P
- Cavalot F
- Ceponis J
- Chacra A
- Chadha C
- Chan JC
- Chang M
- Chen JF
- Chen LL
- Cheng C
- Cheung W
- Chiasson JL
- Chizhov P
- Choi KM
- Chou CW
- Christopher J
- Christopher J
- Chuang LM
- Chuang LM
- Chung C
- Cinlikov I
- Cipullo MA
- Civeira Murillo F
- Claudi T
- Clayton T
- Clergeot A
- Cohen A
- Cohen J
- Cole B
- Colman P
- Comlekci A
- Connery L
- Constance C
- Cooper L
- Cooperman M
- Cornel J
- Cornel JH
- Coronel Arroyo JA
- Costa e Forti A
- Couffinhal T
- Courreges JP
- Crenier L
- Crisan C
- Cure CA
- Cushman W
- Cutfield R
- Cypryk K
- Dabrowska M
- DAgostino R
- Dalan R
- Daly M
- Darawsha M
- Darbyshire J
- Davies M
- Davies M
- Davis T
- Dayamani P
- De Jong D
- De Lemos J
- De Looze F
- de Loredo L
- De Meireles M
- de Teresa L
- Dean J
- DeHart D
- Del Cañizo FJ
- Del Vecchio L
- Delibasi T
- Delibasi T
- dEmden M
- Demin A
- Den Hartog F
- Descamps O
- Deshpande M
- Detweiler R
- DeVore A
- Dezső E
- Distiller L
- Distiller L
- Dong J
- Donovan D
- Dora S
- Doran Z
- Dreval A
- Dreval AV
- Dshabrailov J
- Dudás M
- Dugano-Daphnis P
- Dulin M
- Dumas R
- Dumitrescu A
- Dunn F
- Eapen Z
- Eaton C
- Eglite R
- Eizyk E
- Eliaschewitz FG
- Ellis G
- Engel SS
- Engel SS
- Erickson B
- Ershova O
- Escobar Cerda EE
- Eskenazi L
- Estevez R
- Extremera BG
- Fabry J
- Feinglos M
- Felício JS
- Ferariu IE
- Filteau P
- Fonseca V
- Force R
- Forker A
- Fosbol E
- Fouche L
- Fox D
- Frisinghelli A
- Fuchs S
- Fulcher G
- Földesi I
- Fülöp T
- Gabriel J
- Gambardella S
- Garceau C
- Garces Flores EE
- Garcia R
- Garg J
- Garg J
- Garvey T
- Gaudiani L
- Ge J
- Gelersztein ES
- Georgieva M
- Gersamija A
- Gerstein HC
- Gerstman M
- Getaneh A
- Gillblad A
- Gillings S
- Gimeno EJ
- Goff D
- Goff D
- Goldberg A
- Goldman S
- Goldstein BJ
- Gorban de Lapertosa SB
- Gouet D
- Govender P
- Govind U
- Grado CR
- Gratsiansky N
- Gray R
- Green J
- Green J
- Green JB
- Gregory V
- Griz LH
- Groop L
- Guimaraes P
- Guler S
- Guo X
- Gómez Medina AM
- Górny G
- Górska M
- Hairston K
- Halvorsen S
- Halvorsen S
- Hamann A
- Hamilton A
- Han SJ
- Hanefeld M
- Hanefeld M
- Hannan K
- Harman-Boehm I
- Harris R
- Harrison R
- Harvey P
- Hasalova Zapletalova J
- Haught W
- Havelkova J
- Hawes J
- Hayden S
- Hayek T
- Hejnicova K
- Henshaw C
- Hermans W
- Hess P
- Hidalgo H Jr
- Higgins A
- Himpel-Boenninghoff A
- Hirsch B
- Hissa MN
- Ho AY
- Ho LT
- Hola O
- Holman RR
- Holman RR
- Holman RR
- Hornackova M
- Horvathova V
- Horvathova V
- Houchin V
- Hramiak I
- Hramiak I
- Hrdina T
- Hristova D
- Hsieh IC
- Huang BH
- Huang CL
- Huang CN
- Hussein Z
- Huynh T
- Hyland K
- Iliev D
- Ilieva E
- Ismail IS
- Ison R
- Istad H
- Jaap A
- Jackson L
- Jacobs G
- Jaffe A
- Jaffrani N
- Jafry B
- Jakuboniene N
- Jakuboniene N
- Jakubowska I
- Jan C
- Jazwinska-Tarnawska E
- Jegere B
- Johansson P
- Johnson A
- Jones H
- Josse R
- Josse RG
- Kaasik Ü
- Kafkova D
- Kaiser S
- Kakurina N
- Kalra S
- Kam G
- Kamaruddin NA
- Kamke W
- Kang HJ
- Kantola I
- Kapsner P
- Karczmarczyk A
- Karlsson T
- Kasperk C
- Katz M
- Kaufman KD
- Kaufman KD
- Kaye W
- Keenan J
- Kellnerova I
- Kennedy I
- Kerrane J
- Kesavadev J
- Ketova G
- Keymeulen B
- Kietselaer B
- Kiiroja K
- Kilvert A
- Kim DM
- Kim IJ
- Kim MH
- Kitowska-Koterla J
- Klyver MI
- Knobler H
- Ko T
- Kociol R
- Koglin J
- Koglin J
- Koltowski L
- Kong AP
- Kong D
- Kooy A
- Koranyi L
- Korn S
- Korn S
- Kornder J
- Koshizaka M
- Kotelnikov M
- Kovacheva S
- Krahulec B
- Krahulec B
- Krebs J
- Krystl T
- Krzyzagorska E
- Kudalkar H
- Kumar A
- Kumar J
- Kutejova V
- Késmárki N
- Labroo A
- Lachin JM
- Lachin JM
- Lai WT
- Lam YY
- Lanas Zanetti FT
- Lanno R
- Larrazabal Miranda Adel P
- Lasiene J
- Lau EY
- Lauro D
- Lazzarini V
- Leblanc T
- Lee IK
- Lee S
- Lehman S
- Leikis R
- Leitane I
- Leite S
- Leiter L
- Leloudis D
- Lembo G
- Lenderink T
- Leotta S
- Levashov S
- Levinger A
- Levinson L
- Lewis S
- Li QM
- Lillestol M
- Lindsay R
- Litchfield J
- Liubenova L
- Lo PH
- Lokhnygina Y
- Lopes R
- Lopes R
- Luedemann J
- Lunt H
- Lupusoru DA
- Luttrell L
- Löndahl M
- Madu I
- Maffei LE
- Mahaffey K
- Mahendran KA
- Maldonado N
- Manchanda M
- Manning P
- Marre M
- Martin-Hidalgo A
- Mathews R
- Mathieu C
- Mathur A
- Mayr P
- McCrimmon R
- McFarron D
- McFarron D
- McGuire DK
- McGuire DK
- McKnight J
- McMurray JJ
- McNeill R
- Mehta R
- Melloni C
- Mentz R
- Mereu L
- Merkel M
- Merrick B
- Metzger F
- Mikulkova I
- Miller D
- Millward B
- Milton J
- Minuchin O
- Misinkova I
- Misra A
- Mithal A
- Mittal S
- Mohamed M
- Mohamed M
- Mohan V
- Molina DI
- Mondillo S
- Morales Alvarado JM
- Morales C
- Morse M
- Morugova T
- Moses R
- Mosseri M
- Moulin P
- Munteanu M
- Mustafina S
- Märtsin K
- Nadar V
- Nagelberg S
- Nagy K
- Naidoo V
- Nam M
- Nash S
- Nayar SK
- Negru D
- Nevrla J
- Newby K
- Nicolau A
- Nieminen S
- Nierop P
- Nieuwoudt G
- Nikitov Z
- Nobels F
- Nordin Z
- Nortje H
- Novo S
- Nubiola A
- Oerter EM
- Ofner P
- Ofner P
- Ohlow MA
- Ohlsson-Önerud Å
- Olivares Cañon CM
- Oparil S
- Oroszlán T
- Osei K
- Ossum Gronert J
- Ott P
- Overhoff U
- Oviedo AI
- Oyesile B
- Panarotto D
- Pandey S
- Pantlikova C
- Papademetriou V
- Park IeB
- Park KS
- Park TS
- Park Y
- Park Y
- Paschen B
- Past M
- Pastare S
- Pasternak D
- Patel C
- Patel K
- Patel N
- Pedley C
- Pedrinelli R
- Pei D
- Pekarskiy S
- Pencina MJ
- Pentela-Nowicka J
- Perez Amador GA
- Perhonen M
- Pesarchick J
- Peterson ED
- Peterson ED
- Peterson ED
- Petr M
- Pfeffer MA
- Piatti P
- Piccini J
- Piesiewicz W
- Pimentel Filho P
- Pintiliei E
- Pirags V
- Pirags V
- Piskorz DL
- Pitale S
- Ples Z
- Pocock SJ
- Pokorney S
- Popescu A
- Potthoff Cárdenas SH
- Prather K
- Prentiss A
- Proietto J
- Przekwas-Jaruchowska M
- Punthakee Z
- Purewal T
- Pécsvárady Z
- Quintero K
- Rabasa-Lhoret R
- Racicka E
- Radbill M
- Raffo Grado CA
- Raisinghani A
- Rajzer M
- Ramanathan GR
- Ramu M
- Raskina T
- Rassi N
- Rassouli N
- Rautio A
- Ravikumar C
- Rechkova E
- Reddy N
- Reddy NK
- Reddy R
- Rees P
- Remmen J
- Remppis R
- Rendell M
- Reyes Rincon A
- Rhee EJ
- Rheeder P
- Ridruejo MC
- Riefflin A
- Riefflin A
- Robbins D
- Roberts A
- Robertson L
- Robinson A
- Robitaille Y
- Rodbard H
- Rodbard HW
- Rodriguez Venegas ME
- Roe M
- Rohlf J
- Rojas Lingan G
- Ronner E
- Rorick T
- Rose L
- Roseman H
- Rovira A
- Rovira A
- Rudolph L
- Saavedra Gajardo VA
- Saavedra SS
- Sadler L
- Sahin I
- Salamon-Ferenc A
- Salvioni A
- Samoylova Y
- Santos M
- Sarac F
- Saraiva JK
- Sarbochova R
- Sathyapalan T
- Saunders K
- Sawicki A
- Sazonova O
- Scheen A
- Scheen A
- Schnall A
- Schramm R
- Schubart U
- Schumm-Draeger PM
- Scott R
- Scott R
- Segiet T
- Seneviratne T
- Serban G
- Sessa HA
- Sgarbi JA
- Shah B
- Shah S
- Shamanna P
- Shanik M
- Shapiro DR
- Sharda A
- Sharma A
- Shaw J
- Shechter M
- SHeinikova G
- Sherenkov A
- Sheu WH
- Shi B
- Shilkina N
- Shimon I
- Shunmugavelu M
- Siddique N
- Sigal R
- Sigalas J
- Silva RP
- Silverman R
- Simpson H
- Simpson R
- Sinay I
- Sinay IR
- Sinha A
- Sirutaviciene A
- Siu SC
- Skowron T
- Skrha J
- Skrha J
- Slavcheva A
- Smolenakova K
- Snyder H
- Sorli C
- Sothiratnam R
- Spasova V
- Sposetti GD
- Srikanta S
- Stalte V
- Standl E
- Standl E
- Stapelberg AM
- Stein PP
- Stein PP
- Stern N
- Stetsyuk O
- Stich M
- Strand J
- Strandberg T
- Strandberg T
- Stranks S
- Stranks S
- Strickler J
- Strotmann HJ
- Stuchlik G
- Stürmer W
- Sulskiene M
- Sundström U
- Suryaprakash G
- Suryawanshi S
- Suryawanshi S
- Sweeney ME
- Szczeh L
- Tai E
- Tajjar A
- Taller A
- Tambascia M
- Tan RS
- Tan Y
- Tang XL
- Tankova T
- Tankova T
- Tarkun I
- Tay L
- Temelkova-Kurktschiev T
- Teterovska D
- Thinesse-Mallwitz M
- Thomas H
- Tillman H
- Tinahones Madueño F
- Tolsma D
- Tomlinson B
- Topliss D
- Torstensson I
- Toserova E
- Townes O
- Tranche S
- Travert F
- Travert F
- Trescolí Serrano C
- Tretyakova T
- Tricoci P
- Trinder Y
- Tritto I
- Trollinger K
- Truffa A
- Tsang CC
- Tsao J
- Tsur A
- Turcinek R
- Turner W
- Turova E
- Tykarski A
- Tykarski A
- Tytko A
- Ukinc K
- Ukwade P
- Ulla MR
- Urbanaviciene L
- Urbancova K
- Urina Triana MA
- Usman M
- Valeeva F
- Valenzuela Rincon A
- Valius L
- Valle T
- Van de Werf F
- Van de Werf F
- Van den Bruel A
- Van der Heijden R
- Van Der Merwe A
- Van Gaal L
- Van Hessen M
- van Kempen W
- Van Zyl L
- Varanauskiene E
- Vejvodova J
- Velichka D
- Velickiene D
- Veresiu IA
- Veresiu IA
- Vico ML
- Vides H
- Viitas L
- Viljoen M
- Vishlitzky V
- Viswanath D
- Vizel S
- Vo A
- Vogel C
- Voitec M
- Vondrakova M
- Voors-Pette C
- Vora P
- Voyce S
- Vélez Pelaez S
- Wainstein J
- Wainstein J
- Waites J
- Waitman JN
- Wang SY
- Weaver J
- Weber Silva DM
- Weintraub H
- Weisnagel S
- Wendisch U
- Wenying Y
- Westendorp I
- Westerberg Maldonado BH
- White H
- White J
- Wilder J
- Wilding J
- Wiles P
- Wilhase A
- Williams M
- Wilson M
- Wolfley A
- Woo V
- Wood M
- Wu P
- Wurziger J
- Wysham C
- Yakov A
- Yale JF
- Yang T
- Yang WY
- Yared K
- Yeung VT
- Yilmaz M
- Yoo SJ
- Yupanqui Lozno H
- Zachoval R
- Zadionchenko V
- Zak R
- Zavaroni DZ
- Zheng SX
- Ziegler O
- Zimanova J
- Zimmerman R
- Zinman B
- Śmiałowski A
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2015
- Field of study
BACKGROUND: Data are lacking on the long-term effect on cardiovascular events of adding sitagliptin, a dipeptidyl peptidase 4 inhibitor, to usual care in patients with type 2 diabetes and cardiovascular disease. METHODS: In this randomized, double-blind study, we assigned 14,671 patients to add either sitagliptin or placebo to their existing therapy. Open-label use of antihyperglycemic therapy was encouraged as required, aimed at reaching individually appropriate glycemic targets in all patients. To determine whether sitagliptin was noninferior to placebo, we used a relative risk of 1.3 as the marginal upper boundary. The primary cardiovascular outcome was a composite of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for unstable angina. RESULTS: During a median follow-up of 3.0 years, there was a small difference in glycated hemoglobin levels (least-squares mean difference for sitagliptin vs. placebo, -0.29 percentage points; 95% confidence interval [CI], -0.32 to -0.27). Overall, the primary outcome occurred in 839 patients in the sitagliptin group (11.4%; 4.06 per 100 person-years) and 851 patients in the placebo group (11.6%; 4.17 per 100 person-years). Sitagliptin was noninferior to placebo for the primary composite cardiovascular outcome (hazard ratio, 0.98; 95% CI, 0.88 to 1.09; P<0.001). Rates of hospitalization for heart failure did not differ between the two groups (hazard ratio, 1.00; 95% CI, 0.83 to 1.20; P = 0.98). There were no significant between-group differences in rates of acute pancreatitis (P = 0.07) or pancreatic cancer (P = 0.32). CONCLUSIONS: Among patients with type 2 diabetes and established cardiovascular disease, adding sitagliptin to usual care did not appear to increase the risk of major adverse cardiovascular events, hospitalization for heart failure, or other adverse events
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
- Attix Cristina
- Attwood John
- Aubin Keith
- Auger Katherine
- Austin Shannon Michelle
- Avila Aaron
- Avis Terry
- Ayele Mulu
- Babayan Primo
- Babbage Anne
- Babbage Sarah
- Bach Phil
- Bachatsang Pasang
- Bacon Joanne
- Badri Hummy
- Baertsch Robert
- Bagguley Claire
- Bailey Jonathan
- Bajorek Eva
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- Bemrose Richard
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- Lowenstein Michael G.
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- McMurray Kimberly L.
- McNinch Jenny
- McPherson John
- McPherson John D.
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- Meador Michael G.
- Medina Catherine
- Mehta Nalini
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- Menuge Noel
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- Mercado George
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- Miller Christie
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- Müller Ines
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- Nakagawa Saori
- Nakamura Etsuko
- Nakato Eriko
- Nanavati Amit N.
- Nandkeshwar Richard
- Nankervis Colin E.
- Naranjo Cleo M.
- Nash William
- Naylor Jerome
- Nazareth Lynne V.
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- Negus David
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- Nelson David O.
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- Okumura Reina
- Okwuonu Geoffrey O.
- Okwuonu Kenneth C.
- Olarnpunsagoon Alisa
- Olivas Jason
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- Oliver Karen
- Olsen Anne S.
- Olson Maynard V.
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- Ow David
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- Patel Bella Mayurkumar
- Patel Dina
- Patel Jalpa N.
- Patel Ritesh
- Patel Shripa
- Patel Vishal V.
- Patrick James
- Paul Heidie A.
- Paul Shelia
- Paulson Edward
- Payton Brett A.
- Pearce Alexandra
- Pearman Charlene
- Pearson Danita
- Pecherer Robert M.
- Peck Anna
- Peck Richard
- Pedan John
- Pelan Sarah
- Pelletier Eric
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- Peng Yi
- Peng Ze
- Peng Ze
- Pennacchio Len A.
- Pennacchio Len A.
- Percy Chantel
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- Perez Lesette M.
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- Perrin William
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- Pourrajabi Nima M.
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- Ricke Darryl O.
- Ridler Kerry
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- Rise Cecil
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- Road JungShing
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- Rong Li
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- Sonnhammer Erik
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- Sun Yue
- Sutherland Grant R.
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- Un Chun
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- Vassiliev Helen
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- Vico Virginie
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- Vine Wendy
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- Vo Andy
- Vo Nu
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- Wagner Mark
- Wagner-McPherson Caryn
- Waldron Lenee
- Waligorski Jason E.
- Walker Davian L.
- Walker Keya
- Walker Sarah
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- Wallace John
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- Wan Ma
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- Wilkinson Jane
- Wilkinson Jane
- Wilkinson Paul
- Willey David
- Williams Albert L.
- Williams Andy
- Williams Bill
- Williams Gabrielle A.
- Williams Leanne
- Williamson Angela L.
- Williamson Helen
- Wills Patricia L.
- Wills Richard
- Wilmer Tamsin
- Wilming Laurens
- Wilson Brian
- Wilson Gareth
- Wilson Margaret
- Wilson Nyree
- Wilson Piers
- Wilson Richard K.
- Wilson Siobhan
- Wilson Steve
- Wilson Wendy
- Wincker Patrick
- Window Philip
- Winster Jenny
- Winzar Claire
- Witt James
- Wleczyk Regina
- Wobus Fred
- Woessner Jeffrey
- Wohldmann Patty
- Wollard Jessica
- Womack Andrew W.
- Wong Benjamin
- Wong Gane K-S
- Wood Diane
- Wood Emma
- Wood Joe
- Wooden Hailey S.
- Wooden Steven H.
- Woodeson Sharon
- Woodfine Kathryn
- Woodmansey Rebecca
- Woods Eric
- Woodwark Cara
- Wooster Richard
- Worley Kim Carlyle
- Woyke Tanja
- Wray Matthew
- Wray Paul
- Wright Charmain
- Wright Debbie
- Wright Kathrine
- Wright Kristin
- Wright Rita A.
- Wu Chungen
- Wu Dongying
- Wu Jiaqian
- Wu Jung-Rung
- Wu Kevin
- Wu Qingfa
- Wu Qingfa
- Wu Ruiming
- Wu Xiao
- Wu Xiaojing
- Wu Zaining
- Wyatt Julia
- Wycoff-Montenegro Melissa
- Wylie Kris
- Wyman Dudley
- Wyman Stacia
- Xi Yan
- Xi Yingying
- Xie Fei
- Xie Gary
- Xie Jane
- Xiong Hui
- Xiong Yuqing
- Xu Alex
- Xu Jing
- Xu Jing
- Xu Ruqin
- Xu Shuhua
- Xu Wei
- Xu Xinlai
- Xu Yan
- Xu Yuning
- Xu Zhihong
- Xu Zuyuan
- Xuan Yali
- Xuan Zhenyu
- Xue Rui
- Yada Tetsushi
- Yadav Shailendra
- Yakub Syed
- Yamamoto Lynn
- Yamamoto Noriko
- Yamamoto Yuko
- Yamashita Yasue
- Yamazaki Satoru
- Yang Hao
- Yang Huanming
- Yang Huanming
- Yang Joan
- Yang Shiaw-Pyng
- Yang Shudong
- Yang Xiaonan
- Yang Xiaonan
- Yang Xiaoping
- Yang Yongkui
- Yano Candance
- Yao Zhijian
- Yao Zhijian
- Yaspo Marie-Laure
- Ye Chen
- Yeager Shane
- Yeh Mimi
- Yen Jennifer
- Yeshitela Rahel Retta
- Yoakum Martin
- Yokobata Kathy
- Yokoyama Jennifer
- Yonezawa Miho
- Yoon Lillienne
- Yoon Vivienne
- Yoshida Satoru
- You Bo
- Young Geneva
- Young Louise
- Young Shelia
- Younger Ruth
- Yu Bing
- Yu Charles
- Yu Fuli
- Yu Jun
- Yu Jun
- Yu Jun
- Yuan Kaiwen
- Yuan Ye
- Yuan Yida
- Yue Shujie
- Yumae Brian
- Yun Rui
- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
- Zhan Guoping
- Zhang Bo
- Zhang Caimin
- Zhang Fengmei
- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Evaluation of a comprehensive intervention with a behavioural modification strategy for childhood obesity prevention: a nonrandomized cluster controlled trial
- Author
- A Bandura
- A Liu
- A Liu
- A Must
- AC Lindsay
- AL Carrel
- CY Ji
- DE Schifter
- DS Freedman
- DS Freedman
- G Blackburn
- G Egger
- Group of China Obesity Task Force
- GS Berenson
- H Spittaels
- Hai-jun Wang
- HH Ditschuneit
- HJ Walter
- I Bourdeaudhuij De
- I Janssen
- JA Stewart
- JF Sallis
- Jing-jing Wang
- JN Davis
- JR Sirard
- Jun Ma
- K Ge
- L Elizondo‐Montemayor
- L Meng
- LD Amorim
- M Guillaume
- M Hakanen
- M Kalavainen
- M Savoye
- M Sothern
- MD Tsiros
- MT Mahar
- MW Kreuter
- MW Kreuter
- N Cameron
- NJ Farpour-Lambert
- O Ben Ounis
- P Royston
- R Baker
- R Dalle Grave
- R Kelishadi
- R Weiss
- R Yu
- RC Klesges
- RE Glasgow
- RG Mcmurray
- RR Wing
- S Kriemler
- SJ Woolford
- TA Lakka
- WB Strong
- Wing-chung Patrick Lau
- WS Agras
- Y Song
- YC Wang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Investigation of hospital discharge cases and SARS-CoV-2 introduction into Lothian care homes
- Author
- Aanensen David M.
- Abudahab Khalil
- Adams Alexander
- Adams Helen
- Afifi Safiah
- Aggarwal Dinesh
- Ahmad Shazaad SY.
- Aigrain Louise
- Alcolea-Medina Adela
- Alikhan Nabil-Fareed
- Allara Elias
- Amato Roberto
- Angyal Adrienn
- Annett Tara
- Aplin Stephen
- Ariani Cristina V.
- Asad Hibo
- Ash Amy
- Ashfield Paula
- Ashford Fiona
- Atkinson Laura
- Attwood Stephen W.
- Auckland Cressida
- Aydin Alp
- Baker David J.
- Baker Paul
- Balcazar Carlos E.
- Ball Jonathan
- Barrett Jeffrey C.
- Barrow Magdalena
- Barton Edward
- Bashton Matthew
- Bassett Andrew R.
- Batra Rahul
- Baxter Chris
- Bayzid Nadua
- Beaver Charlotte
- Beckett Angela H.
- Beckwith Shaun M.
- Bedford Luke
- Beer Robert
- Beggs Andrew
- Bellis Katherine L.
- Berry Louise
- Bertolusso Beatrice
- Best Angus
- Betteridge Emma
- Bibby David
- Bicknell Kelly
- Binns Debbie
- Birchley Alec
- Bird Paul W.
- Bishop Chloe
- Blacow Rachel
- Blakey Victoria
- Blane Beth
- Bolt Frances
- Bonfield James
- Bonner Stephen
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Boyd Olivia
- Bradley Declan T.
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgett Stephen
- Bronner Iraad F.
- Brooks Ellena
- Broos Alice
- Brown Julianne R.
- Bucca Giselda
- Buchan Sarah L.
- Buck David
- Bull Matthew
- Burns Phillipa J.
- Burton-Fanning Shirelle
- Byaruhanga Timothy
- Byott Matthew
- Campbell Sharon
- Carabelli Alessandro M.
- Cargill James S.
- Carlile Matthew
- Carvalho Sílvia F.
- Casey Anna
- Castigador Anibolina
- Catalan Jana
- Chalker Vicki
- Chaloner Nicola J.
- Chand Meera
- Chappell Joseph G.
- Charalampous Themoula
- Chatterton Wendy
- Chaudhry Yasmin
- Churcher Carol M.
- Clark Gemma
- Clarke Phillip
- Cogger Benjamin J.
- Cole Kevin
- Collins Jennifer
- Colquhoun Rachel
- Connor Thomas R.
- Cook Kate F.
- Coombes Jason
- Corden Sally
- Cormie Claire
- Cortes Nicholas
- Cotic Marius
- Cotton S.
- Cotton Seb
- Cottrell Simon
- Coupland Lindsay
- Cox Alison
- Cox MacGregor
- Craine Noel
- Crawford Liam
- Cross Aidan
- Crown Matthew R.
- Crudgington Dorian
- Cumley Nicola
- Curran Martin D.
- Curran Tanya
- Cutino-Moguel Teresa
- da Silva Filipe Ana
- Dabrer Gavin
- Darby Alistair C.
- Davidson Rose K.
- Davies Alisha
- Davies Robert M.
- Davis Thomas
- de Angelis Daniela
- De Lacy Elen
- de Oliveira Martins Leonardo
- de Silva Thushan I.
- Debebe Johnny
- Delgado Callico Laia
- Denton-Smith Rebecca
- Dervisevic Samir
- Dewar R.
- Dewar Rebecca
- Dey Jayasree
- Dias Joana
- Dobie Donald
- Dorman Matthew J.
- Downing Fatima
- Driscoll Megan
- du Plessis Louis
- Duckworth Nichola
- Durham Jillian
- Eastick Kirstine
- Easton Lisa J.
- Eccles Richard
- Edgeworth Jonathan
- Edwards Sue
- El Bouzidi Kate
- Eldirdiri Sahar
- Ellaby Nicholas
- Elliott Scott
- Eltringham Gary
- Ensell Leah
- Erkiert Michelle J.
- Essex Sarah
- Evans Cariad
- Evans Johnathan M.
- Everson William
- Fairley Derek J.
- Fallon Karlie
- Fanaie Arezou
- Farr Ben W.
- Fearn Christopher
- Feltwell Theresa
- Ferguson Lynne
- Fina Laia
- Flaviani Flavia
- Fleming Vicki M.
- Forrest Sally
- Foster-Nyarko Ebenezer
- Foulkes Benjamin H.
- Foulser Luke
- Fragakis Mireille
- Frampton Dan
- Francois Sarah
- Fraser Christophe
- Freeman Timothy M.
- Fryer Helen
- Fuchs Marc
- Fuller William
- Gajee Kavitha
- Galai Katerina
- Gallagher Abbie
- Gallagher Eileen
- Gallagher Michael D.
- Gallis Marta
- Gaskin Amy
- Gatica-Wilcox Bree
- Geidelberg Lily
- Gemmell Matthew
- Georgana Iliana
- George Ryan P.
- Gifford Laura
- Gilbert Lauren
- Girgis Sophia T.
- Glaysher Sharon
- Goldstein Emily J.
- Golubchik Tanya
- Gomes Andrea N.
- Gonçalves Sónia
- Goodwin Scott
- Goudarzi Salman
- Gourtovaia Marina
- Graham Clive
- Graham Lee
- Grant Paul R.
- Green Angie
- Green Luke R.
- Greenaway Jane
- Gregory Richard
- Guest Martyn
- Gunson Rory N.
- Gupta Ravi K.
- Gutierrez Bernardo
- Haas J.G.
- Haldenby Sam T.
- Hamilton William L.
- Hansford Samantha E.
- Haque Tanzina
- Harris Kathryn A.
- Harrison Ewan M.
- Harrison Ian
- Hart Jennifer
- Hartley John A.
- Harvey Matthew
- Harvey William T.
- Hassan-Ibrahim Mohammed O.
- Heaney Judith
- Helmer Thomas
- Henderson John H.
- Hesketh Andrew R.
- Hey Jessica
- Heyburn David
- Higginson Ellen E.
- Hill Jack D.
- Hill Verity
- Hilson Rachel A.
- Hilvers Ember
- Holden Matthew TG.
- Hollis Amy
- Holmes Alison H.
- Holmes Christopher W.
- Holmes Nadine
- Hopes Richard
- Hornsby Hailey R.
- Hosmillo Myra
- Houlihan Catherine
- Howson-Wells Hannah C.
- Hsu Sharon N.
- Hubb Jonathan
- Huckson Hannah
- Hughes Joseph
- Hughes Margaret
- Hughes Warwick
- Hutchings Stephanie
- Idle Giles
- Illingworth Chris J.
- Impey Robert
- Irish-Tavares Dianne
- Iturriza-Gomara Miren
- Izuagbe Rhys
- Jackson Ben
- Jackson Chris
- Jackson David K.
- Jackson Kathryn A.
- Jackson Leigh M.
- Jahun Aminu S.
- James Keith
- James Victoria
- Jeanes Christopher
- Jeffries Aaron R.
- Jeremiah Sarah
- Jermy Andrew
- John Michaela
- Johnson Kate
- Johnson Rob
- Johnston Ian
- Jones Christopher R.
- Jones Hannah
- Jones Neil
- Jones Owen
- Jones Sophie
- Joseph Amelia
- Judges Sarah
- Kay Gemma L.
- Kay Sally
- Keatley Jon-Paul
- Keeley Alexander J.
- Kele Beatrix
- Kenyon Anita
- Kermack Leanne M.
- Khakh Manjinder
- Kidd Stephen P.
- Killough Nicholas F.
- Kimuli Maimuna
- Kirk Stuart
- Kitchen Christine
- Kitchman Katie
- Knight Bridget A.
- Koshy Cherian
- Kraemer Moritz UG.
- Kumziene-Summerhayes Sara
- Kwiatkowski Dominic
- Lackenby Angie
- Laing Kenneth G.
- Lampejo Temi
- Langford Cordelia F.
- Lavin Deborah
- Lawton Andrew I.
- Le-Viet Thanh
- Lee David
- Lee Jack CD.
- Lensing Stefanie V.
- Leonard Steven
- Levett Lisa J.
- Lewis Jonathan
- Lewis Kevin
- Liddle Jennifier
- Liggett Steven
- Lillie Patrick J.
- Lindsey Benjamin B.
- Lister Michelle M.
- Livett Rich
- Lo Stephanie
- Loman Nicholas J.
- Loose Matthew W.
- Louka Stavroula F.
- Loveson Katie F.
- Lowdon Sarah
- Lowe Hannah
- Lowe Helen L.
- Lucaci Anita O.
- Ludden Catherine
- Lynch Jessica
- Lyons Ronan A.
- Machin Nicholas W.
- MacIntyre-Cockett George
- Mack Andrew
- Macklin Ben
- Maclean Alasdair
- Macnaughton Emily
- Madona Pinglawathee
- Maes Mailis
- Maftei Laurentiu
- Mahanama Adhyana IK.
- Mahungu Tabitha W.
- Mair Daniel
- Maksimovic Joshua
- Malone Cassandra S.
- Maloney Daniel
- Manesis Nikos
- Manley Robin
- Mantzouratou Anna
- Marchbank Angela
- Mariappan Arun
- Markov Anna
- Martincorena Inigo
- Martinez Nunez Rocio T.
- Mather Alison E.
- Maxwell Patrick
- Mayhew Megan
- Mbisa Tamyo
- McCann Clare M.
- McCarthy Shane A.
- McCluggage Kathryn
- McClure Patrick C.
- McCrone J.T.
- McHugh M.P.
- McHugh Martin P.
- McKenna James P.
- McKerr Caoimhe
- McManus Georgina M.
- McMurray Claire
- McMurray Claire L.
- McNal Alan
- Meadows Lizzie
- Medd Nathan
- Megram Oliver
- Menegazzo Mirko
- Merrick Ian
- Michell Stephen L.
- Michelsen Michelle L.
- Mirfenderesky Mariyam
- Mirza Jeremy
- Miskelly Julia
- Moles-Garcia Emma
- Moll Robin J.
- Molnar Zoltan
- Monahan Irene M.
- Mondani Matteo
- Mookerjee Siddharth
- Moore Catherine
- Moore Christopher
- Moore Jonathan
- Moore Nathan
- Morcrette Helen
- Morgan Mari
- Morgan Sian
- Mori Matilde
- Morris Arthur
- Moses Samuel
- Mower Craig
- Muir Peter
- Mukaddas Afrida
- Munemo Florence
- Munn Robert
- Murray Abigail
- Murray Darren R.
- Murray Leanne J.
- Mutingwende Manasa
- Myers Richard
- Nastouli Eleni
- Nebbia Gaia
- Nelson Andrew
- Nelson Charlotte
- Nicholls Sam
- Nichols Jenna
- Nicodemi Roberto
- Nomikou Kyriaki
- O'Brien Sarah
- O'Grady Justin
- O'Toole Áine
- Odedra Mina
- Ohemeng-Kumi Natasha
- Oliver Karen
- Orton Richard J.
- Osman Husam
- Pacchiarini Nicole
- Padgett Debra
- Page Andrew J.
- Park Emily J.
- Park Naomi R.
- Parker Matthew D.
- Parmar Surendra
- Partridge David G.
- Pascall David
- Patel Amita
- Patel Bindi
- Paterson Steve
- Payne Brendan AI.
- Peacock Sharon J.
- Pearson Clare
- Pelosi Emanuela
- Percival Benita
- Perkins Jon
- Perry Malorie
- Pinckert Malte L.
- Platt Steven
- Podplomyk FD Olga
- Pohare Manoj
- Pond Marcus
- Pope Cassie F.
- Poplawski Radoslaw
- Powell Jessica
- Poyner Jennifer
- Prestwood Liam
- Price Anna
- Price James R.
- Prieto Jacqui A.
- Pritch David T.
- Prosolek Sophie J.
- Pugh Georgia
- Pusok Monika
- Pybus Oliver G.
- Pymont Hannah M.
- Quail Michael A.
- Quick Joshua
- Radulescu Clara
- Raghwani Jayna
- Ragonnet-Cronin Manon
- Rainbow Lucille
- Rajan Diana
- Rajatileka Shavanthi
- Ramadan Newara A.
- Rambaut Andrew
- Ramble John
- Randell Paul
- Randell Paul A.
- Ratcliffe Liz
- Raviprakash Veena
- Raza Mohammad
- Redshaw Nicholas M.
- Rey Sara
- Reynolds Nicola
- Richter Alex
- Robertson David L.
- Robinson Esther
- Robson Samuel C.
- Rogan Fiona
- Rooke Stefan
- Rowe Will
- Roy Sunando
- Rudder Steven
- Ruis Chris
- Rushton Steven
- Saeed Kordo
- Samaraweera Buddhini
- Sambles Christine M.
- Sanderson Roy
- Sanderson Theo
- Sang Fei
- Sass Thea
- Scher Emily
- Scott Carol
- Scott Garren
- Sehmi Jasveen
- Shaaban Sharif
- Shah Divya
- Shaw Jessica
- Shelest Ekaterina
- Shepherd James G.
- Sheridan Liz A.
- Sheriff Nicola
- Shirley Lesley
- Sillitoe John
- Silviera Siona
- Simpson David A.
- Singh Aditi
- Singleton Dawn
- Skvortsov Timofey
- Sloan Tim J.
- Sluga Graciela
- Smith Colin P.
- Smith Darren L.
- Smith Ken
- Smith Kim S.
- Smith Louise
- Smith Nikki
- Smith Perminder
- Smollett Katherine L.
- Snell Luke B.
- Somassa Thomas
- Southgate Joel
- Spellman Karla
- Spencer Chapman Michael H.
- Spurgin Lewis G.
- Spyer Moira J.
- Stanley Rachael
- Stanley William
- Stanton Thomas D.
- Starinskij Igor
- Stockton Joanne
- Stonehouse Susanne
- Storey Nathaniel
- Studholme David J.
- Sudhanva Malur
- Swindells Emma
- Taha Yusri
- Tan Ngee Keong
- Tang Julian W.
- Tang Miao
- Taylor Ben EW.
- Taylor Joshua F.
- Taylor Sarah
- Temperton Ben
- Templeton K.
- Templeton Kate E.
- Thomas Claire
- Thomas-McEwen Peter MD.
- Thomson Emma C.
- Thomson Laura
- Thornton Alicia
- Thurston Scott AJ.
- Todd John A.
- Tomb Rachael
- Tong Lily
- Tonkin-Hill Gerry
- Tovar-Corona Jaime M.
- Trebes Amy
- Trotter Alexander J.
- Tsatsani Ioulia
- Turnbull Robyn
- Twohig Katherine A.
- Umpleby Helen
- Underwood Anthony P.
- Vamos Edith E.
- Vasylyeva Tetyana I.
- Vattipally Sreenu
- Vernet Gabrielle
- Vipond Barry B.
- Volz Erik M.
- Walsh Sarah
- Wang Dennis
- Warne Ben
- Warwick-Dugdale Joanna
- Wastnedge Elizabeth
- Watkins Joanne
- Watson DipHE Louisa K.
- Waugh Sheila
- Webster Hermione J.
- Weldon Danni
- Westwick Elaine
- Whalley Thomas
- Wheeler Helen
- Whitehead Mark
- Whiteley Max
- Whitwham Andrew
- Wierzbicki Claudia
- Willford Nicholas J.
- Williams Catryn
- Williams Charlotte A.
- Williams Cheryl
- Williams Chris
- Williams Lesley-Anne
- Williams Rachel J.
- Williams Rebecca
- Williams Thomas
- Williamson Kathleen A.
- Wilson-Davies Eleri
- Witele Eric
- Withell Karen T.
- Witney Adam A.
- Wolverson Paige
- Wong Nick
- Workma Trudy
- Wright Derek W.
- Wright Victoria
- Wyatt Tim
- Wyllie Sarah
- Xu-McCrae Li
- Yavus Mehmet
- Yaze Geraldine
- Yeats Corin A.
- Yebra Gonzalo
- Yew Wen C.
- Young Gregory R.
- Young Jamie
- Zarebski Alex E.
- Zhang Peijun
- Publication venue
- 'Elsevier BV'
- Publication date
- 09/03/2023
- Field of study
Background
The first epidemic wave of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in Scotland resulted in high case numbers and mortality in care homes. In Lothian, over one-third of care homes reported an outbreak, while there was limited testing of hospital patients discharged to care homes.
Aim
To investigate patients discharged from hospitals as a source of SARS-CoV-2 introduction into care homes during the first epidemic wave.
Methods
A clinical review was performed for all patients discharges from hospitals to care homes from 1st March 2020 to 31st May 2020. Episodes were ruled out based on coronavirus disease 2019 (COVID-19) test history, clinical assessment at discharge, whole-genome sequencing (WGS) data and an infectious period of 14 days. Clinical samples were processed for WGS, and consensus genomes generated were used for analysis using Cluster Investigation and Virus Epidemiological Tool software. Patient timelines were obtained using electronic hospital records.
Findings
In total, 787 patients discharged from hospitals to care homes were identified. Of these, 776 (99%) were ruled out for subsequent introduction of SARS-CoV-2 into care homes. However, for 10 episodes, the results were inconclusive as there was low genomic diversity in consensus genomes or no sequencing data were available. Only one discharge episode had a genomic, time and location link to positive cases during hospital admission, leading to 10 positive cases in their care home.
Conclusion
The majority of patients discharged from hospitals were ruled out for introduction of SARS-CoV-2 into care homes, highlighting the importance of screening all new admissions when faced with a novel emerging virus and no available vaccine
SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway
- Author
- Aanensen David M.
- Abraham Priyanka
- Abudahab Khalil
- Adams Alexander
- Adams Helen
- Adele Sandra
- Afifi Safiah
- Aggarwal Dinesh
- Ahmad Shazaad S. Y.
- Aigrain Louise
- Alcolea-Medina Adela
- Alikhan Nabil-Fareed
- Allara Elias
- Amato Roberto
- Angyal Adrienn
- Annett Tara
- Ansari M. Azim
- Aplin Stephen
- Ariani Cristina V.
- Asad Hibo
- Asamaphan Patawee
- Ash Amy
- Ashfield Paula
- Ashford Fiona
- Ashraf Shirin
- Atkinson Laura
- Attwood Stephen W.
- Auckland Cressida
- Austin James
- Aydin Alp
- Baker David J.
- Baker Paul
- Balcazar Carlos E.
- Ball Jonathan
- Barnes Eleanor
- Barrett Jeffrey C.
- Barrow Magdalena
- Barton Edward
- Bashton Matthew
- Bassett Andrew R.
- Batra Rahul
- Baxter Chris
- Bayzid Nadua
- Beaver Charlotte
- Beckett Angela H.
- Beckwith Shaun M.
- Bedford Luke
- Beer Robert
- Beggs Andrew
- Bellis Katherine L.
- Berry Louise
- Bertolusso Beatrice
- Best Angus
- Betteridge Emma
- Bibby David
- Bicknell Kelly
- Binns Debbie
- Birchley Alec
- Bird Paul W.
- Bishop Chloe
- Blacow Rachel
- Blakey Victoria
- Blane Beth
- Bolt Frances
- Bonfield James
- Bonner Stephen
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Bouzidi Kate El
- Boyd Olivia
- Bradley Declan T.
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgett Stephen
- Bronner Iraad F.
- Brooks Ellena
- Broos Alice
- Brown Anthony
- Brown Julianne R.
- Bucca Giselda
- Buchan Sarah L.
- Buck David
- Bull Matthew
- Burns Phillipa J.
- Burton-Fanning Shirelle
- Byaruhanga Timothy
- Byott Matthew
- Campbell Sharon
- Cantoni Diego
- Carabelli Alessandro M.
- Cargill James S.
- Carlile Matthew
- Carvalho Sílvia F.
- Casey Anna
- Castigador Anibolina
- Catalan Jana
- Chalker Vicki
- Chaloner Nicola J.
- Chand Meera
- Chappell Joseph G.
- Charalampous Themoula
- Chatterton Wendy
- Chaudhry Yasmin
- Churcher Carol M.
- Clark Gemma
- Clarke Phillip
- Cogger Benjamin J.
- Cole Kevin
- Collins Jennifer
- Colquhoun Rachel
- Connor Thomas R.
- Cook Kate F.
- Coombes Jason
- Corden Sally
- Cormie Claire
- Cortes Nicholas
- Cotic Marius
- Cotton Seb
- Cottrell Simon
- Coupland Lindsay
- Cowton Vanessa
- Cox Alison
- Cox MacGregor
- Craine Noel
- Crawford Liam
- Cross Aidan
- Crown Matthew R.
- Crudgington Dorian
- Cumley Nicola
- Curran Martin D.
- Curran Tanya
- Cutino-Moguel Teresa
- da Silva Filipe Ana
- da Silva Filipe Ana
- Dabrera Gavin
- Darby Alistair C.
- Davidson Rose K.
- Davies Alisha
- Davies Robert M.
- Davis Chris
- Davis Thomas
- de Angelis Daniela
- De Lacy Elen
- De Lorenzo Giuditta
- de Oliveira Martins Leonardo
- de Silva Thushan
- de Silva Thushan I.
- Debebe Johnny
- Deeks Alexandra
- Denton-Smith Rebecca
- Dervisevic Samir
- Dewar Rebecca
- Dey Jayasree
- Dias Joana
- Dobie Donald
- Dorman Matthew J.
- Downing Fatima
- Driscoll Megan
- du Plessis Louis
- Duckworth Nichola
- Dunachie Susanna
- Dunachie Susanna
- Duncan Christopher
- Durham Jillian
- Eastick Kirstine
- Easton Lisa J.
- Eccles Richard
- Edgeworth Jonathan
- Edwards Sue
- Eldirdiri Sahar
- Ellaby Nicholas
- Elliott Scott
- Eltringham Gary
- Ensell Leah
- Erkiert Michelle J.
- Essex Sarah
- Evans Cariad
- Evans Johnathan M.
- Everson William
- Fairley Derek J.
- Fallon Karlie
- Fanaie Arezou
- Farr Ben W.
- Fearn Christopher
- Feltwell Theresa
- Ferguson Lynne
- Fina Laia
- Flaviani Flavia
- Fleming Vicki M.
- Forrest Sally
- Foster-Nyarko Ebenezer
- Foulkes Benjamin H.
- Foulser Luke
- Fragakis Mireille
- Frampton Dan
- Francois Sarah
- Fraser Christophe
- Freeman Timothy M.
- Fryer Helen
- Fuchs Marc
- Fuller William
- Furnon Wilhelm
- Gajee Kavitha
- Galai Katerina
- Gallagher Abbie
- Gallagher Eileen
- Gallagher Michael D.
- Gallis Marta
- Gaskin Amy
- Gatica-Wilcox Bree
- Geidelberg Lily
- Gemmell Matthew
- Georgana Iliana
- George Ryan P.
- Gifford Laura
- Gilbert Lauren
- Girgis Sophia T.
- Glaysher Sharon
- Goldstein Emily J.
- Golubchik Tanya
- Gomes Andrea N.
- Gonçalves Sónia
- Goodfellow Ian G.
- Goodwin Scott
- Goudarzi Salman
- Gourtovaia Marina
- Graham Clive
- Graham Lee
- Grant Paul R.
- Green Angie
- Green Luke R.
- Greenaway Jane
- Gregory Richard
- Grove Joe
- Guest Martyn
- Gunson Rory
- Gunson Rory N.
- Gupta Ravi K.
- Gutierrez Bernardo
- Haldenby Sam T.
- Hamilton William L.
- Hansford Samantha E.
- Haque Tanzina
- Harris Kathryn A.
- Harrison Ewan M.
- Harrison Ian
- Hart Jennifer
- Hartley John A.
- Harvey Matthew
- Harvey William T.
- Harvey William T.
- Hassan-Ibrahim Mohammed O.
- Haughney John
- Heaney Judith
- Helmer Thomas
- Henderson John H.
- Hesketh Andrew R.
- Hey Jessica
- Heyburn David
- Higginson Ellen E.
- Hill Jack D.
- Hill Verity
- Hilson Rachel A.
- Hilvers Ember
- Holden Matthew T. G.
- Holden Matthew T. G.
- Holland Poppy
- Hollis Amy
- Holmes Alison H.
- Holmes Christopher W.
- Holmes Nadine
- Hopes Richard
- Hornsby Hailey R.
- Hosmillo Myra
- Houlihan Catherine
- Howson-Wells Hannah C.
- Hsu Sharon N.
- Hubb Jonathan
- Huckson Hannah
- Hughes Joseph
- Hughes Joseph
- Hughes Margaret
- Hughes Warwick
- Hutchings Stephanie
- Idle Giles
- Illingworth Chris J.
- Impey Robert
- Irish-Tavares Dianne
- Iturriza-Gomara Miren
- Izuagbe Rhys
- Jackson Ben
- Jackson Chris
- Jackson David K.
- Jackson Kathryn A.
- Jackson Leigh M.
- Jahun Aminu S.
- James Keith
- James Victoria
- Jeanes Christopher
- Jeffries Aaron R.
- Jeremiah Sarah
- Jermy Andrew
- John Michaela
- Johnson Kate
- Johnson Rob
- Johnston Ian
- Jones Christopher R.
- Jones Hannah
- Jones Neil
- Jones Owen
- Jones Sophie
- Joseph Amelia
- Judges Sarah
- Kay Gemma L.
- Kay Sally
- Keatley Jon-Paul
- Keeley Alexander J.
- Kele Beatrix
- Kenyon Anita
- Kermack Leanne M.
- Khakh Manjinder
- Kidd Stephen P.
- Killough Nicholas F.
- Kimuli Maimuna
- Kirk Stuart
- Kitchen Christine
- Kitchman Katie
- Klenerman Paul
- Klenerman Paul
- Knight Bridget A.
- Koshy Cherian
- Kraemer Moritz U. G.
- Kronsteiner Barbara
- Kumziene-Summerhayes Sara
- Kwiatkowski Dominic
- Lackenby Angie
- Laing Kenneth G.
- Lampejo Temi
- Langford Cordelia F.
- Lavin Deborah
- Lawton Andrew I.
- Le-Viet Thanh
- Lee David
- Lee Jack C. D.
- Lensing Stefanie V.
- Leonard Steven
- Levett Lisa J.
- Lewis Jonathan
- Lewis Kevin
- Liddle Jennifier
- Liggett Steven
- Lillie Patrick J.
- Lindsey Benjamin B.
- Lister Michelle M.
- Livett Rich
- Lo Stephanie
- Logan Nicola
- Loman Nicholas J.
- Loose Matthew W.
- Louka Stavroula F.
- Loveson Katie F.
- Lowdon Sarah
- Lowe Hannah
- Lowe Helen L.
- Lucaci Anita O.
- Ludden Catherine
- Lynch Jessica
- Lyons Ronan A.
- Lythgoe Katrina
- Machin Nicholas W.
- MacIntyre-Cockett George
- Mack Andrew
- Macklin Ben
- Maclean Alasdair
- MacLean Oscar A.
- Macnaughton Emily
- Madona Pinglawathee
- Maes Mailis
- Maftei Laurentiu
- Mahanama Adhyana I. K.
- Mahungu Tabitha W.
- Mair Daniel
- Maksimovic Joshua
- Malone Cassandra S.
- Maloney Daniel
- Manali Maria
- Manesis Nikos
- Manley Robin
- Mantzouratou Anna
- Marchbank Angela
- Mariappan Arun
- Martincorena Inigo
- Martinez Nunez Rocio T.
- Mather Alison E.
- Maxwell Patrick
- Mayhew Megan
- Mbisa Tamyo
- McCann Clare M.
- McCarthy Shane A.
- McCluggage Kathryn
- McClure Patrick C.
- McCrone J. T.
- McHugh Martin P.
- McKenna James P.
- McKerr Caoimhe
- McManus Georgina M.
- McMurray Claire
- McMurray Claire L.
- McNally Alan
- Meadows Lizzie
- Medd Nathan
- Megram Oliver
- Menegazzo Mirko
- Merrick Ian
- Michell Stephen L.
- Michelsen Michelle L.
- Mirfenderesky Mariyam
- Mirza Jeremy
- Miskelly Julia
- Moles-Garcia Emma
- Moll Robin J.
- Molnar Zoltan
- Monahan Irene M.
- Mondani Matteo
- Mookerjee Siddharth
- Moore Catherine
- Moore Christopher
- Moore Jonathan
- Moore Nathan
- Moore Shona
- Morcrette Helen
- Morgan Mari
- Morgan Sian
- Mori Matilde
- Morriss Arthur
- Moses Samuel
- Mower Craig
- Muir Peter
- Mukaddas Afrida
- Munemo Florence
- Munn Robert
- Murcia Pablo R.
- Murray Abigail
- Murray Darren R.
- Murray Leanne J.
- Murray Sam M.
- Mutingwende Manasa
- Myers Richard
- Nastouli Eleni
- Nebbia Gaia
- Nelson Andrew
- Nelson Charlotte
- Nicholls Sam
- Nichols Jenna
- Nicodemi Roberto
- Nomikou Kyriaki
- O?Brien Sarah
- O?Grady Justin
- O?Toole Áine
- Odedra Mina
- Ohemeng-Kumi Natasha
- Oliver Karen
- Orton Richard
- Orton Richard J.
- Osman Husam
- Pacchiarini Nicole
- Padgett Debra
- Page Andrew J.
- Palmarini Massimo
- Park Emily J.
- Park Naomi R.
- Parker Matthew D.
- Parmar Surendra
- Partridge David G.
- Pascall David
- Pascall David J.
- Patel Amita
- Patel Arvind H.
- Patel Bindi
- Paterson Steve
- Payne Brendan A. I.
- Payne Rebecca
- Peacock Sharon J.
- Pearson Clare
- Pelosi Emanuela
- Percival Benita
- Perkins Jon
- Perry Malorie
- Pinckert Malte L.
- Pinto Rute Maria
- Platt Steven
- Podplomyk Olga
- Pohare Manoj
- Pond Marcus
- Pope Cassie F.
- Poplawski Radoslaw
- Powell Jessica
- Poyner Jennifer
- Prestwood Liam
- Price Anna
- Price James R.
- Prieto Jacqui A.
- Pritchard David T.
- Prosolek Sophie J.
- Pugh Georgia
- Pusok Monika
- Puxty Kathryn
- Pybus Oliver G.
- Pymont Hannah M.
- Quail Michael A.
- Quick Joshua
- Radulescu Clara
- Raghwani Jayna
- Ragonnet-Cronin Manon
- Rainbow Lucille
- Rajan Diana
- Rajatileka Shavanthi
- Ramadan Newara A.
- Rambaut Andrew
- Ramble John
- Randell Paul
- Randell Paul A.
- Ratcliffe Liz
- Raviprakash Veena
- Ray Surajit
- Raza Mohammad
- Redshaw Nicholas M.
- Rey Sara
- Reynolds Nicola
- Richter Alex
- Richter Alex
- Robertson David L.
- Robertson David L.
- Robinson Esther
- Robson Samuel C.
- Rogan Fiona
- Rooke Stefan
- Rowe Will
- Roy Sunando
- Rudder Steven
- Ruis Chris
- Rushton Steven
- Ryan Felicity
- Saeed Kordo
- Samaraweera Buddhini
- Sambles Christine M.
- Sanderson Roy
- Sanderson Theo
- Sang Fei
- Sass Thea
- Scher Emily
- Scott Carol
- Scott Garren
- Scott Sam
- Sehmi Jasveen
- Shaaban Sharif
- Shaaban Sharif
- Shah Divya
- Shaw Jessica
- Shelest Ekaterina
- Shepherd James G.
- Sheridan Liz A.
- Sheriff Nicola
- Shirley Lesley
- Sillitoe John
- Silva Vanessa
- Silviera Siona
- Simpson David A.
- Singh Aditi
- Singleton Dawn
- Skvortsov Timofey
- Sloan Tim J.
- Sluga Graciela
- Smith Colin P.
- Smith Darren L.
- Smith Ken
- Smith Kim S.
- Smith Louise
- Smith Nikki
- Smith Perminder
- Smollett Katherine
- Smollett Katherine L.
- Snell Luke B.
- Somassa Thomas
- Southgate Joel
- Spellman Karla
- Spencer Chapman Michael H.
- Spurgin Lewis G.
- Spyer Moira J.
- Stanley Rachael
- Stanley William
- Stanton Thomas D.
- Starinskij Igor
- Stockton Joanne
- Stonehouse Susanne
- Storey Nathaniel
- Studholme David J.
- Sudhanva Malur
- Swindells Emma
- Szemiel Agnieszka
- Taha Yusri
- Tan Ngee Keong
- Tang Julian W.
- Tang Miao
- Taylor Ben E. W.
- Taylor Joshua F.
- Taylor Sarah
- Temperton Ben
- Templeton Kate
- Templeton Kate E.
- Thomas Claire
- Thomson Emma C.
- Thomson Emma C.
- Thomson Laura
- Thornton Alicia
- Thurston Scott A. J.
- Todd John A.
- Tomb Rachael
- Tong Lily
- Tong Lily
- Tonkin-Hill Gerry
- Torok M. Estee
- Tovar-Corona Jaime M.
- Trebes Amy
- Trotter Alexander J.
- Tsatsani Ioulia
- Turnbull Robyn
- Turtle Lance
- Twohig Katherine A.
- Umpleby Helen
- Underwood Anthony P.
- Vamos Edith E.
- Vasylyeva Tetyana I.
- Vattipally Sreenu
- Vernet Gabrielle
- Vink Elen
- Vipond Barry B.
- Volz Erik M.
- Walsh Sarah
- Wang Dennis
- Warne Ben
- Warwick-Dugdale Joanna
- Wastnedge Elizabeth
- Watkins Joanne
- Watson Louisa K.
- Waugh Sheila
- Webster Hermione J.
- Weldon Danni
- Westwick Elaine
- Whalley Thomas
- Wheeler Helen
- Whitehead Mark
- Whiteley Max
- Whitwham Andrew
- Wierzbicki Claudia
- Wilkie Craig
- Willett Brian J.
- Willford Nicholas J.
- Williams Catryn
- Williams Charlotte A.
- Williams Cheryl
- Williams Chris
- Williams Lesley-Anne
- Williams Rachel J.
- Williams Rebecca
- Williams Thomas
- Williamson Kathleen A.
- Wilson-Davies Eleri
- Witele Eric
- Withell Karen T.
- Witney Adam A.
- Wolverson Paige
- Wong Nick
- Workman Trudy
- Wright Derek W.
- Wright Victoria
- Wyatt Tim
- Wyllie Sarah
- Xu-McCrae Li
- Yavus Mehmet
- Yaze Geraldine
- Yeats Corin A.
- Yebra Gonzalo
- Yebra Gonzalo
- Yew Wen C.
- Young Gregory R.
- Young Jamie
- Zarebski Alex E.
- Zhang Peijun
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 31/08/2022
- Field of study
Vaccines based on the spike protein of SARS-CoV-2 are a cornerstone of the public health response to COVID-19. The emergence of hypermutated, increasingly transmissible variants of concern (VOCs) threaten this strategy. Omicron (B.1.1.529), the fifth VOC to be described, harbours multiple amino acid mutations in spike, half of which lie within the receptor-binding domain. Here we demonstrate substantial evasion of neutralization by Omicron BA.1 and BA.2 variants in vitro using sera from individuals vaccinated with ChAdOx1, BNT162b2 and mRNA-1273. These data were mirrored by a substantial reduction in real-world vaccine effectiveness that was partially restored by booster vaccination. The Omicron variants BA.1 and BA.2 did not induce cell syncytia in vitro and favoured a TMPRSS2-independent endosomal entry pathway, these phenotypes mapping to distinct regions of the spike protein. Impaired cell fusion was determined by the receptor-binding domain, while endosomal entry mapped to the S2 domain. Such marked changes in antigenicity and replicative biology may underlie the rapid global spread and altered pathogenicity of the Omicron variant
Genomic reconstruction of the SARS-CoV-2 epidemic in England.
- Author
- Aanensen DM
- Abnizova I
- Abudahab K
- Adams A
- Adams H
- Afifi S
- Aggarwal D
- Ahmad SSY
- Aigrain L
- Alcolea A
- Alderton A
- Ali M
- Alikhan N-F
- Allara E
- Allen L
- Amato R
- Anderson R
- Angyal A
- Annett T
- Aplin S
- Ariani C
- Ariani CV
- Asad H
- Ash A
- Ashfield P
- Ashford F
- Atkinson L
- Attwood SW
- Auckland C
- Austin-Guest S
- Aydin A
- Baker DJ
- Baker P
- Bala S
- Balcazar CE
- Ball J
- Barrett J
- Barrett JC
- Barrow M
- Barton E
- Bashton M
- Bassett A
- Bassett AR
- Batra R
- Battleday K
- Baxter C
- Bayzid N
- Beal J
- Beale M
- Beaver C
- Beckett AH
- Beckwith SM
- Bedford L
- Beer R
- Beggs A
- Bellany S
- Bellerby T
- Bellis K
- Bellis KL
- Berger D
- Berriman M
- Berry L
- Bertolusso B
- Best A
- Betteridge E
- Bevan P
- Bibby D
- Bicknell K
- Binley S
- Binns D
- Birchley A
- Bird PW
- Birney E
- Bishop C
- Bishop J
- Blackburn K
- Blacow R
- Blakey V
- Blane B
- Bolt F
- Bonfield J
- Bonner S
- Bonsall D
- Boswell T
- Bosworth A
- Boughton N
- Bourgeois Y
- Bowker S
- Boyd O
- Bradley DT
- Breen C
- Brendler-Spaeth T
- Bresner C
- Breuer J
- Bridgett S
- Bronner I
- Bronner IF
- Brooklyn T
- Brooks E
- Broos A
- Brown JR
- Bucca G
- Buchan SL
- Buck D
- Buddenborg SK
- Bull M
- Burns PJ
- Burton-Fanning S
- Bush R
- Byaruhanga T
- Byott M
- Caetano C
- Cagan A
- Campbell S
- Carabelli AM
- Cargill JS
- Carlile M
- Carter N
- Cartwright J
- Carvalho SF
- Casey A
- Castigador A
- Catalan J
- Chalker V
- Chaloner NJ
- Chand M
- Chand M
- Chapman L
- Chappell JG
- Charalampous T
- Chatterton W
- Chaudhry Y
- Chillingworth T-J
- Churcher CM
- Clapham P
- Clark G
- Clark R
- Clarke A
- Clarke C
- Clarke P
- Cogger BJ
- Cole D
- Cole K
- Collins J
- Colquhoun R
- Connor TR
- Cook E
- Cook KF
- Coombes J
- Coppola M
- Corden S
- Cormie C
- Cornell L
- Cornwell C
- Cortes N
- Corton C
- Cotic M
- Cotton S
- Cottrell S
- Coupland L
- Cox A
- Cox M
- Crackett A
- Craine N
- Cranage A
- Craven H
- Craw S
- Crawford L
- Crawford M
- Cross A
- Crown MR
- Crudgington D
- Cumley N
- Curran MD
- Curran T
- Cutts T
- da Silva Filipe A
- Dabrera G
- Dabrowska M
- Darby AC
- Davidson RK
- Davies A
- Davies M
- Davies R
- Davies RM
- Davis T
- Dawson J
- Day C
- de Angelis D
- De Lacy E
- De Maio N
- de Oliveira Martins L
- de Silva TI
- Debebe J
- Densem A
- Denton-Smith R
- Dervisevic S
- Dewar R
- Dey J
- Dias J
- Dibling T
- Dobie D
- Dockree C
- Dodd D
- Dogga S
- Dorman M
- Dorman MJ
- Dougan G
- Dougherty M
- Dove A
- Downing F
- Drummond L
- Drury E
- du Plessis L
- Duckworth N
- Dudek M
- Durham J
- Durrant L
- Easthope E
- Eastick K
- Easton LJ
- Eccles R
- Eckert S
- Edgeworth J
- Edwards S
- El Bouzidi K
- Eldirdiri S
- Ellaby N
- Elliott S
- Ellis P
- Eltringham G
- Ensell L
- Erkiert MJ
- Essex S
- Evans C
- Evans JM
- Everson W
- Fairley DJ
- Fallon K
- Fanaie A
- Farr B
- Farr BW
- Fearn C
- Feltwell T
- Fenton M
- Ferguson L
- Ferrero M
- Fina L
- Flack N
- Flaviani F
- Fleming VM
- Fordham H
- Forrest S
- Forsythe G
- Foster-Nyarko E
- Foulkes BH
- Foulser L
- Fragakis M
- Frampton D
- Francis M
- Francois S
- Fraser A
- Fraser C
- Freeman A
- Freeman TM
- Fryer H
- Fuchs M
- Fuller W
- Funk S
- Gajee K
- Galai K
- Gallagher A
- Gallagher E
- Gallagher MD
- Gallis M
- Galvin A
- Garcia-Casado M
- Gaskin A
- Gatica-Wilcox B
- Gedny A
- Geidelberg L
- Gemmell M
- Georgana I
- George RP
- Gerstung M
- Gifford L
- Gilbert L
- Girgis S
- Girgis ST
- Glaysher S
- Glover J
- Goater R
- Goldman N
- Goldstein EJ
- Golubchik T
- Gomes AN
- Goncalves S
- Gonçalves S
- Gonçalves S
- Goodfellow IG
- Goodwin S
- Goudarzi S
- Gould O
- Gourtovaia M
- Graham C
- Graham L
- Grant PR
- Gray A
- Gray E
- Green A
- Green LR
- Greenaway J
- Gregory R
- Griffiths C
- Gu Y
- Guerin F
- Guest M
- Gunson RN
- Gupta RK
- Gutierrez B
- Haldenby ST
- Hamilton W
- Hamilton WL
- Hanks H
- Hansford SE
- Haque T
- Harris KA
- Harrison E
- Harrison EM
- Harrison I
- Harrott A
- Harry E
- Hart J
- Hartley JA
- Harvey M
- Harvey WT
- Harvison J
- Hassan-Ibrahim MO
- Heaney J
- Heath P
- Hellewell J
- Helmer T
- Henderson JH
- Hernandez-Koutoucheva A
- Hesketh AR
- Hey J
- Heyburn D
- Higginson EE
- Hill JD
- Hill V
- Hilson RA
- Hilvers E
- Hobbs R
- Holden MTG
- Holland D
- Hollis A
- Holmes AH
- Holmes CW
- Holmes N
- Holmes S
- Hopes R
- Hornett G
- Hornsby HR
- Hosmillo M
- Hough N
- Houlihan C
- Howson-Wells HC
- Hsu SN
- Hubb J
- Huckle L
- Huckson H
- Hughes J
- Hughes M
- Hughes W
- Hughes-Hallet L
- Hunter A
- Hutchings S
- Idle G
- Illingworth CJ
- Impey R
- Inglis S
- Iqbal S
- Irish-Tavares D
- Iturriza-Gomara M
- Izuagbe R
- Jackson A
- Jackson B
- Jackson C
- Jackson D
- Jackson DK
- Jackson KA
- Jackson LM
- Jahun AS
- James K
- James V
- Jamrozy D
- Jeanes C
- Jeffries AR
- Jeremiah S
- Jermy A
- John M
- Johnson K
- Johnson R
- Johnston I
- Jones CR
- Jones H
- Jones M
- Jones N
- Jones O
- Jones S
- Joseph A
- Judges S
- Jung AW
- Kallepally K
- Kane L
- Kay GL
- Kay K
- Kay S
- Keatley J
- Keatley J-P
- Keeley AJ
- Keith A
- Kenyon A
- Kermack LM
- Khakh M
- Kidd SP
- Kimuli M
- King A
- Kirk S
- Kitchen C
- Kitchin L
- Kitchman K
- Kleanthous M
- Klimekova M
- Knight BA
- Korlevic P
- Koshy C
- Kraemer MUG
- Krasheninnkova K
- Kumziene-Summerhayes S
- Kwiatkowski D
- Kwiatkowski D
- Lackenby A
- Laing KG
- Lampejo T
- Lane G
- Langford C
- Langford CF
- Laverack A
- Lavin D
- Law K
- Lawniczak M
- Lawton AI
- Le-Viet T
- Lee D
- Lee JCD
- Lensing S
- Lensing SV
- Leonard S
- Letchford L
- Levett LJ
- Lewis J
- Lewis K
- Lewis-Wade A
- Liddle J
- Liddle J
- Liggett S
- Lillie PJ
- Lin Q
- Lindsay S
- Lindsey BB
- Linsdell S
- Lister MM
- Livett R
- Lo S
- Loman NJ
- Long R
- Loose MW
- Louka SF
- Lovell J
- Lovell J
- Loveson KF
- Lowdon S
- Lowe H
- Lowe HL
- Lucaci AO
- Ludden C
- Ludden C
- Lynch J
- Lyons RA
- Lythgoe K
- Machin NW
- MacIntyre-Cockett G
- Mack A
- Mack J
- Macklin B
- Maclean A
- Macnaughton E
- Maddison M
- Madona P
- Maes M
- Maftei L
- Mahanama AIK
- Mahungu TW
- Mair D
- Maksimovic J
- Makunin A
- Malone CS
- Maloney D
- Mamun I
- Manesis N
- Manley R
- Mansfield J
- Mantzouratou A
- Marchbank A
- Mariappan A
- Marriott N
- Martin M
- Martincorena I
- Martinez Nunez RT
- Masters KM
- Mather AE
- Maxwell P
- Mayhew M
- Mayho M
- Mbisa T
- McCann CM
- McCarthy S
- McCarthy SA
- McClintock J
- McClure PC
- McCrone JT
- McGuigan S
- McHugh MP
- McHugh S
- McKenna JP
- McKerr C
- McManus GM
- McMinn L
- McMurray C
- McMurray CL
- McNally A
- Meadows C
- Meadows L
- Medd N
- Megram O
- Menegazzo M
- Merrick I
- Michell SL
- Michelsen ML
- Mirfenderesky M
- Mirza J
- Miskelly J
- Mobley E
- Moles-Garcia E
- Moll R
- Moll RJ
- Molnar Z
- Monahan IM
- Mondani M
- Monteiro TC
- Mookerjee S
- Moore C
- Moore C
- Moore J
- Moore N
- Morcrette H
- Morgan M
- Morgan S
- Mori M
- Morra M
- Morriss A
- Morrow L
- Moses S
- Mower C
- Muir P
- Mukaddas A
- Munemo F
- Munn R
- Murie K
- Murray A
- Murray DR
- Murray LJ
- Mutingwende M
- Myers R
- Nash S
- Nastouli E
- Nathwani C
- Naydenova P
- Neaverson A
- Nebbia G
- Nelson A
- Nelson C
- Nelson R
- Nerou E
- Nguyen T
- Nicholls S
- Nichols J
- Nicholson J
- Nicodemi R
- Nimz T
- Noell GG
- Nomikou K
- Odedra M
- Ohan V
- Ohemeng-Kumi N
- Oliver K
- Olney C
- Ormond D
- Orton RJ
- Osman H
- Oszlanczi A
- O’Brien S
- O’Grady J
- O’Meara S
- O’Toole Á
- Pacchiarini N
- Padgett D
- Page AJ
- Palmer S
- Pang YF
- Panovska-Griffiths J
- Pardubska B
- Park EJ
- Park N
- Park NR
- Parker MD
- Parmar A
- Parmar S
- Partridge DG
- Pascall D
- Patel A
- Patel B
- Patel G
- Patel M
- Paterson S
- Payne BAI
- Payne M
- Peacock S
- Peacock SJ
- Pearson C
- Pelosi E
- Percival B
- Perkins J
- Perry M
- Petersen A
- Pinckert ML
- Platt S
- Plowman D
- Podplomyk O
- Pohare M
- Pond M
- Pope CF
- Poplawski R
- Powell J
- Poyner J
- Preston T
- Prestwood L
- Price A
- Price JR
- Prieto JA
- Pritchard DT
- Prosolek SJ
- Puethe C
- Pugh G
- Pusok M
- Pybus OG
- Pymont HM
- Quail M
- Quail MA
- Quick J
- Radulescu C
- Raghwani J
- Ragonnet-Cronin M
- Rainbow L
- Rajan D
- Rajatileka S
- Ramadan NA
- Rambaut A
- Ramble J
- Rance R
- Randell P
- Randell PA
- Ratcliffe L
- Raviprakash V
- Rawlings S
- Raza M
- Redshaw N
- Redshaw NM
- Rey S
- Reynolds J
- Reynolds M
- Reynolds N
- Rice S
- Richardson M
- Richter A
- Roberts C
- Robertson DL
- Robinson D
- Robinson E
- Robinson K
- Robinson M
- Robson SC
- Rogan F
- Rogers H
- Rojo EM
- Rooke S
- Roopra D
- Rose M
- Rowe W
- Roy S
- Rudd L
- Rudder S
- Ruis C
- Rushton S
- Sadri R
- Saeed K
- Saint C
- Salmon N
- Samaraweera B
- Sambles CM
- Sanderson R
- Sanderson T
- Sanderson T
- Sang F
- Sass T
- Saul D
- Scher E
- Schwach F
- Schwach F
- Scott C
- Scott G
- Seekings P
- Sehmi J
- Shaaban S
- Shah D
- Shaw J
- Shelest E
- Shepherd JG
- Sheridan LA
- Sheriff N
- Shirley L
- Sillitoe J
- Silviera S
- Simms A
- Simpson DA
- Singh A
- Singleton D
- Sinnott M
- Sinnott M
- Sivadasan S
- Siwek B
- Sizer D
- Skeldon K
- Skelton J
- Skvortsov T
- Slater-Tunstill J
- Sloan TJ
- Sloper L
- Sluga G
- Smerdon N
- Smith C
- Smith C
- Smith CP
- Smith DL
- Smith J
- Smith K
- Smith K
- Smith KS
- Smith L
- Smith M
- Smith N
- Smith P
- Smith S
- Smith T
- Smollett KL
- Sneade L
- Snell LB
- Somassa T
- Soria CD
- Sousa C
- Souster E
- Southgate J
- Sparkes A
- Spellman K
- Spencer Chapman MH
- Spencer-Chapman M
- Spurgin LG
- Spyer MJ
- Squares J
- Stanley R
- Stanley R
- Stanley W
- Stanton TD
- Starinskij I
- Steed C
- Stickland T
- Still I
- Stockton J
- Stonehouse S
- Storey N
- Stratton MR
- Strickland M
- Studholme DJ
- Suciu M
- Sudhanva M
- Swann A
- Swiatkowska A
- Swift E
- Swindells E
- Sycamore N
- Symons E
- Szluha S
- Taha Y
- Taluy E
- Tan NK
- Tang JW
- Tang M
- Tao N
- Taylor BEW
- Taylor JF
- Taylor K
- Taylor S
- Taylor S
- Temperton B
- Templeton KE
- Thomas C
- Thompson M
- Thompson S
- Thomson EC
- Thomson L
- Thomson M
- Thomson N
- Thornton A
- Thurston S
- Thurston SAJ
- Todd JA
- Tomb R
- Tong L
- Tonkin-Hill G
- Toombs D
- Topping B
- Torok ME
- Tovar-Corona J
- Tovar-Corona JM
- Trebes A
- Trotter AJ
- Tsatsani I
- Turnbull R
- Turtle L
- Twohig KA
- Umpleby H
- Underwood AP
- Ungureanu D
- Uphill J
- Urbanova J
- Vamos EE
- Van Vuuren PJ
- Vancollie V
- Vasylyeva TI
- Vattipally S
- Verdejo CJ
- Vernet G
- Vipond BB
- Voak P
- Volz E
- Volz EM
- Vöhringer HS
- Walker D
- Walker M
- Waller M
- Walsh S
- Wang D
- Ward G
- Warne B
- Warwick-Dugdale J
- Wastnedge E
- Watkins J
- Watson LK
- Waugh S
- Weatherhogg C
- Webb N
- Webster HJ
- Weldon D
- Wells A
- Wells E
- Westwick E
- Westwood L
- Whalley T
- Wheeler H
- Whipp T
- Whitehead M
- Whiteley M
- Whiteley T
- Whitton G
- Whitwham A
- Widaa S
- Wierzbicki C
- Willford NJ
- Williams C
- Williams C
- Williams C
- Williams CA
- Williams L-A
- Williams M
- Williams R
- Williams RJ
- Williams T
- Williamson KA
- Wilson M
- Wilson-Davies E
- Witele E
- Withell KT
- Witney AA
- Wolverson P
- Wong N
- Workman T
- Wright DW
- Wright S
- Wright V
- Wyatt T
- Wyllie S
- Xu-McCrae L
- Yavus M
- Yaze G
- Yeats CA
- Yebra G
- Yew WC
- Young GR
- Young J
- Zamudio ME
- Zarebski AE
- Zhang P
- Publication venue
- Nature
- Publication date
- 01/01/2021
- Field of study
The evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus leads to new variants that warrant timely epidemiological characterization. Here we use the dense genomic surveillance data generated by the COVID-19 Genomics UK Consortium to reconstruct the dynamics of 71 different lineages in each of 315 English local authorities between September 2020 and June 2021. This analysis reveals a series of subepidemics that peaked in early autumn 2020, followed by a jump in transmissibility of the B.1.1.7/Alpha lineage. The Alpha variant grew when other lineages declined during the second national lockdown and regionally tiered restrictions between November and December 2020. A third more stringent national lockdown suppressed the Alpha variant and eliminated nearly all other lineages in early 2021. Yet a series of variants (most of which contained the spike E484K mutation) defied these trends and persisted at moderately increasing proportions. However, by accounting for sustained introductions, we found that the transmissibility of these variants is unlikely to have exceeded the transmissibility of the Alpha variant. Finally, B.1.617.2/Delta was repeatedly introduced in England and grew rapidly in early summer 2021, constituting approximately 98% of sampled SARS-CoV-2 genomes on 26 June 2021
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