Alternative NAD(P)H dehydrogenase and alternative oxidase: proposed physiological roles in animals

The electron transport systems in mitochondria of many organisms contain alternative respiratory enzymes distinct from those of the canonical respiratory system depicted in textbooks. Two of these enzymes, the alternative NADH dehydrogenase and the alternative oxidase, were of interest to a limited circle of researchers until they were envisioned as gene therapy tools for mitochondrial disease treatment. Recently, these enzymes were discovered in several animals. Here, we analyse the functioning of alternative NADH dehydrogenases and oxidases in different organisms. We propose that both enzymes ensure bioenergetic and metabolic flexibility during environmental transitions or other conditions which may compromise the operation of the canonical respiratory system. The electron transport systems in mitochondria of many organisms contain alternative respiratory enzymes distinct from those of the canonical respiratory system depicted in textbooks. Two of these enzymes, the alternative NADH dehydrogenase and the alternative oxidase, were of interest to a limited circle of researchers until they were envisioned as gene therapy tools for mitochondrial disease treatment. Recently, these enzymes were discovered in several animals. Here, we analyse the functioning of alternative NADH dehydrogenases and oxidases in different organisms. We propose that both enzymes ensure bioenergetic and metabolic flexibility during environmental transitions or other conditions which may compromise the operation of the canonical respiratory system

Constraining the origin of the planetary debris surrounding ZTF J0139+5245 through rotational fission of a triaxial asteroid

White dwarfs containing orbiting planetesimals or their debris represent crucial benchmarks by which theoretical investigations of post-main-sequence planetary systems may be calibrated. The photometric transit signatures of likely planetary debris in the ZTF J0139+5245 white dwarf system have an orbital period of about 110 d. An asteroid which breaks up to produce this debris may spin itself to destruction through repeated close encounters with the star without entering its Roche radius and without influence from the white dwarf’s luminosity. Here, we place coupled constraints on the orbital pericentre (q) and the ratio (β) of the middle to longest semiaxes of a triaxial asteroid which disrupts outside of this white dwarf’s Roche radius (rRoche) soon after attaining its 110-d orbit. We find that disruption within tens of years is likely when β ≲ 0.6 and q ≈ 1.0–2.0rRoche, and when β ≲ 0.2 out to q ≈ 2.5rRoche. Analysing the longer time-scale disruption of triaxial asteroids around ZTF J0139+5245 is desirable but may require either an analytical approach relying on ergodic theory or novel numerical techniques

Minimally Parametric Power Spectrum Reconstruction from the Lyman-alpha Forest

Current results from the Lyman alpha forest assume that the primordial power spectrum of density perturbations follows a simple power law form, with running. We present the first analysis of Lyman alpha data to study the effect of relaxing this strong assumption on primordial and astrophysical constraints. We perform a large suite of numerical simulations, using them to calibrate a minimally parametric framework for describing the power spectrum. Combined with cross-validation, a statistical technique which prevents over-fitting of the data, this framework allows us to reconstruct the power spectrum shape without strong prior assumptions. We find no evidence for deviation from scale-invariance; our analysis also shows that current Lyman alpha data do not have sufficient statistical power to robustly probe the shape of the power spectrum at these scales. In contrast, the ongoing Baryon Oscillation Sky Survey (BOSS) will be able to do so with high precision. Furthermore, this near-future data will be able to break degeneracies between the power spectrum shape and astrophysical parameters.Comment: 11 pages plus appendices, 8 figures. v2: matches version published in MNRAS. Some clarifications to discussion and exposition, updated reference

2-Server PIR with sub-polynomial communication

A 2-server Private Information Retrieval (PIR) scheme allows a user to retrieve the $i$th bit of an $n$-bit database replicated among two servers (which do not communicate) while not revealing any information about $i$ to either server. In this work we construct a 1-round 2-server PIR with total communication cost $n^{O({\sqrt{\log\log n/\log n}})}$. This improves over the currently known 2-server protocols which require $O(n^{1/3})$ communication and matches the communication cost of known 3-server PIR schemes. Our improvement comes from reducing the number of servers in existing protocols, based on Matching Vector Codes, from 3 or 4 servers to 2. This is achieved by viewing these protocols in an algebraic way (using polynomial interpolation) and extending them using partial derivatives

Restorative justice : Transformation Project Prison Ministry\u27s reason for growth and motivation of the volunteers

https://place.asburyseminary.edu/ecommonsatsdissertations/1836/thumbnail.jp

Coreografías

Traducción al castellano del intercambio de correspondencia entre Jacques Derrida y Christie V. McDonald, en el otoño de 1981. A partir de las preguntas de McDonald, el filósofo reflexiona en torno a temas como el género, la diferencia sexual, los movimientos feministas, los feminismos, el lugar de la mujer, y el aporte que una perspectiva como la deconstrucción ofrece a su abordaje

Angular dependent magnetothermopower of alpha-(ET)2KHg(SCN)4

The magnetic field and angular dependencies of the thermopower and Nernst effect of the quasi-two-dimensional organic conductor alpha-(ET)2KHg(SCN)4 are experimentally measured at temperatures below (4 K) and above (9 K) the transition temperature to fields of In addition, a theoretical model which involves a magnetic breakdown effect between the q1D and q2D bands is proposed in order to simulate the data. Analysis of the background components of the thermopower and Nernst effect imply that at low temperatures, in the CDW state, the properties of alpha-(ET)2KHg(SCN)4 are determined mostly by the orbits on the new open Fermi sheets. Quantum oscillations observed in the both thermoelectric effects, at fields above 8 T, originate only from the alpha orbit.Comment: 25 pages, 18 figure

Genome sequence of canine herpesvirus

Canine herpesvirus is a widespread alphaherpesvirus that causes a fatal haemorrhagic disease of neonatal puppies. We have used high-throughput methods to determine the genome sequences of three viral strains (0194, V777 and V1154) isolated in the United Kingdom between 1985 and 2000. The sequences are very closely related to each other. The canine herpesvirus genome is estimated to be 125 kbp in size and consists of a unique long sequence (97.5 kbp) and a unique short sequence (7.7 kbp) that are each flanked by terminal and internal inverted repeats (38 bp and 10.0 kbp, respectively). The overall nucleotide composition is 31.6% G+C, which is the lowest among the completely sequenced alphaherpesviruses. The genome contains 76 open reading frames predicted to encode functional proteins, all of which have counterparts in other alphaherpesviruses. The availability of the sequences will facilitate future research on the diagnosis and treatment of canine herpesvirus-associated disease