517 research outputs found
Close entrainment of massive molecular gas flows by radio bubbles in the central galaxy of Abell 1795
We present new ALMA observations tracing the morphology and velocity structure of the molecular gas in the central galaxy of the cluster Abell 1795. The molecular gas lies in two filaments that extend 5â7âkpc to the N and S from the nucleus and project exclusively around the outer edges of two inner radio bubbles. Radio jets launched by the central active galactic nucleus have inflated bubbles filled with relativistic plasma into the hot atmosphere surrounding the central galaxy. The N filament has a smoothly increasing velocity gradient along its length from the central galaxyâs systemic velocity at the nucleus to â370kmsâ1 â370kmsâ1 , the average velocity of the surrounding galaxies, at the furthest extent. The S filament has a similarly smooth but shallower velocity gradient and appears to have partially collapsed in a burst of star formation. The close spatial association with the radio lobes, together with the ordered velocity gradients and narrow velocity dispersions, shows that the molecular filaments are gas flows entrained by the expanding radio bubbles. Assuming a Galactic XCO factor, the total molecular gas mass is 3.2â±â0.2 Ă 109âMâ. More than half lies above the N radio bubble. Lifting the molecular clouds appears to require an infeasibly efficient coupling between the molecular gas and the radio bubble. The energy required also exceeds the mechanical power of the N radio bubble by a factor of 2. Stimulated feedback, where the radio bubbles lift low-entropy X-ray gas that becomes thermally unstable and rapidly cools in situ, provides a plausible model. Multiple generations of radio bubbles are required to lift this substantial gas mass. The close morphological association then indicates that the cold gas either moulds the newly expanding bubbles or is itself pushed aside and shaped as they inflate
Impact of cooking on vitamin D-3 and 25(OH)D-3 content of pork products
Publication history: Accepted - 29 July 2022; Published online - 2 August 2022Little is known regarding the impact of cooking on vitamin D content in pork, despite meat being a major contributor to vitamin D intakes.
This paper investigated the effect of household cooking (pan-fry/roast/grill/sous-vide/sauté), on the vitamin D3 and 25-hydroxyvitamin D3 (25(OH)D3) concentration/retention in pork loin, mince and sausages. We hypothesised that vitamin D concentrations would be higher in cooked vs raw pork, and retention would differ between products.
Cooking significantly increased vitamin D3 (+49 %) and 25(OH)D3 (+33 %) concentrations. All cooked loin vitamin D3 concentrations were significantly lower than mince/sausage. Vitamin D3 retention was > 100 % for all samples (102â135 %), except sautĂ© mince (99 %) which still did not differ significantly from 100 % retention. Sous-vide cooking resulted in the highest vitamin D3 retention (135 %).
Likely owing to water/fat loss, household cooking of pork results in favourable retention of vitamin D3 and 25(OH)D3. The type of pork product has greater influence than cooking method.This work was funded as part of a Department for the Economy (DfE; Northern Ireland) Co-operative Awards in Science and Technology (CAST) PhD studentship, supported by Devenish Nutrition Limited
Biological anthropology in the Indo-Pacific Region: New approaches to age-old questions
Biological anthropological research, the study of both modern and past humans, is a burgeoning field in the Indo-Pacific region. It is becoming increasingly apparent that the unique environments of the Indo-Pacific have resulted in an archaeological record that does not necessarily align with those in the northern hemisphere. New, regionally-specific archaeological models are being developed, and biological anthropological research has an important role to play in establishing past human experience within these models. In the Indo-Pacific, research using ancient and modern human tissues is adding insight into global processes of prehistoric settlement and migrations, subsistence change and human biosocial adaptation. This review synthesises current themes in biological anthropology in this region. It highlights the diverse methods and approaches used by biological anthropologists to address globally-relevant archaeological questions. In recent decades a collaborative approach between archaeologists, biological anthropologists and local communities has become the norm in the region. The many positive outcomes of this multi-disciplinary approach are highlighted here through the use of regionally-specific case studies. This review ultimately aims to stimulate further collaborations between archaeologists, biological anthropologists and the communities in the region, and demonstrate how the evidence from Indo-Pacific research may be relevant to global archaeological models
Symmetry Nonrestoration in a Gross-Neveu Model with Random Chemical Potential
We study the symmetry behavior of the Gross-Neveu model in three and two
dimensions with random chemical potential. This is equivalent to a four-fermion
model with charge conjugation symmetry as well as Z_2 chiral symmetry. At high
temperature the Z_2 chiral symmetry is always restored. In three dimensions the
initially broken charge conjugation symmetry is not restored at high
temperature, irrespective of the value of the disorder strength. In two
dimensions and at zero temperature the charge conjugation symmetry undergoes a
quantum phase transition from a symmetric state (for weak disorder) to a broken
state (for strong disorder) as the disorder strength is varied. For any given
value of disorder strength, the high-temperature behavior of the charge
conjugation symmetry is the same as its zero-temperature behavior. Therefore,
in two dimensions and for strong disorder strength the charge conjugation
symmetry is not restored at high temperature.Comment: 16 pages, 3 figure
Viability analysis and apoptosis induction of breast cancer cells in a microfluidic device: effect of cytostatic drugs
Breast cancer is the leading cause of cancer deaths among non-smoking women worldwide. At the moment the treatment regime is such that patients receive different chemotherapeutic and/or hormonal treatments dependent on the hormone receptor status, the menopausal status and age. However, in vitro sensitivity testing of tumor biopsies could rationalize and improve the choice of chemo- and hormone therapy. Lab-on-a-Chip devices, using microfluidic techniques, make detailed cellular analysis possible using fewer cells, enabling working with a patientsâ own cells and performing chemo- and hormone sensitivity testing in an ex vivo setting. This article describes the development of two microfluidic devices made in poly(dimethylsiloxane) (PDMS) to validate the cell culture properties and analyze the chemosensitivity of MCF-7 cells (estrogen receptor positive human breast cancer cells) in response to the drug staurosporine (SSP). In both cases, cell viability was assessed using the life-stain Calcein-AM (CAAM) and the death dye propidium iodide (PI). MCF-7 cells could be statically cultured for up to 7Â days in the microfluidic chip. A 30Â min flow with SSP and a subsequent 24Â h static incubation in the incubator induced apoptosis in MCF-7 cells, as shown by a disappearance of the aggregate-like morphology, a decrease in CAAM staining and an increase in PI staining. This work provides valuable leads to develop a microfluidic chip to test the chemosensitivity of tumor cells in response to therapeutics and in this way improve cancer treatment towards personalized medicine
Improving vitamin D content in pork meat by UVB biofortification
Publication history: Accepted - 11 January 2023; Published online - 14 January 2023Vitamin D deficiency is prevalent worldwide and identification of alternative food-based strategies are urgently warranted. In two studies, 12-week old crossbred pigs (Duroc x (Large White x Landrace)) were exposed daily to narrowband UVB radiation for âŒ10 weeks or control (no UVB exposure) until slaughter. In Study 1 (n = 48), pigs were exposed to UVB for 2 min and in Study 2 (n = 20), this duration was tripled to 6 min. All pigs were fed the maximum permitted 2000 IU vitamin D3/kg feed. Loin meat was cooked prior to vitamin D LC-MS/MS analysis. In Study 1, pork loin vitamin D3 did not differ between groups. Study 2 provided longer UVB exposure time and resulted in significantly higher loin vitamin D3 (11.97 vs. 6.03 ÎŒg/kg), 25(OH)D3 (2.09 vs. 1.65 ÎŒg/kg) and total vitamin D activity (22.88 vs. 14.50 ÎŒg/kg) concentrations, compared to control (P < 0.05). Pigs remained healthy during both studies and developed no signs of erythema. Biofortification by UVB radiation provides an effective strategy to further safely increase the naturally occurring vitamin D content of pork loin, alongside feed supplementationThis work was funded as part of a Department for the Economy (DfE) Co-operative Awards in Science and Technology (CAST) PhD studentship, supported by Devenish Nutrition Limited and Agri-Food Quest Competence Centre (AFQCC)
A Galaxy-scale Fountain of Cold Molecular Gas Pumped by a Black Hole
We present Atacama Large Millimeter/submillimeter Array and Multi-Unit Spectroscopic Explorer observations of the brightest cluster galaxy in Abell 2597, a nearby (z = 0.0821) cool core cluster of galaxies. The data map the kinematics of a three billion solar mass filamentary nebula that spans the innermost 30 kpc of the galaxy's core. Its warm ionized and cold molecular components are both cospatial and comoving, consistent with the hypothesis that the optical nebula traces the warm envelopes of many cold molecular clouds that drift in the velocity field of the hot X-ray atmosphere. The clouds are not in dynamical equilibrium, and instead show evidence for inflow toward the central supermassive black hole, outflow along the jets it launches, and uplift by the buoyant hot bubbles those jets inflate. The entire scenario is therefore consistent with a galaxy-spanning "fountain," wherein cold gas clouds drain into the black hole accretion reservoir, powering jets and bubbles that uplift a cooling plume of low-entropy multiphase gas, which may stimulate additional cooling and accretion as part of a self-regulating feedback loop. All velocities are below the escape speed from the galaxy, and so these clouds should rain back toward the galaxy center from which they came, keeping the fountain long lived. The data are consistent with major predictions of chaotic cold accretion, precipitation, and stimulated feedback models, and may trace processes fundamental to galaxy evolution at effectively all mass scales
Measurement of the B0-anti-B0-Oscillation Frequency with Inclusive Dilepton Events
The - oscillation frequency has been measured with a sample of
23 million \B\bar B pairs collected with the BABAR detector at the PEP-II
asymmetric B Factory at SLAC. In this sample, we select events in which both B
mesons decay semileptonically and use the charge of the leptons to identify the
flavor of each B meson. A simultaneous fit to the decay time difference
distributions for opposite- and same-sign dilepton events gives ps.Comment: 7 pages, 1 figure, submitted to Physical Review Letter
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