Tipping the balance: targeting the thymus for production of immune cells protective against Auto-Immune Disease

The thymus is the unique site of production of T-cells, an essential arm of the adaptive immune system which is targeted by vaccinations as a defense against infectious diseases. In generating a potent cohort of pathogen- clearing T-cells, small numbers of cells capable of attacking tissues within the body are also produced. Under normal conditions these are kept in check by “regulatory” cells, however if the balance of “auto-immune” and regulatory cells is altered, it has the potential to trigger auto-immune diseases, such as rheumatoid arthritis and diabetes. Using mouse models, we aim to investigate the potential to manipulate thymic production of anti-inflammatory T-cells to aid treatment of auto-immune disease

Homogenization of daily temperature and humidity series in the UK

Building on previous experience with continental and global data sets, we use a quantile-matching approach to homogenize temperature and humidity series measured by a network of 220 stations in the United Kingdom (UK). The data set spans 160 years at daily resolution, although data coverage varies greatly in time, space, and across variables. We use the homogenized data to analyse trends of the mean values as well as the lowest and highest quantiles of the distribution over the last 100 and 50 years. For the latter period, we find large regional differences, particularly between the southeastern and the northern part of the UK. The southeast has seen a faster warming, particularly for maximum temperatures in spring and summer, and a reduction of relative humidity; the northern mainland has become more humid and only slightly warmer. These differences become more evident for the highest quantiles and reflect a well-known pattern of climate change affecting the extra-tropics. Among the studied variables, the increases of wet bulb temperature and specific humidity are the most spatially homogeneous and are statistically significant for most stations in all seasons except winter

Comparison of “Zero Emission” Vehicles with Petrol and Hybrid Cars in Terms of Total CO2 Release—A Case Study for Romania, Poland, Norway and Germany

publishedVersio

PTFE mapping in gas diffusion media for PEMFCs using fluorescence microscopy

Differentiating between the various polytetrafluoroethylene based structures inside polymer electrolyte membrane fuel cells with a degree of certainty is necessary to optimize manufacturing processes and to investigate possible degradation mechanisms. We have developed a novel method using fluorescence microscopy for distinguishing the origin and location of PTFE and/or Nafion® in Membrane Electrode assemblies and the gas diffusion media from different sources and stages of processing. Fluorescent material was successfully diffused into the PTFE based structures in the GDM by addition to the ‘ink’ precursor for both the microporous layer and the catalyst layer; this made it possible to map separately both layers in a way that has not been reported before. It was found that hot pressing of membrane coated structures resulted in physical dispersion of those layers away from the membrane into the GDM itself. This fluorescence technique should be of interest to membrane electrode assembly manufacturers and fuel cell developers and could be used to track the degradation of different PTFE structures independently in the future

PTFE mapping in gas diffusion media for PEMFCs using fluorescence microscopy

Differentiating between the various polytetrafluoroethylene based structures inside polymer electrolyte membrane fuel cells with a degree of certainty is necessary to optimize manufacturing processes and to investigate possible degradation mechanisms. We have developed a novel method using fluorescence microscopy for distinguishing the origin and location of PTFE and/or Nafion® in Membrane Electrode assemblies and the gas diffusion media from different sources and stages of processing. Fluorescent material was successfully diffused into the PTFE based structures in the GDM by addition to the ‘ink’ precursor for both the microporous layer and the catalyst layer; this made it possible to map separately both layers in a way that has not been reported before. It was found that hot pressing of membrane coated structures resulted in physical dispersion of those layers away from the membrane into the GDM itself. This fluorescence technique should be of interest to membrane electrode assembly manufacturers and fuel cell developers and could be used to track the degradation of different PTFE structures independently in the future

Making It: Institutionalizing Collaborative Innovation in Public Higher Education

[EN] This descriptive case study provides a broad overview of JMU X-Labs, an academic maker space (in other words, a teaching lab with fabrication and digital production technologies) that hosts team-taught, project-driven multidisciplinary courses. The JMU X-Labs serves the students and faculty of James Madison University[MSR-m1] , a mid-sized, public, and undergraduate-focused university in the United States. The narrative proceeds from two different but overlapping points of view: how courses at JMU X-Labs are designed and taught; and how administration of JMU X-Labs supports them. The authors refer to specific courses, pedagogical methods, and problem-solving strategies to illustrate the narrative, and they argue throughout that pedagogy and administration are indelibly intertwined in how the organization operates. Gesturing to the broad applicability and transferability of the JMU X-Labs model, the authors mark some of areas of further research that would benefit a more robust understanding of how the organization operates and grows. Finally, the authors speculate how the dynamics of this young and growing organization may answer some core and difficult questions pertaining to innovation in higher education.[MSR-m1]James Madison University (JMU) Clearlyl referenced in abstract and opening paragraph below to explain institutional context as per reviewer request. http://ocs.editorial.upv.es/index.php/HEAD/HEAD18Mccarthy, S.; Barnes, A.; Holland, KS.; Lewis, E.; Ludwig, P.; Swayne, N. (2018). Making It: Institutionalizing Collaborative Innovation in Public Higher Education. Editorial Universitat Politècnica de València. 1549-1557. https://doi.org/10.4995/HEAD18.2018.8247OCS1549155

Failure of interpolation in the intuitionistic logic of constant domains

This paper shows that the interpolation theorem fails in the intuitionistic logic of constant domains. This result refutes two previously published claims that the interpolation property holds.Comment: 13 pages, 0 figures. Overlaps with arXiv 1202.1195 removed, the text thouroughly reworked in terms of notation and style, historical notes as well as some other minor details adde

Observational limits on type 1 active galactic nucleus rate in COSMOS

We present black hole masses and accretion rates for 182 Type 1 active galactic nuclei (AGNs) in COSMOS. We estimate masses using the scaling relations for the broad H β, Mg ii, and C iv emission lines in the redshift ranges 0.16 < z < 0.88, 1 < z < 2.4, and 2.7 < z < 4.9. We estimate the accretion rate using an Eddington ratio LI/L_(Edd) estimated from optical and X-ray data.We find that very few Type 1 AGNs accrete below LI/L_(Edd) ∼ 0.01, despite simulations of synthetic spectra which show that the survey is sensitive to such Type 1 AGNs. At lower accretion rates the broad-line region may become obscured, diluted, or nonexistent. We find evidence that Type 1 AGNs at higher accretion rates have higher optical luminosities, as more of their emission comes from the cool (optical) accretion disk with respect to shorter wavelengths. We measure a larger range in accretion rate than previous works, suggesting that COSMOS is more efficient at finding low accretion rate Type 1 AGNs. However, the measured range in accretion rate is still comparable to the intrinsic scatter from the scaling relations, suggesting that Type 1 AGNs accrete at a narrow range of Eddington ratio, with LI/L_(Edd) ∼ 0.1

Magellan Spectroscopy of AGN Candidates in the COSMOS Field

We present spectroscopic redshifts for the first 466 X-ray and radio-selected AGN targets in the 2 deg^2 COSMOS field. Spectra were obtained with the IMACS instrument on the Magellan (Baade) telescope, using the nod-and-shuffle technique. We identify a variety of Type 1 and Type 2 AGN, as well as red galaxies with no emission lines. Our redshift yield is 72% down to i_AB=24, although the yield is >90% for i_AB<22. We expect the completeness to increase as the survey continues. When our survey is complete and additional redshifts from the zCOSMOS project are included, we anticipate ~1100 AGN with redshifts over the entire COSMOS field. Our redshift survey is consistent with an obscured AGN population that peaks at z~0.7, although further work is necessary to disentangle the selection effects.Comment: 19 pages, 14 figures. Accepted to ApJS special COSMOS issue. The full electronic version of Table 2 can be found at http://shaihulud.as.arizona.edu/~jtrump/tab2.tx