Spectrometric study of condensed phase species of thorium and palladium-based modifiers in a complex matrix for electrothermal atomic absorption spectrometry

The chemical and morphological transformations of condensed phase species of a thorium-based modifier were studied over the temperature range 200–2500 °C, without and with the presence of aluminium and silicon as matrix components, and in some instances, arsenic as an analyte element. A similar study was also conducted with palladium as the modifier, for comparison. Results were derived using scanning electron microscopy (SEM), energy dispersive (ED) X-ray spectrometry, Raman microanalysis and attenuated total reflectance (ATR) Fourier transform-infrared (FT-IR) spectrometry. Comparable results were found using pyrolytic and non-pyrolytic graphite platforms, with processes occurring at slightly higher temperatures on the pyrolytic graphite platform. With thorium as the modifier, metal oxides were the predominant species on the platform surface at relatively low temperatures (<1500 °C), whereas metal phases became prevalent at high temperatures, when thorium and aluminium tended to behave independently from one other. Some spatial variations in the composition of the salt residues on different regions of the platform were observed (from the region closest to the slot in the tube, to the region furthest from the slot). Nonetheless, thorium metal remained on the graphite platform to higher temperatures than did aluminium metal. In the presence of arsenic, the existence of mixtures of thorium and arsenic oxides, just before the appearance temperature of gas phase arsenic atoms, was confirmed by SEM studies, ED X-ray spectra and Raman microanalysis. This suggests that any modifying effect of thorium on arsenic occurs while the modifier is in the oxide phase rather than in the metal phase. The presence of silicon added as silica, did not influence significantly the thermochemical behaviour of mixtures of thorium and aluminium. However, coexistence of silicon and arsenic oxides at the appearance temperature of the atomic absorption signal of arsenic was obtained, confirming that silicon can act as an internal modifier for arsenic. In the presence of palladium, aluminium exhibited greater interaction with the modifier; consequently, aluminium metal was retained on the platform surface to higher temperatures than thorium, which could explain how interference effects of aluminium on e.g. arsenic are avoided or reduced. Similarly, there was evidence for interaction of palladium and arsenic in the reduced state. However, when aluminium and silicon were present, the transformation of the palladium oxide to the metallic state was affected, which could diminish the modifying benefits of palladium for arsenic in the presence of aluminium

CA19-9 as a Potential Target for Radiolabeled Antibody-Based Positron Emission Tomography of Pancreas Cancer.

Introduction. Sensitive and specific imaging of pancreas cancer are necessary for accurate diagnosis, staging, and treatment. The vast majority of pancreas cancers express the carbohydrate tumor antigen CA19-9. The goal of this study was to determine the potential to target CA19-9 with a radiolabeled anti-CA19-9 antibody for imaging pancreas cancer. Methods. CA19-9 was quantified using flow cytometry on human pancreas cancer cell lines. An intact murine anti-CA19-9 monoclonal antibody was labeled with a positron emitting radionuclide (Iodine-124) and injected into mice harboring antigen positive and negative xenografts. MicroPET/CT were performed at successive time intervals (72 hours, 96 hours, 120 hours) after injection. Radioactivity was measured in blood and tumor to provide objective confirmation of the images. Results. Antigen expression by flow cytometry revealed approximately 1.3 × 10(6) CA19-9 antigens for the positive cell line and no expression in the negative cell line. Pancreas xenograft imaging with Iodine-124-labeled anti-CA19-9 mAb demonstrated an average tumor to blood ratio of 5 and positive to negative tumor ratio of 20. Conclusion. We show in vivo targeting of our antigen positive xenograft with a radiolabeled anti-CA19-9 antibody. These data demonstrate the potential to achieve anti-CA19-9 antibody based positron emission tomography of pancreas cancer

Cloud Chamber: A Performance with Real Time Two-Way Interaction between Subatomic Particles and Violinist

‘Cloud Chamber’ - a composition by Alexis Kirke, Antonino Chiaramonte, and Anna Troisi - is a live performance in which the invisible quantum world becomes visible as a violinist and subatomic particle tracks interact together. An electronic instrument was developed which can be “played” live by radioactive atomic particles. Electronic circuitry was developed enabling a violin to create a physical force field that directly affects the ions generated by cosmic radiation particles. This enabled the violinist and the ions to influence each other musically in real time. A glass cloud chamber was used onstage to make radioactivity visible in bright white tracks moving within, with the tracks projected onto a large screen

Use of cell morphology to evaluate the effect of a peroxidase gene on cell death induction thresholds in tobacco

Tobacco suspension cultures were subjected to a range of heat stresses and used to compare morphological aspects of programmed cell death (PCD) and necrosis. Cells undergoing PCD were found to display characteristic death morphology, caused by cytoplasmic retraction of the protoplast, and to have cleaved DNA. We evaluated if the morphological characteristics of PCD could be used to monitor changes in cell death induction thresholds in transgenic cell cultures with high levels of peroxidase activity. Again, using a heat shock assay, we show that tobacco cell cultures with elevated levels of peroxidase have higher cell death induction threshold levels than wild type tobacco cell cultures. Thus, assessing PCD associated morphological changes can report on the effect of altering peroxidase genes on cell death activation in tobacco. This study demonstrates that PCD morphology could routinely be used to monitor the effects of introduced genes on programmed cell death induction thresholds in plants

Carcass Trait Trends for Steers and Heifers Finished Through the Tri-County Steer Carcass Futurity Cooperative from 2002 Through 2018

Objective: The objective was to evaluate trends in carcass characteristics for steers and heifers finished through the Tri-County Steer Carcass Futurity Cooperative. Study Description: Data analyzed included 74,207 steers and 33,529 heifers finished at the Tri-County Steer Carcass Futurity Cooperative (Lewis, IA) and harvested from 2002 through 2018. Steers and heifers were harvested at liveweights of 1,235.0 +/- 119.8 lb and 1,124.2 +/- 106.7 lb, respectively. Carcass trait trends evaluated for steers and heifers included calculated yield grade score, backfat thickness, hot carcass weight, kidney, pelvic, heart, fat percentage, marbling score, and ribeye area. Results: Calculated yield grade scores increased from 2002 through 2018 for steers and heifers. Fat thickness increased 0.08 in for steers and 0.07 in for heifers, both peaking in 2017 at 0.55 and 0.59 in, respectively. Hot carcass weights ranged from 727 to 780 lb for steers and increased over the 17-year period. Hot carcass weights for heifers ranged from 671 to 711 lb and increased slightly from 2002 through 2018. Kidney, pelvic, heart, fat percentage did not change for steers and heifers. Marbling score increased from 422 to 456 for steers and 449 to 493 for heifers. Ribeye area increased slightly for steers while decreasing slightly for heifers over the 17-year period. The Bottom Line: Corresponding with increases in fat thickness and minimal to no improvement in ribeye area, yield grade scores increased over the past 17 years. Genetic selection pressure on marbling within the beef industry is evident from these data

The future of Earth observation in hydrology

In just the past 5 years, the field of Earth observation has progressed beyond the offerings of conventional space-agency-based platforms to include a plethora of sensing opportunities afforded by CubeSats, unmanned aerial vehicles (UAVs), and smartphone technologies that are being embraced by both for-profit companies and individual researchers. Over the previous decades, space agency efforts have brought forth well-known and immensely useful satellites such as the Landsat series and the Gravity Research and Climate Experiment (GRACE) system, with costs typically of the order of 1 billion dollars per satellite and with concept-to-launch timelines of the order of 2 decades (for new missions). More recently, the proliferation of smart-phones has helped to miniaturize sensors and energy requirements, facilitating advances in the use of CubeSats that can be launched by the dozens, while providing ultra-high (3-5 m) resolution sensing of the Earth on a daily basis. Start-up companies that did not exist a decade ago now operate more satellites in orbit than any space agency, and at costs that are a mere fraction of traditional satellite missions. With these advances come new space-borne measurements, such as real-time high-definition video for tracking air pollution, storm-cell development, flood propagation, precipitation monitoring, or even for constructing digital surfaces using structure-from-motion techniques. Closer to the surface, measurements from small unmanned drones and tethered balloons have mapped snow depths, floods, and estimated evaporation at sub-metre resolutions, pushing back on spatio-temporal constraints and delivering new process insights. At ground level, precipitation has been measured using signal attenuation between antennae mounted on cell phone towers, while the proliferation of mobile devices has enabled citizen scientists to catalogue photos of environmental conditions, estimate daily average temperatures from battery state, and sense other hydrologically important variables such as channel depths using commercially available wireless devices. Global internet access is being pursued via high-altitude balloons, solar planes, and hundreds of planned satellite launches, providing a means to exploit the "internet of things" as an entirely new measurement domain. Such global access will enable real-time collection of data from billions of smartphones or from remote research platforms. This future will produce petabytes of data that can only be accessed via cloud storage and will require new analytical approaches to interpret. The extent to which today's hydrologic models can usefully ingest such massive data volumes is unclear. Nor is it clear whether this deluge of data will be usefully exploited, either because the measurements are superfluous, inconsistent, not accurate enough, or simply because we lack the capacity to process and analyse them. What is apparent is that the tools and techniques afforded by this array of novel and game-changing sensing platforms present our community with a unique opportunity to develop new insights that advance fundamental aspects of the hydrological sciences. To accomplish this will require more than just an application of the technology: in some cases, it will demand a radical rethink on how we utilize and exploit these new observing systems

Sale Price of Holstein Feeder Steer Lots Relative to Other Breed Descriptions Sold Through Superior Livestock Video Sales from 2010 Through 2018

Objective: The objective of this study was to determine the relative value of Holstein feeder steer lots compared to steer lots of other breed descriptions sold through video auctions while adjusting for all other factors that significantly influenced sale price. Study Description: Data were analyzed from 14,075 lots of feeder steers sold via 211 livestock video auctions from 2010 through 2018. All lot characteristics that could be accurately quantified or categorized were used to develop a multiple regression model with backwards selection. A lot was categorized into one of four breed descriptions: 1) English, English crossed; 2) English-Continental crossed; 3) Brahman influenced; and 4) Holstein. The Bottom Line: The relative price discount for Holstein feeder steer lots compared with other breed descriptions appears to have increased from 2010–2018, and thus is likely indicating lessening interest in the feedlot sector to feed Holstein steers to harvest

System, Apparatus and Method for Pedal Control

An apparatus, method, and system for controlling motion in six degrees of freedom is described. The apparatus includes a support structure, a first pedal and a second pedal. A first set of three independent articulating mechanisms is operatively connected to the support structure and the first pedal. The first set of three independent articulating mechanisms, in combination, enable motion of the first pedal in three control axes corresponding to three discrete degrees of freedom. A second set of three independent articulating mechanisms, operatively connected to the second pedal, enable motion, in combination, in three control axes corresponding to a discrete second set of three degrees of freedom. The apparatus may also include first and second sensors configured to detect the motion of the first and second pedals