Roughness Signature of Tribological Contact Calculated by a New Method of Peaks Curvature Radius Estimation on Fractal Surfaces

This paper proposes a new method of roughness peaks curvature radii calculation and its application to tribological contact analysis as characteristic signature of tribological contact. This method is introduced via the classical approach of the calculation of radius of asperity. In fact, the proposed approach provides a generalization to fractal profiles of the Nowicki's method [Nowicki B. Wear Vol.102, p.161-176, 1985] by introducing a fractal concept of curvature radii of surfaces, depending on the observation scale and also numerically depending on horizontal lines intercepted by the studied profile. It is then established the increasing of the dispersion of the measures of that lines with that of the corresponding radii and the dependence of calculated radii on the fractal dimension of the studied curve. Consequently, the notion of peak is mathematically reformulated. The efficiency of the proposed method was tested via simulations of fractal curves such as those described by Brownian motions. A new fractal function allowing the modelling of a large number of physical phenomena was also introduced, and one of the great applications developed in this paper consists in detecting the scale on which the measurement system introduces a smoothing artifact on the data measurement. New methodology is applied to analysis of tribological contact in metal forming process

Face Video Competition

The final publication is available at Springer via http://dx.doi.org/10.1007/978-3-642-01793-3_73Person recognition using facial features, e.g., mug-shot images, has long been used in identity documents. However, due to the widespread use of web-cams and mobile devices embedded with a camera, it is now possible to realise facial video recognition, rather than resorting to just still images. In fact, facial video recognition offers many advantages over still image recognition; these include the potential of boosting the system accuracy and deterring spoof attacks. This paper presents the first known benchmarking effort of person identity verification using facial video data. The evaluation involves 18 systems submitted by seven academic institutes.The work of NPoh is supported by the advanced researcher fellowship PA0022121477of the Swiss NSF; NPoh, CHC and JK by the EU-funded Mobio project grant IST-214324; NPC and HF by the EPSRC grants EP/D056942 and EP/D054818; VS andNP by the Slovenian national research program P2-0250(C) Metrology and Biomet-ric System, the COST Action 2101 and FP7-217762 HIDE; and, AAS by the Dutch BRICKS/BSIK project.Poh, N.; Chan, C.; Kittler, J.; Marcel, S.; Mc Cool, C.; Rua, E.; Alba Castro, J.... (2009). Face Video Competition. En Advances in Biometrics: Third International Conference, ICB 2009, Alghero, Italy, June 2-5, 2009. Proceedings. 715-724. https://doi.org/10.1007/978-3-642-01793-3_73S715724Messer, K., Kittler, J., Sadeghi, M., Hamouz, M., Kostyn, A., Marcel, S., Bengio, S., Cardinaux, F., Sanderson, C., Poh, N., Rodriguez, Y., Kryszczuk, K., Czyz, J., Vandendorpe, L., Ng, J., Cheung, H., Tang, B.: Face authentication competition on the BANCA database. In: Zhang, D., Jain, A.K. (eds.) ICBA 2004. LNCS, vol. 3072, pp. 8–15. Springer, Heidelberg (2004)Messer, K., Kittler, J., Sadeghi, M., Hamouz, M., Kostin, A., Cardinaux, F., Marcel, S., Bengio, S., Sanderson, C., Poh, N., Rodriguez, Y., Czyz, J., Vandendorpe, L., McCool, C., Lowther, S., Sridharan, S., Chandran, V., Palacios, R.P., Vidal, E., Bai, L., Shen, L.-L., Wang, Y., Yueh-Hsuan, C., Liu, H.-C., Hung, Y.-P., Heinrichs, A., Muller, M., Tewes, A., vd Malsburg, C., Wurtz, R., Wang, Z., Xue, F., Ma, Y., Yang, Q., Fang, C., Ding, X., Lucey, S., Goss, R., Schneiderman, H.: Face authentication test on the BANCA database. In: Int’l. Conf. Pattern Recognition (ICPR), vol. 4, pp. 523–532 (2004)Phillips, P.J., Flynn, P.J., Scruggs, T., Bowyer, K.W., Chang, J., Hoffman, K., Marques, J., Min, J., Worek, W.: Overview of the Face Recognition Grand Challenge. In: IEEE Computer Society Conference on Computer Vision and Pattern Recognition, pp. 947–954 (2005)Bailly-Baillière, E., Bengio, S., Bimbot, F., Hamouz, M., Kittler, J., Marithoz, J., Matas, J., Messer, K., Popovici, V., Porée, F., Ruiz, B., Thiran, J.-P.: The BANCA Database and Evaluation Protocol. In: Kittler, J., Nixon, M.S. (eds.) AVBPA 2003. LNCS, vol. 2688. Springer, Heidelberg (2003)Turk, M., Pentland, A.: Eigenfaces for Recognition. Journal of Cognitive Neuroscience 3(1), 71–86 (1991)Martin, A., Doddington, G., Kamm, T., Ordowsk, M., Przybocki, M.: The DET Curve in Assessment of Detection Task Performance. In: Proc. Eurospeech 1997, Rhodes, pp. 1895–1898 (1997)Bengio, S., Marithoz, J.: The Expected Performance Curve: a New Assessment Measure for Person Authentication. In: The Speaker and Language Recognition Workshop (Odyssey), Toledo, pp. 279–284 (2004)Poh, N., Bengio, S.: Database, Protocol and Tools for Evaluating Score-Level Fusion Algorithms in Biometric Authentication. Pattern Recognition 39(2), 223–233 (2005)Martin, A., Przybocki, M., Campbell, J.P.: The NIST Speaker Recognition Evaluation Program, ch. 8. Springer, Heidelberg (2005

MicroRNAs in pulmonary arterial remodeling

Pulmonary arterial remodeling is a presently irreversible pathologic hallmark of pulmonary arterial hypertension (PAH). This complex disease involves pathogenic dysregulation of all cell types within the small pulmonary arteries contributing to vascular remodeling leading to intimal lesions, resulting in elevated pulmonary vascular resistance and right heart dysfunction. Mutations within the bone morphogenetic protein receptor 2 gene, leading to dysregulated proliferation of pulmonary artery smooth muscle cells, have been identified as being responsible for heritable PAH. Indeed, the disease is characterized by excessive cellular proliferation and resistance to apoptosis of smooth muscle and endothelial cells. Significant gene dysregulation at the transcriptional and signaling level has been identified. MicroRNAs are small non-coding RNA molecules that negatively regulate gene expression and have the ability to target numerous genes, therefore potentially controlling a host of gene regulatory and signaling pathways. The major role of miRNAs in pulmonary arterial remodeling is still relatively unknown although research data is emerging apace. Modulation of miRNAs represents a possible therapeutic target for altering the remodeling phenotype in the pulmonary vasculature. This review will focus on the role of miRNAs in regulating smooth muscle and endothelial cell phenotypes and their influence on pulmonary remodeling in the setting of PAH

Accumulation of fibronectin in the heart after myocardial infarction: a putative stimulator of adhesion and proliferation of adipose-derived stem cells

Stem cell therapy is a promising treatment after myocardial infarction (MI). A major problem in stem cell therapy, however, is that only a small proportion of stem cells applied to the heart can survive and differentiate into cardiomyocytes. We hypothesized that fibronectin in the heart after MI might positively affect stem cell adhesion and proliferation at the site of injury. Therefore, we investigated the kinetics of attachment and proliferation of adipose-tissue-derived stem cells (ASC) on fibronectin and analysed the time frame and localization of fibronectin accumulation in the human heart after MI. ASCs were seeded onto fibronectin-coated and uncoated culture wells. The numbers of adhering ASC were quantified after various incubation periods (5-30 min) by using DNA quantification assays. The proliferation of ASC was quantified after culturing ASC for various periods (0-9 days) by using DNA assays. Fibronectin accumulation after MI was quantified by immunohistochemical staining of heart sections from 35 patients, after different infarction periods (0-14 days old). We found that ASC attachment and proliferation on fibronectin-coated culture wells was significantly higher than on uncoated wells. Fibronectin deposition was significantly increased from 12 h to 14 days post-infarction, both in the infarction area and in the border-zone, compared with the uninfarcted heart. Our results suggest that a positive effect of fibronectin on stem cells in the heart can only be achieved when stem cell therapy is applied at least 12 h after MI, when the accumulation of fibronectin occurs in the infarcted heart. © 2008 The Author(s)

Ethnic Identity of Older Chinese in Canada

In Canada’s multicultural society, ethnic identity is important to the elderly and can influence areas such as access to services, health promotion and care. Often, the complex nature of ethnic identity is underestimated when looking at cultural groups. This study aims to: (a) validate the factor structure of a Chinese ethnic identity measure for older Chinese in Canada, (b) examine the level of ethnic identity of the participants, and (c) examine the correlates of ethnic identity in these older individuals. Using data from a large, national research project on the elderly Chinese in Canada, this study analyzed the results gathered from a total of 2,272 participants. Principal component analysis, maximum-likelihood confirmatory factor analysis, and multiple regression analysis were performed. The results indicated that ethnic identity of the older Chinese is a multi-dimensional construct made up of three factors: (a) culture related activities, (b) community ties, (c) linkage with country of origin, and (d) cultural identification. The findings have provided a better understanding of how ethnic identity can be measured among the aging Chinese population in Canada

Upregulated Genes In Sporadic, Idiopathic Pulmonary Arterial Hypertension

BACKGROUND: To elucidate further the pathogenesis of sporadic, idiopathic pulmonary arterial hypertension (IPAH) and identify potential therapeutic avenues, differential gene expression in IPAH was examined by suppression subtractive hybridisation (SSH). METHODS: Peripheral lung samples were obtained immediately after removal from patients undergoing lung transplant for IPAH without familial disease, and control tissues consisted of similarly sampled pieces of donor lungs not utilised during transplantation. Pools of lung mRNA from IPAH cases containing plexiform lesions and normal donor lungs were used to generate the tester and driver cDNA libraries, respectively. A subtracted IPAH cDNA library was made by SSH. Clones isolated from this subtracted library were examined for up regulated expression in IPAH using dot blot arrays of positive colony PCR products using both pooled cDNA libraries as probes. Clones verified as being upregulated were sequenced. For two genes the increase in expression was verified by northern blotting and data analysed using Student's unpaired two-tailed t-test. RESULTS: We present preliminary findings concerning candidate genes upregulated in IPAH. Twenty-seven upregulated genes were identified out of 192 clones examined. Upregulation in individual cases of IPAH was shown by northern blot for tissue inhibitor of metalloproteinase-3 and decorin (P < 0.01) compared with the housekeeping gene glyceraldehydes-3-phosphate dehydrogenase. CONCLUSION: Four of the up regulated genes, magic roundabout, hevin, thrombomodulin and sucrose non-fermenting protein-related kinase-1 are expressed specifically by endothelial cells and one, muscleblind-1, by muscle cells, suggesting that they may be associated with plexiform lesions and hypertrophic arterial wall remodelling, respectively

Discovery and progress in our understanding of the regulated secretory pathway in neuroendocrine cells

In this review we start with a historical perspective beginning with the early morphological work done almost 50 years ago. The importance of these pioneering studies is underscored by our brief summary of the key questions addressed by subsequent research into the mechanism of secretion. We then highlight important advances in our understanding of the formation and maturation of neuroendocrine secretory granules, first using in vitro reconstitution systems, then most recently biochemical approaches, and finally genetic manipulations in vitro and in vivo

The genome of the sea urchin Strongylocentrotus purpuratus

We report the sequence and analysis of the 814-megabase genome of the sea urchin Strongylocentrotus purpuratus, a model for developmental and systems biology. The sequencing strategy combined whole-genome shotgun and bacterial artificial chromosome (BAC) sequences. This use of BAC clones, aided by a pooling strategy, overcame difficulties associated with high heterozygosity of the genome. The genome encodes about 23,300 genes, including many previously thought to be vertebrate innovations or known only outside the deuterostomes. This echinoderm genome provides an evolutionary outgroup for the chordates and yields insights into the evolution of deuterostomes

Impact of safety-related dose reductions or discontinuations on sustained virologic response in HCV-infected patients: Results from the GUARD-C Cohort

Background: Despite the introduction of direct-acting antiviral agents for chronic hepatitis C virus (HCV) infection, peginterferon alfa/ribavirin remains relevant in many resource-constrained settings. The non-randomized GUARD-C cohort investigated baseline predictors of safety-related dose reductions or discontinuations (sr-RD) and their impact on sustained virologic response (SVR) in patients receiving peginterferon alfa/ribavirin in routine practice. Methods: A total of 3181 HCV-mono-infected treatment-naive patients were assigned to 24 or 48 weeks of peginterferon alfa/ribavirin by their physician. Patients were categorized by time-to-first sr-RD (Week 4/12). Detailed analyses of the impact of sr-RD on SVR24 (HCV RNA <50 IU/mL) were conducted in 951 Caucasian, noncirrhotic genotype (G)1 patients assigned to peginterferon alfa-2a/ribavirin for 48 weeks. The probability of SVR24 was identified by a baseline scoring system (range: 0-9 points) on which scores of 5 to 9 and <5 represent high and low probability of SVR24, respectively. Results: SVR24 rates were 46.1 % (754/1634), 77.1% (279/362), 68.0% (514/756), and 51.3% (203/396), respectively, in G1,2, 3, and 4 patients. Overall, 16.9% and 21.8% patients experienced 651 sr-RD for peginterferon alfa and ribavirin, respectively. Among Caucasian noncirrhotic G1 patients: female sex, lower body mass index, pre-existing cardiovascular/pulmonary disease, and low hematological indices were prognostic factors of sr-RD; SVR24 was lower in patients with 651 vs. no sr-RD by Week 4 (37.9% vs. 54.4%; P = 0.0046) and Week 12 (41.7% vs. 55.3%; P = 0.0016); sr-RD by Week 4/12 significantly reduced SVR24 in patients with scores <5 but not 655. Conclusions: In conclusion, sr-RD to peginterferon alfa-2a/ribavirin significantly impacts on SVR24 rates in treatment-naive G1 noncirrhotic Caucasian patients. Baseline characteristics can help select patients with a high probability of SVR24 and a low probability of sr-RD with peginter-feron alfa-2a/ribavirin