„Effects of Mixed Signals on Employer Attractiveness: A Mixed-Method Study Based on Signalling and Convention Theory“

Traditional recruiting activities are marked by information asymmetry and organisational information control, leading to uncertainty among applicants about employer attractiveness. New technologies profoundly change the picture. Recruiting websites provide more thorough, yet controlled information; online employer reviews offer employee‐generated information mostly out of organisational control. While this diminishes information asymmetry, applicants have to handle incongruent information. It remains largely unclear how so‐called "mixed Signals" affect employer attractiveness and how applicants interpret them. To address the issue, we developed an integrated theoretical framework based on signalling and convention theory to better understand how applicants interpret and evaluate signals about employers. We then conducted a mixed‐method study to examine how congruent and mixed signals influence perceived employer attractiveness. Our results show that while congruent signals increase employer attractiveness and mixed‐signal situations reduce it, distinct evaluative patterns emerge when potential applicants reflect and judge employers. Implications for future research and practice are discussed

Consequences of voluntary job changes in Germany: A multilevel analysis for 1985-2013

Analyzing the development of the consequences of voluntary job changes in Germany between 1985 and 2013, the study focuses on income gains and job satisfaction increases. Drawing on arguments of the job-search literature on the one hand and the proliferation of choices on the other we investigate whether the returns of job changes have increased or decreased. Results show that income gains have decreased over time while the job satisfaction surplus has remained stable. We further conclude that in determining the outcomes of job changes over time, structural factors seem to be more important than individual ones

ivPair: context-based fast intra-vehicle device pairing for secure wireless connectivity

The emergence of advanced in-vehicle infotainment (IVI) systems, such as Apple CarPlay and Android Auto, calls for fast and intuitive device pairing mechanisms to discover newly introduced devices and make or break a secure, high-bandwidth wireless connection. Current pairing schemes are tedious and lengthy as they typically require users to go through pairing and verification procedures by manually entering a predetermined or randomly generated pin on both devices. This inconvenience usually results in prolonged usage of old pins, significantly degrading the security of network connections. To address this challenge, we propose ivPair, a secure and usable device pairing protocol that extracts an identical pairing pin or fingerprint from vehicle\u27s vibration response caused by various factors such as driver\u27s driving pattern, vehicle type, and road conditions. Using ivPair, users can pair a mobile device equipped with an accelerometer with the vehicle\u27s IVI system or other mobile devices by simply holding it against the vehicle\u27s interior frame. Under realistic driving experiments with various types of vehicles and road conditions, we demonstrate that all passenger-owned devices can expect a high pairing success rate with a short pairing time, while effectively rejecting proximate adversaries attempting to pair with the target vehicle

PENGARUH LIMBAH SERBUK BESI SEBAGAI PENGGANTI SEJUMLAH AGREGAT HALUS TERHADAP CAMPURAN ASPAL

The obieaive of this research examining stability andfla+, value was to iwestigste the impact of the utility of iron Jillings waste as a subtitute matqlal for the mtmber of suprisingly small sggregates in the mixture of asphalt. In lhis research, the portion of irontilings waste which given were 5 %o, I0 % and I 5 % of the heauy mixture smooth aggregotes. The stobility quantitative value was 2093 kg in 15 % iron Jilings contents. The higatflow quaftitative value was 3,5 mm in 5 % iron tilings contents. The result of characteristic validdion Mmshall on the number of sabtituted smooth aggregates which used iron/ilings gave o standard coflictent specfrcation 8M.2005. So based on thal, the iron/illings waste technically could be received as a subtitute material for the mixture of suprisingly small aggregates

New records of lichen species from western Mongolia

New records of lichens are compiled for the Mongolian Altai and the Khangai, western Mongolia. All records are from the forest-steppe. A total of 31 species are reported for the first time from the Mongolia Altai and another 18 species are new for the Khangai. Nineteen species, namely Arthonia mediella, Bacidia circumspecta, Blastenia furfuracea, Calicium viride, Caloplaca chlorina, Cyphelium karelicum, Lecanora allophana, L. boligera, L. cadubriae, L. subintricata, Lepraria ecorticata, L. rigidula, Leptogium subtile, Ochrolechia szatalaënsis, O. turneri, Placynthiella dasaea, Rinodina freyi, R. septentrionalis, and R. trevisanii, are new to Mongolia. The finding of Lepraria ecorticata from the Altai is the only one from Central Asia, whereas Rinodina freyi was not known from the whole of Asia so far

A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK/PI3K induced malignant growth

Somatic mutations activating MAPK/PI3K signalling play a pivotal role in both tumours and brain developmental disorders. We developed a zebrafish model of brain tumour based on somatic expression of oncogenes that activate MAPK/PI3K signalling in neural progenitor cells. HRASV12 was the most effective in inducing both heterotopia and invasive tumours. Tumours, but not heterotopias, require persistent activation of phospho‑(p)ERK and express a gene signature similar to the mesenchymal glioblastoma subtype, with a strong YAP component. Application of a 8-gene signature to human brain tumours establishes that YAP activation distinguishes between mesenchymal glioblastoma and low grade glioma in a wide TCGA sample set including gliomas and glioblastomas (GBMs). This suggests that the activation of YAP may be an important event in brain tumour development, promoting malignant versus benign brain lesions. Indeed, co-expression of dominant active YAP (YAPS5A) and HRASV12 abolishes the development of heterotopias and leads to the sole development of aggressive tumours. Thus, we have developed a model proving that neurodevelopmental disorders and brain tumours may originate from the same somatic mutations activating oncogenes and established that YAP activation is a hallmark of malignant brain tumours

Изучение байесовского подхода к анализу медико-биологических данных в курсе медицинской и биологической физики

Background: The clinical behaviour of colon cancer is heterogeneous. Five-year overall survival is 50-65% with all stages included. Recurring somatic chromosomal alterations have been identified and some have shown potential as markers for dissemination of the tumour, which is responsible for most colon cancer deaths. We investigated 115 selected stage II-IV primary colon cancers for associations between chromosomal alterations and tumour dissemination. Methods: Follow-up was at least 5 years for stage II-III patients without distant recurrence. Affymetrix SNP 6.0 microarrays and allele-specific copy number analysis were used to identify chromosomal alterations. Fisher's exact test was used to associate alterations with tumour dissemination, detected at diagnosis (stage IV) or later as recurrent disease (stage II-III). Results: Loss of 1p36.11-21 was associated with tumour dissemination in microsatellite stable tumours of stage II-IV (odds ratio = 5.5). It was enriched to a similar extent in tumours with distant recurrence within stage II and stage III subgroups, and may therefore be used as a prognostic marker at diagnosis. Loss of 1p36.11-21 relative to average copy number of the genome showed similar prognostic value compared to absolute loss of copies. Therefore, the use of relative loss as a prognostic marker would benefit more patients by applying also to hyperploid cancer genomes. The association with tumour dissemination was supported by independent data from the The Cancer Genome Atlas. Conclusion: Deletions on 1p36 may be used to guide adjuvant treatment decisions in microsatellite stable colon cancer of stages II and III

TP53 outperforms other androgen receptor biomarkers to predict abiraterone or enzalutamide outcome in metastatic castration-resistant prostate cancer

Purpose: To infer the prognostic value of simultaneous androgen receptor (AR) and TP53 profiling in liquid biopsies from patients with metastatic castration-resistant prostate cancer (mCRPC) starting a new line of AR signaling inhibitors (ARSi). Experimental Design: Between March 2014 and April 2017, we recruited patients with mCRPC (n = 168) prior to ARSi in a cohort study encompassing 10 European centers. Blood samples were collected for comprehensive profiling of Cell Search-enriched circulating tumor cells (CTC) and circulating tumor DNA (ctDNA). Targeted CTC RNA sequencing (RNA-seq) allowed the detection of eight AR splice variants (ARV). Low-pass whole-genome and targeted gene-body sequencing of AR and TP53 was applied to identify amplifications, loss of heterozygosity, mutations, and structural rearrangements in ctDNA. Clinical or radiologic progression-free survival (PFS) was estimated by Kaplan-Meier analysis, and independent associations were determined using multivariable Cox regression models. Results: Overall, no single AR perturbation remained associated with adverse prognosis after multivariable analysis. Instead, tumor burden estimates (CTC counts, ctDNA fraction, and visceral metastases) were significantly associated with PFS. TP53 inactivation harbored independent prognostic value [HR 1.88; 95% confidence interval (CI), 1.18-3.00; P = 0.008], and outperformed ARV expression and detection of genomic AR alterations. Using Cox coefficient analysis of clinical parameters and TP53 status, we identified three prognostic groups with differing PFS estimates (median, 14.7 vs. 7.51 vs. 2.62 months; P < 0.0001), which was validated in an independent mCRPC cohort (n = 202) starting first-line ARSi (median, 14.3 vs. 6.39 vs. 2.23 months; P < 0.0001). Conclusions: In an all-comer cohort, tumor burden estimates and TP53 outperform any AR perturbation to infer prognosis. See related commentary by Rebello et al., p. 169