Alterations in prefrontal-limbic functional activation and connectivity in chronic stress-induced visceral hyperalgesia.

Repeated water avoidance stress (WAS) induces sustained visceral hyperalgesia (VH) in rats measured as enhanced visceromotor response to colorectal distension (CRD). This model incorporates two characteristic features of human irritable bowel syndrome (IBS), VH and a prominent role of stress in the onset and exacerbation of IBS symptoms. Little is known regarding central mechanisms underlying the stress-induced VH. Here, we applied an autoradiographic perfusion method to map regional and network-level neural correlates of VH. Adult male rats were exposed to WAS or sham treatment for 1 hour/day for 10 days. The visceromotor response was measured before and after the treatment. Cerebral blood flow (CBF) mapping was performed by intravenous injection of radiotracer ([(14)C]-iodoantipyrine) while the rat was receiving a 60-mmHg CRD or no distension. Regional CBF-related tissue radioactivity was quantified in autoradiographic images of brain slices and analyzed in 3-dimensionally reconstructed brains with statistical parametric mapping. Compared to sham rats, stressed rats showed VH in association with greater CRD-evoked activation in the insular cortex, amygdala, and hypothalamus, but reduced activation in the prelimbic area (PrL) of prefrontal cortex. We constrained results of seed correlation analysis by known structural connectivity of the PrL to generate structurally linked functional connectivity (SLFC) of the PrL. Dramatic differences in the SLFC of PrL were noted between stressed and sham rats under distension. In particular, sham rats showed negative correlation between the PrL and amygdala, which was absent in stressed rats. The altered pattern of functional brain activation is in general agreement with that observed in IBS patients in human brain imaging studies, providing further support for the face and construct validity of the WAS model for IBS. The absence of prefrontal cortex-amygdala anticorrelation in stressed rats is consistent with the notion that impaired corticolimbic modulation acts as a central mechanism underlying stress-induced VH

Test of Local Scale Invariance from the direct measurement of the response function in the Ising model quenched to and to below TCT_C

In order to check on a recent suggestion that local scale invariance [M.Henkel et al. Phys.Rev.Lett. {\bf 87}, 265701 (2001)] might hold when the dynamics is of Gaussian nature, we have carried out the measurement of the response function in the kinetic Ising model with Glauber dynamics quenched to $T_C$ in $d=4$, where Gaussian behavior is expected to apply, and in the two other cases of the $d=2$ model quenched to $T_C$ and to below $T_C$, where instead deviations from Gaussian behavior are expected to appear. We find that in the $d=4$ case there is an excellent agreement between the numerical data, the local scale invariance prediction and the analytical Gaussian approximation. No logarithmic corrections are numerically detected. Conversely, in the $d=2$ cases, both in the quench to $T_C$ and to below $T_C$, sizable deviations of the local scale invariance behavior from the numerical data are observed. These results do support the idea that local scale invariance might miss to capture the non Gaussian features of the dynamics. The considerable precision needed for the comparison has been achieved through the use of a fast new algorithm for the measurement of the response function without applying the external field. From these high quality data we obtain $a=0.27 \pm 0.002$ for the scaling exponent of the response function in the $d=2$ Ising model quenched to below $T_C$, in agreement with previous results.Comment: 24 pages, 6 figures. Resubmitted version with improved discussions and figure

Swimming exercise enhances brain plasticity in fish

It is well-established that sustained exercise training can enhance brain plasticity and boost cognitive performance in mammals, but this phenomenon has not received much attention in fish. The aim of this study was to determine whether sustained swimming exercise can enhance brain plasticity in juvenile Atlantic salmon. Brain plasticity was assessed by both mapping the whole telencephalon transcriptome and conducting telencephalic region-specific microdissections on target genes. We found that 1772 transcripts were differentially expressed between the exercise and control groups. Gene ontology (GO) analysis identified 195 and 272 GO categories with a significant overrepresentation of up- or downregulated transcripts, respectively. A multitude of these GO categories was associated with neuronal excitability, neuronal signalling, cell proliferation and neurite outgrowth (i.e. cognition-related neuronal markers). Additionally, we found an increase in proliferating cell nuclear antigen (pcna) after both three and eight weeks of exercise in the equivalent to the hippocampus in fish. Furthermore, the expression of the neural plasticity markers synaptotagmin (syt) and brain-derived neurotrophic factor (bdnf) were also increased due to exercise in the equivalent to the lateral septum in fish. In conclusion, this is the first time that swimming exercise has been directly linked to increased telencephalic neurogenesis and neural plasticity in a teleost, and our results pave the way for future studies on exercise-induced neuroplasticity in fish.</p

Compilability of Abduction

Abduction is one of the most important forms of reasoning; it has been successfully applied to several practical problems such as diagnosis. In this paper we investigate whether the computational complexity of abduction can be reduced by an appropriate use of preprocessing. This is motivated by the fact that part of the data of the problem (namely, the set of all possible assumptions and the theory relating assumptions and manifestations) are often known before the rest of the problem. In this paper, we show some complexity results about abduction when compilation is allowed