Toys That Listen: A Study of Parents, Children, and Internet-Connected Toys

Hello Barbie, CogniToys Dino, and Amazon Echo are part of a new wave of connected toys and gadgets for the home that listen. Unlike the smartphone, these devices are always on, blending into the background until needed. We conducted interviews with parent-child pairs in which they interacted with Hello Barbie and CogniToys Dino, shedding light on children’s expectations of the toys’ “intelligence” and parents’ privacy concerns and expectations for parental controls. We find that children were often unaware that others might be able to hear what was said to the toy, and that some parents draw connections between the toys and similar tools not intended as toys (e.g., Siri, Alexa) with which their children already interact. Our findings illuminate people’s mental models and experiences with these emerging technologies and will help inform the future designs of interactive, connected toys and gadgets. We conclude with recommendations for designers and policy makers.https://digitalcommons.law.uw.edu/techlab/1002/thumbnail.jp

Phenomenon of Early Marriage on Girls in The Cintapuri Village in Banjarmasin City (Phenomenological Study)

In this modern era, child marriage still remains a practice in some regions. This phenomenon damages the normal life of families and negatively affects the human capitals of Indonesia. Higher number of child marriages would lead to increase in the divorce rates than normal, as those involved in this marriage have not developed the necessary emotional control for solving problems that might arise during these marriages. This led many to the path of divorce. The goal of this research is to understand the factors that led to child marriage in Cintapuri Village, Banjar Regency, Banjarmasin. This research uses the qualitative descriptive method with phenomenological model. Subjects in this research were teenage girls married in the age of 14-16 with Junior High School (SMP) being their last education level, parents, and village governance apparatus in Cintapuri Village, Banjar Regency, Banjarmasin. The data from this research was collected through careful observations and interviews with people related to the research’s objective. The result of this research shows there are several factors leading to the rampant cases of child marriage, such as economical, educational, and cultural factors. Looked through from an economical point-of-view, many parents are marrying their children off to alleviate their economic burden. From an educational point-of-view, many parents are not aware of the adverse effects of child marriage and the laws that regulate the minimum age of marriage, because of the lack of education. From a cultural point-of-view, parents are feeling nervous and ashamed for the fact that their daughter do not have a partner yet, leading them in search of a suitable partner for their daughter even though their daughter do not always approve of the parent’s suitable partner. Keywords: child marriage, divorce, economy, education, cultur

Intercultural Communication Interaction of Multicultural Society in West Kalimantan Province: Ethnographic Studies

Indonesia has a society with various cultures, due to which there are many ethnic groups with their respective cultural structures and living side by side, which is called multicultural. West Kalimantan Province is one of the regions in Indonesia where multicultural societies live side by side, known as TIDAYU, namely the Tionghua or Chinese, Dayaknese and Melayu or Malays, which are the three largest tribes in West Kalimantan and divided in various places in West Kalimantan. In fact, one of the cities in West Kalimantan, namely Singkawang City was rewarded as the number one most tolerant city in 2018 based on the assessment of the SETARA Institute in collaboration with the Indonesian Ministry of Home Affairs and the Pancasila Ideology Development Agency, and was again ranked number one in 2021. Based on the research results using ethnology-based qualitative method, people in West Kalimantan have been accustomed to cultural diversity from an early age; therefore, the life of the multicultural society in West Kalimantan has a high level of tolerance and intercultural communication in West Kalimantan runs in harmony and respects each other. Keywords: intercultural communication, interaction, multicultural society, toleranc

The Recent Volcanic History of Axial Seamount: Geophysical Insights into Past Eruption Dynamics with an Eye Toward Enhanced Observations of Future Eruptions

To understand the processes that form oceanic crust as well as the role of submarine volcanoes in exchanging heat and chemicals with the ocean and in supporting chemosynthetic biological communities, it is essential to study underwater eruptions. The world’s most advanced underwater volcano observatory—the Ocean Observatories Initiative Cabled Array at Axial Seamount—builds upon ~30 years of sustained geophysical monitoring at this site with autonomous and remote systems. In April 2015, only months after the Cabled Array’s installation, it recorded an eruption at Axial Seamount, adding to the records of two prior eruptions in 1998 and 2011. Between eruptions, magma recharge is focused beneath the southeast part of the summit caldera, leading to steady inflation and increasing rates of seismicity. During each eruption, the volcano deflates over days to weeks, coincident with high levels of seismicity as a dike is emplaced along one of the volcano’s rifts and lava erupts on the seafloor. Cabled Array seismic data show that motions on an outward-dipping ring fault beneath the caldera accommodate the inflation and deflation. Eruptions appear to occur at a predictable level of inflation; hence, it should be possible to time deployments of additional cabled and autonomous instrumentation to further enhance observations of the next eruption

Infecção latente por tuberculose e a atenção primária em saúde como coordenadora do cuidado

A tuberculose representa um desafio global para a saúde pública e está entre as principais causas de mortalidade em escala mundial. No Brasil, em 2021, houve o registro de 68.271 novos casos da doença,  sendo estimado que 5 a 15% desses pacientes desenvolva a forma latente da doença. Este estudo busca retratar e analisar os desafios ao diagnóstico e manejo da  infecção Latente por Tuberculose  (ILTB) na atenção primária em saúde. Por meio da metodologia de relato de caso, este estudo busca descrever a gestão de um quadro clínico de ILTB  manejado por uma equipe de saúde da família do município de  Foz do Iguaçu, Paraná. Por meio dos resultados dessa análise, conclui-se, que a  abordagem da ILTB requer uma visão longitudinal e integral, sendo a APS crucial na  articulação  de estratégias que   promovam uma  assistência integral, abordando, para isso, os diversos componentes da rede de atenção à saúde

Hotspot SF3B1 mutations induce metabolic reprogramming and vulnerability to serine deprivation.

Cancer-associated mutations in the spliceosome gene SF3B1 create a neomorphic protein that produces aberrant mRNA splicing in hundreds of genes, but the ensuing biologic and therapeutic consequences of this missplicing are not well understood. Here we have provided evidence that aberrant splicing by mutant SF3B1 altered the transcriptome, proteome, and metabolome of human cells, leading to missplicing-associated downregulation of metabolic genes, decreased mitochondrial respiration, and suppression of the serine synthesis pathway. We also found that mutant SF3B1 induces vulnerability to deprivation of the nonessential amino acid serine, which was mediated by missplicing-associated downregulation of the serine synthesis pathway enzyme PHGDH. This vulnerability was manifest both in vitro and in vivo, as dietary restriction of serine and glycine in mice was able to inhibit the growth of SF3B1MUT xenografts. These findings describe a role for SF3B1 mutations in altered energy metabolism, and they offer a new therapeutic strategy against SF3B1MUT cancers

The microRNA miR-124 controls gene expression in the sensory nervous system of Caenorhabditis elegans

miR-124 is a highly conserved microRNA (miRNA) whose in vivo function is poorly understood. Here, we identify miR-124 targets based on the analysis of the first mir-124 mutant in any organism. We find that miR-124 is expressed in many sensory neurons in Caenorhabditis elegans and onset of expression coincides with neuronal morphogenesis. We analyzed the transcriptome of miR-124 expressing and nonexpressing cells from wild-type and mir-124 mutants. We observe that many targets are co-expressed with and actively repressed by miR-124. These targets are expressed at reduced relative levels in sensory neurons compared to the rest of the animal. Our data from mir-124 mutant animals show that this effect is due to a large extent to the activity of miR-124. Genes with nonconserved target sites show reduced absolute expression levels in sensory neurons. In contrast, absolute expression levels of genes with conserved sites are comparable to control genes, suggesting a tuning function for many of these targets. We conclude that miR-124 contributes to defining cell-type-specific gene activity by repressing a diverse set of co-expressed genes

The JWST Galactic Center Survey -- A White Paper

The inner hundred parsecs of the Milky Way hosts the nearest supermassive black hole, largest reservoir of dense gas, greatest stellar density, hundreds of massive main and post main sequence stars, and the highest volume density of supernovae in the Galaxy. As the nearest environment in which it is possible to simultaneously observe many of the extreme processes shaping the Universe, it is one of the most well-studied regions in astrophysics. Due to its proximity, we can study the center of our Galaxy on scales down to a few hundred AU, a hundred times better than in similar Local Group galaxies and thousands of times better than in the nearest active galaxies. The Galactic Center (GC) is therefore of outstanding astrophysical interest. However, in spite of intense observational work over the past decades, there are still fundamental things unknown about the GC. JWST has the unique capability to provide us with the necessary, game-changing data. In this White Paper, we advocate for a JWST NIRCam survey that aims at solving central questions, that we have identified as a community: i) the 3D structure and kinematics of gas and stars; ii) ancient star formation and its relation with the overall history of the Milky Way, as well as recent star formation and its implications for the overall energetics of our galaxy's nucleus; and iii) the (non-)universality of star formation and the stellar initial mass function. We advocate for a large-area, multi-epoch, multi-wavelength NIRCam survey of the inner 100\,pc of the Galaxy in the form of a Treasury GO JWST Large Program that is open to the community. We describe how this survey will derive the physical and kinematic properties of ~10,000,000 stars, how this will solve the key unknowns and provide a valuable resource for the community with long-lasting legacy value.Comment: This White Paper will be updated when required (e.g. new authors joining, editing of content). Most recent update: 24 Oct 202