59 research outputs found
Quantum Transport through Nanostructures with Orbital Degeneracies
Geometric symmetries cause orbital degeneracies in a molecule's spectrum. In
a single-molecule junction, these degeneracies are lifted by various
symmetry-breaking effects. We study quantum transport through such
nanostructures with an almost degenerate spectrum. We show that the master
equation for the reduced density matrix must be derived within the
singular-coupling limit as opposed to the conventional weak-coupling limit.
This results in signatures of the density matrix's off-diagonal elements in the
transport characteristics
Quantum transport through single-molecule junctions with orbital degeneracies
We consider electronic transport through a single-molecule junction where the
molecule has a degenerate spectrum. Unlike previous transport models, and
theories a rate-equations description is no longer possible, and the quantum
coherences between degenerate states have to be taken into account. We present
the derivation and application of a master equation that describes the system
in the weak-coupling limit and give an in-depth discussion of the parameter
regimes and the new phenomena due to coherent on-site dynamics
Franck-Condon blockade in suspended carbon nanotube quantum dots
Understanding the influence of vibrational motion of the atoms on electronic
transitions in molecules constitutes a cornerstone of quantum physics, as
epitomized by the Franck-Condon principle of spectroscopy. Recent advances in
building molecular-electronics devices and nanoelectromechanical systems open a
new arena for studying the interaction between mechanical and electronic
degrees of freedom in transport at the single-molecule level. The tunneling of
electrons through molecules or suspended quantum dots has been shown to excite
vibrational modes, or vibrons. Beyond this effect, theory predicts that strong
electron-vibron coupling dramatically suppresses the current flow at low
biases, a collective behaviour known as Franck-Condon blockade. Here we show
measurements on quantum dots formed in suspended single-wall carbon nanotubes
revealing a remarkably large electron-vibron coupling and, due to the high
quality and unprecedented tunability of our samples, admit a quantitative
analysis of vibron-mediated electronic transport in the regime of strong
electron-vibron coupling. This allows us to unambiguously demonstrate the
Franck-Condon blockade in a suspended nanostructure. The large observed
electron-vibron coupling could ultimately be a key ingredient for the detection
of quantized mechanical motion. It also emphasizes the unique potential for
nanoelectromechanical device applications based on suspended graphene sheets
and carbon nanotubes.Comment: 7 pages, 3 figure
Barriers and opportunities for implementation of a brief psychological intervention for post-ICU mental distress in the primary care setting â results from a qualitative sub-study of the PICTURE trial
Sex difference and intra-operative tidal volume: Insights from the LAS VEGAS study
BACKGROUND: One key element of lung-protective ventilation is the use of a low tidal volume (VT). A sex difference in use of low tidal volume ventilation (LTVV) has been described in critically ill ICU patients.OBJECTIVES: The aim of this study was to determine whether a sex difference in use of LTVV also exists in operating room patients, and if present what factors drive this difference.DESIGN, PATIENTS AND SETTING: This is a posthoc analysis of LAS VEGAS, a 1-week worldwide observational study in adults requiring intra-operative ventilation during general anaesthesia for surgery in 146 hospitals in 29 countries.MAIN OUTCOME MEASURES: Women and men were compared with respect to use of LTVV, defined as VT of 8âmlâkg-1 or less predicted bodyweight (PBW). A VT was deemed 'default' if the set VT was a round number. A mediation analysis assessed which factors may explain the sex difference in use of LTVV during intra-operative ventilation.RESULTS: This analysis includes 9864 patients, of whom 5425 (55%) were women. A default VT was often set, both in women and men; mode VT was 500âml. Median [IQR] VT was higher in women than in men (8.6 [7.7 to 9.6] vs. 7.6 [6.8 to 8.4] mlâkg-1 PBW, Pâ<â0.001). Compared with men, women were twice as likely not to receive LTVV [68.8 vs. 36.0%; relative risk ratio 2.1 (95% CI 1.9 to 2.1), Pâ<â0.001]. In the mediation analysis, patients' height and actual body weight (ABW) explained 81 and 18% of the sex difference in use of LTVV, respectively; it was not explained by the use of a default VT.CONCLUSION: In this worldwide cohort of patients receiving intra-operative ventilation during general anaesthesia for surgery, women received a higher VT than men during intra-operative ventilation. The risk for a female not to receive LTVV during surgery was double that of males. Height and ABW were the two mediators of the sex difference in use of LTVV.TRIAL REGISTRATION: The study was registered at Clinicaltrials.gov, NCT01601223
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Protective intraoperative ventilation with higher versus lower levels of positive end-expiratory pressure in obese patients (PROBESE): study protocol for a randomized controlled trial
Background: Postoperative pulmonary complications (PPCs) increase the morbidity and mortality of surgery in obese patients. High levels of positive end-expiratory pressure (PEEP) with lung recruitment maneuvers may improve intraoperative respiratory function, but they can also compromise hemodynamics, and the effects on PPCs are uncertain. We hypothesized that intraoperative mechanical ventilation using high PEEP with periodic recruitment maneuvers, as compared with low PEEP without recruitment maneuvers, prevents PPCs in obese patients. Methods/design The PRotective Ventilation with Higher versus Lower PEEP during General Anesthesia for Surgery in OBESE Patients (PROBESE) study is a multicenter, two-arm, international randomized controlled trial. In total, 2013 obese patients with body mass index â„35 kg/m2 scheduled for at least 2 h of surgery under general anesthesia and at intermediate to high risk for PPCs will be included. Patients are ventilated intraoperatively with a low tidal volume of 7 ml/kg (predicted body weight) and randomly assigned to PEEP of 12 cmH2O with lung recruitment maneuvers (high PEEP) or PEEP of 4 cmH2O without recruitment maneuvers (low PEEP). The occurrence of PPCs will be recorded as collapsed composite of single adverse pulmonary events and represents the primary endpoint. Discussion To our knowledge, the PROBESE trial is the first multicenter, international randomized controlled trial to compare the effects of two different levels of intraoperative PEEP during protective low tidal volume ventilation on PPCs in obese patients. The results of the PROBESE trial will support anesthesiologists in their decision to choose a certain PEEP level during general anesthesia for surgery in obese patients in an attempt to prevent PPCs. Trial registration ClinicalTrials.gov identifier: NCT02148692. Registered on 23 May 2014; last updated 7 June 2016. Electronic supplementary material The online version of this article (doi:10.1186/s13063-017-1929-0) contains supplementary material, which is available to authorized users
26th Annual Computational Neuroscience Meeting (CNS*2017): Part 3 - Meeting Abstracts - Antwerp, Belgium. 15â20 July 2017
This work was produced as part of the activities of FAPESP Research,\ud
Disseminations and Innovation Center for Neuromathematics (grant\ud
2013/07699-0, S. Paulo Research Foundation). NLK is supported by a\ud
FAPESP postdoctoral fellowship (grant 2016/03855-5). ACR is partially\ud
supported by a CNPq fellowship (grant 306251/2014-0)
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