The Singing \u27Vice\u27: Music and Mischief in Early English Drama

The \u27Vice\u27 — a corrupt character frequent in early English drama — engages in mischief ranging from the benignly annoying to the outright wicked. His activities typically include subterfuge that results in the seduction of the dramatic hero, other characters, and even members of the audience. Music is a frequent device in the Vice\u27s project. From the standpoints of Baudrillard\u27s theory of seduction and of sixteenth-century and contemporary perspectives on theatrical music, improvisation, acting, and ethopoieia, this essay explores the role of singing in what Robert Weimann and Douglas Bruster term the Vice\u27s \u27personation\u27. The effect of the Vice\u27s musicality in the representation and achievement of seduction in plays from Mankind to Shakespeare is also considered, with particular emphasis on three intervening interludes: John Heywood\u27s comedy A Play of the Wether, Bale\u27s history play King Johan, and Pickering\u27s pseudo-classical revenge tragedy Horestes

John Rastell’s London Stage: Reconstructing Repertory and Collaborative Practice

The study of repertory has greatly illuminated practices among playwrights and playing companies in the later sixteenth century. The repertory approach has yet to be applied to early and mid-Tudor drama, although this method holds out the promise of recovering the collaborative practices connected with John Rastell\u27s stage -- the first public stage in London. This article urges scholars active in repertory studies to take a fresh look at Henrician drama and theatrical practices, and employs Heywood and Rastell\u27s play Gentylnes and Nobylyte as a case study in the forces that shape repertory in this earlier period

AJAX by Sophocles: A New Performance Translation

AJAX by Sophokles A new performance translation by Maura Giles-Watson Directed by Ray Chambers and Lisa Berger Original Cast 2017 Production Old Globe/USD Shiley Graduate Theatre Program Athena / Chorus 9: Nora Carroll Odysseus / Chorus 10: Talley Beth Gale Ajax: Lorenzo Landini Chorus Leader 1: Samantha Sutliff Chorus Leader 2: Sam Avishay Chorus Leader 3: Larica Schnell Chorus 4: Suzelle Palacios Tekmessa: Christina Okolo Angelos / Chorus 8: Jose Martinez Teucer / Chorus 5: Renardo Pringle Jr. Menelaus / Chorus 6: Daniel Joeck Agamemnon / Chorus 7: Ajinkya Desai Nicole Ries, Stage Manager Kate Morton, Assistant Stage Manager Maura Giles-Watson, Dramatur

Digital Humanities in the Classroom and Beyond: 1) How Scaffolding Saved the Day -- Integrating Omeka into Classroom Curricula 2) New Ecologies of Collaboration -- Digital Humanities and Renaissance Drama

This session will feature perspectives on digital humanities from presenters at two different institutions: 1) How Scaffolding Saved the Day: Integrating Omeka into Classroom Curricula This presentation chronicles a university’s journey to bring digital exhibiting into classrooms across the curriculum. What began as an idea for a different kind of class project became an opportunity that invites students to embrace humanities in a new light and present it on a world stage. While the experience of curating digital exhibits using Omeka transformed the student learning process, it brought numerous challenges to library staff. To overcome these challenges, the presenters embraced flipped-classroom methods and developed a scaffolded approach to providing instruction throughout the semester. Presenters will offer suggestions for developing scalable and sustainable digital humanities projects that engage students and faculty in digital literacy and demonstrate the value of new and different, outward-facing alternative research projects. 2) New Ecologies of Collaboration: Digital Humanities and Renaissance Drama This presentation on the current state of DH + Renaissance Drama Studies will address the way that DH is changing the field by raising the profile of collaborative research methods and projects, and will explore emerging models for collaboration between scholars and librarians

Contrasting Phenotypes in Resistance to Thyroid Hormone Alpha Correlate with Divergent Properties of Thyroid Hormone Receptor α1 Mutant Proteins.

BACKGROUND: Resistance to thyroid hormone alpha (RTHα), a disorder characterized by tissue-selective hypothyroidism and near-normal thyroid function tests due to thyroid receptor alpha gene mutations, is rare but probably under-recognized. This study sought to correlate the clinical characteristics and response to thyroxine (T4) therapy in two adolescent RTHα patients with the properties of the THRA mutation, affecting both TRα1 and TRα2 proteins, they harbored. METHODS: Clinical, auxological, biochemical, and physiological parameters were assessed in each patient at baseline and after T4 therapy. RESULTS: Heterozygous THRA mutations occurring de novo were identified in a 17-year-old male (patient P1; c.788C>T, p.A263V mutation) investigated for mild pubertal delay and in a 15-year-old male (patient P2; c.821T>C, p.L274P mutation) with short stature (0.4th centile), skeletal dysplasia, dysmorphic facies, and global developmental delay. Both individuals exhibited macrocephaly, delayed dentition, and constipation, together with a subnormal T4/triiodothyronine (T3) ratio, low reverse T3 levels, and mild anemia. When studied in vitro, A263V mutant TRα1 was transcriptionally impaired and inhibited the function of its wild-type counterpart at low (0.01-10 nM) T3 levels, with higher T3 concentrations (100 nM-1 μM) reversing dysfunction and such dominant negative inhibition. In contrast, L274P mutant TRα1 was transcriptionally inert, exerting significant dominant negative activity, only overcome with 10 μM of T3. Mirroring this, normal expression of KLF9, a TH-responsive target gene, was achieved in A263V mutation-containing peripheral blood mononuclear cells following 1 μM of T3 exposure, but with markedly reduced expression levels in L274P mutation-containing peripheral blood mononuclear cells, even with 10 μM of T3. Following T4 therapy, growth, body composition, dyspraxia, and constipation improved in P1, whereas growth retardation and constipation in P2 were unchanged. Neither A263V nor L274P mutations exhibited gain or loss of function in the TRα2 background, and no additional phenotype attributable to this was discerned. CONCLUSIONS: This study correlates a milder clinical phenotype and favorable response to T4 therapy in a RTHα patient (P1) with heterozygosity for mutant TRα1 exhibiting partial, T3-reversible, loss of function. In contrast, a more severe clinical phenotype refractory to hormone therapy was evident in another case (P2) associated with severe, virtually irreversible, dysfunction of mutant TRα1

Toward improving practices for submission of diagnostic tissue blocks for National Cancer Institute clinical trials

OBJECTIVES: The National Cancer Institute (NCI) National Clinical Trials Network performs phase II and III clinical trials, which increasingly rely on the submission of diagnostic formalin-fixed, paraffin-embedded tissue blocks for biomarker assessment. Simultaneously, advances in precision oncology require that clinical centers maintain diagnostic specimens for ancillary, standard-of-care diagnostics. This has caused tissue blocks to become a limited resource for advancing the NCI clinical trial enterprise and the practice of modern molecular pathology. METHODS: The NCI convened a 1-day workshop of multidisciplined experts to discuss barriers and strategic solutions to facilitate diagnostic block submission for clinical trial science, from the perspective of patient advocates, legal experts, pathologists, and clinical oncologists. RESULTS: The expert views and opinions were carefully noted and reported. CONCLUSIONS: Recommendations were proposed to reduce institutional barriers and to assist organizations in developing clear policies regarding diagnostic block submission for clinical trials

In-flight calibration and verification of the Planck-LFI instrument

In this paper we discuss the Planck-LFI in-flight calibration campaign. After a brief overview of the ground test campaigns, we describe in detail the calibration and performance verification (CPV) phase, carried out in space during and just after the cool-down of LFI. We discuss in detail the functionality verification, the tuning of the front-end and warm electronics, the preliminary performance assessment and the thermal susceptibility tests. The logic, sequence, goals and results of the in-flight tests are discussed. All the calibration activities were successfully carried out and the instrument response was comparable to the one observed on ground. For some channels the in-flight tuning activity allowed us to improve significantly the noise performance.Comment: Long technical paper on Planck LFI in flight calibration campaign: 109 pages in this (not final) version, 100 page in the final JINST versio

ClimateBench v1.0: A benchmark for data-driven climate projections

Many different emission pathways exist that are compatible with the Paris climate agreement, and many more are possible that miss that target. While some of the most complex Earth System Models have simulated a small selection of Shared Socioeconomic Pathways, it is impractical to use these expensive models to fully explore the space of possibilities. Such explorations therefore mostly rely on one-dimensional impulse response models, or simple pattern scaling approaches to approximate the physical climate response to a given scenario. Here we present ClimateBench - a benchmarking framework based on a suite of CMIP, AerChemMIP and DAMIP simulations performed by a full complexity Earth System Model, and a set of baseline machine learning models that emulate its response to a variety of forcers. These emulators can predict annual mean global distributions of temperature, diurnal temperature range and precipitation (including extreme precipitation) given a wide range of emissions and concentrations of carbon dioxide, methane and aerosols, allowing them to efficiently probe previously unexplored scenarios. We discuss the accuracy and interpretability of these emulators and consider their robustness to physical constraints such as total energy conservation. Future opportunities incorporating such physical constraints directly in the machine learning models and using the emulators for detection and attribution studies are also discussed. This opens a wide range of opportunities to improve prediction, consistency and mathematical tractability. We hope that by laying out the principles of climate model emulation with clear examples and metrics we encourage others to tackle this important and demanding challenge