216 research outputs found
Deposition of impurity metals during campaigns with the JET ITER-like Wall
- Author
- Publication venue
- Publication date
- 01/01/2019
- Field of study
Post mortem analysis shows that mid and high atomic number metallic impurities are present in deposits on JET plasma facing components with the highest amount of Ni and W, and therefore the largest sink, being found at the top of the inner divertor. Sources are defined as “continuous” or “specific”, in that “continuous” sources arise from ongoing erosion from plasma facing surfaces and “specific” are linked with specific events which decrease over time until they no longer act as a source. This contribution evaluates the sinks and estimates sources, and the balance gives an indication of the dominating processes. Charge exchange neutral erosion is found to be the main source of nickel, whereas erosion of divertor plasma facing components is the main source of tungsten. Specific sources are shown to have little influence over the global mid- and high-Z impurity concentrations in deposits.Peer reviewe
Subcallosal cingulate deep brain stimulation for treatment-resistant depression: a multi-site, randomized, sham-controlled trial
- Author
- Abosch Aviva
- Berman Joshua
- Connolly Christopher
- DeBattista Charles
- Espinoza Randall T
- Grosse Robert
- Hamani Clement
- Henderson Jaimie M
- Holloway Kathryn L
- Holtzheimer Paul
- Husain Mustafa M
- Lam Raymond W
- Lisanby Sarah H
- Lozano Andres M.
- Matthews Keith
- Mayberg Helen S
- McClintock Shawn
- McKhann Guy M
- Mogilner Alon Y
- Neimat Joseph S
- Pandurangi Ananda K
- Patil Parag G
- Peichel DeLea
- Petrides Georgios
- Pilitsis Julie G
- Rittberg Barry R
- Rothschild Anthony J
- Slavin Konstantin V
- Taylor Stephan F
- Whitworth Louis A
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/11/2017
- Field of study
Distribution and Extinction of Ungulates during the Holocene of the Southern Levant
- Author
- A Dolev
- A Frumkin
- A Horowitz
- A Jerozolimski
- A Mazar
- AVD Driesch
- BW Brook
- CL Redman
- DA Burney
- Dennis Marinus Hansen
- DJ Brewer
- Ella Tsahar
- F Neumann
- FH Van Den Brink
- Guy Bar-Oz
- H Mendelssohn
- H-P Uerpmann
- I Finkelstein
- Ido Izhaki
- J Damuth
- M Bar-Matthews
- M Broshi
- M Cardillo
- M Zohary
- M Zohary
- MB Quemsiyeh
- MW Beck
- N Liphschitz
- O Bar-Yosef
- PS Martin
- R Karschon
- RE Bodmer
- RM Nowak
- RM Nowak
- S Lev-Yadun
- S Lev-Yadun
- Simcha Lev-Yadun
- TE Levy
- TM Blackburn
- U Baruch
- U Baruch
- W Brook
- Y Yom-Tov
- ZS Amr
- Publication venue
- Public Library of Science
- Publication date
- 29/04/2009
- Field of study
BACKGROUND: The southern Levant (Israel, Palestinian Authority and Jordan) has been continuously and extensively populated by succeeding phases of human cultures for the past 15,000 years. The long human impact on the ancient landscape has had great ecological consequences, and has caused continuous and accelerating damage to the natural environment. The rich zooarchaeological data gathered at the area provide a unique opportunity to reconstruct spatial and temporal changes in wild species distribution, and correlate them with human demographic changes. METHODOLOGY: Zoo-archaeological data (382 animal bone assemblages from 190 archaeological sites) from various time periods, habitats and landscapes were compared. The bone assemblages were sorted into 12 major cultural periods. Distribution maps showing the presence of each ungulate species were established for each period. CONCLUSIONS: The first major ungulate extinction occurred during the local Iron Age (1,200-586 BCE), a period characterized by significant human population growth. During that time the last of the largest wild ungulates, the hartebeest (Alcelaphus buselaphus), aurochs (Bos primigenius) and the hippopotamus (Hippopotamus amphibius) became extinct, followed by a shrinking distribution of forest-dwelling cervids. A second major wave of extinction occurred only in the 19th and 20th centuries CE. Furthermore, a negative relationship was found between the average body mass of ungulate species that became extinct during the Holocene and their extinction date. It is thus very likely that the intensified human activity through habitat destruction and uncontrolled hunting were responsible for the two major waves of ungulate extinction in the southern Levant during the late Holocene
Modernizing Reference Genome Assemblies
- Author
- A Itsara
- Aye Wollam
- C Alkan
- Colin Kremitzki
- Darren Grafham
- Deanna M. Church
- Derek Albracht
- Elaine R. Mardis
- Evan E. Eichler
- F Antonacci
- Fiona Cunningham
- George Weinstock
- Glen Threadgold
- Glenn Harden
- Graham R.S. Ritchie
- Guy Griffiths
- H. C Mefford
- H. C Mefford
- Holland Kotkiewicz
- Hsiu-Chuan Chen
- J Schmutz
- J. M Kidd
- J. M Kidd
- J. R Lupski
- James Torrance
- Joanna Collins
- Jonathan Wood
- K Pelak
- Katherine Auger
- Kerstin Howe
- L Feuk
- Lee Trani
- Lucinda Fulton
- Lucy Matthews
- M. C Zody
- Matthew Dunn
- Milinn Kremitzki
- N. A Doggett
- Nathan Bouk
- P. H Sudmant
- Paul Flicek
- Paul Heath
- R Li
- R. M Durbin
- Richa Agarwala
- Richard K. Wilson
- Robert Fulton
- S Brunak
- S Gnerre
- S. B Ng
- Sarah Pelan
- Siobhan Whitehead
- Susan Rock
- T. J Ley
- Tim Hubbard
- Tina Graves
- Valerie A. Schneider
- W. J Kent
- Will Chow
- William M. McLaren
- Y Xue
- Publication venue
- Public Library of Science
- Publication date
- 01/07/2011
- Field of study
Techno-Ecological Synergy: A Framework for Sustainable Engineering
- Author
- Abson D. J.
- Alison G.
- Anastas P. T.
- Arrow K.
- Arrow K. J.
- Bakshi B. R.
- Balmford A.
- Bare J. C
- Bhavik R. Bakshi
- Bockstael N. E.
- Boithias L.
- Borucke M.
- Bovea M. D.
- Braungart M.
- Burkhard B.
- Comello S.
- Costanza R.
- Curran M. A.
- Daily G. C.
- de Baan L.
- de Groot R. S
- Faber N.
- Geyer R.
- Goldman R. L.
- Graedel T. E.
- Guinée J. B.
- Guy Ziv
- Hau J. L.
- Heal G.
- Hertwich E. G.
- Hoekstra A. Y.
- Kadlec R. H.
- Koellner T.
- Koellner T.
- Krausmann F.
- Lave L. B.
- Lenzen M.
- Lenzen M.
- Luttropp C.
- MA
- Matthews H. S.
- McDonough W.
- Michael D. Lepech
- Muller N. Z.
- Nelson E.
- Nowak D. J.
- Odum H. T.
- O’Rourke D.
- Redford K. H.
- Richard T.
- Rockstrom J.
- Schulp C. J. E.
- Schulte R. P.O.
- Singh S.
- Singh S.
- Stürck J.
- Suh S.
- Ukidwe N. U.
- Urban R. A.
- Van Oudenhoven A. P. E.
- Villamagna A. M.
- Vörösmarty C. J.
- Yu Y.
- Zhang Y.
- Zhang Y.
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- 20/01/2015
- Field of study
Even though the importance of ecosystems in sustaining all human activities is well-known, methods for sustainable engineering fail to fully account for this role of nature. Most methods account for the demand for ecosystem services, but almost none account for the supply. Incomplete accounting of the very foundation of human well-being can result in perverse outcomes from decisions meant to enhance sustainability and lost opportunities for benefiting from the ability of nature to satisfy human needs in an economically and environmentally superior manner. This paper develops a framework for understanding and designing synergies between technological and ecological systems to encourage greater harmony between human activities and nature. This framework considers technological systems ranging from individual processes to supply chains and life cycles, along with corresponding ecological systems at multiple spatial scales ranging from local to global. The demand for specific ecosystem services is determined from information about emissions and resource use, while the supply is obtained from information about the capacity of relevant ecosystems. Metrics calculate the sustainability of individual ecosystem services at multiple spatial scales and help define necessary but not sufficient conditions for local and global sustainability. Efforts to reduce ecological overshoot encourage enhancement of life cycle efficiency, development of industrial symbiosis, innovative designs and policies, and ecological restoration, thus combining the best features of many existing methods. Opportunities for theoretical and applied research to make this framework practical are also discussed
Best Practices for Scientific Computing
- Author
- Ben Waugh
- C Ma
- C. Titus Brown
- D Currie
- D Kane
- D Kelly
- D Matthews
- D. A. Aruliah
- DA Kelt
- DC Lees
- Ethan P. White
- F Ferrari
- F Pérez
- G Chang
- G Chang
- G Wilson
- Greg Wilson
- Ian M. Mitchell
- J Pitt-Francis
- J Segal
- J Segal
- Jonathan A. Eisen
- Kathryn D. Huff
- L Hatton
- L Hatton
- M Vardi
- Mark D. Plumbley
- Matt Davis
- ME Fagan
- Neil P. Chue Hong
- P Dubois
- Paul Wilson
- PF Dubois
- PF Dubois
- R Sanders
- Richard T. Guy
- S Killcoyne
- Steven H. D. Haddock
- WS Noble
- Y Pouillon
- Z Merali
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 26/09/2013
- Field of study
Scientists spend an increasing amount of time building and using software.
However, most scientists are never taught how to do this efficiently. As a
result, many are unaware of tools and practices that would allow them to write
more reliable and maintainable code with less effort. We describe a set of best
practices for scientific software development that have solid foundations in
research and experience, and that improve scientists' productivity and the
reliability of their software.Comment: 18 page
Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study.
- Author
- Aamir A
- Abbas J
- Abbas N
- Abbott TEF
- Abdalla M
- Abdikadir H
- Abuhussein N
- Acquaah F
- Adamson R
- Adeleye O
- Adeogun A
- Adlan A
- Aftab R
- Afzal Z
- Agarwal M
- Aglan H
- Agnew CJF
- Agrawal R
- Ahern D
- Ahluwalia J
- Ahluwalia V
- Ahmad A
- Ahmad K
- Ahmed H
- Ahmed I
- Ahmed L
- Ahmed N
- Ahmed P
- Ainger E
- Ainsworth P
- Aishwarya G
- Ajibola-Taylor O
- Akhbari M
- Akhtar A
- Akhtar R
- Akpenyi O
- Al-Ausi M
- Al-Huneidi R
- Al-Khudairi R
- Al-Masri S
- Al-Mousawi A
- Al-Saadi N
- Alagappan A
- Alberts J
- Alfa-Wali M
- Ali A
- Ali B
- Ali I
- Ali M
- Ali Q
- Ali S
- Alturki N
- Alwandi A
- Amani L
- Amarnath T
- Amer M
- Amin H
- Amin MN
- Amoah R
- Amoah-Arko A
- Anandarajah C
- Ananthavarathan P
- Andah EJE
- Andrew K
- Andrews H
- Ang A
- Ang HL
- Ang JJ
- Ani C
- Anilkumar A
- Anto N
- Anwar S
- Apperley H
- Appleton S
- Aquilina T
- Archer M
- Arif T
- Arneill M
- Arnell S
- Arnold TJ
- Arshad A
- Arthur J
- Arulkumaran N
- Arya J
- Asad M
- Asemota N
- Ashaye T
- Ashdown T
- Ashour R
- Ashraf MR
- Ashwood J
- Asif U
- Atkin G
- Atkins B
- Attalla M
- Aubrey-Jones D
- Auckburally S
- Auld F
- Auluck I
- Azam S
- Aziz R
- Azizi A
- Azmi F
- Babatunde F
- Babu VS
- Bachi A
- Bagga R
- Bains H
- Bajwa DS
- Baker A
- Baker C
- Balai E
- Balian V
- Ball M
- Bamford M
- Bana R
- Banfield DA
- Bannard-Smith J
- Barai I
- Barclay J
- Barfi L
- Barker C
- Barker M
- Barmayehvar B
- Barnfield J
- Barnor-Ahiaku E
- Baron C
- Barr CJ
- Barraclough J
- Baryan HK
- Basra M
- Bassam N
- Bath MF
- Battle J
- Beasley W
- Beattie G
- Beattie S
- Beatty M
- Beghal G
- Begum F
- Behranwala K
- Belchos J
- Belgaid DR
- Belgaumkar A
- Bell S
- Ben-Gal O
- Benchetrit S
- Bennett M
- Benons N
- Bernal TL
- Bertelli M
- Berthaume-Hawkins SD
- Best R
- Betts A
- Bevan K
- Bews-Hair M
- Bhambra R
- Bhamra N
- Bhangu A
- Bhatte S
- Bhatti A
- Bhide I
- Bhome R
- Bhudia R
- Bhullar S
- Bienias A
- Billyard C
- Bird C
- Birkinshaw F
- Black J
- Blake E
- Blazeby JM
- Bleakley A
- Bloom I
- Bogle R
- Bolton W
- Borakati A
- Boraluwe-Rallage H
- Borg CM
- Botha A
- Boualbanat Y
- Boulton APR
- Bountra K
- Bowley D
- Boyd G
- Boyles L
- Bradley P
- Brannick S
- Brayley J
- Brecher J
- Breen H
- Bristow S
- Britton N
- Broad J
- Brobbey P
- Brock E
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- Brown R
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- Bruce C
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- Budd E
- Bull K
- Burgin A
- Burke D
- Burke J
- Burnage S
- Burns N
- Burrows A
- Busti S
- Butler A
- Cabdi NMO
- Cadden F
- Cairns C
- Calabria C
- Calciu A
- Campbell A
- Campbell B
- Campbell G
- Campbell HS
- Cannon SP
- Cant M
- Capella S
- Cardus C
- Cardwell A
- Cargill Z
- Caroll P
- Carr G
- Carr R
- Carr W
- Carse S
- Carter N
- Carter R
- Castle A
- Cato L
- Cave D
- Cecil E
- Chadwick H
- Chadwick M
- Chan F
- Chan L
- Chan M
- Chan SSN
- Chan-lam N
- Chandler E
- Chandler S
- Chandramoorthy L
- Chandramoorthy S
- Chang A
- Chang LH
- Chang M
- Chappelow I
- Chapple K
- Charnley R
- Chaudhry A
- Chaudhry S
- Chauhan P
- Chavan A
- Chean CS
- Chen L
- Chen Y
- Chenciner L
- Cheng J
- Chesner R
- Cheung W
- Chin YR
- China Z
- Chitsabesan P
- Chohan K
- Choi JE
- Chong A
- Chong P
- Choo S
- Chopada A
- Chouari T
- Choudhary Y
- Choudhry M
- Choy CH
- Christie S
- Christopher E
- Chudek D
- Chui J
- Church M
- Church R
- Cipparrone M
- Claireaux HA
- Clark K
- Clarke B
- Clement KD
- Clements B
- Clements SE
- Cobley H
- Coe P
- Cohen J
- Coldicutt O
- Cole A
- Coleman M
- Collaborative S
- Collins J
- Collishaw A
- Common M
- Concannon K
- Conchie H
- Connelly A
- Connor M
- Cookson P
- Cope EA
- Cope T
- Copeland M
- Copley HC
- Coppel J
- Corbridge O
- Cotter M
- Courquin GR
- Court J
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- Craig ARJ
- Craig N
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- Cremen S
- Cresswell B
- Crewe A
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- Croghan N
- Croitoru C
- Cromwell D
- Cronbach P
- Crook H
- Crozier L
- Cruddas L
- Cullum R
- Cumber E
- Cumming S
- Cummings D
- Cunliffe L
- Cunningham L
- Curtis A
- Curtis J
- D'Auria M
- D'Souza F
- Dada J
- Dalal F
- Dalrymple J
- Daly D
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- Das E
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- Dawe V
- Dawood S
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- De Cates C
- De Freitas M
- Dean S
- Debnath D
- Deekonda P
- Deepak S
- Deery L
- Delvi A
- Denley S
- Dennahy IS
- Dennis R
- Dennis Y
- Desai H
- Desai K
- Devalia S
- Dhaliwal R
- Dhillon AK
- Dhillon P
- Dhir T
- Dhuna S
- Diamond J
- Dib NP
- Dickson G
- Dietrich A
- Dindyal S
- Dixon O
- Do V
- Dobrzynska M
- Doherty C
- Donaldson G
- Donohoe C
- Doshi A
- Doull C
- Downes C
- Doyle C
- Drake TM
- Draper A
- Dudley B
- Duff F
- Duffield J
- Duggal A
- Dumann E
- Dunleavy K
- Dunne E
- Dupaguntla YS
- Durand C
- Durbacz M
- Durham-Hall A
- Durno J
- Durrigan T
- Duthie F
- Dutta A
- Dyal A
- Dynes K
- Easby S
- Easdon S
- Eastwood M
- Ebhogiaye O
- Eccles L
- Ecclestone T
- Eddama M
- Edgerton K
- Edozie F
- Edwin C
- Egan E
- Eiben I
- Eiben P
- Eilon T
- El Matary R
- El Tokhy O
- El-Sawy D
- El-Taji O
- Elangovan S
- Elbuzidi M
- Elder P
- Elias J
- Ellerby N
- Elliot J
- Elliott J
- Elsaddig M
- Elseedawy E
- Emberton J
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- Engledow A
- English W
- Epanomeritakis E
- Episkopos C
- Epstein J
- Esmail R
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- Evans R
- Ezzat A
- Fafemi O
- Falamarzi A
- Fam M
- Faraj A
- Farhan-Alanie MMH
- Farmer N
- Farooq M
- Farooqi M
- Farrar E
- Farwana M
- Faulkner S
- Fawole A
- Fearnhead N
- Feldman M
- Fenton K
- Ferris B
- Filipescu T
- Finch E
- Fitzgerald I
- Fitzgerald JE
- Fitzpatrick H
- Flack V
- Flamini T
- Fletcher D
- Foley MP
- Fong J
- Fowler AJ
- Fox H
- Fozard T
- France B
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- Francois V
- Francombe J
- Freeman SK
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- Frost J
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- Gabriel R
- Gaddah M
- Gadsby C
- Gaffing S
- Galea M
- Gallogly P
- Galloway F
- Gammeri E
- Gani A
- Ganyani R
- Gao C
- Gardner I
- Gardner S
- Gardner T
- Garner C
- Garsaa T
- Gaukroger A
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- Gentry R
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- Gerard L
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- Ghailan N
- Gharatya A
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- Glasbey JC
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- Gnanappiragasam D
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- Hamid H
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- Hung YMA
- Hungwe C
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- Huppatz IW
- Huq T
- Hurst P
- Hussain A
- Hussain M
- Hussain SF
- Hussain ST
- Hussein N
- Hutchinson S
- Ibrahim B
- Ibrahim I
- Ijeomah A
- Ikogho O
- Ikram B
- Ilenkovan N
- Imam SZ
- Imran H
- Ingleton R
- Ingram H
- Innes R
- Iqbal F
- Iqbal S
- Iroegbu U
- Ishaq H
- Islam Y
- Ismail O
- Ito G
- Ivo T
- Jackman T
- Jackson CES
- Jacob-Ramsdale B
- Jain D
- Jain P
- Jamal S
- James F
- Javaid NR
- Jawad L
- Jawad ZAR
- Jebakumar R
- Jeffreys N
- Jeyabaladevan S
- Ji C
- Jiang J
- Jiao LR
- John I
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- Kamarajah S
- Kambasha C
- Kaminski F
- Kanabar S
- Kanapeckaite L
- Kandage D
- Kandhari N
- Kandiah K
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- Kapp J
- Kaptanis S
- Karaj J
- Karam E
- Karbowiak M
- Karim MA
- Karim MJ
- Karmarkar A
- Karsan RB
- Karunatilleke AS
- Katira A
- Katsaiti I
- Kaur G
- Kausar A
- Kazmi Z
- Keane K
- Kee JY
- Keelan G
- Kelkar A
- Kelly D
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- Kenefick N
- Kennedy ED
- Keogh C
- Kerin M
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- Kersey T
- Kershaw S
- Keshvala C
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- Keyte A
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- Khodatars K
- Khoo E
- Kiandee M
- Kidanu D
- Kiely A
- Killington K
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- Knight C
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- Komoriyama A
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- STARSurg Collaborative Writing Committee, Data analysis, Steering committee, Advisory group, Regional leads, Collaborators and validators
- STARSurg Collaborative Writing Committee, Data analysis, Steering committee, Advisory group, Regional leads, Collaborators and validators, Nepogodiev, D
- Stechman M
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- Publication venue
- 'Wiley'
- Publication date
- 18/05/2018
- Field of study
Background: Acute illness, existing co-morbidities and surgical stress response can all contribute to postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. The aim of this study was prospectively to develop a pragmatic prognostic model to stratify patients according to risk of developing AKI after major gastrointestinal surgery. Methods: This prospective multicentre cohort study included consecutive adults undergoing elective or emergency gastrointestinal resection, liver resection or stoma reversal in 2-week blocks over a continuous 3-month period. The primary outcome was the rate of AKI within 7 days of surgery. Bootstrap stability was used to select clinically plausible risk factors into the model. Internal model validation was carried out by bootstrap validation. Results: A total of 4544 patients were included across 173 centres in the UK and Ireland. The overall rate of AKI was 14·2 per cent (646 of 4544) and the 30-day mortality rate was 1·8 per cent (84 of 4544). Stage 1 AKI was significantly associated with 30-day mortality (unadjusted odds ratio 7·61, 95 per cent c.i. 4·49 to 12·90; P < 0·001), with increasing odds of death with each AKI stage. Six variables were selected for inclusion in the prognostic model: age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker. Internal validation demonstrated good model discrimination (c-statistic 0·65). Discussion: Following major gastrointestinal surgery, AKI occurred in one in seven patients. This preoperative prognostic model identified patients at high risk of postoperative AKI. Validation in an independent data set is required to ensure generalizability
Use of anticoagulants and antiplatelet agents in stable outpatients with coronary artery disease and atrial fibrillation. International CLARIFY registry
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- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2015
- Field of study
Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans
- Author
- Abbasi Z
- Abdul-Hamid M Akhlil
- Abel Paul D
- Abrams Paul H
- Adab Fawzi A
- Adamson Andrew
- Adeyoju A
- Adolfson Jan
- Afzal Naveed
- Ahiaku Ernest K N
- Ahmed Munir
- Al Sudani Mohammed L
- Al-Samarraie Amir S M
- Al-Samerraie [Unknown]
- Al-Singary Waleed
- Al-Sudani [Unknown]
- Alcock Christopher
- Alexander Kimberly
- Ali Zulfiqar
- Almond David J
- Alonzi Roberto
- Aly Markus
- Amin Al Olama Ali
- Anderson John
- Andrews Henry
- Andrews Steven
- Anjum Iqbal
- Anson Ken
- Anyamene Nicola A
- Apakama Ike
- Aparcia F
- Archbold J A A
- Arndt Volker
- Ash D
- Ashford Richard F U
- Auvinen Anssi
- Azzabi A
- Badenoch David
- Bahl Amit
- Bailey Karen
- Bailey M J
- Ball Andrew J
- Banerjee G
- Barber Jim
- Barber N
- Baria [Unknown]
- Barnes Douglas G
- Barros-Silva Joao
- Barwell Julian
- Bashir J
- Basu Pradip
- Bates Christopher A
- Batra Jyotsna
- Bax N A
- Baxter-Smith D
- Bdesha Amar
- Beacock Christopher J M
- Beaney Ronald P
- Beard Ralph
- Beatty John D
- Beck Rupert
- Beese Gail
- Beesley Sharon
- Bell C Richard W
- Bellringer James
- Benlloch Garcia Sara
- Benson Richard
- Beresford [Unknown]
- Bevis Christopher R A
- Bhana Rajanee
- Bhanot S
- Bhatnagar A
- Bhatt R I
- Birch Brian
- Birtle Alison
- Bishop M
- Biyani C Shekhar
- Blacklock A R E
- Blades Rosemary
- Bliss Peter
- Bloomfield David J
- Boddy S
- Bollina Prasad
- Bonnington Sue
- Booth C M
- Bose Pradeep
- Bott Michael C
- Bottomley David
- Boucher Nigel R
- Bowen J
- Bower Mark
- Bowsher W G
- Boyd P J R
- Bradshaw Lynne
- Bramble F James
- Brenner Hermann
- Brewster Simon F
- Briggs Tim
- Brock Cathryn
- Brock Sue
- Bromage Stephen
- Broms Michael
- Brough Richard
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- Brown Paul
- Brown Paul M
- Brown Richard
- Brown Stephen
- Browning Tony J
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- Burgess Neil A
- Burns-Cox Nicholas
- Butterbach Katja
- Butterworth Paul C
- Cahill D
- Callaghan P S
- Calleary John
- Calleja M
- Calman Frances
- Camilleri Philip
- Campbell Alister
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- Cannon-Albright Lisa
- Carnell Dawn M
- Carr T W
- Carter Adam C
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- Carter Simon
- Castle Bruce M
- Catto James
- Cavalli-Bjoerkman Carin
- Chadwick David
- Chahal Rohit
- Chakraborti P
- Chappell [Unknown]
- Charig C
- Chetiyawardana Anula D
- Chilton Christopher
- Chinegwundoh F I
- Chong Irene
- Choudhury Ananya
- Chow Wai-Man
- Christmas Timothy J
- Christova Svetlana
- Churn Mark J
- Cieza-Borrella Clara
- Clarke Noel W
- Clavijo-Eisele Jorge
- Clements Judith A
- Coe M
- Coetzee Gerhard A
- Cohen N P
- Coker C
- Cole David J
- Cole O
- Cole Trevor
- Collins Angus
- Collins Gerald
- Collinson Matthew
- Conn I
- Connell C
- Conti David V
- Cook Audrey
- Cook Margaret
- Cooke Peter
- Cooksey Graeme
- Coombs L
- Cooper Debbie
- Copland Robert F
- Cornaby Andrew J
- Cornford P A
- Corolis [Unknown]
- Corr John
- Costello C B
- Coull Mrs N
- Cowan Richard
- Cox Angela
- Cox Robert
- Coyle C
- Crew Jeremy
- Crisp John C
- Cross W
- Cruger Dorthe
- Crundwell Malcolm
- Cummings [Unknown]
- Cybulski Cezary
- Dadaev Tokhir
- Dahar Nazeer
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- Darrad J
- Daruwala Pallon
- Das Gautam
- Datta Shibendra
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- Davies Joseph
- Davis Michael
- Davison Owen W
- Dawkins Guy
- Dawson Chris
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- Dearnaley David
- Desai Ken M
- Deutsch George P
- Dick John
- Dickinson Andrew J
- Dickson Jeanette
- Dikov Tihomir
- Dinneen Michael
- Dixit Sanjay
- Dobbs H Jane
- Doble A
- Doble Andrew
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- Doherty Alan
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- Down Liz
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- Duffy Peter
- Dunn Michael
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- Easton Douglas
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- Feggetter Jeremy
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- Fitzgerlad Liesel M
- Fletcher Matthew
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- Foster Paul W
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- Freedman Mathew
- Frim Olivera
- Gale Joanna
- Gallegos Christopher
- Gelister James S
- George Anne
- Ghana [Unknown]
- Gibbs Stephanie
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- Gillatt David
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- Glenister James
- Goode Thomas D
- Gordon E M
- Govindasami Koveela
- Gower Richard L
- Graham John
- Green Damian
- Greenland Jonathan
- Grieve Robert
- Griffiths Thomas R L
- Gronberg Henrik
- Gujral Sandy
- Gupta Nishi
- Gurun Riza Murat
- Gustafsson Sven
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- Guy Peter J
- Haiman Christopher A
- Haldar Neil
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- Haley James
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- Hamdy Freddie
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- Hammonds John
- Hampson S J
- Hanbury Damien C
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- Harland Stephen J
- Harney John M
- Harper Peter
- Harris D
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- Harvey-Hills N
- Hawkyard Simon
- Hazel Steve
- Hazelett Dennis J
- Heath Catherine M
- Heathcote Peter
- Hehir Michael
- Hellawell Giles O
- Henderson Brian E
- Hendry David
- Henley Mike
- Henrique Rui
- Henry Ann
- Herbert Pippa
- Herkommer Kathleen
- Hetherington John
- Hickish Tamas
- Hicks James A
- Hilman Serena
- Hindley Richard
- Hindmarsh John R
- Hines John
- Hingorani M
- Ho Edwin T S
- Hodgson Shirley
- Hoffman U
- Holden David
- Holding Peter
- Hollingdale A
- Hollins Graham W
- Holmes Simon A V
- Holt Sarah
- Hopper John L
- Horan Gail
- Horwich Alan
- Hoskin Peter
- Howell Graham P
- Howson Joanne
- Hrouda D
- Huddart Robert
- Hudson Liz
- Hughes Michael
- Hughes Owen
- Hughes Rob
- Humber Caroline
- Iacovou John W
- Ibrahim A
- Inglis John A
- Irving Stuart
- Irwin C
- Iversen Peter
- Izatt Louise
- Izegbu Victor
- Jameel Basharat
- James Michael J
- James N
- James R Lester
- Javle Pradip
- Jenkins P
- Jhavar Sameer
- Johansson Jan-Erik
- Jones Chris R
- Jones David A
- Jones Gareth
- Jones Mandy
- Joseph J
- Joss Shelagh
- Jugurnauth-Little Sara
- Kachakova Darina
- Kaisary Amir
- Kaliski Alexandre L
- Kaneva Radka
- Kapur G
- Karim O
- Karlsson Ami
- Karp Stephen J
- Kedda Mary-Anne
- Keeley F X
- Kelkar Anand R
- Kelleher J P
- Kelly John
- Kenwrick Sue
- Kerr Kris
- Key Tim J
- Khan F
- Khaw Kay-Tee
- Khoo Vincent
- Kibel Adam S
- Kierzek Andrzej
- Kimber Rachel M
- Kinder R
- Kirby Roger S
- Kirk David
- Kirkbride Peter
- Kirollos Magdi M
- Klarskov Peter
- Kluzniak Wojciech
- Kockelbergh Roger
- Koenig Philip C W C
- Kooiman Gordon G
- Koreich O
- Kote-Jarai Zsofia
- Koupparis Anthony
- Kourah Mohamed
- Kraus Sigurd
- Kujala Paula
- Kujawa Magda L
- Kulkarni Ravi
- Kumar M
- Kumar Rajeev
- Kunkler Ian H
- Kynaston H
- Kynaston Howard
- Lachlan Katherine L
- Laing Robert
- Lalloo Fiona
- Lancashire M
- Lane Athene
- Langley Stephen E M
- Laniado Marc
- Larner T R
- Lau Maurice W
- Lawrence W T
- Lawson Anne
- Le Roux Pieter J
- Leader Mary
- Lee A
- Lee J O
- Lee L
- Lemburger R John
- Lennon Teresa
- Leone Priscilla
- Leongamornlert Daniel
- Lester Jason
- Leung Hing
- Lewis D Christopher
- Lewis J
- Li Qiuyan
- Lim Hui-Yi
- Lin Hui-Yi
- Liston Thomas
- Livni Naomi
- Livsey Jacqueline
- Lloyd S
- Locke Imogen
- Lodge Richard
- Logue John
- Longmuir Mark
- Lophatananon Artitaya
- Lophatonanon Artitaya
- Lubinski Jan
- Lucas Malcolm G
- Luedeke Manuel
- Luscombe C J
- Lydon Anna
- Lynch Michael
- Lynn Naing N K
- Lyons Norma
- MacDermott James P A
- Macdonagh Ruaraidh P
- Macdonald [Unknown]
- Madaan Sanjeev
- Madhava Kudingila R
- Maeaettaenen Liisa
- Maguire Joseph
- Maher E R
- Mahmood Rana
- Maia Sofia
- Maier Christiane
- Mair Graeme H M
- Malone Greg
- Malone Peter R
- Mangar Stephen A
- Mantle Mark
- Mark I
- Marsden Gemma
- Mason M D
- Mason Malcolm
- Mason Robert
- Matanhelia [Unknown]
- Matenhelia Shyam
- Matthews Philip N
- McAleese J
- McBride Donna
- Mcdonnell Shannon K
- McDonnell Shannon K
- McFarlane Jonathan
- McGrath [Unknown]
- McIlhenny Craig
- McInerney Paul
- McIntosh Gregor
- McKinna F
- McLaren Duncan
- McLarty Esther
- McMenemin Rhona
- McNeill Alan
- McNicholas T A
- Meddings Robert N
- Mee A David
- Melcher Lucinda
- Memon [Unknown]
- Menzes Pravin
- Michael Agnieszka
- Miller Marek
- Mills Robert
- Mitchell S
- Mitev Vanio
- Mithal Natasha
- Mitkova Atanaska
- Mitra Anita
- Mobb Gillian E
- Moffat Leslie E F
- Mokete [Unknown]
- Money-Kyrle Julian
- Montgomery Bruce
- Moody Hilary
- Moody Martin P
- Morgan Angela
- Morley Roland
- Morris Sean B
- Morrison Patrick
- Mort Diana
- Mostafid Amir H
- Motiwala Hanif
- Mufti Gulzar
- Muir Gordon
- Muir Kenneth
- Mumtaz Faiz
- Murphy Michael
- Murray Alexandra
- Murray Keith W
- Murrell Shirley
- Murtola Teemu
- Muthukumar D
- Naerger Harry
- Namasivayam Siva
- Nargund Vinod
- Nawrocki [Unknown]
- Neal David E
- Neilson Donald
- Nethersell A
- Newby Jacqueline C
- Newman Hugh
- Newton R
- Nielsen Sune F
- Nordestgaard Børge G
- O'Boyle P J
- O'Brien J
- O'Brien Tim S
- O'Donnell H
- O'Donoghue E
- O'Donoghue Neil
- O'Reilly P
- O'Rourke J S
- O'Sullivan Joe
- O'Sullivan Patricia
- Oakley Neil
- Ogden Chris
- Ohja Hemant
- Oliver Tim
- Omara Tracy
- Ong Eng K
- Osborn David
- Ostler Peter
- Owen J
- Palfrey Edward
- Panades Miguel
- Panakis Niki
- Pancharatnam M
- Pandha Hardev
- Pantelides Michalakis L
- Panwar U
- Parikh Omi
- Park Hyun
- Park Jong Y
- Parker Chris
- Parker Christopher H
- Parys Bohdan T
- Pascoe Sarah
- Pashayan Nora
- Patel Anup
- Paterson Joan
- Pathack S
- Pati Jhumur
- Patterson Helen
- Pattu [Unknown]
- Paul A
- Paul Alan
- Paulo Paula
- Payne Heather
- Peake David
- Pedersen John
- Pedley I
- Pengelly A
- Peracha Amjad M
- Perry Matthew
- Persad Raj
- Peters John
- Pharoah Paul
- Philp N H
- Philp T
- Pickering Lisa M
- Pigott Katharine
- Pinto Pedro
- Plail R
- Plowman P Nicholas
- Pocock Richard D
- Pope A J
- Popert Rick
- Popov Elenko
- Porter Tim
- Potter John M
- Pow-Sang Julio
- Powell Christopher
- Powell Philip
- Powles Thomas B
- Prasad Krishna
- Prasad Seshadri Sri
- Prejbisz J W
- Prescott Stephen
- Protheroe Andrew
- Qureshi Khaver N
- Raby Nigel
- Radlein Selina
- Ragavan Narasimhan
- Raju Palaniappa G S
- Ramachandra Prakash B
- Raman R
- Rane Abhay
- Rankin Julia
- Rao Y
- Ratan Hari L
- Ravi Ramachandran
- Ravishankar K
- Read [Unknown]
- Reddy Paul J
- Rimington Peter R
- Rinckleb Antje
- Rincon Maria
- Riska Shaun
- Ritchie Peter A
- Roberts J Trevor
- Robertson Andrew
- Robinson Angus
- Robinson Anne C
- Robinson Lee Q
- Rochester Mark A
- Roder Andreas
- Rogers P B
- Rosario Derek
- Rosenbaum Tomas P
- Rothwell Neil
- Rowbotham Carl
- Rowe [Unknown]
- Rowley Kathryn
- Ruddy Deborah
- Rundle John
- Russell John M
- Ryan P G
- Sabharwal A
- Saggar Anand K
- Samanci Ali
- Sangar Vijay K
- Santos Joana
- Saunders Edward J
- Saunders Pamela
- Sawyer Emma J
- Saxby M F
- Schaid Daniel J
- Schleutker Johanna
- Schumacher Fredrick
- Schwaibold Hartwig
- Scoble John E
- Scrase Christopher
- Selim [Unknown]
- Sellers Thomas
- Sells Henry
- Sethia Krishna K
- Severi Gianluca
- Shackley David C
- Shaffer [Unknown]
- Shah Nihil
- Shakespeare D
- Shanley Sue
- Sharma Neerah K
- Sheehan Denise J
- Sherwin Elizabeth
- Shum Poh Lin
- Side Lucy
- Sidek Norma
- Signorello Lisa B
- Sikora Karol
- Simcock R
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- Siva M
- Slavov Chavdar
- Smith James
- Smith Michael F
- Sokal Michael
- Sole Graham M
- Southey Melissa C
- Speakman Mark J
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- Sreenivasan Thiagarajan
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- Sriram Rajagopalan
- Staffurth John N
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- Stattin Paer
- Stegmaier Christa
- Stephens Sarah
- Stewart D
- Stockdale Andrew
- Stott Mark A
- Stower M J
- Strachan John R
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- Sugden Elaine
- Summerton Duncan
- Sundar Santhanam
- Sundaram S K
- Suresh Gokarakonda
- Susnerwala Shabbir
- Swami Kuchibhotla S
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- Tahir Saad
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- Toussi Hamid
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- Turner Megan
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- Van As Nicholas
- Vasanthan Subramaniam
- Vesey Sean
- Vilarino-Varela Maria
- Violet John
- Virdi Jaspal
- Viñuela Ana
- Vlahova Aleksandrina
- Vogel Walther
- Wade Robert
- Wahlfors Tiina
- Waite Katherine
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- Wallinder Hans
- Wang Liang
- Watkin Nicholas A
- Watson M E
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- Waymont Brian
- Weaver Andrew
- Webb Ralph J
- Wedderburn Andrew
- Weischer Maren
- Wells Paula
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- Whelan P
- Whillis D
- Whitmore Ian
- Wiklund Fredrik
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- Wiles Vicki
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- Williams John H
- Williams Simon
- Willis Michael
- Wills Michael I
- Wilson J R
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- Wu Huihai
- WYLIE [Unknown]
- Wylie James P
- Wynne Chris
- Yeadon Trina
- Zachariah Babu
- Zang Angelika
- Zarkar A
- Zheng Wei
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2015
- Field of study
Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have
fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in
25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16
regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of
correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP,
while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in
Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium
(LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region.
Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant
enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the
refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa,
an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of
PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent
signals within the same regio
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.
- Author
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- Wiegand-Loehnert C
- Wighton E
- Wigmore G
- Wijeysundera D
- Wikner M
- Wild J
- Wildes T
- Wildi S
- Williams A
- Williams M
- Williams S
- Wilscott-Davids C
- Wilson A
- Wilson D
- Wilson L
- Wilson N
- Wima S
- Winch D
- Winstone U
- Winterton D
- Wir WM
- Wise R
- Wittmann M
- Wolfer A
- Wollaston J
- Wong C
- Wong CW
- Wong JY
- Wong K
- Wong KWK
- Wong SM
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- Wong WL
- Woodgate A
- Woolsey A
- Woon YL
- Worreth M
- Wouters P
- Wrench I
- Wright S
- Wu C
- Wu C
- Wu J
- Wu J
- Wu Q
- Wu S
- Wyffels P
- Wylie K
- Xia J
- Xia Y
- Xia Z-Y
- Xiao W
- Xiao W
- Xie G
- Xie J
- Xie J
- Xie K
- Xifara A
- Xiong X
- Xiong Y
- Xouplidis K
- Xu G-J
- Xu L
- Xu L
- Xu Q
- Xu S
- Xue R
- Yagnik A
- Yan Y
- Yang J
- Yang L
- Yang Q
- Yang S
- Yang T
- Yang Y
- Yao S
- Yao Y
- Yap HL
- Yarwood J
- Yassaee A
- Ye H
- Ye H
- Yegnaram S
- Yeh E
- Yin N
- Yip CP
- Yong J
- Yu HC
- Yu S
- Yu T
- Yu Y
- Yuan D
- Yuan F
- Yuan J
- Yuan J
- Yuan Y
- Yuliana A
- Zaimi D
- Zakynthinos S
- Zamudio D
- Zangrillo A
- Zapata DDM
- Zbitnew G
- Zeidan L
- Zeng Q
- Zerman L
- Zettergren J
- Zhang B
- Zhang E
- Zhang H
- Zhang H
- Zhang H
- Zhang J
- Zhang K
- Zhang L
- Zhang M
- Zhang M
- Zhang Q
- Zhang R
- Zhang S
- Zhang W
- Zhang X
- Zhang X
- Zhang X
- Zhang X
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Y
- Zhao B
- Zhao B
- Zhao C
- Zhao J
- Zhao J
- Zhao L
- Zhao L
- Zhao S
- Zhao T
- Zhao W
- Zhao W
- Zhao X
- Zhen J
- Zheng K
- Zheng L
- Zheng T
- Zhong Y
- Zhou C
- Zhou D
- Zhou H
- Zhou H
- Zhou J
- Zhou J
- Zhou J
- Zhou X-J
- Zhu X
- Zhu X
- Zhu Y
- Zhu Z
- Zhuang X
- Zilis G
- Zin NHM
- Zingerle N
- Zingg U
- Zoerner F
- Zonneveldt H
- Zou X
- Zoulamoglou M
- Zsisku L
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700
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