La estancia perfecta en hoteles de 4 y 5 estrellas de Sevilla a través del análisis de los comentarios en Tripadvisor: determinación de los principales ítems

Universidad de Sevilla. Grado en Turism

Mapping the more highlights items by Tripadvisor comments when choosing a hotel in Seville

Tripadvisor se ha convertido en una fuente de información primordial a la hora de elegir un hotel. De esta forma, los comentarios vertidos en su web pasan a ser un factor determinante para muchos usuarios en la selección de su alojamiento, hecho al que no permanece ajeno el empresario hotelero. Por tanto, estudios como el que aquí se presentan ayudan a identificar cuáles son los ítems más valorados por el cliente, haciéndole experimentar una estancia diez. Así pues, en esta investigación se analiza los comentarios calificados como excelente en los hoteles de 4 y 5 estrellas de Sevilla, de tal forma que los resultados determinan la ubicación, los servicios, las instalaciones y las habitaciones como los aspectos más valorados.Tripadvisor has become a prime source of information when choosing a hotel. Thus, the comments in the Tripadvisor web become a determining factor for many users in selecting their accommodation, a fact that hoteliers cannot ignore. Therefore, studies such as presented here help to identify the most valued items by clients, making their stay experience as perfect. Hence, in this research the comments rated as excellent in 4 and 5 stars’ hotels in Seville are analyzed, so the results determine that location, services, facilities and rooms as the most valued aspects

The perfect stay in 4 and 5 star hotels in Seville through the analysis of comments on TripAdvisor. Determination of the main items

Si en algo coinciden hoy en día la mayor parte de los empresarios hoteleros es que las opiniones online realizadas por los usuarios turísticos suponen una gran fuente de información para la oferta turística. Por ello, se cree necesario analizar cuáles son los principales ítems valorados para considerar una estancia perfecta en hoteles de cuatro y cinco estrellas de la ciudad de Sevilla. Para ello, se utilizará como base de datos la web de viajes TripAdvisor, y como herramienta de análisis cualitativo el software NVivo10. Los datos obtenidos apuntan a que los ítems más valorados son la ubicación, los servicios ofrecidos y las instalaciones, las habitaciones, el trato y la eficacia del personal, el precio, la calidad y la limpieza.Today, if anything matches most hoteliers is that online tourist opinions made by users are a great source of information for tourism. Therefore, it is believed that it is necessary to analyze what are the main appreciated items in order to consider a perfect stay in hotels of four and five stars in the city of Seville. To do this, the TrivAdvisor web will be used as a database and the NVivo10 software as a qualitative analysis tool. The data obtained suggest the most valued items are location, services and facilities, as well as rooms, dealing and staff efficiency, price, quality and cleanliness

The involvement of McpB chemoreceptor from Pseudomonas aeruginosa PAO1 in virulence

Work in Dr. Manzanera’s laboratory was funded by the Spanish Ministry for Economy and Competitiveness, within the context of the research projects CTM2017-84332-R, and CGL2017-91737-EXP. Dr. Krell’s laboratory was supported by FEDER funds and Fondo Social Europeo through grants from the Junta de Andalucía (grant CVI-7335) and the Spanish Ministry for Economy and Competitiveness (grants BIO2013-42297 and BIO2016-76779-P). We thank Prof. Caroline Harwood (University of Washington) for providing a P. aeruginosa PAO1 wt strain and the mcpB mutant, that were used for initial experiments not reported here.Supplementary information accompanies this paper at https://doi.org/10.1038/s41598-019-49697-7.Pseudomonas aeruginosa is an opportunistic human pathogen causing infections in a variety of plant and animal hosts. The gene mcpB, part of the chemosensory gene cluster II, encodes a soluble chemoreceptor whose function remains unknown. Previous studies show that the cheB2 gene, also located in the chemosensory cluster II, is involved in a specific response during infection and it is required for full pathogenicity of P. aeruginosa. To determine whether the McpB (or Aer2) chemoreceptor is involved in virulence processes, we generated a mcpB mutant and tested its phenotype using a virulence-measuring system. This system was developed by our group and is based on different bioassays using organisms living at different soil trophic levels, including microbial, nematode, arthropod, annelid, and plant model systems. The deletion of mcpB resulted in an attenuation of bacterial virulence in different infection models, and wild-type virulence was restored following genetic complementation of the mutant strain. Our study indicates that the McpB chemoreceptor is linked to virulence processes and may constitute the basis for the development of alternative strategies against this pathogen.CTM2017-84332-RCGL2017-91737-EXPFEDER funds and Fondo Social Europeo through grants from the Junta de Andalucía (grant CVI-7335)Spanish Ministry for Economy and Competitiveness (grants BIO2013-42297 and BIO2016-76779-P

Deciphering the Nature of Trp73 Isoforms in Mouse Embryonic Stem Cell Models: Generation of Isoform-Specific Deficient Cell Lines Using the CRISPR/Cas9 Gene Editing System

This article belongs to the Special Issue The Isoforms of the p53 Gene Family and Their Role in Cancer and Aging：Selection Papers from International p53/p63/p73 Isoforms Workshop[EN] The p53 family has been widely studied for its role in various physiological and pathological processes. Imbalance of p53 family proteins may contribute to developmental abnormalities and pathologies in humans. This family exerts its functions through a profusion of isoforms that are generated by different promoter usage and alternative splicing in a cell type dependent manner. In particular, the Trp73 gene gives rise to TA and DN-p73 isoforms that confer p73 a dual nature. The biological relevance of p73 does not only rely on its tumor suppression effects, but on its pivotal role in several developmental processes. Therefore, the generation of cellular models that allow the study of the individual isoforms in a physiological context is of great biomedical relevance. We generated specific TA and DN-p73-deficient mouse embryonic stem cell lines using the CRISPR/Cas9 gene editing system and validated them as physiological bona fide p73-isoform knockout models. Global gene expression analysis revealed isoform-specific alterations of distinctive transcriptional networks. Elimination of TA or DN-p73 is compatible with pluripotency but prompts naïve pluripotent stem cell transition into the primed state, compromising adequate lineage differentiation, thus suggesting that differential expression of p73 isoforms acts as a rheostat during early cell fate determinationSIThis work was supported by Grants PID2019-105169RB-I00 from Spanish Ministerio de Ciencia e Innovación cofinanced by FEDER funds (to M.C.M.) and LE021P17 from Junta de Castilla y Leon. L.L.-F. was a holder of a postdoctoral contract “Juan de de la Cierva-Incorporacion” from Ministerio de Ciencia e Innovación. N.M.-G. and H.A.-O. are supported by a predoctoral scholarship from the Asociación Española contra el Cáncer (AECC). M.M.-L. was a recipient of a Torres Quevedo contract from Ministerio de Ciencia e Innovación at Biomar Microbial Technologies. Á.D.-M., J.V.-F. and L.M.-A. are funded by Junta de Castilla y Leó

Plan de formación inicial en habilidades docentes para el profesorado de la Facultad de Educación

Memoria ID-0088. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2017-2018

Safety and preliminary efficacy on cognitive performance and adaptive functionality of epigallocatechin gallate (EGCG) in children with Down syndrome. A randomized phase Ib clinical trial (PERSEUS study)

Purpose: Although some caregivers are using epigallocatechin gallate (EGCG) off label in hopes of improving cognition in young adults with Down syndrome (DS), nothing is known about its safety, tolerability, and efficacy in the DS pediatric population. We aimed to evaluate safety and tolerability of a dietary supplement containing EGCG and if EGCG improves cognitive and functional performance. Methods: A total of 73 children with DS (aged 6-12 years) were randomized. Participants received 0.5% EGCG (10 mg/kg daily dose) or placebo for 6 months with 3 months follow up after treatment discontinuation. Results: In total, 72 children were treated and 66 completed the study. A total of 38 participants were included in the EGCG group and 35 in the placebo group. Of 72 treated participants, 62 (86%) had 229 treatment-emergent adverse events (AEs). Of 37 participants in the EGCG group, 13 (35%) had 18 drug-related treatment-emergent AEs and 12 of 35 (34%) from the placebo group had 22 events. In the EGCG group, neither severe AEs nor increase in the incidence of AEs related to safety biomarkers were observed. Cognition and functionality were not improved compared with placebo. Secondary efficacy outcomes in girls point to a need for future work. Conclusion: The use of EGCG is safe and well-tolerated in children with DS, but efficacy results do not support its use in this population. (C) 2022 The Authors. Published by Elsevier Inc. on behalf of American College of Medical Genetics and Genomics

COVID-19 Severity and Survival over Time in Patients with Hematologic Malignancies: A Population-Based Registry Study

Mortality rates for COVID-19 have declined over time in the general population, but data in patients with hematologic malignancies are contradictory. We identified independent prognostic factors for COVID-19 severity and survival in unvaccinated patients with hematologic malignancies, compared mortality rates over time and versus non-cancer inpatients, and investigated post COVID-19 condition. Data were analyzed from 1166 consecutive, eligible patients with hematologic malignancies from the population-based HEMATO-MADRID registry, Spain, with COVID-19 prior to vaccination roll-out, stratified into early (February–June 2020; n = 769 (66%)) and later (July 2020–February 2021; n = 397 (34%)) cohorts. Propensity-score matched non-cancer patients were identified from the SEMI-COVID registry. A lower proportion of patients were hospitalized in the later waves (54.2%) compared to the earlier (88.6%), OR 0.15, 95%CI 0.11–0.20. The proportion of hospitalized patients admitted to the ICU was higher in the later cohort (103/215, 47.9%) compared with the early cohort (170/681, 25.0%, 2.77; 2.01–3.82). The reduced 30-day mortality between early and later cohorts of non-cancer inpatients (29.6% vs. 12.6%, OR 0.34; 0.22–0.53) was not paralleled in inpatients with hematologic malignancies (32.3% vs. 34.8%, OR 1.12; 0.81–1.5). Among evaluable patients, 27.3% had post COVID-19 condition. These findings will help inform evidence-based preventive and therapeutic strategies for patients with hematologic malignancies and COVID-19 diagnosis.Depto. de MedicinaFac. de MedicinaTRUEFundación Madrileña de Hematología y HemoterapiaFundación Leucemia y LinfomaAsociación Madrileña de Hematología y Hemoterapiapu

The perfect stay in 4 and 5 star hotels in Seville through the analysis of comments on TripAdvisor - Determination of the main items

Si en algo coinciden hoy en día la mayor parte de los empresarios hoteleros es que las opiniones online realizadas por los usuarios turísticos suponen una gran fuente de información para la oferta turística. Por ello, se cree necesario analizar cuáles son los principales ítems valorados para considerar una estancia perfecta en hoteles de cuatro y cinco estrellas de la ciudad de Sevilla. Para ello, se utilizará como base de datos la web de viajes TripAdvisor, y como herramienta de análisis cualitativo el software NVivo10. Los datos obtenidos apuntan a que los ítems más valorados son la ubicación, los servicios ofrecidos y las instalaciones, las habitaciones, el trato y la eficacia del personal, el precio, la calidad y la limpiezaToday, if anything matches most hoteliers is that online tourist opinions made by users are a great source of information for tourism. Therefore, it is believed that it is necessary to analyze what are the main appreciated items in order to consider a perfect stay in hotels of four and five stars in the city of Seville. To do this, the TrivAdvisor web will be used as a database and the NVivo10 software as a qualitative analysis tool. The data obtained suggest the most valued items are location, services and facilities, as well as rooms, dealing and staff efficiency, price, quality and cleanlines