509 research outputs found
Reducing radiation in chronic total occlusion percutaneous coronary interventions.
The field of percutaneous intervention for chronic total occlusion (CTO) has enjoyed significant innovations in the recent years. Novel techniques and technologies have revolutionized the field and have resulted in considerably higher success rates even in patients with high anatomical complexity. Successful CTO recanalization is associated with significant clinical benefits, such as the improvement of angina and quality of life, reduced rates of surgical revascularization, improvement of left ventricular function and decreased mortality rates. However, complex CTO procedures often require prolonged x-ray exposure which have been associated with adverse long term outcomes
GAPPS (Grading and Assessment of Pharmacokinetic-Pharmacodynamic Studies) a critical appraisal system for antimicrobial PKPD studies - development and application in pediatric antibiotic studies
Introduction: There are limited data on optimal dosing of antibiotics in different age groups for neonates and children. Clinicians usually consult pediatric formularies or online databases for dose selection, but these have variable recommendations, are usually based on expert opinion and are not graded based on the existing pharmacokinetic-pharmacodynamic (PKPD) studies. We describe here a potential new tool that could be used to grade the strength of evidence emanating from PKPD studies.
Areas covered: A scoring system was developed (GAPPS tool) to quantify the strength of each PK assessment and rate the studies quality in already published articles. GAPPS was evaluated by applying it to pediatric PKPD studies of antibiotics from the 2019 Essential Medicines List for children (EMLC), identified through a search of PubMed.
Expert opinion: Evidence for most antibiotic dose selection decisions was generally weak, coming from individual PK studies and lacked PKPD modeling and simulations. However, the quality of evidence appears to have improved over the last two decades.
Incorporating a formal grading system, such as GAPPS, into formulary development will provide a transparent tool to support decision-making in clinical practice and guideline development, and guide PKPD authors on study designs most likely to influence guidelines
Weakened magnetic braking as the origin of anomalously rapid rotation in old field stars
A knowledge of stellar ages is crucial for our understanding of many
astrophysical phenomena, and yet ages can be difficult to determine. As they
become older, stars lose mass and angular momentum, resulting in an observed
slowdown in surface rotation. The technique of 'gyrochronology' uses the
rotation period of a star to calculate its age. However, stars of known age
must be used for calibration, and, until recently, the approach was untested
for old stars (older than 1 gigayear, Gyr). Rotation periods are now known for
stars in an open cluster of intermediate age (NGC 6819; 2.5 Gyr old), and for
old field stars whose ages have been determined with asteroseismology. The data
for the cluster agree with previous period-age relations, but these relations
fail to describe the asteroseismic sample. Here we report stellar evolutionary
modelling, and confirm the presence of unexpectedly rapid rotation in stars
that are more evolved than the Sun. We demonstrate that models that incorporate
dramatically weakened magnetic braking for old stars can---unlike existing
models---reproduce both the asteroseismic and the cluster data. Our findings
might suggest a fundamental change in the nature of ageing stellar dynamos,
with the Sun being close to the critical transition to much weaker magnetized
winds. This weakened braking limits the diagnostic power of gyrochronology for
those stars that are more than halfway through their main-sequence lifetimes.Comment: 25 pages, 3 figures in main paper, 6 extended data figures, 1 table.
Published in Nature, January 2016. Please see https://youtu.be/O6HzYgP5uyc
for a video description of the resul
Tobacco Arp3 is localized to actin-nucleating sites in vivo
The polarity of actin is a central determinant of intracellular transport in plant cells. To visualize actin polarity in living plant cells, the tobacco homologue of the actin-related protein 3 (ARP3) was cloned and a fusion with the red fluorescent protein (RFP) was generated. Upon transient expression of these fusions in the tobacco cell line BY-2 (Nicotiana tabacum L. cv. Bright Yellow 2), punctate structures were observed near the nuclear envelope and in the cortical plasma. These dots could be shown to decorate actin filaments by expressing RFPâARP3 in a marker line, where actin was tagged by GFP (green fluorescent protein)âFABD (fimbrin actin-binding domain 2). When actin filaments were disrupted by latrunculin B or by prolonged cold treatment, and subsequently allowed to recover, the actin filaments reformed from the RFPâARP3 structures, that therefore represented actin nucleation sites. The intracellular distribution of these sites was followed during the formation of pluricellular files, and it was observed that the density of RFPâARP3 increased in the apex of the polarized, terminal cells of a file, whereas it was equally distributed in the central cells of a file. These findings are interpreted in terms of position-dependent differences of actin organization
Bone Marrow Stem Cell Treatment for Ischemic Heart Disease in Patients with No Option of Revascularization: A Systematic Review and Meta-Analysis
PMCID: PMC3686792This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Transformation of spin information into large electrical signals via carbon nanotubes
Spin electronics (spintronics) exploits the magnetic nature of the electron,
and is commercially exploited in the spin valves of disc-drive read heads.
There is currently widespread interest in using industrially relevant
semiconductors in new types of spintronic devices based on the manipulation of
spins injected into a semiconducting channel between a spin-polarized source
and drain. However, the transformation of spin information into large
electrical signals is limited by spin relaxation such that the magnetoresistive
signals are below 1%. We overcome this long standing problem in spintronics by
demonstrating large magnetoresistance effects of 61% at 5 K in devices where
the non-magnetic channel is a multiwall carbon nanotube that spans a 1.5 micron
gap between epitaxial electrodes of the highly spin polarized manganite
La0.7Sr0.3MnO3. This improvement arises because the spin lifetime in nanotubes
is long due the small spin-orbit coupling of carbon, because the high nanotube
Fermi velocity permits the carrier dwell time to not significantly exceed this
spin lifetime, because the manganite remains highly spin polarized up to the
manganite-nanotube interface, and because the interfacial barrier is of an
appropriate height. We support these latter statements regarding the interface
using density functional theory calculations. The success of our experiments
with such chemically and geometrically different materials should inspire
adventure in materials selection for some future spintronicsComment: Content highly modified. New title, text, conclusions, figures and
references. New author include
The APOKASC Catalog: An Asteroseismic and Spectroscopic Joint Survey of Targets in the Kepler Fields
We present the first APOKASC catalog of spectroscopic and asteroseismic
properties of 1916 red giants observed in the Kepler fields. The spectroscopic
parameters provided from the Apache Point Observatory Galactic Evolution
Experiment project are complemented with asteroseismic surface gravities,
masses, radii, and mean densities determined by members of the Kepler
Asteroseismology Science Consortium. We assess both random and systematic
sources of error and include a discussion of sample selection for giants in the
Kepler fields. Total uncertainties in the main catalog properties are of order
80 K in Teff , 0.06 dex in [M/H], 0.014 dex in log g, and 12% and 5% in mass
and radius, respectively; these reflect a combination of systematic and random
errors. Asteroseismic surface gravities are substantially more precise and
accurate than spectroscopic ones, and we find good agreement between their mean
values and the calibrated spectroscopic surface gravities. There are, however,
systematic underlying trends with Teff and log g. Our effective temperature
scale is between 0-200 K cooler than that expected from the Infrared Flux
Method, depending on the adopted extinction map, which provides evidence for a
lower value on average than that inferred for the Kepler Input Catalog (KIC).
We find a reasonable correspondence between the photometric KIC and
spectroscopic APOKASC metallicity scales, with increased dispersion in KIC
metallicities as the absolute metal abundance decreases, and offsets in Teff
and log g consistent with those derived in the literature. We present mean
fitting relations between APOKASC and KIC observables and discuss future
prospects, strengths, and limitations of the catalog data.Comment: 49 pages. ApJSupp, in press. Full machine-readable ascii files
available under ancillary data. Categories: Kepler targets, asteroseismology,
large spectroscopic survey
Predicting the detectability of oscillations in solar-type stars observed by Kepler
Asteroseismology of solar-type stars has an important part to play in the
exoplanet program of the NASA Kepler Mission. Precise and accurate inferences
on the stellar properties that are made possible by the seismic data allow very
tight constraints to be placed on the exoplanetary systems. Here, we outline
how to make an estimate of the detectability of solar-like oscillations in any
given Kepler target, using rough estimates of the temperature and radius, and
the Kepler apparent magnitude.Comment: 21 pages, 6 figures, accepted for publication Astrophysical Journa
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